Impact of Bone Marrow Proliferation Degree on Diagnosis of Aplastic Anemia Based on Initial Bone Marrow Examination 1994.2.9

Impact of Bone Marrow Proliferation Degree on Diagnosis of Aplastic Anemia Based on Initial Bone Marrow Examination 1994.2.9

Out of 541 cases of aplastic anemia, 271 were classified as bone marrow hyperplasia and 270 as hypoplasia. A comparison was made between the two groups regarding transformation, recovery, and survival rates. It was found that in the hypoplastic group: 60% remained unchanged, 34% progressed to active hyperplasia, 3% experienced repeated changes, and 3% developed leukemia. In the hyperplastic group, 44% remained unchanged, 44% progressed to hypoplasia, 9.3% experienced repeated changes, and 2.7% developed leukemia. The hypoplastic group had a clinical recovery rate of 15.9%, while the hyperplastic group had 14.6%. Regarding survival rates, the hypoplastic group’s 1-year, 5-year, and 10-year survival rates were 70.43%, 57.66%, and 51.51%, respectively—all lower than the hyperplastic group’s 86.7%, 71.24%, and 63.34%. Statistical analysis showed significant differences.