Two Practical Tips, November 18, 1996

Two Practical Tips, November 18, 1996

1. In chronic renal failure, mannitol can prevent disease progression, but if ineffective, discontinue use and switch to furosemide. The dose of furosemide should be high, starting at 100 mg and increasing to 200 mg, administered intravenously twice daily. If the diuretic effect remains insufficient, continue increasing the dose; some patients may require up to 1,000 mg per day.

2. Systemic lupus erythematosus, while damaging the kidneys, liver, heart, blood vessels, nerves, and serous cavities, also significantly affects the blood coagulation mechanism and the clotting function of platelets (platelet quality). At such times, hemostatic drugs are not placebos. 6-Aminocaproic acid 6 g, hemostatic aminobenzoic acid 0.6 g (antifibrinolytic), hemostatic agent 4 g—all have a substantial effect on improving platelet quality. Consequently, clinically, the widely used and currently popular hemostatic agent is thrombin extracted from Brazilian pit viper venom, which can be administered intravenously, intramuscularly, or locally, with each vial containing 1 unit (ku), paired with a solvent vial. Generally, there are no adverse reactions, or only mild allergic reactions; if they occur, handle them according to standard procedures. Currently, there is no dedicated clinical study on the use of hemostatic agents in pregnant women.