2 Reflections and Prospects

2 Reflections and Prospects

Pei’s Shengxue Granules are a purely traditional Chinese medicine preparation that integrates warming the kidneys, strengthening the spleen, replenishing qi, and nourishing blood, following the principle of “tonifying the body’s vital energy and consolidating the root.” Since Professor Pei Zhengxue first formulated this prescription, it has been widely used in clinical practice for more than thirty years. Practice has proven that Pei’s Shengxue Granules are not only effective against leukemia but also have significant clinical efficacy against malignant tumors, especially those caused by radiation and chemotherapy-induced immune dysfunction. In recent years, preliminary animal experiments have also shown that its effects are consistent with the therapeutic outcomes achieved in clinical practice.

The basis for this research project comes from the inspiration drawn from Professor Pei Zhengxue’s more than forty years of clinical experience, fully embodying the idea of using clinical experience to guide experimental research and avoiding the blindness of experimental studies. In future research, we will make full use of new achievements in modern science and technology to conduct in-depth studies on the material basis and related mechanisms of Pei’s Shengxue Granules’ regulation of immune function, explore Professor Pei’s ideas and methods of combining traditional Chinese and Western medicine for tumor prevention and treatment, and provide more microscopic explanations for his clinical prescriptions.

Research on Pei Zhengxue’s series of prescriptions

References

[1] Sun Yan, Shi Yuankai. Clinical Oncology Handbook. Beijing: People’s Health Publishing House, 2007: 7

[2] Liver Cancer Specialist Committee of the Chinese Anti-Cancer Association, Clinical Oncology Collaboration Committee of the Chinese Anti-Cancer Association, Liver Cancer Group of the Liver Disease Branch of the Chinese Medical Association. Expert Consensus on Standardized Diagnosis and Treatment of Primary Liver Cancer. Journal of Clinical Oncology, 2009, 14(3): 259

[3] China Cancer Prevention and Control Program Outline. China Tumor, 2004, 02: 65–68

[4] Guo Wei, Zhao Zezhen, Shan Bao’en et al. Experimental Report on the Anti-Mutation and Anti-Tumor Activities of Six Traditional Chinese Herbs. Cancer·Deformation·Mutation, 2002, 14(2): 95–97

[5] Zhao Zezhen, Wei Lizhen. Rapid Synchronized Test on the Anti-Mutation and Pro-Mutation Effects of 22 Edible Chinese Medicinal Herbs. Cancer·Deformation·Mutation, 2002, 12(2): 87–89

[6] Zhang W, Leonard T, Bath-Hextall F, et al. Chinese Herbal Medicine for Atopic Eczema. Cochrane Database Syst Rev. 2005; CD002291

[7] Chen X, Murakami T, Oppenheim JJ, Howard OM. Triptolide, a Constituent of Immunosuppressive Chinese Herbal Medicine, Is a Potent Suppressor of Dendritic-Cell Maturation and Trafficking. Blood. 2005; 106: 2409–2416

[8] Tamura R, Takahashi HK, Xue D, et al. Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumor Necrosis Factor-α and Interleukin- in Human Peripheral Blood Mononuclear Cells. J Int Med Res. 2004; 32: 25–32

[9] Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A Study on the Immune Receptors for Polysaccharides from the Roots of Astragalus membranaceus, a Chinese Medicinal Herb. Biochem Biophys Res Commun. 2004; 320: 1103–1111

[10] Qiu D, Kao PN. Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f. Drugs R D. 2003; 4: 1–18

[11] Tejeda M, Gaal D, Barna K, et al. The Antitumor Activity of the Somatostatin Structural Derivative (TT2232) on Different Human Tumor Xenografts[J]. Anticancer Res, 2003, 23(5A): 4061–4066

[12] Jean Marx. ANGIOGENESIS: A Boost for Tumor Starvation. Science, 2003, July 25, 301: 452–454

[13] Rakesh K Jain. Molecular Regulation of Vessel Maturation. Nature Medicine, 2003, 9(6): 685–693

[14] Pei Zhengxue. Tonifying the Body’s Vital Energy and Consolidating the Root with Immunity. Collection of Pei Zhengxue’s Medical Experience, Gansu Science and Technology Press, 2003: 95–97

[15] Pei Zhengxue. Casual Talk on the Treatment of Leukemia. Collection of Pei Zhengxue’s Medical Cases and Conversations, Gansu Science and Technology Press, 2004: 24–25

[16] Pei Zhengxue. Tonifying the Body’s Vital Energy and Consolidating the Root with Immunity. Collection of Pei Zhengxue’s Medical Experience, Gansu Science and Technology Press, 2003: 234–246

[17] Pei Zhengxue. Acute Monocytic Leukemia. Practical Internal Medicine Combining Traditional Chinese and Western Medicine, People’s Health Publishing House, 1996: 321–336

[18] Pei Zhengxue. A Brief Overview of Clinical Treatment of Esophageal Cancer. Chinese Medicine Journal, 2002.7

[19] Xue Wenhan. Professor Pei Zhengxue’s Experience in Treating Primary Liver Cancer. Journal of Traditional Chinese Medicine Classics, Taiwan, 1998.12

[20] Li Min, Xue Wenhan, Li Wei et al. Observation of the Therapeutic Effects of Pei’s “Lanzhou Formula” Combined with Chemotherapy in 10 Cases of Cancer Treatment. National Medicine Forum, 1998: 206

Research on Pei Zhengxue’s series of prescriptions

References

[21] Pei Zhengxue. Radionuclide Therapy and “Tonifying the Body’s Vital Energy and Consolidating the Root.” Collection of Pei Zhengxue’s Medical Cases and Conversations, Gansu Science and Technology Press, 2004: 31–33

[22] Bai Lijun. Experimental Study on the Effects of Pei’s Shengxue Granules on the Bone Marrow Hematopoietic System of Aplastic Anemia Model Mice. Master’s Thesis, 2006

[23] Wang Ning. Experimental Study on the Effects of Pei’s Shengxue Granules on the Apoptosis of H₂₂ Tumor Cells and the Expression of p53 and Caspase-3 Proteins. Master’s Thesis, 2008

[24] Wang Zhuo. Experimental Study on the Effects of Pei’s Shengxue Granules on the Apoptosis of H₂₂ Tumor Cells and the Expression of NF-κB. Master’s Thesis, 2008

[25] Zhang Guiqiong. Experimental Study on the Effects of Pei’s Shengxue Granules on the Proliferation Activity of Splenic Lymphocytes and the Secretion of Cytokines in H₂₂ Tumor-Bearing Mice. Master’s Thesis, 2007

[26] Qian Hongjiang. Analysis of the Expression and Significance of EGF and PCNA in the Gastric Mucosa[J]. Shandong Medicine, 2006, 46(23): 86–87

[27] Hu Qingjun, Shi Chaohui. The Expression of EGFR and PCNA in Esophageal Cancer and Their Clinical Significance[J]. Shandong Medicine, 2005, 45(5): 42–43

[28] Woodburn JR. The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy[J]. Pharmacol Ther, 1999, 82(2–3): 241–250 [29] Wang Wenqi, Xu Hanfeng. The relationship between epidermal growth factor and its receptor and liver cancer. Foreign Medical Sciences: Oncology Section, 2005, 32(3): 212-214

[30] Liu Lifeng, Liu Yuhe, Shen Weigao, et al. Structure, origin, distribution, function of interleukin-1 and its relationship with diseases [J]. Peking University Journal, 2006, 7(5): 416

[31] Zhang Jun, Jin Hu, Meng Qingrun, et al. Determination of plasma IL-1 activity and TNF-α content in patients with liver cancer. Chinese Journal of Occupational Medicine, 2003, 16(1): 4

[32] Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological experimental methodology. 3rd edition, Beijing: People's Health Publishing House, 2002: 1757-1827

[33] Dai Xinyi, Chen Linxiang, Zhou Daihan, et al. Experimental study on the tumor-inhibiting and immunomodulatory effects of Shentao Ruangan Wan on tumor-bearing animals. Chinese Journal of Oncology, 2001, 10(7): 426-428

[34] Li Yikui. Pharmacological experimental methodology for traditional Chinese medicine. Shanghai: Shanghai Scientific and Technological Publishing House, 1991: 36

[35] Sun Zhen, Chen Shiliang, Gu Wenying, Tao Wenyi. Experimental study on the in vivo antitumor effects of Grifola frondosa polysaccharides. Pharmaceutical Biotechnology, 2001, 8(5): 279-283

[36] Ma Dongzhu, Sun Keren, Zhao Li, et al. Effects of drug AC-88 on the mRNA levels of TNF-α, IL-1β, and IL-6 in T cells of tumor-bearing mice, as well as on their proliferative function. Cancer, Mutation, and Deformation, 2003, 15(4): 207-208

---

The Effect of Peishiruanganxiaopiwan on Serum TNF-α and IFN-γ in H₂₂ Tumor-Bearing Mice

Dan Jinmei