Procaine Infusion Relieves Acute Renal Colic February 17, 1995

Procaine Infusion Relieves Acute Renal Colic February 17, 1995

Procaine has been used clinically as an anesthetic for a long time. Because it stabilizes nerve cell membranes and reduces their permeability, when nerve impulses arrive, sodium and potassium ions cannot enter or exit the cells, severely limiting the cell’s ability to depolarize and generate action potentials, thus relieving spasms. Additionally, after intravenous injection, this drug can cross the blood-brain barrier, blocking the stimulus from the lesion to the central nervous system, causing vasodilation and increased renal blood flow, thereby lowering blood pressure and promoting diuresis. Thus, this drug can treat renal edema, stroke, asthma, allergic purpura, acute cholecystitis, renal colic, and other conditions. Overall, its main function is to relieve spasms. The dosage and rate are 3.2–4.2mg per minute, meaning adding 5 vials (2mL each) of 2% procaine to 500mL of saline. The usual rate is to complete the infusion in 100 minutes, i.e., 4mg per minute.