3.3.6 Traditional Chinese Medicine Inhibits Angiogenesis in Liver Cancer

3.3.6 Traditional Chinese Medicine Inhibits Angiogenesis in Liver Cancer

The growth of malignant tumors relies on angiogenesis; newly formed blood vessels not only provide ample oxygen to tumor cells but also serve as pathways for tumor cell metastasis. Therefore, in recent years, research into how to inhibit tumor angiogenesis has become one of the important means of stopping tumor growth and is considered the most promising targeted therapy for cancer. Angiopoietin and vascular endothelial growth factor are key factors in tumor angiogenesis. Studies on single herbs, such as Bletilla striata, resveratrol, and gecko, have shown that they can inhibit tumor angiogenesis by downregulating the expression of vascular endothelial growth factor protein. Research on herbal compound formulas, such as Du Meng's experiment injecting 10 μL/mL Coix seed injection into arteries, found that there were very few new blood vessels, with better angiogenesis inhibition than the vitamin E group (0.1 mg/mL). Biejia Jianwan significantly reduced the microvascular count in mice with tumors, achieving anti-tumor effects in tumor-bearing mice. Shenmai injection affects tumor angiogenesis by inhibiting the proliferation and migration of vascular endothelial cells.

4 Modern Medical Understanding of Primary Liver Cancer