Hyperlipidemia and Lipoprotein Disorder—July 8, 1997

Hyperlipidemia and Lipoprotein Disorder—July 8, 1997

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Hyperlipidemia refers to elevated levels of cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) in the blood, along with decreased levels of high-density lipoprotein (HDL). The normal range for TC is 2.8–6 mmol/L, for TG is 0.45–1.36 mmol/L, and LDL, also known as β-lipoprotein, while HDL, or α-lipoprotein, are both associated with coronary heart disease: the former shows a positive correlation with the incidence of coronary heart disease, whereas the latter shows a negative correlation. Pure hyperlipidemia does not exist; both TC and TG must be bound to a certain amount of protein to remain suspended in the serum. Therefore, hyperlipidemia is essentially lipoproteinemia. According to WHO guidelines, lipoproteinemia is classified into five types: I, II, III, IV, and V. Isolated elevation of cholesterol typically falls under type II, while isolated elevation of TG usually falls under type IV. Types I, III, and V are relatively rare in China, accounting for only about 10% of all cases of hyperlipidemia, including a large number of familial hyperlipidemias. Familial hyperlipidemia is characterized by yellowish warts appearing on the face and subcutaneously. Type IV accounts for approximately 60%, while type II accounts for about 40%; type II is further divided into IIa and IIb, each comprising roughly 20%. Treatment for hyperlipidemia: a diet rich in legumes has a significant effect on lowering cholesterol but little effect on TG. Mung bean powder has a clear lipid-lowering effect; vitamin C also significantly lowers lipids, reducing both cholesterol and triglycerides, and can alleviate angina pectoris and myocardial infarction. Jiangzhiping is a compound preparation containing antipyrine, with 75 mg of antipyrine, 0.5 mg of nandrolone, 30 mg of niacin, 10 mg of heparin, and 5 mg of vitamin B6, effective for both type II and type IV. Maishu and Xinmaining have similar effects, with an 83% lipid-lowering rate. Traditional Chinese medicines such as Salvia miltiorrhiza, hawthorn, Artemisia capillaris, Alisma orientalis, Cassia seed, Panax notoginseng, Polygonum cuspidatum, Polygonum multiflorum, seaweed, and tea tree root all have some lipid-lowering effect.