II. Alkaline Supplement Formula

II. Alkaline Supplement Formula

5% NaHCO₃ (ml) = (50 – CO₂-P) × 0.5 × body weight (kg). For an adult weighing 50 kg, an increase of 2 units in CO₂-P requires 50 ml; an increase of 1 unit in CO₂-P requires 25 ml, and 250 ml can raise CO₂-P by 10 units.

New Insights into Hypertension and Coronary Heart Disease, April 1999

Historically, the threshold for hypertension was considered to be a systolic blood pressure of 140 mmHg and a diastolic blood pressure of 90 mmHg. According to the Chinese Journal of Internal Medicine (March 1999), a blood pressure of 139 mmHg systolic and 82.6 mmHg diastolic was considered concerning; obesity serves as a key factor in the development of hypertension, while diet and emotional state are critical preconditions for hypertension progression. Traditional understandings of hypertension focused primarily on lipid levels, blood viscosity, and sustained diastolic pressure. However, current research suggests that, in addition to lipid levels, blood glucose, blood viscosity, and diastolic pressure, an elevated systolic blood pressure is equally important. Clinically, whether in men or women, and regardless of age, the threshold for hypertension should be set at 139 mmHg. Of course, another crucial factor is the presence of complications affecting target organs such as the heart, brain, kidneys, retina, and peripheral vessels.

Overview of Prostaglandin Research, April 1999

When the skin surface is damaged, the body partially secretes prostaglandins, leading to four pathological changes: redness, heat, swelling, and pain. Aspirin can inhibit the secretion of prostaglandins, thereby alleviating local symptoms. In the 1930s, GolGPatl and Enlel discovered a substance in human semen that had both hypotensive and uterotonic effects. At the time, it was believed that this substance was produced by the prostate gland, so it was named prostaglandin (PG). By the 1960s, biochemical studies around the world revealed that PG was not exclusively produced by the prostate but was widely present throughout the body, acting as a powerful biological agent in various organs and tissues. Subsequently, a series of prostaglandins—including PGE and PGD—were synthesized. In the mid-1970s, researchers discovered that platelets and blood vessel walls could respectively synthesize two opposing prostaglandin compounds: ① Thromboxane A2 (TXA2); ② Prostacyclin (PGL2). From then on, research on PG gained momentum worldwide, earning recognition as one of the major milestones in international medical history during the 20th century. PG is primarily released locally, where it exerts its effects—this is one of the distinguishing characteristics of PG compared to other endocrine hormones.

PG acts as a local regulator of cellular functions, with regulation mediated through neurotransmitters and neural reflexes. Although PGs produced by different tissues share similar structures, their actions vary greatly. Each organ and tissue produces PGs with unique functions, and these PGs often work together to promote or counteract each other. Therefore, the effects of PG should be understood on a case-by-case basis, rather than being generalized.

1. Obstetrics and Gynecology: PGE is a potent stimulant for the pregnant uterus, making it useful in induced abortions, labor induction, labor augmentation, and contraception. Particularly in contraception, PGE has sparked great hope among people.
2. Cardiology: Since thromboxane A2 (TXA2) and prostacyclin (PGL2) possess opposite properties, maintaining the integrity and patency of blood vessels, it has been found that the levels of PGL2 in the serum of hypertensive patients are reduced. Animal experiments have demonstrated that PGL2 has a strong vasodilatory effect. Clinical trials have confirmed the hypotensive effects of PGL2. Meanwhile, the vasodilatory effects of PGL2 have also been clinically proven—they can relieve angina pectoris and protect myocardial tissue in patients who have experienced myocardial infarction. Brain infarction is thought to be caused by increased TXA2 and decreased PGL2; TXA2 has an extremely short half-life, transforming into TXB2 in just 30 seconds. Consequently, higher concentrations of TXB2 often correlate with lower concentrations of PGL2, making it more likely for brain infarction to occur. Thus, PGL2 can be used to treat brain infarction.
3. Respiratory Medicine: PGE is widely present in the bronchi and lungs. PGE and PGE2 have strong vasodilatory effects, while PGF has the opposite effect. Asthma patients often exhibit higher PGF levels than healthy individuals, and the effects of PCE are 5–100 times greater than those of isopropylate, with longer duration. PCE has also shown clear therapeutic efficacy in the treatment of ARDS.
4. Digestive System: In the stomach, PG can reduce the activity of Hp, decrease gastric acid secretion, and either strengthen or weaken intestinal peristalsis depending on the individual’s condition. In summary, PG plays a role in regulating the digestive tract’s functions in a way that promotes healing.

Major Insights into Hematological Disorders, April 1999

In March of Jiyou, Qiao Dong, a patient with aplastic anemia, suddenly developed jaundice and hepatitis, with positive HBSAg. He was promptly treated with Xiao Chaihu combined with Sanhuang, Yin Chen Hao, Dan, Qi, Dang, Shao, Qin, Bai, Wu Xiao, and other herbs. His jaundice quickly subsided, liver function returned to normal, and his condition improved. Simultaneously, his three-line cell counts rose to normal levels. Over the past decade, his three-line cell counts had never reached such ideal levels. This child had been suffering from aplastic anemia since the age of six, and I had been treating him consistently—first with kidney-tonifying formulas, kidney-tonifying and spleen-strengthening formulas, and spleen-strengthening formulas. My overall experience showed that strengthening the spleen was less effective than tonifying the kidneys. Although effective over the past decade, we had never achieved such remarkable results (HGB 13.8 g, RBC 4.6 million, WBC 4500, PLT 60,000). This year, I treated a patient with liver disease combined with gastric ulcer bleeding. Using the method of “soothing the liver,” his hemoglobin levels rose very rapidly, reaching as high as 16.8 g. Looking back, 20 years ago, when I treated Engineer Qian’s leukemia with the Jinche Danqi Tang formula—soothing the liver and nourishing the liver—was highly effective. From this experience, I concluded that the “soothing the liver and nourishing the liver” approach to treating aplastic anemia is a truly effective method. For more than 30 years, people have debated over whether to strengthen the spleen or tonify the kidneys in the treatment of aplastic anemia. I proposed that the “soothing the liver” approach has truly emerged as a new and promising option. In the future, clinical practice should further validate this approach.

Microcirculatory Dysfunction of the Gastric Mucosa in Portal Hypertension, May 1999

According to the Microcirculation Journal (January 1999), patients with portal hypertension often exhibit obvious congestion, edema, tortuous and dilated veins in the gastric mucosa, focal thickening of the mucosa, diffuse dilation of capillaries, and cellular exudation—but inflammatory changes are relatively rare, setting them apart from typical ulcers and gastritis. At the same time, the gastric mucosal secretory function increases, and gastric acid levels tend to rise. As a result, patients often experience abdominal pain, abdominal distension, loss of appetite, vomiting, and loose stools.

Introduction to Several Western Medications, May 1999

1. Metoclopramide and Ranitidine: H2-receptor antagonists with strong antacid effects. They are commonly used not only for gastric and duodenal ulcers but also for chronic gastritis, HBG (liver cirrhosis), and gastrointestinal bleeding. Both medications can be employed in these conditions. Metoclopramide is administered at 0.2 g twice daily; Ranitidine is administered at 0.15 g twice daily.
2. 654-2 (Belladonna alkaloid): 10 mg per vial, with effects similar to atropine, but with toxic side effects that are only 1/20 of atropine’s. First invented by Professor Yang Guodong in China, this medication is highly effective in treating infectious shock, with doses up to 20 mg per vial, repeated every 10 minutes. Typically, a dose of 20 mg is mixed with 250 ml of NS, which can treat chronic gastrointestinal bleeding and low blood pressure, as well as treat bradycardia, bronchial asthma, and pain associated with pancreatic and biliary diseases, including gastric colic.
3. Panaximin: 25 mg, vasodilator, used to treat angina pectoris. Recent reports suggest that this medication can dilate renal arterioles and increase blood flow in patients with chronic renal failure.

Current Status of Rheumatic Fever, May 1999

Rheumatic fever is an autoimmune disorder caused by Group A Streptococcus type I, which can lead to fever, arthritis, and myocarditis. Since the 1960s, the incidence of rheumatic fever has declined significantly worldwide. Some foreign scholars once believed that this disease was on the verge of eradication. However, since the outbreak of rheumatic fever in Salt Lake City, USA, in the 1980s, reports of rising cases have continued to emerge around the globe. In China, the incidence of rheumatic fever has also been steadily increasing since the 1990s. Currently, the diagnostic criteria for rheumatic fever still follow the standards established in the 1960s, relying on methods such as erythrocyte sedimentation rate and C-reactive protein (CRP). Recently, serum albumin (mucin) and glycoprotein electrophoresis—comparing to erythrocyte sedimentation rate and CRP—have proven to be more sensitive. Complement C levels begin to change as early as the day following the onset of rheumatic fever.

Traditional Chinese Medicine Treatment of Fungal Vaginitis, May 1999

1. Sitz Baths with Herbal Infusions: Originally, I used four herbs—Ku Shen, She Chong Zi, Ming Fang, and Huang Bo—to perform sit baths for treating vaginal itching and vulvar discomfort. Recently, a comprehensive report published in the Chinese Medical Journal (February 1999) by Comrade Zhang Zongfang of Beijing China-Japan Friendship Hospital suggested adding Tu Fu Ling, Bai Xian Pi, Di Fu Zi, Bai Bu, Zǐ Cao, Yin Chen Hao, and other herbs.
2. Powdered and Granular Formulations: These are external applications; in addition to the above herbs, you can also add Xiong Huang, Bing Pian, Er Cha, Wu Bei Zi, Xue Jie, and Qing Fen.
3. Oral Formulas: Use Longdan Cao, Bai Hua She She Cao, Ku Shen, Bai Xian Pi, Di Fu Zi, Huang Bo, Huang Qin, Huang Lian, Ye Hua Ju, and Longdan Xie Gam Tang.
4. Clinical Diagnosis via Ultrasound, May 1999

In 1958, Donalda and others developed the world’s first ultrasound scanner. Since then, the technology has advanced rapidly, with continuous improvements to the instruments. Ultrasound has opened up new possibilities for modern medicine. When people sing, their sound waves have frequencies between 16 and 20 kHz; sound waves above 20 kHz are ultrasonic waves, which the human ear cannot hear—but they can propagate through the human body (solid matter). The speed at which sound waves travel through the body depends on the density of the tissue; the denser the tissue, the faster the wave travels. Reflections from the interface between two tissues can be projected onto a screen using an ultrasound scanner, giving ultrasound diagnostic significance. Ultrasound is most effective for diagnosing the liver, gallbladder, spleen, kidneys, and uterus.

Liver Diagnosis

1. Hepatitis: During acute hepatitis, the liver area may become swollen, with reduced echogenicity within the liver, while the walls of the portal vein show relatively enhanced echogenicity, forming multiple small signs. Chronic hepatitis often presents with enhanced echogenicity (slightly) or even normalization of echogenicity; in general, diffuse enhancement of echogenic points or bands is characteristic of chronic liver disease. Ultrasound diagnosis of hepatitis is non-specific; accurate diagnosis requires combining clinical findings with laboratory tests.
2. Fatty Liver: Due to fat deposition, the liver shows widespread enhancement of echogenicity, with dark areas in the deeper parts of the liver, and weakened or unclear echoes in the hepatic vessels—these are hallmarks of fatty liver.
3. Liver Cirrhosis: ① The liver surface appears uneven, with bright spots and bright patches inside, primarily concentrated in the anterior portion of the liver, while the posterior portion shows attenuated dark areas; ② The walls of the portal vein become thicker, with an expanded lumen; later, the hepatic vein may open; ③ The spleen becomes enlarged, with a thickness exceeding 4.0 cm; ④ Ascites develops. Patients with liver cirrhosis often experience enlargement of the hepatic lobe and atrophy of the right lobe.
4. Portal Hypertension: ① When the portal vein diameter exceeds 1.4 cm, portal hypertension may develop; ② Splenomegaly occurs; ③ Ascites develops; ④ Collateral circulation is established, such as the reopening of the umbilical vein, dilation of the gastric coronary vein, and communication between the splenic and gastric veins.
5. Portal Obstruction: A strong echo or isoechoic mass may be visible in the portal vein, and its location can be pinpointed. The portal vein loses its normal shape, with sponge-like collateral branches surrounding it—these are veins resulting from the expansion of collateral circulation.
6. Buddchiani Syndrome: Changes caused by obstruction of the hepatic vein or inferior vena cava. The hepatic vein or inferior vena cava is narrowed proximally, while its distal portion expands, leading to ascites and enlargement of the hepatic lobe.
7. Differences Between Liver Cysts and Abscesses: The former are often thin, while the latter are often thick.
8. Stress Ulcers, June 1999

Patients experiencing extreme exhaustion, cachexia, advanced cancer, or high fever are most susceptible to stress ulcers. These ulcers can lead to massive gastrointestinal bleeding, spreading rapidly throughout the entire gastrointestinal tract and ultimately causing death. Recently, several cases of massive hemorrhage were reported at the Integrated Medicine Department of the Provincial Cancer Hospital—two cases of liver cancer, one case of ovarian cancer, two cases of liver cirrhosis, and one case of subhepatic liver disease—all of whom were almost invariably accompanied by stress ulcers. These ulcers are part of a systemic response, not localized vessel rupture; therefore, attempting to locate the source of bleeding is inaccurate! Attempting to stop the bleeding with a three-cavity, two-bag catheter is also incorrect! Attempting to stop the bleeding surgically is likewise flawed! Western medicine can treat the underlying disease, provide systemic support, use hemostatic drugs, and administer large volumes of blood transfusion. Traditional Chinese medicine, however, uses theories of blood heat excess and qi deficiency failing to regulate blood flow to treat the condition—using formulas such as Da Huang, Huang Lian, Huang Qin, Sheng Ozu, Rou Gui, Hua Rui Shi, and Han San Qi. These herbs can be ground into powder and taken orally, or they can be decocted and divided for administration. Additionally, the Western medicine Methyldopa (intravenous infusion) is also commonly used, as this medication can neutralize and reduce gastric acid levels.

Thrombotic Thrombocytopenic Purpura—Hemolytic Uremic Syndrome (TTP-HUS), June 1999

In advanced stages of malignant tumors, in addition to the aforementioned conditions such as exhaustion, cachexia, DIC, and stress ulcers, this condition can also occur. The clinical manifestations of TTP-HUS include: ① a severe reduction in platelet count; ② hemolytic anemia (increased indirect bilirubin levels); severe anemia, where blood transfusions fail to elevate HGB, and smears reveal fragmented red blood cells; ③ elevated urea nitrogen levels, with Pro+ to ++++ in urine, along with tubules and red blood cells; ④ high fever and infection, accompanied by widespread skin hemorrhages. This condition is difficult to distinguish from DIC; checking the prothrombin time, coagulation time, and the 3P test can help differentiate between the two.

The Concept of Psychosomatic Diseases, June 1999

Psychosomatic diseases, also known as psychophysiological disorders, are closely linked to the psychological factors of the human body, with organic changes in the body’s organs reflecting the profound impact of psychological factors on disease occurrence, progression, outcome, and prognosis. Psychological factors are closely tied to an individual’s living environment, social factors, changes in status, and emotional fluctuations. Today, it is widely recognized that psychosomatic diseases include hypertension, cardiovascular disease, cerebrovascular disease, diabetes, peptic ulcers, bronchial asthma, rheumatoid arthritis, neurodermatitis, and others. Yet, doctors often focus solely on the disease itself when treating patients, neglecting psychological and social factors—this is a fatal flaw in modern medicine. Traditional Chinese medicine had already proposed the concepts of “right qi resides within, and evil cannot invade” and “when evil gathers, qi must be deficient” as early as 2000 years ago. The Suwen chapter “The Great Essentials of True Truth” states: “If righteous qi is stored within, evil cannot take hold.” Task output rules: Translate this markdown block from Chinese to English. Preserve markdown markers, links, and formatting. Keep headings and list structure unchanged. Return only the translated block.

Input: 论》并提出了人身十二脏与时节、七情、六欲之关系。总之人与自然、

社会相统一，即所谓之天人合一论。

瘧症之治疗 1999.6.24

中医谓此证乃"痿而不用也""大筋软短，小筋弛长，弛长为痿，

软短为拘"。此病与现代医学之多发性神经炎、神经根炎、进行性肌

营养不良症、重症肌无力、小儿麻痹、上行性脊髓炎、癔病等类似，余

治疗此病常用之方如下：①黄芪、当归、制乳没、圆肉、山药、胡桃肉、

马钱子、鹿角胶、土鳖虫，此为张锡纯振痿汤。②桃仁、红花、当归、川

芎、赤芍、生地、秦艽、川楝子、牛膝、姜虫、全蝎、侧柏叶、木瓜、伸筋

草。（赵炳南氏经验方）③生石膏20g,寒水石20g、紫石英20g、白石英

20g、生龙牡各15g、滑石20g、桂枝10g、干姜6g、大黄6g、生地12g、当归

10g、牛膝10g、木瓜10g、秦艽10g、威灵仙10g。（风引汤《金匮要略》）

④桂枝、牛膝、附子、香附、胆星、乌头、马钱子、郁金、甘草、当归、川

芎、赤芍、半夏、陈皮、莪术、厚朴。（先父经验方）⑤生龙牡、炒枣仁、

生苡仁、木瓜、萆薢、白芍、甘草、大云、龙眼肉、当归、菟丝子、杜仲。

（先父经验方）⑥威灵仙、丹皮、生地、山萸、山药、丹参、茯苓、泽泻、乌梅、花粉、天冬、清风藤、海风藤、络石藤、鸡血藤、巴戟天、黄芪。

⑦黄芪、桂枝、白芍、甘草、生姜、大枣、细辛、木通、麻黄、附子。

出血干细胞移植的临床应用 1999.7.17

出血干细胞的应用始于20世纪60年代后期，80年代始有较大

发展，我国血液病专家在这方面曾做出过重大贡献。出血干细胞的

移植分为自体移植及同种异体基因移植，根据干细胞之来源不同

分为骨髓干细胞移植和外周血干细胞移植。国内北京医科大学陆

道培院士最早开展了异基因骨髓移植治疗白血病之工作。目前已积

累400例，每年以100例速度向前发展。90年代以来国内一些单位

尚开展了异基因外周血干细胞移植，同样取得了明显疗效。自体造

血干细胞的移植国内自80年代开始，已完成了3500例，每年以300

例速度增长。自体造血干细胞之移植，虽然缺乏抗白血病之作用，

但因无须他人作供体，客观上可使白血病患者病死率降低，因而亦

不失其在临床推广之意义。最近在美、英、法、日等国相继建立了脐

血库，利用脐血库之供血为500余例患者进行异体基因移植，取得

了可喜之成绩，国内近期亦有成功的报告。自体干细胞之移植的主

要困惑是复发率高，近年来资料报告，移植前的体内外净化对减少

复发有一定作用。

几个经验方的论述 1999.8.7

1.己卯六月，余在荟萃堂专家门诊部治一紫癜肾患者，尿蛋

白+++，尿潜血+++，余以下方治之，凡7剂，尿蛋白减至+，尿潜血

（～），此方之组成为：柴胡10g、防风12g、当归10g、乌梅4枚、川芎6g、赤芍10g、生地12g、桃仁10g、红花6g、侧柏叶10g、野菊花10g、地肤子10g、甘草6g、仙鹤草15g、紫草10g、茜草10g、车前草10g、丹参10g。按：上方中桃红四物丹，专门治紫癜；胡风归梅；侧柏野地生四草均为治

疗紫癜之专方，用此治疗紫癜肾产生了明显疗效，其中之道理引人

深思。

2.己卯四月，余治疗一类风湿性关节炎之患者采用：五加皮

10g、生苡仁30g、牛膝10g、破故纸10g、骨碎补10g、薄荷4g、羌独活

15g、海风藤15g、秦艽10g、青风藤10g、何首乌10g、寻骨风12g、白芍

15g、甘6g、桂枝10g、川草乌各15g(先煎1小时）、马钱子1个（油

炸），服上方后患者谓："7剂药解除了10年顽疾，真神方也。"鉴于此，

余认为此方与桂枝芍药知母汤可谓治疗风湿性、类风湿性关节炎之

姊妹方，亦可用于其他自身免疫性疾患。

3.己卯五月，余治血小板减少性紫癜二例，例一为陕西病儿

李某，例二为兰州病者刘某，前者之血小板2万，经治疗后上升至

5.2万；后者之血小板持续不升，在1万～3万间徘徊，曾在兰医一

院住院治疗，未见明显疗效，经治疗上升至12万。用方：仙鹤草

20g、大枣4枚、生苡仁15g、赤小豆15g、黄柏6g、山栀子10g、甘草

6g、牡蛎15g、益母草15g、丹皮6g、丹参10g、连翘15g,合裴氏升血

颗粒服用。

慢性肺部疾患之呼吸衰竭 1999.8.9

慢性肺部疾患发生急性呼吸衰竭，通常由于阻塞性气道通气障

碍，此种情况通常有两种病理变化：

1.蓝色肿胀：肺的损害在很大程度上局限于气道，病人在很大

程度上以缺氧及高二氧化碳为特点，此时肺组织因缺氧后呈现蓝色

肿胀，治疗以高浓度给氧和镇静剂为最佳。

2.红色肿胀：肺的损害主要系肺气肿，气管阻塞较少，以呼吸困

难为主，呼吸阻塞不著，CO2分压大于6.4mmHg,因肺部表现以淤血

为主，故呈粉红色肿胀。

呼吸衰竭之治疗：①给02；②抗菌素；③支气管扩张剂：舒喘宁、

氨茶碱等；④呼吸中枢兴奋剂：可拉明1～2.5g间断给药，可静滴入，

吗二苯吡酮是可用之药，用法同可拉明。

呼吸衰竭之并发症 1999.8.10

呼吸衰竭时，肺的换气功能与通气功能障碍伴pH值下降，引起

下列五方面之病理变化：

1.全身毛细血管之痉挛，DIC,心衰，肾衰。

2.高碳酸血症，呼吸性酸中毒，肺性脑病。

3.代谢障碍：酸性代谢产物之堆积，酸中毒（代谢性）昏迷。

4.电解质之紊乱：细胞外K+增多，细胞内Na+增多。前者引致心

律失常、房颤，后者引致细胞水肿、脑水肿。

5.胃酸增多，应激溃疡，消化道出血。

综上所述，呼吸衰竭为疾病临危之表现，通常抢救不力，则上述五方面接踵而至，对生命之威胁堪称大焉，其实休克之晚期也是上

述表现之五方面。

休克的诊断及治疗 1999.8.12

①P>100次／分；②四肢冰冷，颜面苍白潮湿；③胸骨指压阳性（再充血时间＞2秒）；④皮肤出现花纹；⑤尿量减少；⑥收缩压＜80mmHg、脉压<20mmHg；⑦血压较原来平均血压低于30%者。凡具

备①②③④项中之2项或⑤⑥⑦三项中的1项则可确诊。

休克之治疗：积极抢救，力争在24小时内脱离休克状态，否则呼

吸衰竭、肾衰、代谢障碍、电解质紊乱、重感染会接踵而至，病情则向

不可逆转之状态进行。

近代之监测手段有：①中心静脉压、肺毛细血管楔压之测定：前

者系通过周围静脉内插管，送至接近右心房之腔静脉内；后者则是

采用气囊漂浮心导管。②动脉压监：测动脉穿刺插管直接测出脉腔

内压，同时利用插管取血，检试血气分析、生化指标。③放置尿管记

录出入量，留取标本化验检测。

慢性肾炎治疗---一得1999.8.30

乙卯夏，余治疗兰州科学院王某，慢性肾炎2年，尿蛋白持

续++～+++，曾有尿血、管型、高血压、浮肿，服济生肾气、桂枝茯苓、

益肾、苏梗、蝉衣、益母草，凡60剂，尿蛋白曾转为阴性，但因感冒复

发，尿蛋白增至+++，再服上方未见明显进步。余思之补肾日久，有

损脾胃，中气不足则致肾气无复，此时此刻正如李东恒所说"补肾莫

若健脾"，余以杷山黄菟汤合苏梗、蝉蜕、益母草，7剂，蛋白消至++，

再服之蛋白消至"+"。余于上方加石葶白茵大皂金、公英败酱加防

风，7剂则蛋白全消矣！此例之治验说明慢性肾炎之治疗在补肾疗法

持续一段后，若疗效徘徊，则宜改服补脾方：杷山合剂、石苇、葶苈

子、白芷、茵陈、大黄、皂角刺。

门冬氨酸钾镁的临床应用 1999.10.11

本剂又名潘南丁，其剂型有针剂、片剂两种。针剂：10ml安瓿，内

含门冬氨酸镁0.4g、门冬氨酸钾0.452g,通常以20～50ml加入250～

500ml5%葡萄糖中静滴，每日1次，10～15天为一疗程，急性心梗之

病人可用10ml稀释于5%葡萄糖中20ml静脉推注，每日可达2次。片

剂：内含0.14g门冬氨酸镁及0.158g门冬氨酸钾，2片，Tid,PO。

本品之主要治疗对象为心律失常，对各种心律失常均有效，最

有效者为心肌炎、洋地黄中毒、预激、低钾等引致之各种心律不齐，

疗效100%,此外对冠心、高心、心脏病引致之心律不齐，疗效亦在

85%以上。心律失常中较有效者心房纤颤、室早、阵发性心动过速。

本品尚可治疗难治性心衰。

镁与消化病 1999.10.12

急性坏死性肠炎、肝硬化、溃疡性结肠炎等均可引致低镁，低镁

反过来可引起消化道功能之改变。低钾、低钙、低镁之情况可在诸种

消化道疾病中出现，以肝硬化、腹泻、呕吐、胆囊及胰腺疾患为大量

缺镁之疾病。总之凡消化道疾患皆见缺镁之症候，缺镁症候之最主

要症状为乏力、纳差、精神不振。治疗此症可用潘南丁静滴，亦可用

硫酸镁，急则静滴、慢则口服，然口服硫酸镁口感差，味极苦，难以下

咽。近来国外生产出了口味较好之镁制剂，可广泛应用之。

笔胰腺炎与胆道蛔虫 1999.10.15

己卯秋，患者王某，女，20岁，1月前曾患急性胰腺炎，在本科服

中药胆胰合剂，消炎，止痛，扩胆治疗，病情好转。1日前又复疼痛，但

系阵发性疼痛，向上钻顶感明显，余断之曰胆道蛔虫，于胆胰合证方

中加乌梅6枚、槟榔10g、桂枝10g、细辛3g,水煎服，又以芒硝10g分次

冲服，痛大减，大便于次日畅通，患者痊愈出院。盖胆道蛔虫症乃中

医之厥阴证也，《伤寒论》326条曰："厥阴之为病消渴，气上撞心，心

中痛热，饥而不食，食则吐蛔，下之利不止。"《伤寒论》338条曰："蛔

厥者，其人当吐蛔，今病者静而复时烦，此为脏寒，蛔上入其膈故烦，

须臾复止，得食而呕又烦者，蛔闻食臭出也。蛔厥者，乌梅丸主之。"

乌梅丸：乌梅10枚、黄连10g、黄柏6g、干姜6g、附片6g、细辛3g、桂枝

10g。此例用药遵此旨，故愈也。

腹型偏头痛 1999.11.24

腹型偏头痛之主要症状是反复发作之腹痛、恶心、呕吐，一般情

况良好，65%之患者（儿科病）有偏头痛之家族史。此病纯属副交感

神经兴奋征候，西医以普奈洛尔、赛庚啶治疗之；中医以吴茱萸汤治

之。

某部长下肢浮肿之治疗 1999.11.26

下肢肿胀2月余，曾在省人民医院诊断为下肢静脉炎，经CT、

ECT、多普勒未见静脉栓塞及炎症。求余诊疗，余以下肢静脉炎之诊

断给当川留灵合剂、四水合剂无效；查该患者血压偏低，又复以补中

益气汤治疗亦无效；此后患者出现少腹胀满、下肢浮肿，经用普瑞博

斯亦未见疗效。后经B超检查见子宫多个肌瘤，下腹腔少量积液，西

医诊断结核性腹膜炎，但查结核菌素实验（一）。余始诊之为盆腔淤血

综合征，影响下肢静脉之回流，乃拟：桂枝、白芍、丹皮、桃仁、乌药、

川楝子、郁金、茯苓、元胡、大腹皮、姜黄、木香、檀香、沉香、大黄、陈

皮、当归、大云、汉三七3g分冲、水蛭10g分冲、山甲6g、王不留行10g,

水煎服。同时服泻火冲剂与古圣Ⅱ号，始效。

慢性肾炎治验 1999.11.27

己卯初冬，余在荟萃堂治一慢性肾炎患者，曾在兰医二院住院2

月余，尿中血球++++，蛋白++，纹丝未动。余诊之，血压130/95mmHg,

浮肿，尚有典型之心前区疼痛感，余给予宽胸、冠心宁、古圣Ⅱ、消风

除湿，另拟一处方如下：瓜蒌6g、薤白10g、半夏6g、赤芍15g、党参

10g、麦冬10g、五味子10g、川芎10g、红花6g、降香10g、丹参20g、汉三

七3g(分冲）、水蛭10g(分冲）、血余炭10g、阿胶10g(烊）。上方服7剂，

病者觉全身舒畅，浮肿消散，尿中血球仅为+。此病之治疗令人深思，

瓜蒌薤白半夏合冠Ⅱ、汉三七、水蛭、党参、麦冬、五味子，同时口服

消风除湿、古圣I、冠心宁，有如此明显之疗效，令人振奋。前因胆胰

合证方治疗再障及血小板减少性紫癜获得良效。后者治心而愈肾；

前者治肝而生血，正说明心肾相交，肝血同源之内涵矣。

两个抗风湿病药 1999.12.1

1.尼氟灭酸（NigeumicAcid):为非甾体消炎镇痛药，并具有消

肿作用，毒性小、副作用不大，不引起钠水潴留，可用于老年患者。除

用于各种关节疼痛外尚可用于上呼吸道炎症、鼻窦炎及扁桃体炎、

滑膜炎等；对支气管炎及肺部炎症亦有较好的疗效。胃病患者及血

象低者禁服。25mg,Tid,po。

2.瑞培林（Rpeonynin):复方保太松0.125g、氨基比林0.125g、安

替林0.125g,因而此药乃一复合制剂，胃病患者及血象低者均不能

使用。

消炎正痛药随感 1999.12.1

甾体是一化合物之基本结构，广泛存在于机体组织及细胞中，

尤其是激素及代谢产物中之某一成分均与甾体相关，消炎止痛药长

期以来分成下列四类：①水杨酸类；②氨基比林类（吡唑酮类）；③氨替匹林类（苯胺类）；④非甾体类，此类之主要代表为消炎痛（吲哚美

辛）、布洛芬、尼氟灭酸。消炎痛25mg,布洛芬0.2g,尼氟灭酸25mg,每日3次，饭后服。鉴于甾体类药物如肾上腺皮质醇类虽有强大之解热

镇痛作用，但却有诸如向心性肥胖、严重依赖性等副作用，故有"非

甾体"清热止痛药之称谓。但非甾体清热止痛药之重大缺陷是对胃

肠道之伤害，时下药界正在研究，试图解决这一问题。

正痛西药概述 1999.12.3

西药之止痛药大体分为四类：①水杨酸类：阿斯匹林；②苯胺

类：安替匹林；③吡唑酮类：氨基比林；④非甾体类：消炎痛（吲哚美

辛）、布洛芬、灭酸（甲灭酸、氯灭酸、氟灭酸）。除此外，尚有鸦片制

剂，如度冷丁、强痛定、可待因等；中药提纯品有高乌甲素（乌头）、颅

痛定（元胡）等。

所谓非甾体止痛药系与醛固酮类如强的松、地塞米松等相区别

之标志词。甾体为机体所有内分泌酶、激素之基本组成结构，肾上腺

皮质激素即以此为结构之基础，鉴于此类药物广泛应用于临床，而

且去痛作用相当显著，但又有明显之副作用，诸如钠水潴留、向心性

肥胖等。由于该药应用之历史较为悠久，副作用之较大，讳药忌医者

大有人在，故消炎痛、布洛芬、灭酸等上市后为了争取市场，减少患

者之疑虑，特别标明"非甾体类消炎止痛药"。其实非甾体类止痛药

何止此类？阿司匹林、安替匹林、氨基比林、高乌甲素、颅痛定等均为

非甾体类。岂是仅消炎痛类耳。布洛芬0.2g,Tid,其缓释片为芬必得

300mg,Tid,PO,为当前非甾体止痛药之代表。

他汀类制剂之临床应用 1999.12.3

他汀类为时下问世之新型去脂药。《中国医药论坛报》670期谓

长期服用，阿托伐他汀与冠状血管成形术（PTCA)进行对照，口服组

之心血管危险发生率仅为13%,成形术组为21%,说明服药组较手

术组在减少危险发生率方面，具有明显之疗效。余3年前患冠心病，

血黏度明显高于常人，TG:3.1mmol/L,经服用舒降之，每日1次，每次 10mg, take vitamin C simultaneously, 100mg each time, three times daily. After six months of medication, all symptoms have disappeared, with significant relief from chest tightness and palpitations. Blood lipid levels are normal, and blood viscosity has also returned to normal.

Chronic Pancreatitis and Fatty Liver - December 5, 1999

Chronic pancreatitis is quite common. Patients often experience upper left abdominal pain that worsens after consuming oily foods, meat, or eggs, radiating to the lower back, left chest, or around the navel. This condition is frequently associated with cholecystitis and gallstones. Clinically, it is often diagnosed based on elevated serum and urine amylase levels; however, most patients' amylase levels return to normal within 48 hours after onset, and urine amylase levels also drop within 72 hours. By one week, amylase levels return to normal. Therefore, this disease rarely has reliable diagnostic markers, leading to frequent misdiagnoses. I myself suffered from this condition in my youth. My father prescribed a traditional herbal formula for treatment, and after seeing positive results, he continued taking the medicine for a year, ultimately recovering completely. Later, I developed a formula—based on my father’s prescription—specifically for combined bile and pancreatic conditions: Chai Hu 10g, Zhi Shi 10g, Bai Shao 10g, Chuan Xiong 6g, Xiang Fu 6g, Gan Cao 6g, Da Huang 6g, Huang Lian 6g, Huang Qin 10g, Dan Shen 10g, Mu Xiang 10g, Cao Kou 6g, Yuan Hu 10g, Chuan Lian Zi 20g, Zhi Lu Mo 6g, and other herbs such as Cheng Jiao 6g, Yuan Hu 10g, Chuan Lian Zi 20g, Zhi Lu Mo 6g, Cheng Jiao 6g, Gan Jiang 6g, Gong Ying 15g, Bao Jiang 15g. This formula can lead to recovery in 80% of patients with chronic pancreatitis, and over more than 40 years of practice, I have treated countless patients without any adverse outcomes. Currently, textbooks do not record cases of concurrent chronic pancreatitis and fatty liver; however, through long-term observation, I have found that nearly 80% of patients with chronic pancreatitis also develop fatty liver. Fatty liver occurs when excess fat accumulates in the interstitial spaces of liver cells. Over time, this fat compresses liver tissue, causing it to lose its function, followed by compensatory fibrosis, eventually leading to cirrhosis. Both fatty liver and fatty diarrhea result from metabolic disorders; when fats cannot be digested or absorbed, fatty diarrhea develops; when they cannot be fully utilized, fatty liver arises. The former is caused by reduced pancreatic enzymes, while the latter is due to increased insulin levels. Chronic inflammation can affect the islets of the pancreas; before the islets’ function is lost, this leads to stimulation of the islets, resulting in excessive islet secretion and subsequent accumulation of hepatic glycogen, excess fat, and even hypoglycemia.

Further Discussion on Quinolone Antibiotics - December 8, 1999

Since the introduction of pipemidic acid in the mid-1980s, these drugs have become widely used worldwide due to their broad antibacterial spectrum, high efficacy, few side effects, and low cost. The first generation included pipemidic acid; the second generation featured flupiracil; the third generation comprised ciprofloxacin; and the fourth generation included levofloxacin and lomefloxacin. Compared to the first generation, the fourth generation offers greater efficacy and a longer half-life of up to 15 hours, making it particularly suitable for intravenous administration every 24 hours—a significant advancement in treatment. However, these medications should be used with caution in children under 18, adolescents, pregnant women, and breastfeeding mothers. Some patients may experience elevated transaminases, while others may experience gastrointestinal reactions or various types of skin rashes. Why should children, pregnant women, and breastfeeding mothers use these medications with caution? These drugs can also impact infant and young child development.

Menstrual Disturbances in the Pelvic Area – December 12, 1999

Patients often experience cyanosis in their lower limbs, which becomes most pronounced when the legs are positioned in a hanging position. At the People’s Hospital of Gansu Province, various examinations were conducted, including Doppler studies, which revealed no deep vein thrombosis in the lower limbs, nor any obvious abnormalities in the heart, lungs, or gastrointestinal tract. Previously, I had tried treating these patients with Dangchuan decoction, Sishui decoction, and Si Miao San, but without significant improvement. Later, at the Second Hospital of Lanzhou, an ultrasound revealed small uterine fibroids and a small amount of fluid in the pelvic cavity. The patient complained of lower abdominal distension, but treatments like cisapride for gastrointestinal issues did not provide relief. It was then that I realized this condition might be related to pelvic inflammation—and could it be diagnosed as pelvic congestion syndrome? Thus, I prescribed Gui Zhi Fu Ling Wan combined with Wu Ling Wan and Xiaoyun San: Gui Zhi, Fu Ling, Dan Pi, Tao Ren, Bai Shao, Wu Yao, Chuan Lian Zi, Yu Jin, Da Yun, Yuan Hu, Da Fu Pi, Turmeric, Mu Xiang, Sandalwood, Shen Xiang, Da Huang, Chen Pi, Dang Gui, Dan Shen, Cao Kou, San Ling, E Jue, Xiaoyun, and other herbs, all decocted in water and taken once daily. After 10 doses, the lower limb swelling significantly improved, and the cyanosis in the lower limbs was no longer present!

Tishuan San for Hemiplegia Following Cerebrovascular Accidents – December 15, 1999

According to a report in Shandong Medical Journal (January 24, 1976), Jiang Dexi reported using 30g of Earthworm, one centipede, and 9g of Bai Zhi to treat hemiplegia following cerebrovascular accidents. Earthworm 30g serves as the primary ingredient, known for its ability to dispel wind-dampness, relieve spasms, promote blood circulation, and treat stroke—making it an excellent remedy for phlegm obstructing the heart and mind, as well as facial asymmetry and mouth/eye deviation. Centipede helps to dispel wind, calm the spirit, break up blood stasis, and assist Earthworm as an auxiliary herb. Bai Zhi dispels wind and relieves pain, as wind is the only force capable of reaching the top of the head, guiding the medicine upward to reach the site of the illness.

A New Understanding of Chronic Pancreatitis – December 22, 1999

Chronic pancreatitis is quite common! Many patients develop fatty liver as a complication, and many cases of left chest pain are mistakenly diagnosed as coronary heart disease. Similarly, many patients experience back pain on the left side, as well as stomach discomfort. At the end of last year, I treated Li, a staff member of the Provincial Committee. Mr. Li had been experiencing back pain on the left side for several years, accompanied by palpitations, shortness of breath, and chest tightness. Although I had tried Guo Lu Xie Bai Ban Xia Tang combined with Coronary Heart Disease No. II for chronic myocardial ischemia, the results were not very effective. I suddenly realized that this patient was suffering from chronic pancreatitis. I prescribed a formula for combined bile and pancreatic conditions, and after 10 doses, he recovered completely.

Another Treatment for Leukemia – December 24, 1999

Yujin 6g, Cao He Che 10g, Dan Shen 30g, Huang Qi 30g, He Shou Wu 20g, Shan Dou Gen 20g, Shan Zha 10g, San Ling 10g, Ban Lan Gen 5g, Qian Teng 10g, Shen Qu 10g, Ze Xie 10g, Dang Shen 10g, Zhi Lu Mo 10g, Sang Shen 10g, Cao Kou 10g, Tao Ren 10g, Huang Jing 10g, Bai Hua She Tiao Cao 10g, Yin Chen 10g, Shan Zhi 10g, E Jue 10g, Da Huang 10g, Mu Li Fan 20g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Cao Kou 10g, Da Huang 10g, Mu Li Fan 20g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g, Can Yi 20g, Chan Yi 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Dan Shen 20g, Su Geng 20g......10mg, take vitamin C simultaneously, 100mg each time, three times daily. After six months of medication, all symptoms have disappeared, with significant relief from chest tightness and palpitations. Blood lipid levels are normal, and blood viscosity has also returned to normal.

Chronic Pancreatitis and Fatty Liver - December 5, 1999

Chronic pancreatitis is quite common. Patients often experience left upper abdominal pain that worsens after consuming oily foods, meat, or eggs, radiating to the lower back, left chest, or around the navel. This condition is frequently associated with cholecystitis and gallstones. Clinically, it is often diagnosed based on elevated serum and urine amylase levels; however, most patients see their amylase levels return to normal within 48 hours after onset, and urine amylase levels also drop within 72 hours. By one week, amylase levels return to normal. Therefore, this disease rarely has reliable diagnostic markers, leading to frequent misdiagnoses. I myself suffered from this condition in my youth. My father prescribed a treatment plan for me, and after seeing positive results, I continued taking the medication for a year, ultimately recovering completely. Later, building upon my father’s prescription, I developed the “Ganpan He Zheng” formula: Chaihu 10g, Zhi Shi 10g, Baishao 10g, Chuanxiong 6g, Xiangfu 6g, Gancao 6g, Dahuang 6g, Huanglian 6g, Huangqin 10g, Danshen 10g, Muxiang 10g, Cao Kou 6g, Yuanhu 10g, Chuanliezi 20g, Zhi Ru Mo 6g, and other herbs. This formula can lead to recovery in 80% of patients with chronic pancreatitis, and over more than 40 years of practice, I have treated countless patients without a single case of recurrence. Currently, textbooks do not record any cases of concurrent chronic pancreatitis and fatty liver; however, through long-term observation, I have found that nearly 80% of patients with chronic pancreatitis also develop fatty liver. Fatty liver occurs when excess fat accumulates in the interstitial spaces of liver cells. Over time, this fat can compress liver tissue, impairing its function, leading to compensatory fatty fibrosis and eventually cirrhosis. Both fatty liver and fatty diarrhea result from metabolic disorders—fat cannot be digested or absorbed, leading to fatty diarrhea; if it is not fully utilized, it leads to fatty liver. The former is caused by reduced pancreatic enzymes, while the latter is due to increased insulin levels. Chronic inflammation can affect the islets of Langerhans; before the islet function is lost, this can stimulate the islets, causing excessive insulin secretion and resulting in the accumulation of hepatic glycogen, excess fat, and hypoglycemia.

Further Discussion on Quinolone Antibiotics – December 8, 1999

Since the introduction of pipemidic acid in the mid-1980s, these drugs have become widely used worldwide due to their broad antibacterial spectrum, high efficacy, few side effects, and low cost. The first generation included pipemidic acid; the second generation featured flupiracil; the third generation comprised ciprofloxacin; and the fourth generation included levofloxacin and lomefloxacin. Compared to the first generation, the fourth generation offers greater efficacy and a longer half-life of up to 15 hours, allowing for once-daily intravenous administration every 24 hours, which holds significant therapeutic value. However, these medications should be used with caution in children under 18, adolescents, pregnant women, and breastfeeding mothers. Some patients may experience elevated transaminases, while others may experience gastrointestinal reactions or various types of skin rashes. Why should children, pregnant women, and breastfeeding mothers use these medications with caution? These drugs can also impact the growth and development of infants and young children.

Professor Xian’s Pelvic Congestion Syndrome – December 12, 1999

Patients often experience cyanosis in their lower limbs, which becomes most pronounced when the legs are positioned downward. At the People’s Hospital of Gansu Province, various tests were conducted, including Doppler ultrasound, which revealed no deep vein thrombosis in the lower limbs, nor any obvious abnormalities in the heart, lungs, or gastrointestinal tract. Previously, I had tried treating the patient with Dangchuan Decoction, Sisui Decoction, and Si Miao San, but without significant improvement. Later, at the Second Hospital of Lanzhou, an ultrasound examination showed small uterine fibroids and a small amount of fluid in the pelvic cavity. The patient complained of lower abdominal distension, but treatments such as cisapride for gastrointestinal issues did not provide relief. It was then that I realized this condition might be related to pelvic inflammation—and could it be diagnosed as pelvic congestion syndrome? Thus, I prescribed Guizhi Fuling Wan combined with Wuling Wan and Xiaohuixie Decoction: Gui Zhi, Fuling, Danpi, Taoren, Baishao, Wuyao, Chuanliezi, Yujin, Dayun, Yuanhu, Daabipi, Turmeric, Muxiang, Sandalwood, Shenxiang, Dahuang, Chenpi, Danggui, Danshen, Cao Kou, Sanling, E’shu, Xiaohuixie, and Xiaohuixie, all decocted in water and taken once daily. After 10 doses, the lower limb swelling significantly improved, and the cyanosis in the lower limbs was no longer present!

Tishuan Powder for Hemiplegia Following Cerebrovascular Accidents – December 15, 1999

According to a report in Shandong Medical Journal (January 24, 1976), Jiang Dexi reported using 30g of earthworm, one centipede, and 9g of Bai Zhi to treat hemiplegia following cerebrovascular accidents. Earthworm is the primary ingredient, known for its ability to dispel wind-cold, relieve spasms, promote blood circulation, and treat stroke—making it an excellent remedy for phlegm obstructing the heart and mind, as well as facial asymmetry and mouth/eye deviation. Centipede helps to dispel wind, calm the spirit, break up blood stasis, and assist earthworm as an auxiliary herb. Bai Zhi relieves wind and reduces pain, as wind is the only force capable of reaching the top of the head, guiding the medicine upward to reach the affected areas.

A New Understanding of Chronic Pancreatitis – December 22, 1999

Chronic pancreatitis is quite common! Many patients develop fatty liver as a complication, and many experience left chest pain that is mistakenly diagnosed as coronary heart disease. Back pain that radiates to the left side is also common, as is stomach pain. At the end of last year, I treated Li, a staff member of the Provincial Committee. Mr. Li had been experiencing back pain slightly to the left for several years, accompanied by palpitations, shortness of breath, and chest tightness. Although he had taken Gualu Xiebai Banxia Tang combined with Coronary Heart Disease No. II for chronic myocardial ischemia, he did not see significant improvement. I suddenly realized that this patient was suffering from chronic pancreatitis. I prescribed the Ganpan He Zheng formula for him, and after 10 doses, he recovered completely.

Another Treatment for Leukemia – December 24, 1999

Yujin 6g, Cao He Che 10g, Danshen 30g, Huangqi 30g, He Shou Wu 20g, Shan Dou Gen 20g, Shan Zha 10g, San Ling 10g, Ban Lan Gen 5g, Qian Tong 10g, Shen Qu 10g, Ze Xie 10g, Dang Shen 10g, Zhi Xie 10g, Cao Ku 10g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Danshen 20g, Su Jing 20g, Taoren 10g, Chi Shao 10g, Dahuang 10g, Mu Li Fen 20g—all decocted in water and taken once daily.

This formula was originally designed specifically for treating liver diseases, and it could be called the “Furong Qiang Gan Tang.” In 1979, I used this formula to treat Engineer Qian from the Provincial Construction Bureau, who had developed chronic myeloid leukemia. His spleen shrank, his blood count recovered, and his white blood cell count dropped from 200,000 to below 10,000. Engineer Qian retired and returned to his hometown in Changzhou, Jiangsu. Before leaving, he specially brought a generous gift to express his gratitude: “Your medical skills are truly extraordinary. The formula you devised is truly a divine remedy.” Over the past 20 years, I have adjusted and modified this formula, and it has consistently proven effective in treating patients with high white blood cell counts from chronic myeloid leukemia. Recently, we treated Jiang Lin, a patient with acute lymphoblastic leukemia. After three years of combining chemotherapy with traditional Chinese medicine, as his survival time extended, the clinical efficacy of Western medicine became increasingly less noticeable. After switching to this formula, his original leukemia cells decreased from 60% to 12%. The patient said that this traditional Chinese medicine was effective and requested that all Western medications be discontinued. This shows that this formula is not only effective for chronic myeloid leukemia but also for acute lymphoblastic leukemia. After all, the liver nourishes and sustains blood; my father always focused on strengthening the spleen and replenishing the kidneys when treating leukemia. Furong Qiang Gan Tang helps to soothe and activate the liver, opening up new avenues in treatment. Fifteen years ago, I published an article titled “Supporting the Body and Strengthening the Roots,” which discussed how modern interpretations of supporting the body and strengthening the roots include regulating the immune system, the autonomic nervous system, the metabolic system, and the endocrine system. The significance of Furong Qiang Gan Tang lies in its ability to regulate the immune system, the autonomic nervous system, the metabolic system, and the endocrine system.

Clinical Cases of Renal Failure – December 24, 1999

Dang Bo Min, a professor in the Department of Fine Arts at Northwest Normal University, suffered from liver cirrhosis and ascites. After treatment with me, his condition improved, but his renal function gradually deteriorated. His BUN reached 25 mmol/L, Cr 580 µmol/L, and CO₂-P was 21 mmol/L. While receiving routine treatments with furosemide, testosterone propionate, and antibiotics, I also administered Xiaofeng Zhuoshi Capsules and Gusheng No. 1, along with traditional Chinese medicine: Sheng Di 12g, Shan Yu 6g, Shan Yao 10g, Dan Pi 6g, Fu Ling 12g, Ze Xie 10g, Gui Zhi 10g, Fu Pian 6g, Niu Xi 10g, Taoren 10g, Chi Shao 10g, Er Hua 15g, Lian Qiao 15g, Cao Kui 15g, Dang Gui 10g, Chuan Xiong 10g, Hong Hua 6g, Yi Mu Cao 10g, Danshen 20g, Su Jing 20g, Cao Kou 10g, Dahuang 10g, Mu Li Fen 20g—both decocted in water and taken once daily. After one month of oral administration, both BUN and Cr were close to normal, and his general condition improved significantly, especially his complexion, which was now indistinguishable from that of healthy individuals. For patients with liver cirrhosis and ascites leading to renal failure, Western medicine refers to this condition as hepatorenal syndrome—a critical situation where BUN levels above 25 mmol/L are indicative of dialysis. Some patients die within one or two years, and most die from systemic infections secondary to colds.

The Evolution of Warm Disease Theory – December 24, 1999

Warm disease originated from cold disease: “When fever and thirst occur without chills, it is warm disease,” according to the Shanghan Lun; “In today’s world, warm disease is merely a form of cold disease,” as stated in the Neijing; “In winter, when cold attacks, warmth will inevitably follow in spring.” Wang Shuhé believed that cold disease was not contagious, while warm disease was contagious: “From the Summer Solstice onward, it is warm disease; from the Summer Solstice onward, it is heat disease.” Sun Simiao’s Qianjin Fang argued that what the Shanghan Lun referred to as “yin-yang poison” was actually part of the category of warm disease—yang poison presents with red spots like brocade patterns, while yin poison causes pale faces and cold extremities, with a weak and fine pulse; the latter can be fatal if left untreated. Warm disease was classified into wind-warm, spring-warm, damp-warm, epidemic-warm, and plague-warm. Epidemic-warm is characterized by widespread sores and ulcers; plague-warm is highly contagious. Wang Andao said, “People often confuse warm disease with cold disease… When we use warm and hot medicines, we end up confusing the names of these medicines, harming people’s lives—shouldn’t we call things by their proper names?” Wang Shishan proposed a new theory of warm disease, stating, “There are cases where people do not contract warm disease from cold in winter… We can call this ‘spring-warm,’ just as we call winter’s cold or autumn’s dampness, or summer’s heat—this is a new type of warm disease.” Later, Ye Tiashi developed the Wei Qi, Ying Blood, and Xue Distinction, while Wu Jutong created the San Jiao Distinction. In diagnosis, they emphasized observing tongue signs, and in prescriptions, they introduced formulas like Sangju Yin, Yin Qiao San, Dajing Fengzhu, Qingying Tang, and Xijiao Dihuang Tang—formulas that used pungent, warm herbs to release exterior pathogens, clear heat, detoxify, and replenish fluids and yin, heavily emphasizing honeysuckle, forsythia, dandelion, bitter grass, rehmannia, and wheat germ.

Random Notes on Reading – December 25, 1999

“Distension arises from areas outside the internal organs, extending beyond the organs to expand the chest and flank, causing skin distension—thus it is named ‘distension.’” (Ling Shu, Chapter on Distension)

These ancient texts are truly timeless and widely quoted; the ancients had a profound understanding of the location of distension, as if by divine insight, knowing that distension originates outside the internal organs. ① Extending beyond the organs (ascites); ② Expanding the chest and flank (pleural effusion); ③ Skin distension (edema). All of these conditions—ascites, pleural effusion, edema—share the same sensation of distension, which is why they are collectively called “distension.” The ancients’ understanding of edema was truly remarkable.

Non-Urethritis – December 26, 1999

Non-urethritis has become increasingly prevalent in recent years, with cases rising year after year. While Western medications like quinolones and azithromycin are effective, their actual efficacy remains limited. Previously, I tried treating this condition with Gui Fu Ba Wei Wan and Huang Jing Liu Cao Dan, and saw some improvement. Recently, I encountered a patient with non-urethritis and adnexitis, and I found that treating her with Gui Zhi Fuling Wan combined with Huang Jing Liu Cao Dan yielded significant results. I’ve recorded the original formula here for future verification.

Gui Zhi 10g, Fu Ling 12g, Baishao 15g, Dan Pi 6g, Taoren 10g, Cao Kui 20g, Baisai 20g, Huang Jing 20g, Han Lian Cao 20g, Deng Xin Cao 6g, Qian Cao 6g, Zi Cao 20g, Long Dan Cao 15g, Che Qian Cao 10g, Wu Che Gu 15g, Sheng Long Mu 15g—both decocted in water and taken once daily.

Tumors Common in Children – December 26, 1999

Common tumors in children include teratoma, nephroblastoma, neuroblastoma, and retinoblastoma. Among these, teratoma is mostly benign, while the other three are malignant.

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1. Teratoma: Common in infants and young children, with a male-to-female ratio of 1:2. Its most common sites are the lumbar-sacral region, accounting for nearly half of all cases; testes and ovaries account for 30%, while the neck and other locations together make up about 20%. Most teratomas are benign, though a small number can become malignant—but they tend to differentiate well. Treatment involves surgical removal, preferably as early as possible; do not delay.
2. Nephroblastoma: Common in infants and young children, with no gender difference. Its most common site is the retroperitoneal space, particularly the upper abdomen. Most cases are malignant, but they tend to differentiate well. Treatment involves surgery combined with chemotherapy.
3. Neuroblastoma: Any area containing neural tissue can be affected; most cases are malignant, requiring surgery combined with chemotherapy.
4. Retinoblastoma: Accounts for 90% of pediatric ophthalmological tumors, with a high degree of malignancy—80% of cases are unilateral, while 20% are bilateral. This tumor is common in children under 3 years old, but it is extremely rare in children over 7 years old.

Two Effective Formulas – December 31, 1999

1. Huo Xue Hua Yu Formula: Dang Gui 10g, Shan Zha 10g, Xiang Fu 6g, Muxiang 6g, Hong Hua 6g, Ze Xie 10g, Wuyao 10g, Qing Pi 6g—both decocted in water and taken once daily. This formula comes from Jing Yue Quan Shu, and it is primarily used to treat gynecological conditions such as menstrual pain due to blood stasis, fibroids, cysts, and pelvic congestion syndrome. The formula is simple and concise: Muxiang, Qing Pi, Xiang Fu, and Wuyao help to regulate qi; Shan Zha and Hong Hua promote blood circulation; Dang Gui provides nourishment and support; Ze Xie, in addition to promoting diuresis, also has the effect of clearing heat, reducing fire, and guiding dampness downward. This formula combines both tonifying and purging properties, making it an effective remedy for women with pelvic inflammatory disease and adnexitis. The formula’s key principle: Dang Gui, Shan Zha, Xiang Fu, and Wuyao.
2. Li Chong Formula: Developed by Zhang Xichun in “Medical Zhong Zhong Can Xi Lu,” this formula consists of San Ling 12g, E’shu 12g, Zhi Mu 15g, Ji Nei Jin 10g, Tianhua Fen 10g, Shan Zha 12g, Chen Cai 30g, Dang Shen 10g, Bai Shao 10g, Huang Qi 30g—both decocted in water and taken once daily. This formula is Zhang’s key formula for treating amenorrhea, dysmenorrhea, fibroids, peritonitis, adhesions, and small amounts of fluid buildup; it is a wonderful formula for gynecological pelvic conditions. The formula’s secret: “San Ling, Mother Chicken, Tian Shan Vinegar—helping to resolve pelvic congestion.”

The Meaning of Cloning and Its Clinical Applications – January 6, 2000

The basic meaning of cloning is asexual reproduction; modern cloning technology is based on in vitro nuclear transfer. In vitro nuclear transfer technology evolved from genetic engineering, which was first successfully achieved in 1979. This technique involves isolating and culturing donor cell DNA, enabling it to fully express the characteristics of the mother’s genes, then implanting it into recipient cells. The genes of both cells are integrated, achieving recombinant gene expression. Cloning technology further extends this process by transplanting the complete genes of asexually reproducing cells into recipient T cells with the nucleus removed, thereby creating new varieties through asexual reproduction.

Several Issues in the Use of Growth Hormone (GRH) – January 6, 2000

Recombinant human growth hormone has shown certain therapeutic benefits in treating children with congenital GH deficiency, but according to Hintg’s research, nearly half of these children have not seen significant improvements in recent years. Professor Ni Guizhen at Beijing Children’s Hospital believes that excessive GRH can inhibit the body’s glucose uptake, leading to hyperglycemia; therefore, she does not recommend GRH therapy for healthy children with short stature.

Intravenous Administration of GIK Can Reduce the Risk of Death from AMI – January 6, 2000

According to a report in the American Medical Forum (December 11, 1999), Argentine physician Rqsaring stated that intravenous infusion of glucose, insulin, and potassium salts (GIK)—known as GIK therapy—can reduce the risk of death from acute myocardial infarction (AMI).

A Wonderful Remedy for Enlarged Tonsils – January 27, 2000

In the Year of Ji Mao, Director Peng Xiaozhong visited me. During our casual conversation, he mentioned that 20 years ago, my father had treated his enlarged tonsils and difficulty swallowing with Western medicine. My father wrote a formula himself: Ma Bo 30g, She Pi 30g—both ground into powder and dissolved in water, taken in small doses for chewing. After three administrations, the throat pain greatly subsided, and he was able to eat smoothly. Peng said this formula was truly miraculous. Ma Bo is a powerful remedy for treating throat pain, renowned for its ability to clear heat, detoxify, reduce swelling, and dissolve masses. She Pi is the skin of the black snake, a precious remedy for dispelling wind and eliminating dampness. As wind is the only force capable of reaching the top of the head, She Pi’s ability to dispel wind and treat swollen, hoarse throats is well-known—but it is rarely used today.

High-Dose Albumin Therapy for Hepatorenal Syndrome – January 31, 2000

The causes of hepatorenal syndrome are extremely complex, but scholars currently believe that vascular spasm within the kidneys leads to insufficient renal blood flow, ischemia of the renal cortex, reduced glomerular filtration, and ultimately, oliguria and decreased urea nitrogen excretion. Administering large doses of albumin (150g initially, then another 60g on the third day) can increase blood volume, helping to relieve vascular spasm in the glomeruli and enhance renal blood flow, thereby improving kidney function. However, given the large dosage, the patient’s cardiac and renal functions must be carefully considered; especially for elderly patients, rapid and large-volume fluid resuscitation can lead to acute heart failure. Moreover, large doses of albumin are expensive—typically costing 7,800 yuan per course (two 150g administrations), which is undoubtedly a heavy burden for most patients.

The Current Status of Hepatitis B Treatment – January 31, 2000

According to a report by Professor Tian Gengshan at Capital Hospital (Guoyi Forum, September 17, 1999), there are three recent medications available for treating hepatitis B: ① Interferon; ② Lamivudine; ③ Acyclovir. 1. Interferon: 1 million units, a one-year course costing 30,000–40,000 yuan, with a HBsAg conversion rate of less than 10%; an e antigen conversion rate of 40%. 2. Lamivudine: 100 mg, taken once daily, costing 8,000 yuan per year, with an HBsAg conversion rate of 5%; an e antigen conversion rate of 30%. 3. Acyclovir: The treatment duration is comparable to interferon, but the medication should not be used for too long—1 month constitutes a course, and after 2–3 months, severe neuromuscular disorders may occur. Compared to the aforementioned medications, the efficacy of traditional Chinese herbal remedies has been reported with numerous inaccuracies; for example, “Turning the Negative into Positive” by Gou Shengliang is nothing more than hearsay (with over 90% conversion rates). Over 20 years of treating hepatitis B, I estimate that the efficacy of the hepatitis B granules and pills I developed resulted in an HBsAg conversion rate of around 20% per year, with an e antigen conversion rate of around 40%.

New Antibiotic for Injection—Phosphomycin Sodium – January 31, 2000

Phosphomycin sodium is a newly emerging broad-spectrum antibiotic, similar to many previously marketed antibiotics—such as tetracycline, erythromycin, penicillin, quinolone, and cephalosporin. This drug is effective against many currently resistant bacteria. Its effectiveness rates are as follows: 100% against influenza bacillus; 100% against Salmonella; 99% against Staphylococcus; 80% against Streptococcus. Its antibacterial spectrum is broader than that of beta-lactam antibiotics, comparable to gentamicin. It is effective against 100% of acute urinary tract infections; 90% of lung infections; 89% of intestinal infections; 100% of pharyngitis and tonsillitis; and 90% of gonorrhea. Each vial contains 2 g, dissolved in saline; up to 10 vials can be dissolved in 250 ml, taken 2–4 times daily, with 4 g per dose being optimal. Since each vial contains 0.64 g of sodium, it is suitable for patients with low sodium levels; for those with impaired cardiac or renal function, slow infusion is necessary. This product’s unique feature is that it can cross the blood-brain barrier, with concentrations in cerebrospinal fluid reaching up to 50%, without directly damaging renal function. It can also reduce the toxicity of other drugs on the kidneys, such as the potential reduction of nephrotoxicity from aminoglycosides.

The Discovery and Significance of Thymosin – January 31, 2000

The thymus is located in the upper portion of the sternum, in the thoracic cavity, and is a large lymphatic organ composed of two connected lobes. The thymus develops rapidly in childhood, but gradually shrinks in adulthood, with its lymphatic tissue being replaced by neighboring tissues. Task output rules: Translate this markdown block from Chinese to English. Preserve markdown markers, links, and formatting. Keep headings and list structure unchanged. Return only the translated block.

Input: Near fat tissue is concealed. It was once believed that after adulthood, the thymus no longer played a significant role.

In 1961, experiments on thymectomized mice revealed a reduction in lymphocytes, leading to a gradual loss of immune function—both cellular immunity and humoral immunity were progressively impaired. Several months after surgery, the mice died due to systemic infections. Additionally, it was found that when mature animals had their thymic tissue removed, lymphocyte counts also declined, and immune function was significantly reduced. These experiments demonstrated that the thymus is not only an important immune organ in young animals but also remains functional even in adult animals; despite thymic tissue atrophy, the thymus still retains its functions and continues to be considered one of the key immune organs. In 1965, Goldstein isolated several peptide substances from animal thymic tissue, which exhibited remarkable immune activity. Experiments proved that these active substances significantly stimulated both T cells and B cells, as well as promoting the production of interleukin-2, colony-stimulating factors, and interferon-γ; they also showed clear stimulation of natural killer (NK) cells and activated killer cells (LAK). By the 1970s, China had successfully developed thymosin injection solutions; by the 1990s, China had successfully developed oral capsules. The dosage for the latter was three times that of the injection dose, yet the therapeutic efficacy remained the same. Thymosin injection solution: 3 mg, intramuscularly, once daily; thymosin enteric-coated capsules: 16 mg, orally, twice daily.

Treatment of Hepatitis B – February 4, 2000

Hepatitis B is widespread in China, with a high incidence rate. Current estimates suggest that there are approximately 120 million people in China who carry the hepatitis B virus. Antiviral treatment involves interferon, which has some efficacy but is not ideal; the e antigen conversion rate is around 40%, while the HBsAg conversion rate is less than 10%. The treatment course typically lasts more than six months, with costs ranging from 30,000 to 40,000 yuan. Lamivudine 100 mg, taken orally, once daily, is convenient to use; the treatment duration is one year, costing 6,000 yuan, with an HBsAg conversion rate of 20%, though the e antigen conversion rate is lower than that achieved with interferon.

Additionally, acyclovir has similar efficacy to interferon, but it comes with more side effects. The efficacy of traditional Chinese medicine varies greatly depending on the combination of herbs used; however, these medications are often bulky and inconvenient to take, and long-term use can cause stomach discomfort.

To reduce liver inflammation, treatments such as glycyrrhizin, Qiangli Ning, and Ganlixin can be administered for more than six months, effectively alleviating inflammatory responses in the liver.

To reduce liver fibrosis, traditional Chinese medicines have shown notable effects in reducing liver fibrosis—currently, Western and Eastern medical treatments lack such drugs. In treating hepatitis B, traditional Chinese medicine also follows these principles: Qingtiao, Banlan, Chaihu, Huangqin, Yinchen, among others, are used to suppress hepatitis B viruses; Danggui, Baishao, Huangqi, Huangjing, Sanling, Ezhú, Yujin, are employed to reduce fibrosis; Baihua Shuete Cao, Ban Zhilian, Jin Yin Hua, Lianqiao, Gongying, and other plants are used to alleviate liver inflammation.

Case Study: Treatment of Focal Nephritis in Children – May 8, 2000

The son of the head of the armed forces in Maqu County, Gannan Prefecture, was 5 years old. He presented with +++ urine protein and + blood in his urine, and sought treatment from me. Initially, treatment with Gui Fu Ba Wei Wan, Gui Zhi Fu Ling Wan, and Yi Shen Tang only provided slight relief; the hematuria did not improve, and the urine protein decreased to ++, though it did not continue to decline. Later, I prescribed Long Dan Xie Gan Tang combined with A Fa Jian Mai, and the hematuria quickly turned negative. Given this case, I concluded that hematuria in children could be treated using Long Dan Xie Gan Tang combined with A Fa, a formula I had previously used for adult patients with hematuria—but without seeing significant results. Is the treatment of hematuria in children different from that in adults?

The Shift in Medical Paradigms – May 9, 2000

The shift in medical paradigms went through several stages:

1. Divine Power Model: In ancient times, religious beliefs dominated people’s thinking, with the notion that God created humans, and disease was a form of divine punishment. When illness occurred, people would pray to God and seek forgiveness from Him, believing that if they received God’s mercy, their illnesses would be cured.

2. Mechanical Model: As divine power-based thinking began to decline under the influence of capitalism, medical paradigms shifted accordingly. During this period, people viewed disease as a disruption within the body that needed timely repair. The emergence of Weiliao’s pathology marked a new era where modern Western medicine began treating diseases like repairing machinery.

3. Biological Model: People came to recognize that the human body is an integrated system composed of various organs, regulated through immune, metabolic, and endocrine mechanisms. This regulation helped resolve localized lesions.

4. Biological, Psychological, and Social Model: The onset of disease is often linked to a patient’s psychological state and social factors. Therefore, treating disease should involve a comprehensive approach that includes psychological therapy and social disease prevention programs.

Cancer Classification – May 18, 2000

1. Malignant tumors originating from ectodermal epithelial cells are referred to as cancers, including adenocarcinoma, squamous cell carcinoma, basal cell carcinoma, papillary cell carcinoma, and transitional cell carcinoma. In general, any organ that communicates with the external environment—such as the stomach, lungs, colon, nasopharynx, oral cavity, larynx, breast, bladder, urethra—can easily develop cancerous growths.

2. Malignant tumors arising from mesodermal connective tissue are known as sarcomas, such as smooth muscle tumors, striated muscle tumors, lymphatic and lymphatic vessels, blood vessels, bone marrow, adipose tissue, fibrous tissue, serous membranes, and other tissues.

3. The names of malignant tumors originating from the inner embryonic layers—such as those of the nervous system, endocrine glands, and gonads—are often inconsistent, lacking unified standards. However, tumors originating from immature tissues are sometimes referred to as “xx-mother cell tumors.”

Applications of Several New Medications – May 25, 2000

1. Terbinafine, administered at 500 mg daily for 6–12 months, is effective in treating various types of pigmentary fungal infections. Even with long-term use, the drug’s tolerability remains excellent. Terbinafine is the first-line treatment for tropical fungal infections, offering both antifungal and anti-fibrotic properties; the fungal cure rate can reach up to 85%. Pigmentary fungal infections are commonly known as “pigmentary fungal diseases,” representing chronic fungal infections characterized by dermal fibrosis accompanied by granulation tissue proliferation. Lesions appear as warty or papillary formations, often arising from bacterial suppuration. The disease progresses slowly over decades, accompanied by irreversible fibrotic tissue growth and the development of neutrophil antibodies. The most common region affected by pigmentary fungal diseases is Madagascar, though scattered cases can be found in other parts of the world.

2. Betaloc for the treatment of chronic heart failure: Betaloc is a second-generation beta-blocker, following the first-generation drug Propranolol. Betaloc is also known as Metoprolol. Betaloc improves the hemodynamics of chronic heart failure, thereby helping to correct heart failure to a certain extent.

Latest Developments in Liver Cancer Treatment – May 26, 2000

Since the late 20th century, researchers have conducted extensive studies on liver cancer treatment. Initially, surgical procedures were combined with low-dose chemotherapy before and after surgery. Later, interventional chemotherapy via hepatic arterial infusion was developed, along with percutaneous transhepatic radiofrequency ablation using radioactive isotopes. Today, international practices include computer-guided, multi-targeted radiofrequency ablation techniques for localizing and destroying liver cancer cells, which have proven highly effective. For tumors smaller than 5 cm, complete tumor destruction can be achieved in a single session; for tumors between 5 and 10 cm, two sessions are required. After ablation, residual tumor tissue remaining in the body can still trigger the body’s immune response, offering potential benefits in preventing recurrence. Professor Wu Jinsheng and Professor Gao Qingjiu at Xi’an Fourth Military Medical University completed the procedure in just 40 minutes—no scalpel was used; all that was needed was to press a switch! Radiofrequency waves are also part of the “y”-wave spectrum; recently, devices like “y-knife” and “X-knife” are all based on radiofrequency technology.

Experience with Henoch-Schönlein Purpura – June 10, 2000

This condition is characterized by capillary toxicity. In addition to purpura, patients may experience abdominal pain, such as mesenteric purpura or subperitoneal purpura affecting abdominal organs; joint pain, caused by purpura in the joint cavities, leads to joint discomfort. In summary, any case of abdominal or joint pain is classified as Henoch-Schönlein syndrome. Western medicine primarily uses adrenal corticosteroids as the first-line treatment for this condition; although they provide immediate relief, the recurrence rate is nearly 100%, and effectiveness varies widely. Traditional Chinese medicine offers a rich array of herbal formulas for treating purpura, each with unique approaches and proven efficacy. My treatment of this condition often yielded remarkable results, recognizing that it is often associated with wind-heat combined with dampness, and that prolonged illness can lead to blood-related conditions. Treatment focuses on dispersing wind-heat, clearing heat and detoxifying, and activating blood circulation to resolve stasis.

1. Three-Flavor Formula: Silver Flower, Forsythia, Herba Artemisiae, Herba Lysimachiae, Poria, White Birch Bark, Rehmannia Root, Kjellia Root, Fangfeng, Biexie, Red Peony Root, Danpi, Licorice, Cicada Skin.

2. Side-Bark Formula: Side-Bark Leaves, Wild Chrysanthemum, Rehmannia Root, Kjellia Root, Herb of Crane, Purple Grass, Plantain, Evening Primrose.

3. Su Jing Formula: Su Jing, Cicada Skin, Motherwort.

4. Four-Element Soup with Modifications: Four-Element Soup with Peach Kernel, Safflower, Chicken Blood Vine, Salvia Miltiorrhiza, Ligusticum Wallichii.

5. Long Dan Xie Gan Tang: Long Dan Grass, Gardenia Fruit, Chaihu, Huangqin, Rehmannia Root, Danggui, Mu Tong, Licorice Tip, Poria, Alisma, Plantain Seed, Eggplant Gelatin, Blood Remnant Charcoal, Mai Dong, Salvia Miltiorrhiza, Danpi. (For patients with glomerulonephritis and hematuria)

6. Six-Element Decoction Combined with Gui Zhi, Bai Shao, Peach Kernel, Safflower, Danggui, Motherwort, Salvia Miltiorrhiza, Silver Flower, Forsythia, Ban Lan Gen. (For patients with glomerulonephritis, hematuria, and proteinuria)

7. Roasted Loquat Leaf, Yam, Huangjing, Tussah Seeds, Euryale Seed, Golden Cherry, Lily, Codonopsis, Astragalus, White Atractylodes, Poria, Licorice. (For recovery periods after purpura-related kidney issues) This formula can be taken long-term and helps prevent recurrence.

Understanding and Treating Hypertension – June 12, 2000

Traditional Chinese Medicine has long recognized that hypertension is rooted in kidney water deficiency and liver yang excess. Kidney water deficiency can lead to symptoms such as bone dryness, hot flashes, and restlessness in the five internal organs. Liver yang excess can cause headaches, dizziness, and other symptoms. When water is insufficient, fire becomes rampant; when heart fire is too strong, patients may experience palpitations, irritability, insomnia, and frequent dreams. When water is lacking, yin becomes deficient; over time, yang also becomes deficient—this is why “isolated yin cannot generate, isolated yang cannot thrive.” The direct result of yang-yin imbalance is qi stagnation and blood stasis. Qi and blood flow smoothly only when yin and yang are in harmony; when yin and yang become severely imbalanced, blockages in qi and blood are inevitable. To treat hypertension, we first focus on nourishing yin and calming yang, using formulas like Qiju Dihuang Tang or Zhen Gan Xi Feng Tang. Subsequently, we can selectively choose the following formulas for clinical application, adjusting them according to the patient’s condition: Zhenwu Tang, Gui Fu Ba Wei Wan, Jisheng Shenqi Wan, Guan Xin No. 1, Xia Ku Cao Compound, Si Wu Yi Huang Gou, Huang Lian Jie Du Tang, Shi Dong Feng Ju Er Chen Can, Wu Jia Sang Tong Su Pin Gui, Zhi Shi Dai Dang Er Chen Sui.

Application of Sandostatin – June 14, 2000

Sandostatin, also known as octreotide, is a synthetic somatostatin peptide. This medication inhibits all endocrine hormones in the body, particularly exerting a strong effect on the gastrointestinal and pancreatic endocrine systems. Due to its ability to suppress growth hormone, Sandostatin is especially effective against carcinoid tumors—and it also shows significant effects on gastrinomas, insulinomas, and glucagonomas. Its powerful inhibitory effects on the gastrointestinal, pancreatic, and intestinal endocrine systems make it useful in treating upper gastrointestinal bleeding, where it provides noticeable therapeutic benefits. Typically, 1 mg of Sandostatin is infused intravenously into 250 ml of normal saline, 1–2 times daily, yielding impressive results.

Chinese Herbal Medicine: Family and Pharmacology – June 21, 2000

There is a clear correlation between the family and pharmacology of Chinese herbal medicine. Plants from the Umbelliferae family—such as Qianghuo, Fangfeng, Shechongzi, Baiyi, Gao Ben, Gualou, Chaihu, Qianhu, Danggui, Chuanxiong—have the properties of dispelling wind, releasing exterior pathogens, eliminating dampness, and relieving pain, all with warm, pungent properties. Plants from the Asteraceae family—such as Dandelion, Herba Lysimachiae, Artemisia, Wild Chrysanthemum, Purple Aster, Dianthus, Burdock, Chrysanthemum, Ajonc, Sparganium, Lysimachia, Peilan, Atractylodes, White Atractylodes, Large Thistle, Yinchen—often possess cooling and detoxifying properties, with warm, pungent flavors. Among these, Atractylodes and White Atractylodes are sweet and warm in nature, aiding in strengthening the spleen and eliminating dampness—though this is an exception. Plants from the Liliaceae family—such as Yu Zhu, Huangjing, Zhi Mu, Beimu, Shan Cigu, Bai Wei, Lily, Poria, Mai Dong, Tian Dong—also nourish yin and generate fluids, though Beimu and Shan Cigu’s softening and dissolving properties do not align well with the primary medicinal uses of these herbs. Plants from the Labiatae family—such as Purple Stone, Xia Ku Cao, Huangqin, Mint, Huoxiang, Dan Shen, Motherwort, Zelan—have the property of clearing heat and draining fire. Plants from the Polygonaceae family—such as Rheum, Turmeric, Herba Vincetoxicum, Red Bean, White Broad Bean, Licorice, Bone Breaker, Lupinus—also have the effect of clearing heat and draining fire. Plants from the Ranunculaceae family—such as Coptis, Rhizoma Atractylodis Macrocephalae, Herba Clematis, Aconit, Danpi, White Peony, Red Peony—have vastly different properties, suggesting that the classification of these families may not fully capture their inherent characteristics. Plants from the Leguminosae family—such as Astragalus,苦参, Shan Dou Gen, Red Kidney Beans, White Broad Beans, Licorice, Bone Breaker, Lupinus—have the effects of tonifying qi, enhancing yang, and eliminating dampness. Plants from the Rosaceae family—such as Peach Kernel, Apricot Kernel, Hawthorn, Rose, Papaya, Citron, Buddha’s Hand—have the effects of activating blood circulation, resolving stasis, and clearing dampness and opening channels.

Modern Research on Rapid Progression Glomerulonephritis – June 28, 2006

The presence of anti-glomerular basement membrane (GBM) antibodies in patients with rapid progression glomerulonephritis (RPGN) is a crucial diagnostic tool for detecting this condition. At the same time, these patients may also exhibit positive cytoplasmic antibodies against neutrophils; such patients are referred to as ANCA-positive, also known as double antibody-positive. Some individuals classify double antibody-positive patients as RPGN type IV. GBM-related diseases typically include: ① Rapid Progression Glomerulonephritis type I; ② Goodpasture’s Syndrome; ③ ANCA-positive. According to data collected by Beijing University of Medical Sciences over the past six years, among 41 cases of GBM antibody-related diseases, 9 involved double antibody-positive patients (ANCA-positive).

Among these three related kidney diseases, rapid progression glomerulonephritis is pathologically characterized by crescentic nephritis, with IgG and C3 deposits on the GBM, and positive anti-GBM antibodies. Goodpasture’s disease is characterized by crescentic nephritis combined with pulmonary hemorrhage and positive anti-GBM antibodies. Patients with ANCA-positive are classified as having the third type. Where exactly are the antigenic determinants of anti-glomerular basement membrane (GBM) antibody-related diseases located? By using monoclonal antibodies (M3, M5) and enzyme-labeled affinity chromatography to purify autoantibodies, three indicators were employed to identify the antigenic determinants on the GBM, ultimately determining that the main antigenic determinant lies in the non-collagenous region of type IV collagen.

What is rapid progression glomerulonephritis? It refers to acute nephritis that develops into renal failure within weeks or months. The prognosis is poor, and it is often referred to as “crescentic nephritis” or “extravascular nephritis.” It can occur either as a primary condition or as a secondary complication. The causes of primary cases remain unclear, while secondary cases may arise from lupus, allergic purpura, infectious endocarditis, and other conditions.

Professor Wang’s Clinical Experience – June 28, 2000

During an inspection tour in Dingxi, the patient suffered from excessive fatigue, improper diet, and diarrhea after an external infection. After receiving antibiotics and large-volume fluid infusions, the fever subsided. The patient experienced agitation, severe insomnia, loss of appetite, palpitations, excessive sweating, weakness, dry mouth with a bitter taste, red tongue with thick, greasy coating, and a pulse that was large, tense, and weak. I prescribed Chaihu, Huangqin, Banxia, Danggui, Licorice, Fresh Ginger, Jujube, Raw Longan, Cinnamon, Coptis, Rheum, Black Soybeans, Gardenia Fruit, Citrus Peel, Zhi Shi, White Atractylodes, Huoxiang, Peilan, Salvia Miltiorrhiza, Wood Odor, Grass Cardamom, Cuttlefish Bones, White Peony, decocted in water and taken as four doses. The patient recovered well, sleep improved, and they began to eat again, feeling slightly better mentally. In the second consultation, I removed Huoxiang, Peilan, and Cuttlefish Bones, adding Qianghuo, Duhuo, Xiangru, Coix Seed, Wood Odor, Herba Vincetoxicum, Fried Jujube Seeds, Chuanxiong, Zhi Mu, and added Danggui, White Peony, White Atractylodes, Poria, Mint, aiming to enhance the liver’s soothing and eye-clearing effects. In the third consultation, the patient had fully recovered, with most symptoms alleviated—only palpitations, shortness of breath, and poor sleep persisted. I added Guipi Tang, Danggui Xiao Yao San, Huang Lian Jie Du, Gui Zhi Chuan Ge Sheng Shi Cao, among other formulas, to support their recovery.

Correctly and Rationally Applying Western Prucalopride in Clinical Practice – July 3, 2000

Prucalopride, also known as Prilosec, has been banned in the United States since last year due to concerns about its potential to cause arrhythmias. Consequently, experts from the National Medical Products Administration consulted with major Chinese manufacturers of Prucalopride—Xi’an Janssen Pharmaceutical Co., Ltd.—and tasked the company with conducting research on the cardiac side effects of this medication in China. The findings indicated that, unlike in the U.S., Prucalopride rarely causes adverse reactions when used in China. Analysis suggested that Americans primarily took this medication for indigestion and chronic gastric disorders; moreover, due to their higher economic status, Americans often took multiple medications concurrently while using Prucalopride. In contrast, Chinese patients tended to take only one medication at a time, making drug interactions less likely.

Compound Danshen Dropping Pills – July 10, 2000

China’s first pharmaceutical preparation to pass US government drug testing and gain approval for distribution across the United States. Known as the “Angel of Heart Protection,” this medication gained recognition for its special efficacy in treating cardiovascular and cerebrovascular diseases, earning FDA certification in December 1997 and profoundly impacting the modernization of traditional Chinese medicine. According to recent statistics from American medical institutions, 49% of coronary heart disease patients are unable to achieve satisfactory treatment outcomes with Western medicine, while 20% of patients experience side effects from Western medications and are forced to discontinue treatment. With growing calls for a return to nature, people are increasingly seeking pure traditional Chinese medicine formulations. In the 1998 National Top Ten Scientific and Technological Advances in Medicine, this medication ranked first.

Prevention and Treatment of Chronic Hepatitis B – July 27, 2000

Professor Zeng of Beijing University of Medical Sciences reported that oxidized matrine (QXY) could inhibit the hepatitis B virus in vitro, and in vivo, it could induce surface antigen conversion to negative levels, with a 90-day conversion rate of 12% and an e antigen conversion rate of 44.5%. Compared to interferon, the therapeutic efficacy of QXY was comparable. Treatment regimen: for the first 45 days, administer QXY 600 mg intravenously, once daily; for the subsequent 45 days, use QXY 400 mg intravenously, once daily, with a 90-day treatment cycle. The accompanying Zhengzheng Granules—60 g of Matrine, 30 g of Astragalus, 5 g of Ginseng Root, 6 g of Licorice—were effective for patients with low white blood cell counts, low blood pressure, and low immune function. Recently, these formulas have shown promising results in treating hepatitis B, with Matrine being a key ingredient in the formulation.

Acidophilic Bronchitis – July 27, 2000

Brightling conducted a study on patients with chronic cough lasting more than two years, discovering that eosinophilic bronchitis is a major cause of chronic cough. This condition presents with chronic cough and increased eosinophilic granulocytes in sputum, but lacks the airway dysfunction characteristic of asthma. Corticosteroids are effective in treating this condition. A sputum test revealing eosinophilic granulocytes exceeding 3% is a hallmark of this disease; among 90 patients with chronic cough, 12 cases were diagnosed with this condition, accounting for 20%; 20 cases had rhinitis, representing 35%; 16 cases had asthma, accounting for 30%; 20% were infected with viral agents; and 8% had gastroesophageal reflux. Currently, inhalation of budesonide is the most effective treatment for this condition, at 400 µg twice daily.

Lupus Nephritis (SLE Nephritis) – July 28, 2000

The average age of SLE nephritis patients is 27 ± 11 years, with a female-to-male ratio of 4:1. The diagnostic criteria for this condition include microscopic biopsy, abnormal kidney specimens, urine protein levels exceeding 0.19 g/24 hours, and a 30% decrease in creatinine clearance. Approximately 36% of SLE patients develop this condition, with 30.7% of them experiencing it five years after the onset of SLE. WHO categorizes… Task output rules: Translate this markdown block from Chinese to English. Preserve markdown markers, links, and formatting. Keep headings and list structure unchanged. Return only the translated block.

Input: Class, 158 early classifications: 1.5% normal kidneys; 22% glomerular membranous nephritis; 22% focal nephritis; 27% diffuse proliferative nephritis; 1% renal sclerosis; typically death occurs after an average follow-up of 109 months.

Successful discontinuation of antihypertensive medications and predictive factors, July 28, 2000

A new research report indicates that some hypertensive patients can discontinue their antihypertensive medications with appropriate treatment. In a clinical trial on non-pharmacological interventions in elderly patients, 975 patients were randomly assigned to either a treatment group—those who were obese or those who were not—and were all subjected to weight loss programs, along with dietary restrictions on sodium intake, following a standardized medication reduction protocol. During the medication reduction phase, blood pressure was measured once per week, and after discontinuation, blood pressure was measured every two weeks for a total of three measurements. If blood pressure returned to normal levels (below 150/90 mmHg), blood pressure was then measured once every three months thereafter. The endpoint criteria for the study were defined as follows: when blood pressure rose above 150/90 mmHg, patients who experienced complications were required to resume antihypertensive medication on their own.

Results showed that 20.6% of patients did not complete the medication reduction process. The overall success rate of discontinuing medication after 30 months was 30.4%. Those who underwent weight loss, reduced sodium intake, and followed a combination of weight loss and sodium restriction experienced a 25%, 32%, and 45% reduction in the likelihood of developing the study endpoints compared to patients who did not undergo these interventions. This suggests that limiting sodium intake and adopting weight-loss strategies are crucial measures in the treatment of hypertension.

Unique Non-Lipid-Lowering Effects of Pravastatin, July 28, 2000

Hyperlipidemia is often associated with thrombosis. When platelet hyperreactivity and fibrinogen—thrombotic factors—are elevated in individuals with hyperlipidemia, their concentrations increase, leading to increased blood viscosity. A comparative study involving pravastatin, simvastatin, and aspirin found that pravastatin was more effective than simvastatin, while simvastatin was more effective than aspirin. These results demonstrated that statin drugs were superior to aspirin, and that statins exhibited significant cardioprotective effects, including stroke prevention, as well as additional benefits such as: ① stabilizing plaques; ② reducing platelet-mediated thrombosis; ③ restoring endothelial function; ④ decreasing inflammatory responses. The first two effects are unique to statin drugs.

Emergency Treatment of Upper Gastrointestinal Bleeding, July 30, 2000

Bleeding above the Treitz ligament is classified as upper gastrointestinal bleeding, encompassing hemorrhages in the esophagus, stomach, duodenum, gallbladder, pancreas, and common bile duct. Bleeding volume exceeding 5 ml, with positive fecal occult blood (OB); bleeding volume greater than 50 ml, resulting in melena; bleeding volume exceeding 250 ml, accompanied by hematemesis; bleeding volume over 500 ml, leading to shock. Normal red blood cell hematocrit ranges from 40% to 50% (slightly lower in women); when bleeding volume reaches 600–1000 ml, it’s considered moderate; when bleeding volume exceeds 1500–2000 ml, it’s considered severe. Red blood cell hematocrit should be maintained at around 40%–50%; for bleeding volumes between 600–1000 ml, 30% of the blood volume may be lost; for bleeding volumes between 1500–2000 ml, 20% of the blood volume may be lost. ① In mild shock, blood pressure may drop to 80–90 mmHg, pulse rate reaches 100 beats per minute, central venous pressure (CVP) shows a slight decrease, with bleeding volume accounting for approximately one-quarter of total blood volume; ② In moderate shock, blood pressure drops to 60–70 mmHg, pulse rate increases to 120 beats per minute, CVP shows a noticeable decline, and bleeding volume accounts for about one-third of total blood volume; ③ In severe shock, blood pressure falls below 60 mmHg, skin appears pale, extremities become cold, CVP is zero, and bleeding volume exceeds half of total blood volume.

Treatment: ① Administer large-volume blood transfusions—each 400 ml of fresh blood can increase hemoglobin levels by 1 g; for transfusions exceeding 2000 ml, citrate-containing blood from stored units can be used, but calcium gluconate should also be administered. Excessive blood transfusion can lead to hyperkalemia, which may subsequently result in acute respiratory distress syndrome. The infusion rate should be kept below 10 ml per minute; for critically ill patients requiring 2000 ml within the first hour, dual-channel administration or pressurized infusion may be beneficial. ② For patients with portal hypertension, vasopressin can be administered via intravenous push at 10 units, or via continuous infusion at 0.3–0.4 units per minute. While this medication has several side effects—including abdominal pain and increased bowel movements, which are common complications—and myocardial ischemia is rarely observed. ③ Recently, somatostatin (octapeptide growth hormone) or octreotide (fourteen-peptide growth hormone) have been employed; the former is administered via intravenous drip at 100 µg added to 10% glucose solution, while the latter is given at 3 mg added to 10% glucose solution. These two medications are currently recognized as the best treatments for reducing portal hypertension. ④ Vasoactive drugs such as alprazolam, dopamine, and isoproterenol can be used. ⑤ Hemostatic agents—such as tranexamic acid, hemostatic敏, and hexamethylenetetramine—can be employed, offering reliable efficacy; administer 1 ku of hemostatic敏 each time, either via intramuscular or intravenous injection. For coagulation enzyme, dissolve 2000 units of coagulation enzyme in 40 ml of cold saline solution and administer as a single dose, or use 8% norepinephrine dissolved in cold saline solution. ⑥ Antacids—such as rabeprazole and metoclopramide can be administered via intravenous drip. ⑦ Correct acid-base balance. ⑧ Cardiotonic and diuretic therapy, with close monitoring of cardiac function. ⑨ Use of gastric tubes and triple-lumen tubes.

Pathogenicity of Hepatitis E, August 3, 2000

This disease was first reported in 1996 by Simons et al. In recent years, Chinese scholars such as Xu Jiazhang have continued to conduct research on this disease and shared valuable insights. First, the pathogenicity of the virus was confirmed, and it was also shown that the virus can cause disease independently. However, most cases of Hepatitis E occur in conjunction with other viral infections, making the disease prone to chronicity and frequently progressing to liver cirrhosis.

Acute Renal Failure, August 4, 2000

Unlike chronic renal failure, this condition involves a rapid rise in blood urea nitrogen and serum creatinine within 2–3 days. Patients do not have a history of chronic renal failure, nor do they suffer from ischemic kidney disease (renal artery hardening). The most common causes of this condition include three factors: ① infection; ② poisoning; and ③ allergy. Medical treatment for this condition often relies on conservative internal medicine approaches, including supportive care, fluid resuscitation, diuresis, anti-infection therapies, and traditional Chinese medicine—though dialysis is not always necessary. Pathologically, this condition often presents with interstitial nephritis and tubular necrosis.

Over the past year, we have identified two cases of this disease: one was Deputy Director Wendefu, and the other was hospitalized patient Wang Mou.

Cardiac Myxoma, August 4, 2000

This is the most common primary heart tumor, typically located in the atrial septum or the foramen ovale. The tumor obstructs the atrioventricular openings, causing blood flow disturbances, resembling mitral stenosis. Common symptoms include: ① palpitations, chest tightness, and shortness of breath; ② dizziness (transient dizziness, even falls); ③ acute pulmonary edema (left ventricular failure), hepatomegaly, and ascites (right ventricular failure); ④ embolisms in the systemic and pulmonary circulations; ⑤ weight loss, anemia, and low-grade fever.

Physical findings may include a third-degree systolic blowing murmur and a diastolic rumbling murmur in the apical region.

This condition can lead to sudden death; once diagnosed, surgery should be performed immediately.

Inflammatory Pseudotumor, August 4, 2000

Most commonly found in the lungs, this condition is known as a pneumonic pseudotumor. It is characterized by a mass-like proliferative lesion, with pathological examination often resembling tumors. Microscopically, the cellular components are complex, making misdiagnosis relatively common. Given the lack of specific clinical manifestations and the absence of distinctive pathological or imaging findings, diagnosis can be challenging. Sometimes, the tumor may rapidly enlarge over a short period, easily being confused with lung cancer. Surgical intervention is usually the preferred treatment option; during surgery, a frozen biopsy can be performed, and the surgical approach is determined based on the diagnosis.

Treatment Efficacy Criteria for Solid Tumors, August 9, 2000