4.3 Professor Pei Zhengxue’s Experience in Treating Chronic Myeloid Leukemia

4.3 Professor Pei Zhengxue’s Experience in Treating Chronic Myeloid Leukemia

Professor Pei Zhengxue, in his clinical practice, primarily employs the “Lanzhou Formula” to address deficiency, while adding ingredients such as Strychnos nux-vomica, Rheum palmatum, Hirudo, Hedyotis diffusa, Scutellaria barbata, Sparganium stoloniferum, and Curcuma wenyujin to clear heat, detoxify, soften hard masses, and disperse nodules when treating excess conditions. He also prescribes Qingdai capsules, achieving excellent therapeutic outcomes. The “Lanzhou Formula” serves as Professor Pei’s principal prescription for treating leukemia; since being officially named at the 1974 National Hematology Conference in Suzhou, it has been widely used across China with remarkable efficacy. Over several decades, Professor Pei has employed this formula, with modifications as needed, to treat hundreds of leukemia patients, most of whom have experienced varying degrees of remission, with some cases achieving complete cure [25]. This formula is derived from a combination and modification of six prescriptions: Liuwei Dihuang Tang, Shengmai San, Ganmai Dazao Tang, and Guizhi Tang. Among these, Lu Dangshen, Taizi Shen, Renshen Xu, and Beishashen strongly tonify middle qi, serving as the primary herbs for reinforcing vital energy and consolidating the root; Dangshen, Mai Dong, and Wu Research on Pei Zhengxue’s Series of Formulas and Medications

Schisandra chinensis is part of Shengmai San, benefiting qi and nourishing yin; Rehmannia glutinosa, Cornus officinalis, and Dioscorea opposita constitute the three tonifying components of Liuwei Dihuang Tang, symbolizing kidney-tonifying and blood-nourishing effects. Notably, large doses of Cornus officinalis can improve bone marrow hematopoietic function, clearly illustrating the principle that “the kidneys govern bones, bones store marrow, and marrow and blood share the same origin.” Licorice, Jujube, and Floating Wheat comprise Ganmai Dazao Tang, which nourishes the heart and calms the spirit—when the heart and spirit are stable, blood is stable as well. Guizhi and Bai Shao harmonize Ying and Wei. Together, these herbs tonify the kidneys and replenish essence, strengthen the spleen and boost qi, just as Zhang Jingyue stated: “When qi is deficient due to lack of essence, one should tonify essence to transform it into qi; when essence is deficient due to lack of qi, one should tonify qi to generate essence.” (From “Jingyue Quanshu · Xulao”) Therefore, the brilliance of this formula lies in simultaneously tonifying the spleen and kidneys. If the spleen is enlarged, add Sparganium stoloniferum, Curcuma wenyujin, Laminaria japonica, Kelp, Rheum palmatum, Hirudo, and Strychnos nux-vomica; if there is fever, add Lonicera japonica, Forsythia suspensa, Taraxacum mongolicum, Patrinia scabiosaefolia, Qinggu San, and Qinghao Biejia Tang. Clinical adjustments are made according to individual symptoms, yielding excellent results.

Conclusion