Senile Osteoporosis, May 19, 1998

Senile Osteoporosis, May 19, 1998

As aging progresses, the body’s gonadal hormone secretion declines, leading to lower levels of estrogen and testosterone. Normally, adrenal cortical function is suppressed by sex hormones; however, when sex hormone levels are insufficient, adrenal cortical hormones become relatively overactive, resulting in central obesity and bone decalcification. On the other hand, as aging advances, parathyroid function declines, causing hypocalcemia. These pathophysiological mechanisms directly contribute to bone damage, with severe cases potentially leading to fractures, most commonly vertebral compression fractures. In extreme cases, paralysis-like symptoms may occur. Treatment includes calcium supplements, estrogen, ethinylestradiol, testosterone, vitamin D, and immobilization.

Additional note: Central obesity indicates high adrenal cortical activity, making the individual prone to irritability, impatience, hypertension, and diabetes; conversely, a well-proportioned physique avoids these issues. Adolescent girls, due to high estrogen levels, have relatively lower adrenal cortical function, thus avoiding central obesity and maintaining a slim figure.