New Injectable Antibiotic—Phosphomycin Sodium—January 31, 2000

New Injectable Antibiotic—Phosphomycin Sodium—January 31, 2000

Phosphomycin sodium is the latest broad-spectrum antibiotic, belonging to a separate class of antibiotics alongside previously marketed drugs such as soil, red, white, Qing, gold, and cephalosporins. This drug is effective against many current drug-resistant bacteria. Its effectiveness rates are as follows: influenza bacillus 100%; Salmonella 100%; Staphylococcus 99%; Streptococcus 80%. Its antibacterial spectrum is broader than β-lactam antibiotics and comparable to gentamicin. It is 100% effective against acute urinary tract infections, 90% against lung infections, 89% against intestinal infections, 100% against pharyngitis and tonsillitis, and 90% against gonorrhea. Each vial contains 2g, which is dissolved in saline solution; a maximum of 10 vials can be dissolved in 250mL, with 2–4 doses per day, ideally 4g each time. Since each 2g vial contains 0.64g of sodium salt, it is suitable for low-sodium patients, but for those with heart or kidney dysfunction, it must be administered slowly. A notable feature of this drug is that it can cross the blood-brain barrier, reaching concentrations of up to 50% in cerebrospinal fluid, without directly harming kidney function, and it can even reduce the toxicity of other drugs on the kidneys—for example, it can lessen the nephrotoxic effects of aminoglycosides.