ABSTRACT

ABSTRACT

Objective: To analyze effect that Lanzhou prescription and chemotherapy drugs which treat chronic myeloid leukemia by clinical observation, and compare with the group of chemotherapy drugs.

Research on Pei Zhengxue’s Series of Formulas and Medicines

with peripheral blood, bone marrow, and changes in clinical symptoms and signs, to explore Pei Lanzhou side to improve bone marrow hematopoietic function, and improve the effect and mechanism of the clinical symptoms. Its full scientific theoretical basis for the widely used in clinical. Methods: Thirty patients were randomly grouped into control group (only western chemotherapy) and treatment group (Lanzhou side western medicine chemotherapy). Patients were enrolled, age, gender, disease duration, and other general information, there was no significant difference between the 3 months of treatment, clinical observations of patients with blood, bone marrow, as well as clinical symptoms and signs, and two groups of patients to compare the efficacy analysis.

Results: (1) By t-test (p < 0.05), the disappearance time of the treatment group compared with the control group was significantly shortened. The rate of disappearance of the X² test (p < 0.05), indicating that treatment group disappearance rate than the control group also improved significantly.

(2) Before and after treatment, the treatment group and control group, Hb, WBC, the PLT change was no significant difference (p > 0.05).

(3) Before and after treatment, the treatment group compared with the control of malignant bone marrow hyperplasia reduce the two groups was statistically significant (p < 0.05).

Conclusion: This clinical study, that the western drug chemotherapy more advantage of Integrative Medicine to improve the symptoms of chronic myeloid leukemia patients with normal bone marrow hematopoietic function than a simple show that Pei Lanzhou side can enhance the bone marrow of normal hematopoietic function, and for Western chemotherapy, treatment of CML synergy-oriented prescriptions provide a basis for future clinical application.

Keyword: chronic myeloid leukemia

Preface

Chronic myeloid leukemia (chronic myeloid leukemia, CML) is a malignant clonal disease caused by the malignant proliferation of hematopoietic stem cells, characterized primarily by abnormal proliferation of immature and late-stage granulocytic cells. Its clinical features include markedly elevated peripheral white blood cell counts with immaturity, and typically prominent splenomegaly. The disease is generally divided into chronic phase (CP), accelerated phase (AP), and blast crisis phase (BP). The disease course is slow, with most patients dying from acute transformation. The annual incidence of CML is 1 per 100,000, accounting for about 15%–20% of adult leukemias; the incidence increases with age, peaking between 50 and 60 years, with a male-to-female ratio of approximately 1.4:1. In China, the annual incidence is 0.36 per 100,000, second only to acute myeloid leukemia and acute lymphoblastic leukemia, ranking third among leukemias, and showing a yearly increasing trend.

The exact etiology of chronic myeloid leukemia remains unclear, possibly related to ionizing radiation, viral infections, chemical substances, genetic factors, or gene/protein mutations. A characteristic feature of this disease is the Philadelphia (Ph) chromosome, namely the t(9;22)(q34;q11) chromosomal translocation. Molecular biological markers are the abnormal alterations in the bcr-abl fusion gene formed by this chromosomal translocation. In recent years, the diagnosis and treatment of CML have made substantial progress based on previous advances.

Research on Pei Zhengxue's Series of Formulas and Medications

"The Lanzhou Formula" is one of the effective prescriptions for treating hematological diseases, summarized by Professor Pei Zhengxue through many years of clinical practice. The Lanzhou Formula takes strengthening the spleen and tonifying the kidney, supporting the body's vital energy and consolidating its foundation as the main principle, while additionally incorporating drugs such as Semen Strychni, Rheum palmatum, and Hirudo to clear heat and detoxify, activate blood circulation and remove blood stasis, thus integrating the methods of reinforcing the body and expelling pathogenic factors into one formula—primarily focusing on tonification, supplemented by purging, achieving both tonification and purging simultaneously.

Chronic myeloid leukemia falls under categories such as "Xulao," "Jiju," and "Zhengjia" in traditional Chinese medicine. TCM believes that the onset of this disease is mainly due to insufficient congenital endowment or postnatal malnutrition leading to deficiency of kidney essence and inadequate nourishment of the zang-fu organs; external invasion of the six pathogenic factors and internal injury from the seven emotions cause disturbances in qi and blood functions and dysfunction of the zang-fu organs. When liver qi becomes stagnant and the stagnation persists, qi stagnation leads to blood stasis, which accumulates internally over time to form masses; dietary imbalance, excessive consumption of rich, sweet, and alcoholic foods damages the spleen and stomach, causing spleen deficiency and impaired transportation and distribution of body fluids, resulting in internal dampness and turbidity that condense into accumulations, where phlegm and qi clash, blood flow is obstructed, and blood stasis forms; irregular living habits and failure to regulate cold and heat lead to external pathogen invasion, damaging the zang-fu organs and injuring blood and marrow, causing qi deficiency and blood depletion, with pathogenic factors clashing with nutritive blood and blocking the meridians, eventually forming accumulations and developing into this disease. Pathogenic toxins accumulate internally, and prolonged accumulation generates heat, which dries up qi and blood, eventually forming knots; pathogenic toxins clash with qi and blood, remaining stagnant and coalescing into masses; pathogenic toxins accumulate and transform into heat, disturbing the nutritive blood and burning the yang meridians, forcing blood to flow erratically. Therefore, clinically patients often present with fever, fatigue, skin ecchymosis, gingival bleeding, nasal bleeding, abdominal distension or pain, and enlargement of the spleen, liver, or lymph nodes. These etiological mechanisms often coexist and interact with each other. In summary, the disease affects the bone marrow and blood, involving all five zang-fu organs, resulting from the mutual clash of qi, blood, phlegm, food, and pathogenic toxins; the basic pathogenesis is deficiency of vital energy and excess of pathogenic factors, with deficiency referring to insufficiency of qi, blood, and yin, and excess referring to the accumulation of phlegm, blood stasis, and toxins.

"Western medical diagnosis, TCM syndrome differentiation, TCM as the mainstay, Western medicine as an adjunct" is the academic viewpoint proposed by Mr. Pei more than thirty years ago regarding the integration of TCM and Western medicine in clinical treatment. This viewpoint has been widely recognized by the domestic TCM-Western medicine integration community and is known as the "Sixteen-Character Principle." This principle not only provides universal guidance for clinical work but also offers new ideas for the current development of TCM scholarship. Western medical diagnosis uses advanced modern medical examination techniques to clarify the diagnosis of the disease; based on Western medical diagnosis, TCM syndrome differentiation is conducted under specific conditions, greatly improving its accuracy. After the Western medical diagnosis clarifies the condition, TCM syndrome differentiation naturally combines the Western medical microscopic, localized, and pathogen-centered perspectives with the TCM macroscopic, holistic, and organism-response-centered perspectives, complementing each other's shortcomings while leveraging their respective strengths, thereby providing a more precise basis for subsequent medication. With TCM as the mainstay and Western medicine as an adjunct, the therapeutic role of TCM formulas is emphasized, aiming at the development of TCM. When necessary, Western medicine can be used as an adjunct to further enhance efficacy.

Rationale for the Study