Professor Pei ZhengxueAcademic Profile

Pei Zhengxue Health Weibo, Volume 3

5. Ouyang Jun

Chapter 435

I often experience fatigue, soreness, and distension in the area between both knees and above the ankles, lasting for more than two years, with the calf being the most affected. What could be the cause, and how should I

From Pei Zhengxue Health Weibo, Volume 3 · Read time 1 min · Updated March 22, 2026

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  1. 5. Ouyang Jun

5. Ouyang Jun

I often experience fatigue, soreness, and distension in the area between both knees and above the ankles, lasting for more than two years, with the calf being the most affected. What could be the cause, and how should I care for and treat this condition?

A: Possible causes include: ① thiamine deficiency or riboflavin deficiency; ② calcium deficiency (only in the elderly); ③ peripheral neuritis; ④ peripheral vascular disease (arteriosclerosis in middle-aged and elderly patients).

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