Lupus Nephritis 2000.7.28

Lupus Nephritis 2000.7.28

The average age of patients with lupus nephritis is 27 ± 11 years, with a female-to-male ratio of 4:1. The diagnostic criteria for this disease are biopsy under light microscopy, abnormal kidney specimens, urine protein > 0.19 g/24h, and a 30% reduction in creatinine clearance. Approximately 36% of SLE patients develop this condition, with 30.7% occurring within five years of SLE onset. According to WHO classification, among 158 early-stage cases: 1.5% have normal kidneys; 22% have glomerular membrane nephritis; 22% have focal nephritis; 27% have diffuse proliferative nephritis; 1% have renal sclerosis; and patients typically die after an average follow-up of 109 months.