Keywords：方药研究, 实验研究, 配方资产, 转化沟通, 1 裴氏升血颗粒抑制肿瘤生长
Section Index
3.6 Effects of Pei’s Shengxue Granules on the Cell Cycle of Tumor Tissues in Tumor-Bearing Mice
As shown in Table 4, the large-, medium-, and small-dose Pei’s Shengxue Granules groups as well as the Zhenqi Fuzheng Granules control group influenced the distribution ratio of the tumor cell cycle. In the model group, the G₀/G₁ phase accounted for 30.95%, while in the treatment groups it increased to varying degrees, with the medium-dose PG group showing the most significant effect, where the G₀/G₁ phase rose to 56.93% (P<0.01); in the model group, the S phase was 56.35%, while in the treatment groups it decreased to varying degrees, with the medium-dose PG group seeing the S phase drop to 30.93% (P<0.01). No subdiploid peak of apoptotic cells was observed in the model group; however, after treatment with various doses of PG, a subdiploid peak of apoptotic cells emerged, with the medium-dose group showing the best effect. Results are shown in Table 4 and Figures 4-1, 4-2, 4-3, and 4-4.
Table 4: Effects of Pei’s Shengxue Granules on the Cell Cycle of Tumor Tissues in Tumor-Bearing Mice (%; X±S)
| Group | Dose (g·kg⁻¹) | Number of Cases | G₀/G₁ | S | G₂/M |
|---|---|---|---|---|---|
| Model Control Group | - | 6 | 30.95±7.19 | 56.35±10.17 | 12.70±1.68 |
| PG Small-Dose Group | 2.56 | 6 | 46.32±6.98 | 38.02±6.03 | 15.66±1.61* |
| PG Medium-Dose Group | 5.06 | 6 | 56.93±9.68* | 30.93±9.79 | 12.14±1.10** |
| PG Large-Dose Group | 10.06 | 6 | 49.67±9.97 | 36.68±6.91* | 13.65±1.99 |
| Zhenqi Fuzheng Granules Control Group | 1.67 | 6 | 54.99±8.67** | 32.87±9.11 | 12.14±1.23** |
Note: Compared with the model group, **P<0.01 *P<0.05
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