2 Effects of Pei's Shengxue Granules on Immune Organs

2 Effects of Pei's Shengxue Granules on Immune Organs

The thymus is the most important central immune organ in the body, serving as the site where T cells develop, differentiate, and mature. T cells are vital immune cells in the human body, capable of mediating cellular immunity and participating in the execution and regulation of various immune functions; the body's anti-tumor immune function is primarily based on cellular immunity [35]. Many animal experiments have shown that the thymus of tumor-bearing hosts often shrinks, loses weight, and experiences a significant reduction in thymic cells. At this point, the body's cellular immune function and related immune capabilities decline, making it difficult to suppress tumor cells. The spleen is the largest peripheral immune organ in the human body, housing various immune cells and serving as the main organ for mounting immune responses against antigens and producing immune effects. Currently, it is believed that the spleen plays a dual role in tumor immunity: in the early stages of tumor development, it exerts a positive immune effect, inhibiting tumor growth; however, in the later stages, the spleen produces large amounts of inhibitory cells and releases active soluble substances that suppress the body's immune function [36].

The results of this experiment show that 5-Fu can reduce the thymus index and spleen index of tumor-bearing mice, while Pei's Shengxue Granules can partially counteract this effect. Notably, the high-dose group combining Pei's Shengxue Granules with 5-Fu showed a significant increase in the thymus index, whereas the medium- and low-dose groups showed no significant difference compared with the use of 5-Fu alone, indicating that the effect of Pei's Shengxue Granules on the thymus index after 5-Fu chemotherapy is dose-dependent. Similarly, the high-, medium-, and low-dose groups combining Pei's Shengxue Granules with 5-Fu all showed a significant increase in the spleen index compared with the use of 5-Fu alone. Statistical analysis confirms that Pei's Shengxue Granules have a clear ameliorative effect on the reduction of thymus and spleen indices caused by 5-Fu chemotherapy.