Nuclear Factor κB https://baike.baidu.com/item/%E6%A0%B8%E5%9B%A0%E5%AD%90%CE%BAB/5958209 NF-κB and Its Relationship with Nephritis as of June 27, 2001

Nuclear Factor κB (NF-κB) and Its Relationship with Nephritis as of June 27, 2001

<!-- translated-chunk:49/63 -->

NF-κB was initially discovered in the nucleus of B cells; it is a dimeric protein that is sensitive to specific cytokines and stimuli. These specific cytokines and stimuli can cause cellular damage and halt nuclear cell growth, under which conditions NF-κB becomes activated. Once activated, NF-κB can regulate genes associated with the aforementioned factors. Recent studies have demonstrated that NF-κB exhibits significant anti-inflammatory, anti-allergic, and anti-apoptotic effects; therefore, NF-κB expression has become one of the most important inflammatory transcription factors. Many drugs also inhibit inflammatory responses by blocking or suppressing NF-κB activity, thereby achieving anti-inflammatory and immunosuppressive effects. During apoptosis, NF-κB is likewise activated; these two functions are independent of each other. Some have suggested that NF-κB may possess certain anti-apoptotic properties, but current evidence is insufficient, and no definitive conclusion has been reached.