Hematopoietic Stem Cell Transplantation HSCT 2000.10.13

Hematopoietic Stem Cell Transplantation (HSCT) 2000.10.13

Using high-dose radiation and chemotherapy to eliminate tumor cells in the body and block the disease mechanism, then transplanting autologous or allogeneic hematopoietic stem cells into the patient to restore blood formation or immune function. The procedure to achieve this goal is called hematopoietic stem cell transplantation. Initially, this method was only applied to leukemia and malignant lymphoma. In recent years, great progress has been made in its application to autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Post-transplant disease recurrence is the main reason for HSCT failure, and treating recurrence is a very difficult problem. The main causes of recurrence are chemotherapy resistance and tumor cell drug resistance. Using immunostimulants such as interleukin-2 and interferon concurrently with chemotherapy drugs can promote transplant success and reduce recurrence; however, postoperative use of hormones and chemotherapy drugs can reduce recurrence but may also lead to immune dysregulation and complications.