Keywords：方药研究, 实验研究, 配方资产, 转化沟通, 3.4 裴氏软肝消痞丸对荷瘤小鼠肿瘤组织中P27表达的影响
Section Index
3.2 Effects of Pei’s Soft Liver and Anti-Flatulence Pill on Tumor Weight and Tumor Inhibition Rate in Tumor-Bearing Mice
The inhibitory effect of PRGXP on tumor weight in tumor-bearing mice is as follows: the average tumor weights of the PRGXP low-, medium-, and high-dose groups, as well as the Cantharidin group, are all lower than that of the model control group, at (0.935 ± 0.227) g, (0.776 ± 0.122) g, (0.926 ± 0.237) g, and (0.925 ± 0.320) g, respectively, all showing statistically significant differences compared with the model control group (p < 0.05). The tumor inhibition rates of the PRGXP low-, medium-, and high-dose groups, as well as the Cantharidin group, are 23.9%, 36.8%, 24.5%, and 24.6%, respectively, with the PRGXP medium-dose group showing a statistically significant difference compared with the Cantharidin group (p < 0.05). See Table 1, Figure 1, and Figure 2:
Table 1: Effects of Pei’s Soft Liver and Anti-Flatulence Pill on Tumor Weight in Tumor-Bearing Mice (x±s)
| Group | Dosage (g·kg⁻¹) | Number of Mice | Average Tumor Weight (g) | Tumor Inhibition Rate (%) |
|---|---|---|---|---|
| Model Control Group | — | 12 | 1.227 ± 0.193 | — |
| PRGXP Low-Dose Group | 1.0 | 12 | 0.935 ± 0.227 | 23.9 |
| PRGXP medium-dose group | 2.0 | 12 | 0.776±0.122 | 36.8 |
| PRGXP high-dose group | 4.0 | 12 | 0.926±0.237 | 24.5 |
| Cantharidin group | 0.25 | 12 | 0.925±0.320 | 24.6 |
Note: *p<0.05 compared with the model control group
(Figures 1 and 2 omitted)
Research on Pei Zhengxue's Series of Formulas and Medicines
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