Classification of acute leukemia national hematological standards established in 1980, revised in 1986 —January 26, 1994

Classification of acute leukemia (national hematological standards established in 1980, revised in 1986)—January 26, 1994

Any case with ≥30% blast cells in the bone marrow can be diagnosed.

1. Acute lymphoblastic leukemia (ALL)

Based on cell morphology, it can be divided into three types: L1, L2, and L3. L1: predominantly small cells; L2: predominantly large cells with irregular nuclei; L3: predominantly large cells with relatively regular nuclei.

2. Acute non-lymphocytic leukemia (ANLL)

M1: undifferentiated promyelocytes, with promyelocytes accounting for ≥90%.

M2: partially differentiated promyelocytes, with promyelocytes ≥30% but <90%.

M3: early promyelocytic leukemia, with early promyelocytes >30%.

① Large granules (in the cytoplasm).

② Small granules.

M4: granulocytic-monocytic leukemia:

① Primarily proliferating blasts and early promyelocytes, with monocytes and monocytic cells >20%.

② Primarily proliferating early monocytes, with blasts and early promyelocytes >20%.

③ Monocytic cells and granulocytic lineage both >30%.

④ Acidophilic granules are large and round, deeply stained, accounting for 1%–30%.

M5: monocytic leukemia: ① Undifferentiated type, with over 80% monocytes; ② Partially differentiated type, with less than 80% monocytes and over 30% early monocytes.

M6: erythroleukemia.

M7: megakaryocytic leukemia.