Keywords：方药研究, 实验研究, 配方资产, 转化沟通, 3.2 裴氏升血颗粒对荷瘤小鼠免疫器官的重要影响
Section Index
3.5 Effect of Pei’s Shengxue Granules on the expression level of caspase-3 protein in H₂₂ tumor tissue in mice
The test results show that different dosages of Pei’s Shengxue Granules all significantly promote the expression level of caspase-3 protein in H₂₂ tumor tissue in mice. The model group had an average fluorescence intensity of 11.2 for caspase-3 protein, while the low-, medium-, and high-dose PG groups had average fluorescence intensities of 25, 34.19, and 35.17 respectively, showing much more pronounced effects compared with the model group, with significant differences (P<0.05). There was no significant difference between the various PG dosage groups and the ZG group (P>0.05). See Table 4 and the caspase-3 flow cytometry diagram on page 90.
Table 4: Effect of Pei’s Shengxue Granules on caspase-3 protein expression in H₂₂ tumor tissue in mice (n=6, x̄±S)
| Group | Dosage (g/kg) | Fluorescence intensity (MnX) |
|---|---|---|
| Con | - | 11.20±5.78 |
| PG | 2.5 | 25.00±11.17* |
| PG | 5.0 | 34.19±11.86* |
| PG | 10.0 | 35.71±12.77* |
| ZG | 1.67 | 37.59±12.13** |
Note: Compared with Con; *P<0.05, **P<0.01. MnX represents the average fluorescence intensity of caspase-3 expression per cell.
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