2 Reflections and Prospects

2 Reflections and Prospects

After successful model establishment and 15 days of feeding, analysis of relevant indicators revealed that, as the dosage of Pei’s Shengxue Granules increased, immune-related indicators showed a clear upward trend; however, no obvious dose-dependent effect was observed among different dosage groups. This may suggest that most traditional Chinese medicines have little or no toxicity, or at least relatively low toxicity. It also implies that for patients in generally good condition, the dosage can be appropriately increased during clinical use. On the other hand, it could also indicate that excessively high doses of traditional Chinese medicines exceed the gastrointestinal load of mice, leading to a series of functional disturbances and even certain side effects. This underscores the importance of carefully controlling the dosage of traditional Chinese medicines, especially for critically ill patients, and calls for further research.

After the experiment concluded, analysis of relevant indicators showed no significant statistical differences between the medium- and high-dose groups of Pei’s Shengxue Granules and the Zhenqi Fuzheng Granules group, suggesting that Pei’s Shengxue Granules may be comparable to Zhenqi Fuzheng Granules in certain aspects of immune regulation, or perhaps requiring adjustments to its dosage to better maximize its therapeutic efficacy. This also points to the need for further exploration and research into the deeper scientific and clinical value of Pei’s Shengxue Granules, so that it can serve human health to the greatest extent possible.

As the immunological mechanisms underlying malignant tumors are gradually elucidated, research on the impact of traditional Chinese medicine on malignant tumor immunity is becoming increasingly active. By establishing animal models and setting up control groups, researchers are studying the effects of traditional Chinese medicine on the immune systems of malignant tumor model mice, progressively delving into molecular and genetic levels to uncover objective evidence supporting the use of traditional Chinese medicine in treating malignant tumors and regulating immune function. However, we must also recognize that experimental research on malignant tumors and studies of immunological objective indicators still lack standardization and systematic approaches, and that the application of modern immunological and genetic technologies lags behind the development of contemporary medicine. Therefore, in the field of malignant tumor experimentation, how to leverage modern immunological and genetic technologies to deepen research and explore the material basis and related mechanisms of traditional Chinese medicine in treating malignant tumors and regulating immune function will become a new challenge for researchers in traditional Chinese medicine.

Theoretical Basis and Level

Immune factors play a very important role in the occurrence and development of tumors. As research on traditional Chinese medicine in both clinical and experimental settings continues to deepen, scholars are gradually exploring the immune regulatory effects of traditional Chinese medicine in tumor treatment. Traditional Chinese medicine has conducted decades of clinical and experimental research on tumor treatment and achieved certain therapeutic effects. However, when it comes to confirming these effects—especially in terms of correcting immune abnormalities and eliminating immune factors that contribute to tumor development—there is still a lack of proven effective formulas. To address this issue, we have established tumor animal models and conducted experimental research. Below are Professor Pei Zhengxue’s insights on the understanding of malignant tumors in traditional Chinese medicine [13, 14]: