3.4 Effects of Pei's Shengxue Granules on Serum IL-1 Concentration in Tumor-Bearing Mice

3.4 Effects of Pei's Shengxue Granules on Serum IL-1 Concentration in Tumor-Bearing Mice

The results show that in the Pei's Shengxue Granules groups of different doses, the serum IL-1 concentrations are all lower than those in the model group, with the medium- and high-dose groups having IL-1 concentrations of 0.099 ± 0.028 ng/ml and 0.078 ± 0.027 ng/ml, respectively, both statistically significant compared with the model group (p < 0.05). In the model group, the serum IL-1 concentration is significantly higher than in the normal group, which is also statistically significant compared with the normal group (p < 0.05). See Table 4 and Figure 5.

Table 4: Effects of Pei's Shengxue Granules on Serum IL-1 Concentration in Tumor-Bearing Mice (x̄±s)

Note: *p<0.05, compared with the model group; ▲p<0.05, compared with the normal group

---

Discussion

Pei’s Shengxue Granules (composed of Rehmannia, Cornus fruit, Chinese yam, Pseudostellaria, Glehnia root, Codonopsis, Cinnamon twig, Schisandra, White peony, and Floating wheat) are a specialized formulation for treating leukemia—known as the “Lanzhou Formula”—developed by Professor Pei Zhengxue based on his more than forty years of clinical experience. This formula is formulated under the overarching principle of “tonifying the body’s vital energy and consolidating the root,” integrating warming the kidneys, strengthening the spleen, replenishing qi, and nourishing blood, with “strengthening the spleen and kidneys” as its core essence. Through continuous practice, refinement, and reorganization, this formulation has been developed. The formula employs the “Four Ginsengs” to comprehensively strengthen the spleen and replenish qi, making them a powerful force in tonifying the postnatal foundation; it also incorporates “Shengmai Powder” to further enhance qi and nourish the lungs, thereby amplifying the effects of the Four Ginsengs. Additionally, it utilizes the core components of “Liuwei Dihuang Decoction,” with a particularly high dosage of Cornus fruit (30g), to further reinforce the innate replenishing effect. “Guizhi Decoction” is regarded as the pinnacle among all formulas, possessing the efficacy of “harmonizing the exterior’s Ying and Wei while calming the interior organs.” Professor Pei believes that the essence of applying this formula here lies in simultaneously reinforcing both the innate and postnatal foundations while enhancing the regulation of Ying and Wei and soothing the internal organs, effectively strengthening the regulation of the autonomic nervous system, metabolic system, endocrine system, and immune system. Furthermore, “Ganmai Dazao Decoction,” traditionally used by ancient practitioners to treat women’s neurosis, is believed by Professor Pei to not only regulate the autonomic nervous system but also calm the mind and stabilize emotions, complementing the functions of other herbs that may be insufficient. In summary, Pei’s Shengxue Granules follow the principle of “tonifying the body’s vital energy and consolidating the root,” strengthening the body’s inherent righteous qi, thereby achieving the effect of “when righteous qi resides within, evil cannot invade,” effectively preventing and treating tumors.

This experiment further explores the anti-tumor mechanism of Pei’s Shengxue Granules by measuring macroscopic indicators such as tumor weight, thymus, and spleen in each group of mice, as well as observing microscopic indicators like EGF and IL-1 in serum.