4 Traditional Chinese Medicine Resources on Syndrome Differentiation and Treatment of this Disease

(4) Traditional Chinese Medicine Resources on Syndrome Differentiation and Treatment of this Disease “Observations on the Efficacy of Self-Compiled Chinese Medicines in Treating 107 Cases of Decompensated Liver Cirrhosis After Hepatitis” used a combination of traditional Chinese and Western medicine, treating 107 cases in stages. During the jaundice phase, the primary treatments focused on clearing heat, promoting diuresis, and detoxifying; for mild to moderate jaundice, use the Liver-Clearing Soup (Yin Chen, Dang Shen, Da Huang, Long Dan Cao, Yu Jin, etc.), while for severe jaundice, use the Liver-Dissolving Soup (Chi Shao, Zhi Zi, Da Huang, etc.). During the non-jaundice phase, focus on supporting righteous qi, resolving stagnation, and clearing residual evils, using the Liver-Regulating Soup (Dan Shen, Dang Shen, Huang Jing, Bai Shao, Yu Jin, Long Dan Cao, Turtle Shell, etc.); concurrently, 100 cases were treated with Western medicine as a control group. The former had an effective rate of 66.36%, with a mortality rate of 25.23%, significantly better than the control group’s 38% and 46%. (“Chinese Journal of Integrated Medicine,” 1988, No. 4) “Treatment of Asymptomatic HBsAg Carriers with 875 Granules” primarily focused on warming yang, supplemented by nourishing qi, protecting yin, and cooling the blood. Using 3g of prepared Fuzi, 7g of Gui Rui, 2g of Gui Zhi, 20g of Nu Zhen Zi, 20g of Sheng Huang Qi, 20g of Sheng Shan Yao, 15g of Bai Shao, 15g of Dan Shen, 15g of Chai Hu, and 7g of Gan Cao, the mixture was made into powder and administered twice daily, 12g each time; children’s dosages were adjusted accordingly. The treatment was administered to 30 carriers. Compared with the control group, who received the compound Shu She Pian, 3 times daily, 3 tablets each time, children’s dosages were adjusted accordingly. The treatment duration was six months. The treatment group saw an HBsAg conversion rate of 40%, an HBeAg conversion rate of 45%, significantly better than the control group. (“Chinese Journal of Traditional Medicine,” 1990, No. 8) “Preliminary Observations on the Improvement of Abnormal Serum Proteins in Chronic Liver Disease Patients Through Ginseng, Sanqi, and Amber Powder” – 33 cases of low albumin, where multiple treatments had failed, were treated with 2 portions each of ginseng and sanqi, and 1 portion of amber powder. The powder was ground into a fine powder, taken 3g each time, 3 times daily, with an average treatment duration of 107.5 days. Results showed that albumin levels increased in 18 cases, globulin levels decreased in 22 cases, and the A/G ratio improved in 22 cases. (“Chinese Journal of Traditional Medicine,” 1990, No. 12) “Research on the Resolution of Severe Jaundice Hepatitis Through a Series of Prescriptions” – 195 cases of severe jaundice hepatitis were treated with red peony, which was used extensively for its blood-heat and damp-heat properties, while the remaining cases were characterized by blood stasis and blood heat. The prescriptions were applied in phases: Formula 1 (Sheng Di 15g, Dan Shen 15g, Ge Gen 30g, Red Peony 60g, Dan Pi 15g); Formula 2 (Red Peony, Dan Shen, Ge Gen, etc., tailored according to syndrome); Formula 3 (Dan Shen, Red Peony, Ge Gen, etc., a standardized formula); Formula 4 was a capsule derived from Formula 3; Formula 5 was a control group, with Red Peony removed from Formula 4. The overall effectiveness rate for jaundice resolution was 85.6%, with the Red Peony formula showing a significant advantage over the control group. (“Chinese Journal of Traditional Medicine,” 1991, No. 2) “Clinical Study on the Treatment of Chronic Active Hepatitis B with Kidney-Nourishing Syrup” – Syrup was made from Ba Ji Tian, Cong Rong, Sang Ji Sheng, Gou Qi Zi, Tu Si Zi, Dang Shen, Hu Zhang, Hu Zhang, Qing Pi, etc.; 20ml per dose, taken twice daily, treating 55 cases. Follow-up visits were conducted for one year, with HBsAg, anti-HBc, and HBeAg conversion rates of 30.77%, 30.43%, and 58.53%, respectively; compared with 49 cases treated with roasted malt, tangerine peel, and Buddha’s hand syrup as a control group, and 50 cases treated with syndrome-based therapy, significant differences were observed. (“Chinese Journal of Integrated Medicine,” 1991, No. 3) “Observations on the Efficacy of Kushen Alkaloid Injection in the Treatment of Chronic Hepatitis B” – 65 cases were treated with 5ml of Kushen Alkaloid injection added to 500ml of 10% glucose solution, slowly infused intravenously. If no reaction occurred, the dose was increased to 100ml on the second day, once daily, for a course of 2 months. 65 cases were treated with Yin Zhi Huang injection and Dan Shen injection, each containing 10ml added to 500ml of 10% glucose solution, also administered intravenously, for a course of 2 months. Both groups showed comparable therapeutic effects on symptoms, signs, and liver function, but the Kushen group experienced HBeAg, anti- HBc, and HBV-DNA conversion rates of 43.1%, 58%, and 37%, respectively, significantly better than the control group’s 9.2% and 0%. (“Chinese Journal of Integrated Medicine,” 1991, No. 4) “Observations on the Treatment of Liver Cirrhosis Following Hepatitis with Peach Kernel Extract and Cordyceps Mycelium” – 10ml of 15% peach kernel extract added to 500ml of 5% glucose solution, administered every other day, while simultaneously taking Cordyceps Mycelium capsules 3 times daily, 1.5g each time, treating 65 cases; conventional symptomatic treatment served as a control group, all for a course of 3 months. In the former group, albumin levels, lymphocyte transformation rates, and T cell subsets significantly increased, IgG and IgA levels decreased markedly, portal vein and splenic vein diameters and splenic volume were noticeably reduced, and 5 cases showed improvements in laparoscopic findings and pathological changes. (“Chinese Journal of Traditional Medicine,” 1991, No. 7) “Clinical Observations on the Use of Bitter Leaf Down in the Treatment of Chronic HBV Infection” – Bitter leaf down produced in Huzhou, Zhejiang, was decocted into a herbal soup, 30ml per dose, taken twice daily, for a course of 3 months, treating 100 cases; compared with Ban Lan Gen granules as a control group, the former showed a 52.4% HBeAg conversion rate, significantly better than the control group’s 8.3%. (“Chinese Journal of Integrated Medicine,” 1992, No. 1) “Treatment of 208 Cases of Chronic Hepatitis B with Ginseng-Sanqi-Interferon Tablets” – Ginseng, sanqi, Yan Hu Suo, Da Huang, Weiling Xian, Sheng Jiang, etc. were combined to make tablets, 50g per bag, with 40g of raw herbs included, taken twice daily, half a bag for adults and a quarter of a bag for children, for a course of 6 months, treating 208 cases; compared with 96 cases treated with Gan Bi Fu, the former had a total effective rate of 74.52%, an HBeAg conversion rate of 51.6%, and an HBV-DNA conversion rate of 51.5%, significantly better than the control group. (“Chinese Journal of Integrated Medicine,” 1992, No. 1) Wang Jing Qi and others used the “Fuzheng Shu Xie” formula (Huang Qi, Taizi Shen, Bai Zhu, Gou Qi Zi, Huang Qin, etc.) to treat 96 cases of chronic hepatitis B, with 21 cases cured, 58 cases showing marked improvement, and 15 cases showing effective results; 2 cases remained ineffective, with a total effective rate of 98%. (“Beijing Chinese Medicine,” 2002, No. 3) Xu Jin Bo and others used Chinese medicine formula No. II for hepatitis B (Guang Dou Gen, Ku Shen, Tu Fu Ling, Huang Qi, Qian Cao, Dan Shen, etc.) in combination with interferon and thymic factor D to treat 53 cases of chronic hepatitis B. The total effective rate was 96.23%, with HBsAg, HBeAg, and HBV-DNA conversion rates of 11.3%, 75.5%, and 77.4%, respectively. (“Practical Chinese Medicine,” 2003, No. 1) Zhang Hui Yun and others treated 106 cases of chronic hepatitis B with Zhi Ling Oral Liquid (Dan Shen, Da Huang, Yin Chen, Chai Hu, Bai Shao, Yu Jin, etc.), with a treatment course of 12 weeks. Results showed 76 cases were markedly effective, 24 cases were effective, with an effective rate of 94.3%. (“Shanghai Chinese Medicine Magazine,” 2003, No. 1) Compound Ye Xia Zhu Capsules (Ye Xia Zhu, Wu Wei Zi, Huang Qi, Hu Zhang, etc.) combined with interferon treatment for chronic hepatitis B yielded a total effective rate of 92.5%, with HBeAg and HBV-DNA conversion rates of 52.8% and 58.2%, respectively. Zhang You Xiang and others used Chinese medicine kidney-nourishing syrups in combination with lamivudine to treat 88 cases of chronic hepatitis B, with a total effective rate of 93.5%, and an ALT normalization rate of 93.5%. (“Chinese Journal of Integrated Medicine,” 2003, No. 2) Li Zheng Wen and others used Kushen Alkaloid Injection in combination with high-dose thymosin to treat 160 cases of chronic hepatitis B, with continuous treatment for 3 months. Results showed ALT and AST normalization rates of 81.9% and 86.3%, respectively, while HBeAg and HBV-DNA conversion rates were 38.7% and 31.1%, respectively. (“Chinese Journal of Integrated Medicine,” 2003, No. 3) Zhao Dong Sheng believed that this disease arises from insufficient righteous qi, unable to drive away external evils, with latent epidemic toxins causing prolonged illness. Therefore, combining antiviral therapy with immunomodulatory therapy—supporting righteous qi while eliminating evil—may enhance therapeutic efficacy. On one hand, highly effective yet low-toxicity antiviral drugs are used to inhibit the synthesis of new HBV-DNA, while Huang Qi, Red Ginseng, Purple River Carriage, Dong Chong Xia Cao,淫 Yang Huo, and Cinnamon are heavily used to warm and tonify the spleen and kidneys, raise yang, and thereby break immune tolerance, stimulating a complete immune response. Once righteous qi recovers and the balance between righteous and evil becomes intense, with ALT levels rising significantly, herbs like White Snake Tongue Grass, Dandelion, Forsythia, and Hu Zhang are added to clear heat and detoxify, aiding righteous qi in driving away evil—and satisfactory therapeutic results were achieved in clinical practice. (“Journal of Traditional Chinese Medicine,” 2005, No. 3) Wang Zheng Shu believed that the clinical manifestations of hepatitis B at each stage fall into five major categories: damp-heat intermingling, heat-toxin internal infiltration, liver qi stagnation, liver-kidney yin deficiency, and脾胃 disharmony. However, these conditions often coexist or are not always clearly defined. Therefore, in clinical practice, it is essential to perform syndrome differentiation, paying close attention to specific problems and analyzing them on a case-by-case basis, flexibly adapting treatment approaches according to different syndromes. Damp-heat intermingling is commonly seen in acute jaundice-type cases, transitional cases, and active chronic hepatitis periods, with the primary focus being to clear heat, promote diuresis, detoxify, and reduce jaundice. The Yin Chen Yuhuang Soup can be modified and adapted accordingly (Yin Chen, Hu Zhang, Huang Zhi Zi, Yu Jin, Huo Xiang, etc.) to treat jaundice.

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