2 Reflections and Prospects

2 Reflections and Prospects

Pei’s Blood-Boosting Granules are a prescription formulated by Professor Pei Zhengxue, based on more than forty years of clinical experience, for treating tumors. This formula integrates warming the kidneys, strengthening the spleen, benefiting qi, and nourishing blood into one, with reinforcing vital energy and nourishing the root as its core principle. Over the years, it has achieved fairly satisfactory therapeutic results in clinical applications for cancer, proving that Pei’s Blood-Boosting Granules are not only highly effective against leukemia but also demonstrate significant clinical efficacy against malignant tumors, especially those caused by weakened immune function due to radiotherapy and chemotherapy. In recent years, preliminary animal experiments have confirmed that its effects are consistent with the therapeutic outcomes observed in clinical practice. To explore its mechanism of action, this study was initiated to investigate the impact of Pei’s Blood-Boosting Granules on H22 tumor cell apoptosis and the protein expression of p53 and Caspase-3. This fully embodies the idea of letting clinical experience guide experimental research, thus avoiding blind experimentation. In future research, we should make full use of new achievements in modern science and technology to conduct in-depth studies on the molecular biological mechanisms of Pei’s Blood-Boosting Granules’ anti-tumor effects, explore Professor Pei’s vision of integrating Chinese and Western medicine in tumor treatment, and provide more microscopic explanations for this clinical prescription.

References

[1] Xia Xiaojun. Introduction to Professor Pei Zhengxue’s Experience in Treating Leukemia. New Traditional Chinese Medicine, 2006

[2] Pei Zhengxue. Acute Monocytic Leukemia. Practical Internal Medicine Combining Chinese and Western Medicine. People’s Health Publishing House, 1996: pp. 321–336

[3] Pei Zhengxue. A Casual Discussion on the Treatment of Leukemia. Collection of Pei Zhengxue’s Medical Talks and Cases. Gansu Science and Technology Press, 2004: pp. 24–25

[4] Pei Zhengxue. Reinforcing Vital Energy and Nourishing the Root vs. Immunity. Collection of Pei Zhengxue’s Medical Experience. Gansu Science and Technology Press, 2003: pp. 234–246

[5] Pei Zhengxue. A Brief Overview of Clinical Treatment for Esophageal Cancer. Journal of Traditional Chinese Medicine, July 2002

[6] Xue Wenhan. Teacher Pei Zhengxue’s Experience in Treating Primary Liver Cancer. Journal of Classical Chinese Medicine, December 1998

[7] Li Min, Xue Wenhan, Li Wei, et al. Observation of the Therapeutic Effects of Pei’s “Lanzhou Formula” Combined with Chemotherapy in 10 Cases of Cancer Treatment. National Medicine Forum, 1998

Research on Pei Zhengxue’s Series of Prescriptions

[8] Zhang Guiqiong. The Impact of Pei’s Blood-Boosting Granules on the Proliferation Activity of Spleen Lymphocytes and Cytokines in H22-Tumor-Bearing Mice [D]. Master’s Thesis, 2007.

[9] Huang Bangrong. An Experimental Study on the Impact of Pei’s Blood-Boosting Granules on the Immune System of H22-Tumor-Bearing Mice [D]. Master’s Thesis, 2007.

[10] Bai Lijun. An Experimental Study on the Impact of Pei’s Blood-Boosting Granules on the Bone Marrow Hematopoietic System of Refractory Anemia Model Mice [D]. Master’s Thesis, 2006.

[11] Wang Xiaoli. An Experimental Study on the Impact of Pei’s Blood-Boosting Granules on the Immune System of Refractory Anemia Model Mice [D]. Master’s Thesis, 2006.

[12] Tejeda M, Gaal D, Barna K, et al. The Antitumor Activity of the Somatostatin Structural Derivative (TT2232) on Different Human Tumor Xenografts [J]. Anticancer Research, 2003, Vol. 23(5A): pp. 4061–4066.

[13] Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological Experimental Methodology [M]. 3rd Edition. Beijing: People’s Health Publishing House, 2002: pp. 1757–1827.

[14] Dai Xinyi, Chen Linxiang, Zhou Daihan, et al. An Experimental Study on the Anti-Tumor Effects of Shen Tao Soft Liver Pills on Tumor-Bearing Animals [J]. China Oncology, 2001, Vol. 10(7): pp. 426–428.

[15] Li Yikui. Pharmacological Experimental Methodology for Traditional Chinese Medicine [M]. Shanghai: Shanghai Science and Technology Press, 1991: p. 36.

[16] Sun Zhen, Chen Shiliang, Gu Wenying, Tao Wenyi. An Experimental Study on the In Vivo Anti-Tumor Effects of Grifola Frondosa Polysaccharides [J]. Pharmaceutical Biotechnology, 2001, Vol. 8(5): pp. 279–283.

[17] Han Rui. Research and Experimental Studies on Anti-Cancer Drugs [M]. Beijing: Joint Publishing House of Peking University Medical School and Peking Union Medical College, 1997: pp. 13–15.

[18] Finlay CA, Hinds PW, Levine AJ, et al. The p53 Proto-Oncogene Can Act as a Suppressor of Transformation [J]. Cell, 1989, Vol. 57: p. 1083.

[19] Harris CC, Hollstein M. Clinical Implications of the p53 Tumor Suppressor Gene [J]. New England Journal of Medicine, 1993, Vol. 329: p. 1318.

[20] Cao Wenguang, Du Ping. Modern Biological Therapy [M]. Beijing: People’s Military Medical Press, 1995: pp. 112–117.

[21] Ahmad M, Srinivasula SM, Hegde R, et al. Identification and Characterization of Murine Caspase-14, a New Member of the Caspase Family [J]. Cancer Research, 1998, Vol. 58(22): pp. 5201–5205.

[22] Peter ME, Krammer PH. Mechanisms of CD95-Mediated Apoptosis [J]. Current Opinion in Immunology, 1998, Vol. 10(5): pp. 545–551.

[23] Tschopp J, Irmler M, Thome M. Inhibition of Fas Death Signals by FLIPs [J]. Current Opinion in Immunology, 1998, Vol. 10(5): pp. 552–558.

[24] Kataoka T, Schroter M, Hahne M. FLIP Prevents Apoptosis Induced by Death Receptors but Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation [J]. Journal of Immunology, 1998, Vol. 161(8): pp. 3936–3942.

[25] Pei Zhengxue. Reinforcing Vital Energy and Nourishing the Root vs. Immunity [M]//Collection of Pei Zhengxue’s Medical Experience. Lanzhou: Gansu Science and Technology Press, 2003: pp. 94–106.

[26] Xue Wenhan. Teacher Pei Zhengxue’s Experience in Treating Primary Liver Cancer [J]. Journal of Classical Chinese Medicine, Taiwan, December 1998.

[27] Pei Zhengxue. Radionuclide Therapy and “Reinforcing Vital Energy and Nourishing the Root” [M]//Collection of Pei Zhengxue’s Medical Talks and Cases. Lanzhou: Gansu Science and Technology Press, 2004: pp. 31–33.

[28] Chen Jing, Chen Peifeng. Zhejiang University of Traditional Chinese Medicine’s Journal of Integrated Chinese-Western Medicine [J]. 2006.

[29] Yang Tiehong, Jia Min, Mei Qibing. The Effect of Angelica Polysaccharide Component AP-3 in Inducing Mouse Spleen Cells to Produce IL-2 and IFN-γ [J]. Journal of Pharmacy, 2006, Vol. 41(1): pp. 54–57.

---

The Impact of Pei’s Blood-Boosting Granules on H22 Tumor Cell Apoptosis and NF-κB Expression

Wang Zhuo