Research on Pei Zhengxue's Formulation Series

2 Reflections and Prospects

Chapter 265

Pei's Ruan Gan Xiao Pi Wan is an effective prescription for treating primary liver cancer, formulated by Professor Pei Zhengxue based on his extensive clinical experience. This formula combines strengthening the spleen a

From Research on Pei Zhengxue's Formulation Series · Read time 1 min · Updated March 22, 2026

Keywords方药研究, 实验研究, 配方资产, 转化沟通, 4.1.7 皂角刺

Section Index

  1. 2 Reflections and Prospects
  2. References
  3. Research on Pei Zhengxue's Series of Prescriptions
  4. Research on Pei Zhengxue’s Series of Formulas and Medicines
  5. Research on Pei Zhengxue’s Series of Formulas and Medicines
  6. Effects of Pei’s Soft Liver and Relieve Distention Pill on the Expression of P27 and Bcl-2 Proteins in H22 Transplanted Liver Cancer Tissue in Mice

2 Reflections and Prospects

Pei's Ruan Gan Xiao Pi Wan is an effective prescription for treating primary liver cancer, formulated by Professor Pei Zhengxue based on his extensive clinical experience. This formula combines strengthening the spleen and replenishing qi, activating blood circulation and removing blood stasis, softening hard masses and dispersing nodules, clearing heat and detoxifying—all in one. Over decades, Pei's Ruan Gan Xiao Pi Wan has achieved relatively satisfactory clinical outcomes in the treatment of liver cancer. The initiation of this research project was inspired by Professor Pei Zhengxue's more than forty years of clinical experience, fully embodying the idea that clinical experience guides experimental research and avoiding blind experimentation. In future studies, we will make full use of new achievements in modern science and technology to conduct in-depth research on the anti-tumor mechanisms of Pei's Ruan Gan Xiao Pi Wan, explore Pei Zhengxue's ideas and methods of integrating traditional Chinese and Western medicine for cancer prevention and treatment, and provide more detailed micro-level explanations for this clinical prescription.

References

[1] Liver Cancer Specialist Committee of the Chinese Anti-Cancer Association, Clinical Oncology Collaboration Committee of the Chinese Anti-Cancer Association, Hepatocellular Carcinoma Group of the Liver Disease Branch of the Chinese Medical Association. Expert Consensus on Standardized Diagnosis and Treatment of Primary Liver Cancer. Journal of Clinical Oncology, 2009, 14(3):259

[2] Outline of China's Cancer Prevention and Control Plan. China Tumor, 2004, 02:65–68

[3] Quan ZW, Wu K, Wang J, et al. Association of p53, p16, and Vascular Endothelial Growth Factor Protein Expressions with the Prognosis and Metastasis of Gallbladder Cancer [J]. J Am Coll Surg, 2001, 193(4):380–383

[4] Huang Guoxian, Zhang Bei, Zhang Yaqi, et al. Effects of Traditional Chinese Medicine on Liver Reserve Function After Interventional Treatment of Liver Cancer. Chinese Journal of Integrated Chinese and Western Medicine Digestive Diseases, 2003, 11(3):149–150

[5] Cai Yuwen, Xing Xiaojing, Wang Xu, et al. Effects of Spleen-Strengthening and Qi-Regulating Formulas on the Expression of p53 and bcl-2 Genes in the HepG2 Human Liver Cancer Cell Line. Chinese Journal of Integrated Chinese and Western Medicine Digestive Diseases, 2009, 17(4):211–213

[6] Wang Shaozhuo, Hong Lili. Clinical Observation on the Application of Modified Four Gentlemen Decoction After Interventional Treatment of Primary Liver Cancer. Tianjin Pharmacy, 2008, 20(1):34–35

[7] Wang Hainan. Progress in Pharmacological Research on Ginseng Saponins. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(11):1201–1206

[8] Yang Yungao, Chen Xianming, Wang Xueliang, et al. Life Science Research. Beijing: Beijing Science and Technology Press, 2005, 409–410

[9] Huang Tingrong, Fei Xinying, Yu Shanshan, et al. Effects of Diaphragm-Underneath Blood Stasis-Dispelling Decoction with Modifications on H22 Tumor-Bearing Mice with Liver Cancer. Chinese Journal of Integrated Chinese and Western Medicine, 2007, 15(5):326–328

[10] Huang Tingrong, Zhou Hong, Fei Xinying. Effects of Diaphragm-Underneath Blood Stasis-Dispelling Decoction with Modifications on the Regulation of bax, bcl-2, and P53 Gene Expression in Human Liver Cancer Cells. Journal of Integrated Chinese and Western Medicine Liver Diseases, 2008, 18(6):355–356, 366

[11] Huang Tingrong. Mechanism Study on the Anti-Liver Cancer Effects of Diaphragm-Underneath Blood Stasis-Dispelling Decoction with Modifications. Wuhan: Hubei College of Traditional Chinese Medicine, 2008

[12] Du Zhichun, Diao Fengsheng. Research on the Anti-Cancer and Anti-Metastasis Effects of Anti-Cancer and Anti-Transformation Decoction on Liver Cancer Lymphatic Metastasis and Its Impact on MMP-9 and CTL. Chinese Journal of Prevention and Treatment, 2008, 15(2):93–96

[13] Shim JS, Kim JH, Lee J, et al. Anti-Angiogenic Activity of a Homoisoflavanone from Cremastra appendiculata [J]. Planta Med, 2004, 70(2):171–173

[14] Li Fushan. Theoretical Discussion on Activating Blood Circulation and Removing Blood Stasis to Prevent Tumor Metastasis. Journal of Nanjing College of Traditional Chinese Medicine, 1993, 9:5–6

[15] Yao Shukun, Song Haicheng, Ding Xiurong, et al. Effects of Liver Tumor Oral Liquid on Peripheral Blood T Cell Subsets in Patients with Primary Liver Cancer [J]. Journal of Basic Traditional Chinese Medicine, 2004, 10(6):37–39

[16] Yao Shukun, Han Junling, Yin Fei. Research on the Preventive Effects of Liver Tumor Oral Liquid on Precancerous Lesions in Rats. Chinese Journal of Integrated Chinese and Western Medicine Digestive Diseases, 2000, 10(5):268–269

[17] Han Junling, Yao Shukun, Yin Fei. Effects of Liver Tumor Oral Liquid on Rat Liver Cancer bcl-2 and H-ras Genes. Hebei Academy of Sciences Journal, 2002, 12(2):22–25

[18] Cui Liu Fu, Yao Shukun, Song Haicheng, et al. Research on the Inhibition of SMMC-7721 Liver Cancer Cell Vascular Endothelial Growth Factor Expression by Liver Tumor Oral Liquid Containing Medicinal Serum. Journal of Basic Traditional Chinese Medicine, 2004, 10(5):50–52

[19] Lu Zaiying, Lu Nanshan. Internal Medicine. Beijing: People's Health Publishing House, 2008, 457–462

[20] Wang Hairong. Re-examination of the Relationship Between Primary Liver Cancer and Hepatitis. West China Medicine, 2000, (2):193–194

[21] Liu Rongzhen, Jiang Feng, Bian Jianchao, et al. Case-Control Study on the Relationship Between Three Types of Hepatitis Virus Infection and Liver Cancer. Chinese Public Health, 1999(5):402

[22] Yu Shunzhang. Epidemiological Study on Susceptibility Factors for Primary Liver Cancer in the Population. Practical Oncology Journal, 2001, (6):361–363

[23] Wang Shanshan, Jiang Pulin, Pang Hongxia, et al. Epidemiological Investigation of the Causes of Primary Liver Cancer in Guangzhou City. Chinese Journal of Epidemiology, 1997, (1):33–36

Research on Pei Zhengxue's Series of Prescriptions

[24] Yu Shunzhang, Zi Xiaolin, Chen Gang, et al. Case-Control Study on the Relationship Between Hepatitis Virus Infection and Liver Cancer in Four Regions of China. Chinese Journal of Epidemiology, 1993, 27(4):214–226

[25] Tu Wenwei, Wang Taicun. Relationship Between Children in High- and Low-Incidence Areas of Liver Cancer in Guangxi Consuming Aflatoxin B₁ and Excreting Aflatoxin M₁ in Urine. Chinese Journal of Epidemiology, 1997, 18(4):218–220

[26] Li Yuan, Su Jianjia, Cao Ji, et al. Using cDNA Array Technology to Study Gene Changes During the Process of Aflatoxin B₁ Inducing Tree Shrew Liver Cancer Formation. Chinese Journal of Liver Diseases, 2003, 11(2):96–99

[27] Pang Chunyan. Research on Microcystin-Induced Changes in P53 and P21 Gene Expression During the Process of Promoting Liver Cancer. Fujian: Fujian Medical University, 2004

[28] Zhang Zhumei, Bian Jianchao. Progress in Research on Alcohol Consumption and Liver Cancer. Chinese Journal of Epidemiology, 2002(6):477–479

[29] Tang Boming, Zhang Zhumei, Wang Qijun, et al. Case-Control Study on Alcohol Consumption and Liver Cancer. Practical Oncology Journal, 2002, 16(2):88–91

[30] Fang Jun, Liu Boqi, Zhang Qinghao, et al. Case-Control Study on the Relationship Between Smoking and Liver Cancer. Yanbian University Medical Journal, 2003(2):106–108

[31] Li Suping, Ding Jianhua, Wu Jianzhong, et al. Estimation of the Separation Ratio and Heritability of Liver Cancer in Taixing City. Journal of Cancer Prevention and Treatment, 2001, 8(6):570–572

[32] Meng Wei, Lu Hongyan, Cai Rulin, et al. Genetic Epidemiological Study on Primary Liver Cancer. Chinese Journal of Epidemiology, 2002(6):193–194

[33] Yao DF, Wu XH, Zhu Y, et al. Quantitative Analysis of Vascular Endothelial Growth Factor, Microvascular Density, and Their Clinicopathologic Features in Human Hepatocellular Carcinoma[J]. Hepatobiliary Pancreat Dis Int, 2005, 4(2):220–226

[34] Ferrara N, Henzel WJ. Pituitary Follicular Cells Secrete a Novel Heparin-Binding Growth Factor Specific for Vascular Endothelial Cells[J]. Biochem Biophys Res Commun, 1989, 161(2):851–858

[35] Huang GW, Yang LY, Yang JQ, et al. Correlation Between Epidermal Growth Factor and Overexpression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma[J]. Zhonghua Zhong Liu Za Zhi, 2002, 24(6):564–566. Chinese [36]Brown LF, Tognazzi K, Dvorak HF, et al. Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma[J]. Am J Pathol, 1996, 148(4):1065-1074

[37]Cao Senlin. Experimental study on the regulation of VEGF and Caspase-6 expression in mouse H22 transplanted hepatocellular carcinoma cells by Huaji Yigan Decoction. Dalian: Dalian Medical University, 2008

[38]von Marschall Z, Cramer T, Höcker M, et al. Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma[J]. Gut, 2001, 48(1):87-96

[39]Volpert OV, Dameron KM, Bouck N. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity[J]. Oncogene, 1997, 14(12):1495-1502

[40]Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression[J]. Cancer Res, 1995, 55(24):6161-6165

[41]Mauleon I, Lombard MN, Muñoz-Alonso MJ, et al. Kinetics of myc-max-mad gene expression during hepatocyte proliferation in vivo: Differential regulation of mad family and stress-mediated .252

Research on Pei Zhengxue’s Series of Formulas and Medicines

[42] Wu Zhiqun. The role of tumor suppressor gene p53 in the pathogenesis of primary liver cancer. Chinese Journal of Modern Medicine, 2008, 18(5): 592-594

[43] Sengupta S, Harris CC. P53: traffic cop at the crossroads of DNA repair and recombination [J]. Nat Rev Mol Cell Biol, 2005, 6(1): 44-55

[44] Attardi LD. The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models [J]. Mutat Res, 2005, 569(1-2): 145-157

[45] Cao ZX, Leng XY. The role of p53 mutation in carcinogenesis of hepatoma and its clinical significance [J]. Surgery of Western Medicine, 2000, (0): 130-133

[46] Nita ME, Alves VA, Carrilho FJ, et al. Molecular aspects of hepatic carcinogenesis [J]. Rev Inst Med Trop Sao Paulo, 2002, 44(1): 39-48

[47] Smela ME, Currier SS, Bailey EA, et al. The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis [J]. Carcinogenesis, 2001, 22(4): 535-545

[48] Li ZW, Wang ZM, Wu XP, et al. Expression levels of p53 and MVD correlate with clinical significance in hepatocellular carcinoma [J]. China Journal of Modern Medicine, 2004, 14(16): 64-72

[49] Lee YI, Han YJ, Lee SY, et al. Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249 [J]. Mol Cell Endocrinol, 2003, 203(1-2): 51-63

[50] The relationship between Ras and VEGF expression in hepatocellular carcinoma. Tumor Prevention and Treatment Research, 2002, 29(3): 187-188

[51] Li Haimin, Zhao Aizhi, Dou Kefeng. The significance of VEGF, p53 protein expression, and MVD in postoperative metastasis and recurrence of hepatocellular carcinoma. Chinese Journal of Modern Medicine, 2005, 15(8): 1223-1226

[52] Jian Zhixiang. Progress and prospects in the treatment of primary liver cancer. Practical Medicine Journal, 2007, 23(6): 773-774

[53] Peng Linji, Lu Daxiang. Research progress in hepatocellular carcinoma treatment. Chinese Gerontology Journal, 2009, 9(5): 628-631

[54] Fan Jia, Zhou Jian, Xu Jue, et al. Selection of indications for liver transplantation in hepatocellular carcinoma: Shanghai Fudan standards. Chinese Medical Journal, 2006, 86(18): 1227-1231

[55] Wulf J, Guckenberger M, Haedinger U, et al. Stereotactic radiotherapy of primary liver cancer and hepatic metastases [J]. Acta Oncol, 2006, 45(7): 838-847

[56] Méndez Romero A, Wunderink W, Hussain SM, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors—a single institution phase i-ii study [J]. Acta Oncol, 2006, 45(7): 831-837

[57] Nag S, DeHaan M, Scruggs G, et al. Long-term follow-up of patients of intrahepatic malignancies treated with iodine-125 brachytherapy [J]. Int J Radiat Oncol Biol Phys, 2006, 64(3): 736-744

[58] Chen Xiaoming, Luo Pengfei, Hu Jingling, et al. Delayed adverse reactions of the liver after transcatheter hepatic arterial lipiodol anticancer drug suspension and embolization for liver cancer. Cancer, 1994, 13(1): 50-53

[59] Guo Jia, Yang Jiamei, Wu Mengchao, et al. The significance of ultrasound-guided interventional anhydrous alcohol intratumoral injection treatment for liver cancer. Chinese Journal of Practical Surgery, 2001, 21(8): 494-495

Research on Pei Zhengxue’s Series of Formulas and Medicines

[60]Markolf H, Niemz. Translated by Zhang Zhenxi et al. Laser Tissue Interactions (Fundamentals and Applications)[M]. Xi'an: Xi'an Jiaotong University Press, 1999: 45-67

[61]Christophi C, Nikfarjam M, Malcontenti-Wilson C, et al. Long-term survival of patients with unresectable colorectal liver metastases treated by percutaneous interstitial laser thermotherapy[J]. World J Surg, 2004, 28(10): 987-994

[62]Seki S, Sakaguchi H, Kadoya H, et al. Laparoscopic microwave coagulation therapy for hepatocellular carcinoma[J]. Endoscopy, 2000, 32(8): 591-597

[63]Wu Mengchao, Chen Han, Shen Feng, et al. The minimally invasive concept in liver cancer treatment[J]. PLA Medical Journal, 2002, 27(2): 101-103

[64]Li YY, Sha WH, Zhou YJ, et al. Short and long term efficacy of high intensity focused ultrasound therapy for advanced hepatocellular carcinoma [J]. J Gastroenterol Hepatol, 2007, 22(12): 2148-2154

[65]Okamoto H, Ohigashi H, Nakamori S, et al. Reciprocal functions of liver tumor cells and endothelial cells. Involvement of endothelial cell migration and tumor proliferation at a primary site in distant metastasis[J]. Eur Surg Res, 2000, 32(6): 374-379

[66]Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis[J]. Cell, 1996, 86(3): 353-364

[67]Li Yikui. Methods of pharmacological experiments on traditional Chinese medicine[M]. Shanghai: Shanghai Science and Technology Press, 1991: 36

[68]Gorrin-Rivas MJ, Arii S, Mori A, et al. Implication of human macrophage metalloelastase and vascular endothelial growth factor gene expression in angiogenesis of hepatocellular carcinoma[J]. Ann Surg, 2000, 231(1): 67-73

[69]Wenming. The biology of vascular endothelial growth factor and its preliminary clinical applications[J]. Basic Medicine and Clinical, 2003, 23(5): 471-477

[70]Ding Anwei. Modern Traditional Chinese Medicine Clinical Handbook[M]. Nanjing: Jiangsu Science and Technology Press, 2000: 623

[71]Yang Yan, Chen Minzhu. The effect of astragaloside on hepatocellular carcinoma cell apoptosis and wtp53 gene expression[J]. Chinese Pharmacology Bulletin, 2001, 17(4): 447-451

[72]Shen Ziyin. Review and evaluation of the impact of traditional Chinese medicine on immune function[J]. Chinese Journal of Integrated Traditional and Western Medicine, 1992, 12(7): 443

[73]Li Ming, Tian Yongyun, Zhu Jie. Introduction to the clinical pharmacological research of astragalus[J]. Chinese Rural Medicine Journal, 2004, 11(3): 51

[74]Li Qi, Wang Yan, Fan Zhongze, et al. The effect of danshenone IIA and its nanoparticles on inducing hepatocellular carcinoma cell apoptosis and influencing the expression of p38MAPK and TGFβ-1 signaling proteins[J]. Tumor, 2008, 28(1): 8-12

[75]Fu Han, He Shuixiang, Xu Junli, et al. The effect of danshenone IIA on the expression of vascular endothelial growth factor in hepatocellular carcinoma cells[J]. Journal of Xi’an Jiaotong University (Medical Edition), 2009, 30(1): 115-118

[76]Xu Junli, He Shuixiang, Chen Jinghong, et al. The effect of danshen on the COX-2 expression in hepatocellular carcinoma SMMC-7721 cells[J]. World Chinese Digestive Journal, 2006, 14(14): 1352-1356

[77]Zhong Zhihong, Chen Wengui, Liu Yonghe, et al. The experimental study on the inhibitory effect of danshenone IIA on the growth of HepG2 cells and the induction of their apoptosis[J]. Journal of Central South University (Medical Edition), 2007, 32(3): 99-103

Research on Pei Zhengxue’s Series of Formulas and Medicines

[78] Li Zhizhong. In vitro study on the induction of apoptosis in human hepatocellular carcinoma cells HepG2 by danshenone IIA. Chongqing: Chongqing University, 2009

[79] Zheng Guocan, Li Zhiying. Experimental study on the antitumor effects and mechanisms of danshen. Practical Oncology Journal, 2005 (1): 33-35

[80] You J, Cui FD, Li QP, et al. A HPLC method for the analysis of germacrone in rabbit plasma and its application to a pharmacokinetic study of germacrone after administration of zedoary turmeric oil[J]. Chromatogr B Analyt Technol Biomed Life Sci, 2005, 823(2): 172-176

[81] Tang Yuan, Li Xiaohui. The anticancer effects and mechanisms of curcuma extract on the HepG2 hepatocellular carcinoma cell line. Chinese Pharmacology Bulletin, 2007, 23(6): 790-794

[82] Zhang Weibin, Tan Min, Xiao Gang, Hu Shaowei. The effect of curcuma oil on inducing apoptosis in mouse HepA hepatocellular carcinoma cells and its influence on bcl-2 protein expression. Modern Integrated Traditional and Western Medicine Journal, 2009, 18(4): 370-371

[83] Liang Chaohui, Zhang Weibin, Hu Shaowei. The study on the effect of curcuma oil on the original-site transplanted HepA hepatocellular carcinoma cells in mice. Shaanxi Traditional Chinese Medicine, 2009 (1): 107-109 [84] Wang Xinmei, Yan Meiyan. Research Progress on the Biological Activity of Algal Polysaccharides. Qilu Pharmaceutical Affairs, 2009, 28(14): 228-231

[85] Liu Kewei, Liang Hui, Gao Hua. Effects of Algal Terpenoids on IL-6 and TNF-α Levels in H22 Mice. Chinese Journal of Marine Drugs, 2009, 28(1): 9-12

[86] Yang Wenhao, Lü Junhua, Xu Shihai. Experimental Study on the Inhibitory Effects of Algal Extracts A1 and A2 on the Proliferation of Hepatocellular Carcinoma and Lung Adenocarcinoma Cells. Liaoning Journal of Traditional Chinese Medicine, 2005, 32(4): 371-372

[87] Li Rong, Xiao Shunhan, Liu Minghua. New Advances in Research on the Antitumor Effects of Soapnut Spines. Sichuan Journal of Physiological Sciences, 2009, 31(1): 29-31

[88] Long Ling, Geng Guoxia, Li Qingwang. The Inhibitory Effect of Soapnut Spines on the Growth of U14 Cervical Cancer in Mice and Their Impact on Proliferating Cell Nuclear Antigen and p53 Expression. Chinese Journal of Traditional Chinese Medicine, 2006, 31(2): 150-153

[89] Cao Xuefeng, Guo Cheng, Zhang Junping et al. Regulatory Effects of Total Flavonoids from Soapnut Spines on Mouse Cytokines. Time Honored National Medicine and Pharmacy, 2002, 13(10): 588-589

[90] Liu Minghua, Huang Xingwu, Xiao Shunhan. Effects of Soapnut Spine Extracts on Tumor Growth and Cytokines in Tumor-Bearing Mice. Cancer Prevention and Treatment Research, 2009, 36(5): 365-367

[91] Qu Jingfeng, Zhang Shaohua. Traditional Chinese Medicine. Beijing: Science Press, 1994: 981

[92] Zhang Shuo, Song Yanqin, Zhou San et al. Regulation of Target Genes by Total Flavonoids from White Flower Snake Tongue Herb in Human Hepatocellular Carcinoma Cells. World Journal of Digestive Diseases of Chinese Overseas, 2007, 15(10): 1060-1066

[93] Meng Qingyu, Lü Xiufang, Ren Fengyun. Effects of White Flower Snake Tongue Herb Polysaccharides on Gene Expression in Bel7402 Cells. Chinese Journal of Gerontology, 2008, 28(13): 1271-1272

[94] Zhang Shuo, Song Yanqin, Zhou San et al. Inhibitory Effects of Total Flavonoids from White Flower Snake Tongue Herb on Hepatocellular Carcinoma Both In Vivo and In Vitro, as Well as Their Influence on the Proliferation Cycle, Apoptosis, and Immune Environment of Transplanted H22 Hepatocellular Carcinoma Cells in Mice. World Journal of Digestive Diseases of Chinese Overseas, 2007, 15(12): 1347-1352

[95] Hu Ling, Wang Hongqi, Cheng Xiaoyan. Effects of White Flower Snake Tongue Herb on Heat Shock Protein 70 Expression in H22 Hepatocellular Carcinoma Cells. Journal of Guangzhou University of Traditional Chinese Medicine, 2007, 24(1): 44-46

[96] Dai Zhijun, Wang Xijing, Ji Zongzheng et al. Synergistic and Detoxifying Effects of Sembranchium Extract on Chemotherapy for H22 Hepatocellular Carcinoma in Tumor-Bearing Mice. Journal of Integrated Chinese and Western Medicine, 2008, 6(7): 720-724


[97] Dai Zhijun, Wang Xijing, Xue Qian et al. Effects of Sembranchium Medicinal Serum on Apoptosis and Mitochondrial Membrane Potential in H22 Hepatocellular Carcinoma Cells. Journal of Integrated Chinese and Western Medicine, 2008, (8): 821-826

[98] Wei Pengya, Pu Hongqin, Wei Xing et al. Induction of Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells by Sembranchium Extract and Its Impact on the Expression of Apoptosis-Related Proteins. Time Honored National Medicine and Pharmacy, 2007, (12): 3020-3022

[99] Lin Jingming, Liu Yu, Luo Rongcheng. Study on the Inhibition of Proliferation of Human Hepatocellular Carcinoma QGY-7701 Cells by Sembranchium. Journal of Southern Medical University, 2006, (5): 591-593

[100] Pei Zhengxue. Collection of Pei Zhengxue’s Medical Experience. Lanzhou: Gansu Science and Technology Press, 2003: 94-106

[101] He Qiuzao, Wu Housheng. Medical Immunology (Second Edition). Shanghai: Shanghai Medical University Press, 1997: 25

[102] Wu Xianzhong, Gao Jinliang. Modern Research on Spleen Deficiency Syndrome. Tianjin: Tianjin Science and Technology Translation Publishing Company, 1992: 255-256

[103] Wu Zhiqun. The Role of the Tumor Suppressor Gene p53 in the Pathogenesis of Primary Hepatocellular Carcinoma. Chinese Journal of Modern Medicine, 2008, (5): 592-594

[104] Greenblatt MS, Bennett WP, Hollstein M, et al. Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis[J]. Cancer Res, 1994, 54(54): 4855-4878

[105] Shi Aixue. Current Status and Trends of p53 Gene Therapy for Malignant Tumors. Southwest National Defense Medicine, 2004, 14(1): 101-102

[106] Bode AM, Dong Z. Post-Translational Modification of P53 in Tumorigenesis[J]. Nat Rev Cancer, 2004, 4(10): 793-805

[107] Harris CC. Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies[J]. J Natl Cancer Inst, 1996, 88(20): 1442-1455

[108] Yoshiji H, Yoshii J, Ikenaka Y, et al. Suppression of the Renin-Angiotensin System Attenuates Vascular Endothelial Growth Factor-Mediated Tumor Development and Angiogenesis in Murine Hepatocellular Carcinoma Cells[J]. Int J Oncol, 2002, 20(6): 1227-1231

[109] Xu Changtai, Yan Xiaojun. p53 Anti-Cancer Gene and Digestive System Tumors. World Journal of Digestive Diseases of Chinese Overseas, 1999, 7(1): 77

Research on Pei Zhengxue’s Series of Formulas and Medicines

Effects of Pei’s Soft Liver and Relieve Distention Pill on the Expression of P27 and Bcl-2 Proteins in H22 Transplanted Liver Cancer Tissue in Mice

Liu Yuan

This chapter is prepared for online research and reading; for external materials, please align with original publications and the review process.