New uses of verapamil hydrochloride Isoptin —January 19, 1994

New uses of verapamil hydrochloride (Isoptin)—January 19, 1994

This drug is a calcium channel blocker, reducing the influx of calcium from outside the cell into the cell, thereby decreasing the excitability of the cardiac conduction system and the heart itself. It prolongs the atrioventricular node refractory period, reduces the amplitude of atrial action potentials, slows myocardial contraction, and lowers myocardial oxygen consumption. Given these mechanisms, the drug can treat various arrhythmias, but is absolutely contraindicated for bradycardia, heart failure, and cardiogenic shock. It should not be used concurrently with beta-blockers (such as propranolol). Recent findings indicate that this drug is effective for the following conditions: ① female neurosis; ② schizophrenia; ③ tardive dyskinesia; ④ mania; ⑤ acute biliary colic; ⑥ adult stuttering. Clinical dosage of Isoptin: usually 40 mg, three times daily, orally; average dosage is 80 mg, three times daily, orally; intravenous drip of 10 mg, either via small infusion or bolus, repeatable after half an hour.