Non-Lipid-Lowering Effects of Statins 2002.3.28

Non-Lipid-Lowering Effects of Statins 2002.3.28

In coronary heart disease, the formation and rupture of atherosclerotic plaques are important factors in disease progression. However, before plaque formation, smooth muscle cells in the vascular endothelium already begin to synthesize fibrous caps, which is a manifestation of endothelial dysfunction. One study shows that statins have a direct effect on rabbit aortic strips and cultured endothelial cells, inducing a strong vasodilatory effect while simultaneously exerting a clear inhibitory effect on inflammatory processes. These effects are achieved by regulating smooth muscle cells (SMCs). Other studies have also confirmed that statins can reduce the number of giant cells and SMCs in atherosclerotic plaques. Recent research found that among 24 patients with carotid artery sclerosis causing insufficient cerebral blood supply, symptoms significantly improved after 3 months of statin treatment, while those who did not receive statins experienced worsening symptoms. In summary, statins not only lower lipids but also have a clear plaque-inhibiting effect, which is related to their advanced impact on vascular wall SMCs.