Application of Procaine Intravenous Infusion in Upper Gastrointestinal Massive Bleeding September 21, 1994

Application of Procaine Intravenous Infusion in Upper Gastrointestinal Massive Bleeding September 21, 1994

This drug has low toxicity, is metabolized in the liver, and excreted by the kidneys. Some say patients with liver disease should use it with caution, but for patients with massive esophageal vein bleeding, appropriate intravenous infusion of this drug has three main effects: ① crossing the blood-brain barrier to achieve sedation; ② mild anesthesia of the mesentery, greatly reducing intestinal peristalsis; ③ lowering the sensitivity of the gastric mucosa to stimuli, thereby inhibiting bleeding.

The usual concentration is 0.04%–0.08%, meaning adding 2mL of 2% procaine to every 500mL of 5% sugar saline, (2% procaine 2mL contains 0.04g, so adding it to 100mL makes it 0.04%, adding 5 vials to 500mL also makes it 0.04%, and adding 10 vials makes it 0.08%). This concentration is 0.02% lower than Vishnyakov’s intravenous blockade concentration of 0.1%. Clinical trials have confirmed that this concentration is relatively safe, with no side effects.