Diagnostic Tests Using Urokinase During Myocardial Infarction 2001.12.23

Diagnostic Tests Using Urokinase During Myocardial Infarction 2001.12.23

PT (prothrombin time), TT (thrombin time), APTT (activated partial thromboplastin time), FIB (fibrinogen quantification)

1. PT 12–15 seconds; deviations of more than 3 seconds either upward or downward are diagnostically significant. Prolonged PT indicates liver disease, vitamin K deficiency, obstructive jaundice, DIC, or the use of anticoagulant medications. Shortened PT indicates hypercoagulability, acute myocardial infarction, cerebral embolism, thrombophlebitis, multiple myeloma, digitalis toxicity, or post-ether anesthesia.

2. TT 12–15 seconds; deviations of more than 3 seconds either upward or downward are diagnostically significant.

3. APTT (activated partial thromboplastin time) 30–50 seconds; deviations of 10 seconds either upward or downward are clinically significant.

4. FIB (fibrinogen quantification) 2–4 g/L; elevated levels indicate diabetes, acute myocardial infarction, cerebrovascular disease, atherosclerosis, hyperlipidemia, thrombophlebitis, acute infectious diseases, and liver disease. Decreased levels are seen in severe hepatitis.

5. 3P (plasma protamine paracoagulation test) Normal results are negative; positive results indicate the presence of thrombin in the blood, often seen during thrombolytic therapy.

6. FDP (fibrin degradation products) are markers of hyperfibrinolysis and should be checked during thrombolysis. Positive results are normal.