1.1.5.1.5 Growth Factors

1.1.5.1.5 Growth Factors

These can promote blood cell generation and are products of genetic engineering, such as recombinant granulocyte–macrophage colony-stimulating factor (rGM-CSF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF), which can rapidly increase white blood cell counts. Research also shows that G-CSF, GM-CSF, and EPO are growth factors acting on later-stage progenitor cells; G-CSF and GM-CSF can increase the number of granulocytes and macrophages, thereby reducing the risk of infection, while EPO can increase hemoglobin levels and alleviate patient anemia. IL-3, SCF, and bFGF act on earlier-stage progenitor cells and stem cells, serving as broad-spectrum hematopoietic growth factors that enhance the effects of G-CSF, GM-CSF, and EPO. Therefore, hematopoietic factors hold great promise for clinical treatment of aplastic anemia.