Recent Status of Lipid-Lowering Drugs, December 25, 1977

Recent Status of Lipid-Lowering Drugs, December 25, 1977

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The main causes of atherosclerosis are lipid metabolism disorders, abnormal coagulation mechanisms, endocrine disorders, and hemodynamic changes. A common feature is elevated levels of cholesterol, triglycerides, and low-density lipoprotein in the blood, known as hyperlipidemia. Drugs that can lower blood lipids are called lipid-lowering agents. In 1973, following a national symposium on coronary heart disease, the therapeutic effects of traditional Chinese herbs opened a new avenue for research into lipid-lowering drugs. Over the past decade, commonly used lipid-lowering Chinese herbs in China include:

1. Polygonum multiflorum: Contains 4% lecithin and rhein.

2. Alisma orientale: Its lipid-lowering effect is stronger than hawthorn, with a 72% efficacy rate against triglycerides.

3. Cassia seed: Its lipid-lowering effect surpasses that of Yishouning and linoleic acid, with a 98% effectiveness rate within six weeks.

4. Polygonum cuspidatum: Contains pterostilbene glycoside, with an 89% efficiency in lowering cholesterol.

5. Ganoderma lucidum: In addition to its obvious lipid-lowering effect, it is also effective for arrhythmias and hypertension.

6. Hawthorn: Contains hawthorn saponins, flavonoids, and triterpenoid acids.

7. Water buffalo horn: Has lipid-lowering effects, but may cause side effects such as loose stools, abdominal bloating, and stomach discomfort.

8. Paulownia leaf: Has lipid-lowering effects, containing flavonoid glycosides and coumarins.

9. Lotus leaf: Has a 79.1% effectiveness rate in lowering cholesterol.