Angiotensin-Converting Enzyme Inhibitors, February 27, 1995

Angiotensin-Converting Enzyme Inhibitors, February 27, 1995

Like nitroglycerin, β-blockers, and calcium channel blockers, these agents have elevated cardiovascular disease treatment to a new level. The first-generation product, captopril, appeared on the U.S. market in 1980, and the second-generation product, enalapril, was launched in 1986. Within just ten years, it became the world's most popular drug.

Captopril, also known as captopril, is a short-acting drug that does not require liver metabolism to take effect and can be administered sublingually. Recently, enalapril has emerged, which is excreted unchanged by the kidneys and only needs to be taken once daily. Currently, there are no domestically produced formulations available.

Indications for this drug: ① hypertension; ② heart failure; ③ coronary heart disease; ④ diabetic nephropathy.