Dopamine and Dobutamine on July 23, 1995

Dopamine and Dobutamine on July 23, 1995

The latter is a derivative of the former, and both have positive inotropic effects, thereby increasing cardiac output. Dopamine’s main function is to dilate visceral blood vessels and reduce peripheral vascular resistance, thus achieving a blood-pressure-raising effect. Both are available in injectable form, 10 mg per vial, usually administered at 20 mg mixed with 250 mL of Ringer’s solution, starting at 20 drops per minute and gradually increasing the drip rate. For those whose blood pressure does not rise significantly, the drip rate can be increased up to 100 drops. Dobutamine differs from dopamine in that it raises blood pressure without relying on endogenous norepinephrine.