1 Anti-tumor Effects of Pei's Shengxue Granules

1 Anti-tumor Effects of Pei's Shengxue Granules

The H₂₂ transplantable tumor model used in this experiment is a typical in vivo model for evaluating drug anti-tumor activity. The method involves transplanting tumor cells into animals and allowing them to proliferate continuously within the body. The advantage of this model is that it maintains the integrity of the organism and allows normal interaction between the body and the external environment, thus providing a more objective reflection of drug anti-tumor efficacy [17]. While observing the inhibitory effect of 5-Fu on tumor growth, this experiment focused on the combined effect of Pei's Shengxue Granules and 5-Fu on tumor growth. The results show that the combination significantly reduces the average tumor weight in H₂₂ tumor-bearing mice, with a maximum tumor suppression rate of 72.4%. It can be concluded that Pei's Shengxue Granules have a certain anti-tumor effect and a clear synergistic effect on the anti-tumor activity of 5-Fu.

Research has found that macrophages (Mφ), natural killer cells (NK), cytotoxic T lymphocytes (CTL), and lymphokine-activated killer cells (LAK) all play important roles in combating tumors, and that traditional Chinese medicines rich in polysaccharides can enhance the activity of Mφ, NK, CTL, and LAK, as well as increase the secretion of angiogenesis inhibitors (AIF) and suppress epidermal growth factor (EGF), thereby achieving multi-faceted inhibition of tumor growth. Due to the complexity of traditional Chinese medicine ingredients, a single herb or a compound formula often has multiple mechanisms of action, which is the advantage of traditional Chinese medicine in targeting multiple links and multiple points in anti-tumor therapy. With the rapid development of cell biology and molecular biology, the cross-disciplinary integration of fields, and the emergence of experts proficient in multiple disciplines, research on anti-tumor traditional Chinese medicine will surely, driven by the modernization of traditional Chinese medicine, deepen and refine the study of herbal compatibility rules, mechanisms of action, and material bases of action, thus promoting the global spread of traditional Chinese medicine and serving all humanity, which is of great significance for the promotion of traditional Chinese medicine culture. It is also necessary to advocate for research on the toxic side effects of anti-tumor traditional Chinese medicines and properly balance the relationship between single-component and multi-component formulations, which will provide crucial guidance for the development of anti-tumor traditional Chinese medicines. It is believed that the development of anti-tumor traditional Chinese medicines with high efficacy, low side effects, and multi-target, multi-link action represents the future hope for anti-tumor traditional Chinese medicines [33, 34].