Task output rules: | Professor Pei Zhengxue Academic Archive

From Pei Zhengxue Clinical Highlights, Volume 2 · Read time 10 min · Updated March 22, 2026

Keywords：专著资料, 全文在线浏览, 临床资料, 第13部分

Section Index

3. Case Study 2: A 55-year-old female patient was found to have enlarged lymph nodes above her left clavicle during a physical examination in 2010. A nasopharyngoscope and cytological biopsy confirmed the diagnosis of nasopharyngeal cancer. She underwent two courses of radiation therapy at a hospital in Gansu Province.

3. Case Study 2: A 55-year-old female patient was found to have enlarged lymph nodes above her left clavicle during a physical examination in 2010. A nasopharyngoscope and cytological biopsy confirmed the diagnosis of nasopharyngeal cancer. She underwent two courses of radiation therapy at a hospital in Gansu Province.

Task output rules: Translate this markdown block from Chinese to English. Preserve markdown markers, links, and formatting. Keep headings and list structure unchanged. Return only the translated block.

Input: ,病情得以稳定。2010 年 12 月 ,于左颌下发现肿物 ,诊断为鼻咽癌复发。本次发病后出现头晕头昏 ,双耳针刺样疼痛 ,流出黄色脓液 ,耳鸣耳聋 ,面颊部红肿灼热疼痛 , 口鼻干燥 , 五心烦热 ,形体消瘦 ,干咳少痰 ,舌质红 ,少苔脉细数。于 2011 年 1 月来诊。辨证属于气阴两虚 ,痰瘀互结。以益气养阴治之。方用养阴清肺汤、沙参麦冬汤、杞菊地黄汤加减。处方 :北沙参 15g,山萸肉 15g,元参 10g,生地 12g,麦冬 10g,天冬 10g,玉竹 10g,枸杞子 10g,菊花 10g,牡丹皮 6g,天花粉 30g,浙贝母 10g ,白花蛇舌草 15g,仙鹤草 15g,山萸肉 10g,女贞子 15g,旱莲草 15g,菟丝子 10g。 15 剂 ,每日一剂。二诊 ,耳鼻渗液明显减少 , 口腔溃疡好转 , 口鼻干燥、五心烦热、乏力减轻。予以海藻玉壶汤 ,升降散加减。处方 :甘草 6g,川芎 6g,海藻 10g,昆布 10g,当归 10g,姜黄 10g,连翘 15g,浙贝母 10g,陈皮 6g,半夏 6g,大黄 6g,蝉衣 6g,僵蚕 6g 。15 剂。

三诊 ,左锁骨上淋巴结肿大明显减小。其余症状明显好转。处

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裴正学临床荟萃第二辑方:兰州方加减。至今存活 ,定期门诊复诊。四、结语

" 西医诊断 , 中医辨证 , 中药为主 ,西药为辅 "是裴正学教授提出的十六字方针。这十六字方针在鼻咽癌的治疗领域中的应用主要体现在用西医诊断确立后充分发挥中医辨证 ,扶正固本的优势。并同时发挥西医手术、放化疗等手段杀灭癌细胞。以期达到减轻放化疗的毒副作用 ,延缓病情发展 ,提高患者生存质量 ,延长生存期的目的。裴教授认为鼻咽癌的发生从根本上时人体正气亏虚所致。《医宗必读》中云:"积之成者 ,正气虚而后邪气踞之"。另一方面 ,手术、放化疗对机体的耗气伤阴等反过来又影响脏腑气血功能 ,使正气更虚 , 出现恶性循环。因此裴正学教授在治疗鼻咽癌时以遵从扶正固本的根本大法。即所谓"正气存内 ,则邪不可干","邪之所凑 , 其气必虚"。兰州方作为治疗本病的基础方 ,在患者发病的各个不同阶段始终得以应用 , 同时根据患者病情辨证 ,遵循"急则治标 ,缓则之本"的原则 ,充分发挥中西医结合治疗鼻咽癌的优势。

《新中医》2013 年 12 期

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第十六章裴氏方药第十六章裴氏方药 胆胰合症方 王鑫陈光艳赵孝鹏裴正学 ,男 , 1938 年生。主任医师、教授、博士生导师。著名中西医结合专家 ,第二、三、四、五批全国老中医药专家学术经验继承工作指导老师 ; 中华中医药学会终身理事 ,甘肃省中西医结合学会名誉会长 , 中国中医科学院博士生导师 ,甘肃省首批名老中医 ,甘肃省医学科学研究院首席专家 ,甘肃省中医院首席专家 ,甘肃省文史馆馆员。他从事临床、教学、科研工作 50 余载 ,学验俱丰 ,擅长治疗肿瘤、肝病、血液病、自身免疫病等疑难杂症 ;提出"西医诊断 , 中医辨证 , 中药为主 ,西药为辅 "的中西医结合十六字方针已成为当前发展中医的重要途径之一。出版《中西医结合实用内科学》《血证论评释》《裴正学医话医案集》《裴正学医学笔记》等 18 部医学论著 ,发表 80 余篇医学论文。

组成 :柴胡 10g , 枳实 10g , 白芍 10g , 甘草 6g , 川芎 6g , 香附 6g ,丹参 20g ,木香 10g ,草蔻 10g ,大黄 6g ,黄连 6g ,黄芩 10g ,元胡 10g ,川楝子 20g ,制乳没各 6g ,干姜 6g ,蒲公英 15g ,败酱草 15g。

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裴正学临床荟萃第二辑 Function: To soothe the liver and stomach, clear heat and dry dampness, promote blood circulation, resolve stasis, and relieve pain. Indication: Chronic pancreatitis, characterized by liver-stomach disharmony, internal damp-heat, and qi stagnation with blood stasis. Usage: Take one dose daily, add an appropriate amount of water; brew the first decoction for 30 minutes, the second decoction for 40 minutes, mix the two decoctions together, and take in two doses, morning and evening, after meals. Formula Explanation: Chronic pancreatitis is a common clinical disease, mainly presenting as chronic dull pain in the upper left abdomen, radiating to the chest and back. Since many patients also have cholecystitis or gallstones, left flank pain is often accompanied by distension and pain in the right flank and back. Some patients may also experience abdominal distension, indigestion, pancreatic-related diarrhea, jaundice, and other symptoms. Traditional Chinese Medicine classifies this disease under categories such as “flank pain,” “abdominal pain,” and “stomach pain.” The diagnosis is often attributed to liver-stomach disharmony, internal damp-heat, and qi stagnation with blood stasis. Treatment should focus on soothing the liver and stomach, clearing heat and drying dampness, promoting blood circulation, resolving stasis, and relieving pain. The “Bile-Pancreas Syndrome Formula” is a specialized treatment formula developed by Pei Zhengxue based on 50 years of clinical experience. This formula uses Chaihu Shu Gan San to soothe the liver, resolve depression, and relieve pain. Sanhuang Xixi Tang, combined with Danshen, Mu Xiang, and Cao Dou Ke, clears heat and dries dampness, soothes the stomach and descends rebellious qi. For those whose flank pain persists despite long-term treatment, blood stasis is often present; as stated in “Clinical Guidelines for Cases”: “When qi has been blocked for a long time, blood will also become diseased, leading to blockage in the channels of qi and blood.” Therefore, Frankincense and Myrrh are used to promote blood circulation and resolve stasis, while Yuan Hu and Chuan Lian Zi relieve pain and promote qi flow. In cases of prolonged illness with deficiency, intestinal rumbling and diarrhea, Ginger is used to warm the middle burner, dispel cold, strengthen the spleen, and stop diarrhea. Dandelion and Herba Patriniae clear heat and promote dampness, aiding the effects of Sanhuang in drying dampness and soothing the stomach. Additions and Subtractions: For jaundice, add Yin Chen 15g, Zhi Zi 15g, Da Huang 6g; for gallstones, add Jin Qian Cao 15g, Hu Zhang 15g, Ban Zhi Lian 15g; for gallbladder polyps, add 4 Ume berries, Weiling Xian 10g, and Zhu Zhen Zi 15g; for chronic gastritis, add Xiang Sha Liu Jun Zi Tang and Ban Xia Xie Xin Tang; for chest pain, add Yue Ju Wan; for intestinal rumbling and diarrhea, add Chuan Jiao 6g, and in severe cases, add Fu Zi Li Zhong Tang; for constipation, increase Da Huang to 10g and then administer it via laxative, and if ineffective, add Xiao Cheng Qi Tang or Da Cheng Qi Tang; for belching and hiccups, add Xuan Fu Hua 10g, Sheng Zha Shi 15g, and for severe flank pain, add Zhi Lu Mo to 10g; for hepatitis or cirrhosis with flank pain, add Dang Gui 10g, Huang Qi 20g, Qin Tiao 10g, Ban Lan Gen 15g; for elevated transaminases, add Jin Yin Hua 15g, Lian Qiao 15g, Wu Wei Zi powder 10g (to be taken separately), and if levels exceed 100U/L, add Bai Hua She Tiao Cao 15g, Ban Zhi Lian 15g, San Qi powder 3g (to be taken separately); for gallbladder cancer, pancreatic cancer, or liver cancer, add Bai Hua She Tiao Cao 15g, Ban Zhi Lian 15g, Hu Zhang 15g, Xia Ku Cao 15g, Zao Xiu 15g.

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Chapter Sixteen: Pei’s Formulas Clinical Application: In addition to chronic pancreatitis, this formula is also effective for liver-stomach disharmony, internal damp-heat, qi stagnation with blood stasis—such as cholecystitis, gallstones, post-gallbladder resection syndrome, hepatitis, cirrhosis, and liver cancer.

January 6, 2014, China Traditional Chinese Medicine News

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Pei Zhengxue Clinical Collection, Volume Two Lanzhou Formula Qi Qin, Qi Xueting, Zheng Fangjiang Pei Zhengxue, born in 1938, is a renowned Chinese-Western medicine expert in China, one of the first 500 nationally recognized senior traditional Chinese medicine practitioners, and one of the first senior traditional Chinese medicine experts in Gansu Province, who received a special government allowance from the State Council. He currently serves as a professor at the Gansu Provincial Academy of Medical Sciences, concurrently serving as an editorial board member of China Journal of Chinese Western Medicine and editor-in-chief of China Journal of Integrated Chinese and Western Medicine, as well as president of the Gansu Provincial Association of Chinese and Western Medicine. Professor Pei Zhengxue has practiced clinical medicine for over 50 years, publishing more than 50 academic papers, possessing a deep academic foundation and extensive clinical experience, specializing in the treatment of various complex and difficult diseases. His specially formulated treatment formula for leukemia was named “Lanzhou Formula” at the National Hematology Conference in 1974 and has been widely used in hospitals across China for many years, yielding remarkable therapeutic results. Composition: Sheng Di 12g, Shan Yao 10g, Shan Yu Rou 30g, Ren Shen Xu 15g, Tai Zi Shen 15g, Bei Sha Shen 15g, Dang Shen 15g, Mai Dong 10g, Wu Wei Zi 6g, Gui Zhi 10g, Bai Shao 10g, Sheng Jiang 6g, Da Zao 4 pieces, Zhi Gan Cao 6g, Fu Mian 30g. Functions: To support the body’s vital energy, strengthen the kidneys, and nourish the spleen. Indications: Leukemia, aplastic anemia, and other blood system diseases. Usage: Soak in about 1500ml of water, steep for 1 hour, then simmer over low heat for 40 minutes. Repeat the process once (for 500ml of water, simmer for 30 minutes), combine the two decoctions, and drink them in two doses throughout the day. Avoid consuming cold, spicy, or irritating foods. Formula Explanation: Leukemia falls within the scope of Traditional Chinese Medicine’s “blood deficiency” or “blood deficiency,” and Professor Pei believes that vital energy deficiency is the fundamental cause of leukemia’s onset and progression. High fever and bleeding in the course of the disease reflect the manifestation of “great excess in great deficiency.” That is, leukemia is not a condition purely characterized by deficiency or excess, but rather…

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Chapter Sixteen: Pei’s Formulas

“Take deficiency as the root, and excess as the symptom.” Accordingly, when treating leukemia, we must not rely solely on “eliminating evil,” nor can we simply “strengthen the body’s vital energy”; instead, we must organically combine strengthening the body’s vital energy with eliminating evil. Therefore, Professor Pei believes that “strengthening the body’s vital energy and nourishing the kidneys and spleen” is the primary principle for treating leukemia. This formula uses Sheng Di, Shan Yao, and Shan Yu Rou to nourish kidney yin and replenish bone marrow; Ren Shen Xu, Tai Zi Shen, Bei Sha Shen, and Dang Shen—four types of ginseng—to nourish qi and nourish blood. Gui Zhi Tang harmonizes the body’s defensive and offensive qi to stabilize the balance of yin and yang in the organs, while Sheng Mai Yin nourishes qi and nourishes yin. Gan Mai Da Zao Tang nourishes the heart and calms the mind; when the heart and mind are calm, the blood becomes stable. When aiming to increase white blood cells, use: Fu Pi or Chuan Wu, Cao Wu, Ma Qian Zi, Guizhi, Dang Gui, Bu Gu Zhi, Tu Si Zi, Sha Yuan Zi, Ji Xue Teng, Huang Qi, Xi Yang Shen, Lu Rong, and others. When aiming to increase platelet counts, use: Zhu Zhen Zi, Han Lian Cao, Yu Zhu, Huang Jing, Da Zao, A Jiao, Lian Qiao, Tu Da Huang, Mu Tou Hui, and others. When aiming to increase red blood cell counts, use: Gui Pi Tang with Ren Shen Xu, Tai Zi Shen, Bei Sha Shen, Yuan Shen, Xi Yang Shen, He Shou Wu, Er Zhi Wan, and Shui Zhi.

Additions and Subtractions: If the total white blood cell count is low, add Bu Gu Zhi or Ji Xue Teng; if the red blood cell count is low, add Zhu Zhen Zi or Han Lian Cao; if the platelet count is low, add Yu Zhu or Huang Jing; for those with poor appetite and abdominal distension, add Mu Xiang or Cao Dou Ke; for those with fever, add Ban Zhi Lian, Bai Hua She Tiao Cao, Sheng Shi Shu, or Han Shui Shi; for those with bleeding, add Dan Pi, Chi Shao, San Qi, or A Jiao.

May 2014, China Traditional Chinese Medicine News

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Pei Zhengxue Clinical Collection, Volume Two Three-Flavor Dispersing Stool Soup Wang Xin, Qi Qin, Zheng Fangjiang Pei Zhengxue, born in 1938, is a chief physician, professor, and doctoral supervisor. He is a renowned Chinese-Western medicine expert, a guiding teacher for the academic inheritance work of the second, third, fourth, and fifth groups of national senior traditional Chinese medicine experts, a lifelong council member of the Chinese Society of Traditional Chinese Medicine, an honorary president of the Gansu Provincial Association of Chinese and Western Medicine, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, one of the first senior traditional Chinese medicine experts in Gansu Province, a chief expert at the Gansu Provincial Academy of Medical Sciences, a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine, and a curator at the Gansu Provincial Museum of History and Culture. He has engaged in clinical practice, teaching, and research for over 50 years, possessing rich clinical experience and expertise in treating tumors, liver diseases, blood disorders, autoimmune diseases, and other complex and difficult conditions. He proposed the “Western diagnosis, Chinese syndrome differentiation, Chinese medicine as the mainstay, Western medicine as a supporting element” sixteen-character principle for integrated Chinese and Western medicine, which has become one of the important pathways for developing traditional Chinese medicine today. He published 18 medical works, including “Practical Internal Medicine of Integrated Chinese and Western Medicine,” “Clinical Commentary on Blood Disorders,” “Medical Talks and Case Studies of Pei Zhengxue,” and “Pei Zhengxue’s Medical Notes,” and authored more than 80 medical papers. Composition: Jin Yin Hua 15g, Lian Qiao 15g, Pu Gong Ying 15g, Bao Jiang 15g, Tu Fu Ling 15g, Bai Lian Pi 20g, Sheng Di 12g, Di Fu Zi 10g, Fang Feng 10g, Lei Feng 10g, Bi Fei 10g, Chi Shao 10g, Dan Pi 6g, Xian He Cao 15g, Zi Cao 15g, Qian Cao 15g, Han Lian Cao 15g, Yi Mu Cao 20g, Deng Xin Cao 6g, Chan Tui 6g, Gan Cao 6g. Function: To disperse wind and clear heat, detoxify and promote dampness elimination, cool the blood and stop bleeding. Indication: Allergic purpura, characterized by wind-heat combined with dampness, affecting the blood vessels. Usage: Take one dose daily, add an appropriate amount of water; brew the first decoction for 30 minutes, the second decoction for 40 minutes, mix the two decoctions together, and drink them in two doses, morning and evening, after meals.

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Chapter Sixteen: Pei’s Formulas

Formula Explanation: Allergic purpura, also known as hemorrhagic capillary toxicity syndrome, is a microvascular allergic hemorrhagic disease. Clinically, it primarily manifests as skin purpura and mucosal bleeding, often accompanied by abdominal pain, joint swelling and pain, or kidney damage. Professor Pei Zhengxue believes that this disease falls under the category of “fā bān” and “blood disorders” in Traditional Chinese Medicine, often arising from wind-heat combined with dampness, entering the blood and damaging the blood vessels. Treatment should focus on dispersing wind-heat, detoxifying and promoting dampness elimination, cooling the blood and stopping bleeding.

The Three-Flavor Dispersing Stool Soup uses Bai Lian Pi, Di Fu Zi, Fang Feng, and Chan Tui to disperse wind and eliminate pathogenic factors; Jin Yin Hua and Lian Qiao to disperse wind and clear heat; Pu Gong Ying, Bao Jiang, Tu Fu Ling, and Lei Feng to detoxify and promote dampness elimination, unblock meridians and relieve pain. When heat enters the blood, causing blood to run wildly, and the need to cool the blood and disperse blood arises, it is also necessary to stop bleeding and calm the blood. Thus, Sheng Di, Chi Shao, and Dan Pi clear heat and cool the blood; Zi Cao and Han Lian Cao cool the blood and stop bleeding; Yi Mu Cao and Qian Cao break up blood stasis and stop bleeding; Xian He Cao constricts and stops bleeding; Deng Xin Cao calms the heart and calms the blood. Gan Cao alone serves to clear heat and detoxify, harmonizing all the herbs. The entire formula disperses wind and clears heat, detoxifies and cools the blood; when wind and heat are dispersed, and blood heat is cleared, the purpura will naturally subside. Additions and Subtractions: For those with deeper heat toxicity and dense purpura patches, add 10g of Ce Bai Ye and 15g of Ye Hua; for those with a clear history of allergies, add 10g of Chai Hu, 10g of Dang Gui, and 4 Ume berries; for those with abdominal pain, add 10g of Xiao Hui Xiang, 10g of Huluba, 6g of Wu Zhu Yu, 10g of Yan Hu Suo, and 20g of Chuan Lian Zi; for purpura primarily affecting both lower limbs, or accompanied by joint pain in the lower limbs, add Si Miao San; for those with severe joint pain, add 15g each of Zhi Chuang Cao Wu, 15g of Xi Xin, 1 piece of Ma Qian Zi (fried in oil), and 20g of Lei Gong Teng (peeled, simmered for 1 hour); for those with kidney involvement due to purpura, and positive urine protein, add 20g of Su Bing, and 6g of Chan Tui. For those with positive occult blood, add 30g of Bai Mao Gen, 10g of Ce Bai Ye, 10g each of Da Xiao Ji, and 3g of San Qi powder (to be taken separately), along with 15g of Zhu Zhen Zi. Clinical Application: Allergic purpura is often closely related to external infections, dietary factors, and other causes. Therefore, patients should avoid eating meat, eggs, milk, and other protein-rich foods, and actively prevent colds. When a cold occurs, switch to Majui Heji (Ma Huang Tang with Sheng Shi Shu, Chuan Qiao, Bai Zhi, Xi Xin, Qiang Du Huo, Fang Feng), and if necessary, administer antibiotics intravenously. If allergic purpura leads to nephritis, and the purpura has subsided, with positive urine protein and occult blood, switch to Fufang Yishen Tang (Taohong Sisi Tang with reduced Sheng Di, plus Yi Mu Cao, Dan Shen, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Bao Jiang, and Ban Lan Gen). Combining the aforementioned additions and subtractions, if there is no improvement, use Yuán Meizhong Qian Shi Tang for urine protein, and use “Yi Xue Xin” A Jiao Tang for occult blood. April 9, 2014, China Traditional Chinese Medicine News, 443

Pei Zhengxue Clinical Collection, Volume Two “Shen Qi San Huang Tang” – Treatment for Thrombocytopenic Purpura Wang Xin, Feng Yongxiao, Bai Lijun Key Reminder: Pei Zhengxue, born in 1938, is a chief physician, professor, and doctoral supervisor. He is a renowned Chinese-Western medicine expert, a guiding teacher for the academic inheritance work of the second, third, fourth, and fifth groups of national senior traditional Chinese medicine experts; a lifelong council member of the Chinese Society of Traditional Chinese Medicine, an honorary president of the Gansu Provincial Association of Chinese and Western Medicine, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, one of the first senior traditional Chinese medicine experts in Gansu Province, a chief expert at the Gansu Provincial Academy of Medical Sciences, a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine, and a curator at the Gansu Provincial Museum of History and Culture. Pei Zhengxue, born in 1938, is a chief physician, professor, and doctoral supervisor. He is a renowned Chinese-Western medicine expert, a guiding teacher for the academic inheritance work of the second, third, fourth, and fifth groups of national senior traditional Chinese medicine experts; a lifelong council member of the Chinese Society of Traditional Chinese Medicine, an honorary president of the Gansu Provincial Association of Chinese and Western Medicine, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, one of the first senior traditional Chinese medicine experts in Gansu Province, a chief expert at the Gansu Provincial Academy of Medical Sciences, a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine, and a curator at the Gansu Provincial Museum of History and Culture. He has engaged in clinical practice, teaching, and research for over 50 years, possessing rich clinical experience and expertise in treating tumors, liver diseases, blood disorders, autoimmune diseases, and other complex and difficult conditions; he proposed the “Western diagnosis, Chinese syndrome differentiation, Chinese medicine as the mainstay, Western medicine as a supporting element” sixteen-character principle for integrated Chinese and Western medicine, which has become one of the important pathways for developing traditional Chinese medicine today. He published 18 medical works, including “Practical Internal Medicine of Integrated Chinese and Western Medicine,” “Clinical Commentary on Blood Disorders,” “Medical Talks and Case Studies of Pei Zhengxue,” and “Pei Zhengxue’s Medical Notes,” and authored more than 80 medical papers.

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Chapter Sixteen: Pei’s Formulas [Shen Qi San Huang Tang] Composition: Dang Shen 15g, Huang Qi 20g, Da Huang 6g, Huang Lian 6g, Huang Cui 10g, Bai Zhu.

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Pei Zhengxue Clinical Collection, Volume Two This formula is a key component in the treatment of thrombocytopenic purpura, particularly when combined with other therapies to address the underlying causes of the condition. It helps to reduce the severity of symptoms such as bleeding, inflammation, and fatigue associated with thrombocytopenia, while also supporting overall health and immune function. The formula's combination of ingredients—such as Shen Qi, Huang Qi, and Da Huang—helps to regulate the body’s vital energy, improve blood circulation, and enhance the body’s natural defenses against infection and disease. By addressing the root causes of thrombocytopenia, this formula aims to alleviate symptoms and improve the patient’s quality of life, ultimately contributing to better outcomes in the treatment of this condition.

10g, White Tribulus Terrestris 20g, Prepared Milkweed 6g, Licorice 6g.
Function: Tonifies Qi and collects blood, clears heat and resolves fire, dissolves blood stasis and stops bleeding, regulates the liver and calms blood.
Indications: Idiopathic thrombocytopenic purpura, where the syndrome is characterized by Qi deficiency and blood heat.
Usage: Take one dose daily with an appropriate amount of water; brew the first decoction for 30 minutes, the second decoction for 40 minutes, then mix the two decoctions together and take in two doses, once in the morning and once in the evening, after meals.

Formula Explanation: Idiopathic thrombocytopenic purpura (ITP) is an immune-mediated thrombocytopenia syndrome. Clinically, it primarily manifests as skin, mucous membrane, and internal organ bleeding, along with a decrease in peripheral blood platelets, while bone marrow megakaryocytes are normal or increased, and there may be maturation disorders. This condition falls under the categories of "blood disorders," "skin lesions," and "hemorrhagic rash" in traditional Chinese medicine.

Pei Zhengxue believes that the underlying cause of this disease is both deficiency and excess, with spleen deficiency and weak Qi, Qi deficiency unable to control blood, being the root cause, while internal heat and stagnation of blood are the external manifestations. Liver dysfunction in controlling blood, and blood stasis lingering in the body are key factors contributing to chronic and difficult-to-treat conditions. Treatment should focus on strengthening the spleen, tonifying Qi, and collecting blood, clearing heat and resolving fire to stop bleeding—this is the primary therapeutic approach, combined with regulating the liver and dissolving blood stasis, which mutually enhance each other’s effects.

The Zhenqi Sanhuang Decoction uses Codonopsis, Atractylodes macrocephala, Astragalus, and Licorice to strengthen the spleen and tonify Qi, thereby achieving the effect of gathering Qi and collecting blood. Tang Rongchuan once said, “In eight out of ten cases of blood disorders, blood is abundant and fire is strong,” and “To clear the heart is to clear fire; to clear fire is to stop bleeding.” Therefore, the Sanhuang Decoction is used to clear heat and resolve fire, cooling the blood and stopping bleeding. The liver stores blood and governs its flow; when the liver fails to release blood properly, blood storage becomes impaired, or when liver qi becomes stagnant and generates fire, causing blood to surge and lead to bleeding and skin lesions. Tang Rongchuan also stated, “The liver stores blood—every blood disorder ultimately revolves around the liver.” Thus, White Tribulus Terrestris is used to soothe the liver, clear heat, regulate the liver, and calm blood. When Qi is deficient and not transported, Qi stagnates and blood stasis forms; blood that has left the vessels can become stagnant and form blood clots, leading to recurrent bleeding that is difficult to heal. If blood stasis is not resolved, new blood cannot be generated; prepared milkweed helps dissolve blood stasis and generate new blood, without causing Qi depletion, making it a more suitable choice. This formula integrates the four principles of “stopping bleeding, resolving blood stasis, calming blood, and replenishing deficiency,” employing both tonification and regulation, addressing both the root and the symptoms, making it an excellent treatment for this condition.

Additions and Subtractions: For patients with long-term illness affecting the kidneys, or those with both kidney and spleen deficiency, add 15g of North Sandalwood, 15g of Prince’s Ginseng, 15g of ginseng root, 12g of Rehmannia Root, and 30g of Cornus Fruit; for those with blood deficiency and blood loss, add 10g of Turtle Shell Gelatin (dissolved), 10g of Antler Gelatin (dissolved), 30g of Chicken Blood Vine, 30g of Herba Lysimachiae, and increase the amount of White Tribulus Terrestris to 30g; for those with Yin deficiency and excessive fire, add 10g of Bamboo Shoot, 20g of Polygonum Cuspidatum, 15g of Rheum Palmatum, 12g of Rehmannia Root, 15g of Forsythia, and Turtle Shell.

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Pei Zhengxue Clinical Collection, Volume 2 15g of Plantago Major; for patients with prolonged illness affecting the meridians, add 6g of Silkworm Moth, 6g of Whole Scorpion, 1 piece of Centipede, and 6g of Earthworm; for patients with heavy bleeding and dense red spots, add 30g of Bambusa Root, 30g of Herba Lysimachiae, 20g of Lotus Root Carbon, 15g of Red Peony, and 15g of Lychnis Chrysotricha; for patients with nosebleeds, add 10g of Rheum Palmatum Carbon, 10g of Paeonia Radix Alba Carbon, 10g of Cassia Seed Carbon, and 10g of Lotus Leaf Carbon; for patients with gingival bleeding, combine with Yu Nu Decoction; for patients with stool bleeding, combine with Huang Tu Decoction; for patients with yin damage from heat, combine with Wan Xiang Chen’s Formula for Idiopathic Thrombocytopenic Purpura.

March 3, 2014, China Journal of Traditional Chinese Medicine

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Chapter 16: Pei’s Formulas
Pei Zhengxue’s Clinical Experience: Kelerang Decoction for Lupus Nephritis
Zhan Wenguo
Lupus nephritis is a chronic inflammatory condition resulting from kidney damage secondary to systemic lupus erythematosus (SLE), and it is one of the leading causes of death in SLE patients, commonly occurring in young women. Its typical clinical features include proteinuria, hematuria, edema, hypertension, joint pain, fever, hepatosplenomegaly, and other symptoms. Some patients test positive for antinuclear antibodies and exhibit decreased complement C3 levels.

In response to these conditions, Professor Pei Zhengxue of Gansu Provincial Cancer Hospital proposed the treatment principle of supporting righteous qi, strengthening the root, eliminating pathogenic factors, and treating the symptoms. The treatment focuses on nourishing the liver and kidneys, nourishing blood and generating fluids, dispelling wind and removing dampness, activating blood circulation and resolving blood stasis, and clearing heat and detoxifying. The Kelerang Decoction, combined with modifications to the Taohong Siwu Decoction, has shown remarkable therapeutic effects. The Kelerang Decoction is a specialized formula compiled by Pei Zhengxue for the treatment of lupus nephritis.

Li Mou, female, 42 years old, presented for her first consultation on March 12, 2010.

Chief Complaint: Low back pain accompanied by edema for 1 month. The patient had previously suffered from systemic lupus erythematosus complicated by lupus nephritis for 2 years. She was treated with prednisone at a maximum dose of 60 mg/day, but her dosage was later reduced to 10 mg/day, and she continued to take 3 tablets of Indomethacin per day, with improvement in her condition. She had not taken any medication for the past month, but still experienced low back pain and sudden onset of edema, which progressed rapidly. She developed nephrotic syndrome and progressive deterioration of renal function, eventually progressing to uremia within weeks to months. The prognosis for this patient was poor. Biochemical tests revealed specific immune complex deposits, lupus cells were found in her blood, her erythrocyte sedimentation rate was elevated, serum globulin levels were increased, urine output was decreased, joint pain in the fingers worsened, she experienced hot flashes, night sweats, insomnia with frequent dreams, fatigue, dizziness, blurred vision, butterfly-shaped pigmentation appeared on her facial area, her tongue was dark red with a thin yellow coating, ecchymoses were present at the edges of the tongue, her pulse was wiry and fine. Her blood pressure was 140/90 mmHg. Laboratory findings included an ESR of 39 mm/h, proteinuria (2+), hematuria (+), and positive antinuclear antibodies.

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Pei Zhengxue Clinical Collection, Volume 2 Western medical diagnosis: Lupus nephritis. Traditional Chinese Medicine Diagnosis: Liver and Kidney Deficiency, Blood Stasis in the Meridians. Treatment should focus on nourishing the liver and kidneys, clearing heat and detoxifying, and activating blood circulation to resolve blood stasis. The formula used was Kelerang Decoction, combined with modifications to the Taohong Siwu Decoction.

Formulation: 10g of Polygonum cuspidatum, 10g of Epimedium, 10g of Cuscuta seeds, 10g of Radix Ophiopogonis, 12g of Rehmannia Root, 10g of Ophiopogon japonicus, 10g of Ligustrum lucidum, 10g of Eucommia ulmoides, 15g of Lychnis chrysotricha, 10g of Alisma, 10g of Angelica sinensis, 10g of Paeonia lactiflora, 6g of Carthamus tinctorius, 10g of Carpobolus, 15g of Houttuynia cordata, 15g of Lysimachia barystachys, 15g of Artemisia selengensis, 15g of Dianthus chinensis, and 10g of Polygonum cuspidatum. Take 14 doses, decocting the herbs in water, once daily.

Second Consultation: After taking the medication, the low back pain and edema subsided, the red patches on the face became lighter in color, though she still experienced insomnia and frequent dreams. Proteinuria remained at 2+, hematuria was negative. She added 20g each of Albizia julibrissin bark and Polygona jatamansi, and continued taking the medication for another 14 doses.

Third Consultation: All symptoms showed significant improvement—proteinuria was negative, hematuria was also negative. Her blood pressure was 120/80 mmHg, her tongue was red, her tongue coating was minimal, and her pulse was fine and rapid. The diagnosis indicated Liver and Kidney Deficiency. She removed White Snake Tongue Grass, Houttuynia cordata, Dianthus chinensis, and Plantago major from the formula, adding 10g of Goji Berries, 10g of Chrysanthemum flowers, 10g of Cornus Fruit, and 10g of Chinese Yam to nourish the liver and kidneys and strengthen the root.

After more than a year of continuous use, her condition improved significantly, and she continues to take the medication to consolidate her therapeutic effects. According to Pei Zhengxue, “Lupus nephritis is characterized by deficiency in the root and excess in the symptoms; liver and kidney deficiency are the root cause, while wind, dampness, heat, and toxic substances, along with phlegm and blood stasis, are the external factors. Nourishing the liver and kidneys, nourishing blood and generating fluids are the fundamental principles for treating this condition, and we should also employ methods to dispel wind, remove dampness, activate blood circulation, and clear heat and detoxify.”

Nourishing the liver and kidneys often involves using Ligustrum lucidum, Lychnis chrysotricha, Goji Berries, Rehmannia Root, Cornus Fruit, Epimedium, Cuscuta seeds, Eucommia ulmoides, and other herbs. When heat and toxins are severe, and when wind and fire are exacerbated, high fever persists, limbs swell, and joints ache—addings such as Honeysuckle, Forsythia, Dandelion, Bidens pilosa, White Snake Tongue Grass, Houttuynia cordata, and other herbs to clear heat and detoxify are beneficial.

When heat damages Yin, it is essential to add Radix Ophiopogonis, Rehmannia Root, Ophiopogon japonicus, Dendrobium officinale, Paeonia lactiflora, and other Yin-nourishing herbs. When the ESR increases, immune complex deposits, lupus cells, and other signs indicate phlegm, dampness, and blood stasis—use raw gypsum, Paeonia lactiflora, Jinyu, Trichosanthes kirilowii, Polygonum cuspidatum, and other herbs to clear heat and remove dampness. When blood stasis obstructs the meridians, add Carthamus tinctorius, Paeonia lactiflora, Angelica sinensis, Red Peony, Chuanxiong, Dendrobium officinale, and other herbs to nourish blood and activate blood circulation to dispel wind—this aligns with the principle of “treat wind by treating blood.”

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April 10, 2014, China Journal of Traditional Chinese Medicine

Chapter 16: Pei’s Formulas
Ma Huang Gui Zhi Compound Qi Qin, Zheng Fangjiang
Pei Zhengxue, male, born in 1938, is a renowned modern scholar of integrated Chinese and Western medicine in China, a guiding teacher for the academic experience inheritance program of senior traditional Chinese medicine experts nationwide, a well-known TCM physician in Gansu Province, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, a chief physician, professor, and chief expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Institute of Medical Sciences, as well as the honorary president of the Gansu Provincial Association for Integrated Chinese and Western Medicine, editor-in-chief of the journal “Integrated Chinese and Western Research,” and a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine,” and a staff member of the Gansu Provincial Museum of History and Culture. Pei Zhengxue has been engaged in clinical practice for 55 years, having published over 80 academic papers, possessing a deep academic foundation and rich clinical experience, specializing in the use of classic formulas to treat tumors, liver diseases, blood disorders, and other complex internal medicine conditions. The Ma Huang Gui Zhi Compound he developed is composed of Ma Huang Decoction, Gui Zhi Decoction, along with Chuanxiong, Bai Zhi, Xi Xin, Qiang Du Huo, and Fang Feng. It has proven highly effective in treating upper respiratory tract infections, neural headaches, acute and chronic rhinitis, sinusitis, cheilitis, oral inflammation, acute and chronic nephritis, and other conditions, making it worthy of wider application.

Composition: 10g of Ma Huang, 10g of Gui Zhi, 10g of Apricot Kernel, 30g of Raw Gypsum, 6g of Chuanxiong, 6g of Bai Zhi, 3g of Xi Xin, 10g of Qiang Du Huo, 10g of Du Huo, 12g of Fang Feng, 6g of Gan Cao, 10g of Cucurbita pepo seeds, 6g of Fresh Ginger, and 4 dates.

Usage: Soak the above herbs in about 1500ml of water for half an hour, then simmer over low heat for 40 minutes. Repeat the decoction (using 500ml of water, simmering for 30 minutes). Combine the two decoctions and drink them in two doses throughout the day. Avoid eating cold, spicy, or irritating foods.

Function: Promotes sweating to relieve exterior symptoms, opens the lungs to stop cough, and clears heat to benefit the throat.

Indications: The Ma Huang Gui Zhi Compound can both disperse cold and warm the meridians to relieve pain, while also harmonizing the vital energy and blood, replenishing deficiency and draining excess—making it effective for treating head and facial ailments such as upper respiratory tract infections, neural tinnitus, chronic rhinitis, sinusitis, and other conditions.

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Pei Zhengxue Clinical Collection, Volume 2 Chronic rhinitis, sinusitis, neural headaches, cheilitis, ophthalmological conditions, and nephritis are all treatable with this formula.
Formula Explanation: Ma Huang and Gui Zhi are pungent and warm, opening the skin and dispersing wind-cold, while also harmonizing the vital energy and blood; Apricot Kernel promotes lung qi, stops cough, and relieves asthma; Raw Gypsum clears lung heat; Qiang Du Huo and Du Huo eliminate wind-cold and dampness in the exterior; Chuanxiong, Bai Zhi, and Xi Xin disperse wind-cold, promote dampness and arthritis, and relieve head and body pain; Gan Cao opens the lungs and promotes qi, clearing the throat.

Additions and Subtractions: For patients with upper respiratory tract infections accompanied by excessive phlegm and chest tightness, add Ma Xing Shi Gan Tang, Dry Ginger, Xi Xin, Wu Wei Zi, and Ban Xia; for patients with white phlegm and itchy throat, add Zhisu San; for patients with thin phlegm and dry throat, add Xing Su San; for patients with fever, add Honeysuckle, Forsythia, Dandelion, Da Qing Ye, and Ban Lan Gen—other antiviral herbs—and use up to 30–60g of Gypsum; for patients with chronic neural headaches that have entered the meridians, add Taohong Siwu Decoction to activate blood circulation and resolve blood stasis; for patients with severe headaches, add White Silkworm Moth, Whole Scorpion, and Centipede—other insect-based remedies to search for wind and relieve pain; if the patient experiences headache due to hyperactivity of liver yang, add Tianma, Gou Teng, and Shi Jue Ming to calm the liver and lower yang, and to suppress wind and relieve pain; for patients with purulent nasal discharge due to rhinitis, add Honeysuckle, Forsythia, and Dandelion to clear heat and detoxify; for patients with allergic rhinitis, add Cicada Egg and Xinyi to open nasal passages; for patients with proteinuria due to nephritis, add Su Jing, Cicada Egg, and Motherwort to reduce proteinuria; for patients with hematuria, add Bambusa Root, Side-Tree Leaves, Ligustrum Lucidum, and Large and Small Thistle to clear heat and stop bleeding.

February 21, 2013, China Journal of Traditional Chinese Medicine

450

Chapter 16: Pei’s Formulas
Hua Yu Lian Yang Tang Zhan Wenguo

Pei Zhengxue, male, born in 1938, is a renowned expert in integrated Chinese and Western medicine in China, one of the first 500 senior traditional Chinese medicine experts nationwide, a distinguished TCM physician in Gansu Province, a chief physician, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, a national-level mentor for advanced students, a lifelong director of the Chinese Society of Traditional Chinese Medicine, a chief expert at Gansu Provincial Cancer Hospital, a professor at the Gansu Provincial Institute of Medical Sciences, and a recipient of a special government allowance from the State Council. He currently serves as a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine” and as the editor-in-chief of “Integrated Chinese and Western Research,” as well as the president of the Gansu Provincial Association for Integrated Chinese and Western Medicine.

Professor Pei Zhengxue has been engaged in clinical practice for over 50 years, having published more than 100 academic papers and authored over 20 monographs. With a deep academic foundation and rich clinical experience, he specializes in treating blood disorders, tumors, digestive system diseases, and various complex internal medicine conditions.

Digestive ulcers fall under the category of “Stomach Pain” in traditional Chinese medicine. Traditional Chinese medicine believes that their onset is related to cold invading the stomach, dietary indiscretion, liver qi disturbing the stomach, and spleen and stomach weakness. Each episode of ulcers is often triggered by diet, emotions, fatigue, cold dampness, and other factors. Clinical manifestations include: discomfort and pain in the upper abdomen, chronic, periodic, and rhythmic; gastric ulcers often occur after eating; duodenal ulcers are more likely to present as hunger pains, nocturnal pains, or accompanied by acid reflux and vomiting. Professor Pei Zhengxue particularly emphasizes the fact that chronic gastric ulcers often enter the meridians, where gastric meridians are congested and stagnant, with both deficiency and excess symptoms, or even symptoms of stomach Yin deficiency, Qi deficiency, spleen Yang deficiency, or kidney Qi deficiency. He stresses the importance of activating blood circulation and resolving blood stasis in the treatment of gastritis and gastric ulcers. Based on the pathological characteristics of digestive ulcers—“chronic illness entering the meridians,” “long-term illness often leads to blood stasis”—Professor Pei Zhengxue focused on activating blood circulation and resolving blood stasis, promoting qi circulation and relieving pain, and formulated the “Hua Yu Lian Yang Tang.”

Composition: 10g of Fried Sophora Flower, 10g of Five-Flavor Berry, 6g each of Prepared Milkweed, 10g of Salvia Miltiorrhiza, 10g of Angelica Sinensis, 30g of Astragalus, 6g of Galangal, 6g of Frankincense, 10g of Ligusticum Chuanxiong, 10g of Curcuma Longa, 6g of Amomum Villosum, 6g of Turmeric, 6g of Ginger, 6g of Citrus Peel, 10g of Citrus Peel, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, ......10g, White Tribulus Terrestris 20g, Prepared Milkweed 6g, Licorice 6g.
Function: Tonifies Qi and collects blood, clears heat and resolves fire, dissolves blood stasis and stops bleeding, regulates the liver to calm blood.
Indications: Idiopathic thrombocytopenic purpura, where the syndrome is characterized by Qi deficiency and blood heat.
Usage: Take one dose daily, add an appropriate amount of water; brew the first decoction for 30 minutes, the second decoction for 40 minutes, mix the two decoctions together, and take in two doses, once in the morning and once in the evening, after meals.

Pei Zhengxue believes that the underlying cause of this disease is both deficiency and excess, with spleen deficiency and weak Qi, Qi deficiency leading to insufficient control, as the root cause; internal heat and dampness, which force blood to run abnormally, serve as the external manifestation. Liver dysfunction in regulating blood flow, combined with blood stasis, are key factors contributing to chronic and difficult-to-cure conditions. Treatment should focus on strengthening the spleen, tonifying Qi, collecting blood, clearing heat, resolving fire, and stopping bleeding—this is the primary therapeutic approach. Additionally, it’s important to regulate the liver and resolve blood stasis, as these approaches complement each other and enhance overall efficacy.

The Zhenqi Sanhuang Decoction uses Codonopsis, Atractylodes macrocephala, Astragalus, and Licorice to strengthen the spleen and tonify Qi, thereby achieving the effects of Qi-tonifying and blood-collecting. Tang Rongchuan once said, “In cases of blood disorders where Qi is abundant and fire is strong, eight out of ten patients experience this condition,” and “To clear the heart is to clear fire; to clear fire is to stop bleeding.” Therefore, the Sanhuang Decoction is used to clear heat and resolve fire, while also cooling the blood and stopping bleeding. The liver stores blood and is responsible for its dispersal; when the liver fails to disperse blood properly, blood stagnates within the body, or when liver qi becomes stagnant and generates fire, causing blood to surge and lead to bleeding and skin lesions. Tang Rongchuan also stated, “The liver stores blood—every case of blood disorder ultimately revolves around the liver.” Thus, White Tribulus Terrestris is used to soothe the liver, clear heat, and regulate the liver to calm blood. When Qi is deficient and not properly transported, Qi stagnation leads to blood stasis; blood that has left the vessels can become stagnant and form blood clots, making bleeding recurrent and difficult to heal. If blood stasis is not resolved, new blood cannot be generated; prepared Milkweed helps dissolve blood stasis and promote new blood formation without harming Qi. This formula integrates the four principles of “stopping bleeding, resolving blood stasis, calming blood, and replenishing deficiency,” combining tonification and detoxification, addressing both the root and the symptoms, making it an excellent treatment for this condition.

Additions and Subtractions: For patients with long-term illness who also suffer from kidney or spleen-kidney deficiency, add 15g of North Sandaishen, 15g of Prince’s Ginseng, 15g of ginseng root, 12g of Rehmannia Root, and 30g of Cornus Fruit; for those with blood deficiency and blood loss, add 10g of Turtle Shell Gelatin (dissolved), 10g of Antler Gelatin (dissolved), 30g of Chicken Blood Vine, 30g of Herba Lysimachiae, and increase the amount of White Tribulus Terrestris to 30g; for those with Yin deficiency and excessive fire, add 10g of Bamboo Shoots, 20g of Polygonum cuspidatum, 15g of Rheum officinale, 12g of Rehmannia Root, 15g of Forsythia, and Turtle Shell.

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Pei Zhengxue Clinical Collection, Volume 2
Tablet 15g; for patients with prolonged illness affecting the meridians, add 6g of Silkworm Moth, 6g of Whole Scorpion, 1 piece of Centipede, and 6g of Earth Worm; for patients with heavy bleeding and dense red spots, add 30g of Bambusa Root, 30g of Herba Lysimachiae, 20g of Lotus Root Carbon, 15g of Purple Herb, and 15g of Red Lotus Leaf; for nosebleeds, add 10g of Rheum Root Carbon, 10g of Cortex Phellodendri, 10g of Cinnamomum Cassia Carbon, and 10g of Lotus Leaf Carbon; for gingival bleeding, combine with Yu Nu Decoction; for stool bleeding, combine with Yellow Clay Soup; for those with yin damage due to heat toxins, combine with Wan Xiang Chen’s Formula for Idiopathic Thrombocytopenic Purpura.

March 3, 2014, China Journal of Traditional Chinese Medicine

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Chapter 16: Pei’s Formulas
Pei Zhengxue’s Clinical Experience: Kelerang Decoction for Lupus Nephritis
Zhan Wenguo
Lupus nephritis is a chronic inflammatory condition resulting from kidney damage secondary to systemic lupus erythematosus (SLE), and it is one of the leading causes of death in SLE patients, commonly occurring in young women. Its typical clinical features include proteinuria, hematuria, edema, hypertension, joint pain, fever, hepatosplenomegaly, and more. Some patients test positive for antinuclear antibodies and exhibit decreased C3 complement levels.

In response to this, Professor Pei Zhengxue of Gansu Provincial Cancer Hospital proposed the principle of supporting righteous qi and consolidating the foundation while eliminating pathogenic factors and treating the symptoms. Treatment focuses on nourishing the liver and kidneys, nourishing blood and generating fluids, dispelling wind and removing dampness, activating blood circulation and resolving blood stasis, and clearing heat and detoxifying. The Kelerang Decoction, combined with modifications to the Taohong Siwu Decoction, has shown remarkable therapeutic effects. The Kelerang Decoction is a specialized formula compiled by Pei Zhengxue for the treatment of lupus nephritis.

Li Mou, female, 42 years old, presented for her first consultation on March 12, 2010.

Chief Complaint: Low back pain accompanied by edema for 1 month. The patient had previously suffered from systemic lupus erythematosus complicated by lupus nephritis for 2 years. She was treated with prednisone at a maximum dose of 60 mg/day, but her dosage was later reduced to 10 mg/day, and she continued to take 3 tablets of Indomethacin per day, with improvement in her condition. She had not taken any medication for the past month, but still experienced low back pain and sudden onset of edema, which progressed rapidly. She developed nephrotic syndrome and progressive deterioration of renal function, eventually developing uremia within weeks to months. The prognosis for this patient was poor. Biochemical tests revealed specific immune complex deposits, lupus cells were found in her blood, her ESR was elevated, serum globulin levels were increased, urine output was reduced, joint pain in her fingers worsened, she experienced hot flashes, night sweats, insomnia with frequent dreams, fatigue, dizziness, blurred vision, butterfly-shaped patches appeared on her facial skin, her tongue was dark red with a thin yellow coating, bruising was present at the edges, and her pulse was wiry and fine. Her blood pressure was 140/90 mmHg. Laboratory findings included an ESR of 39 mm/h, proteinuria (2+), hematuria (+), and positive antinuclear antibodies.

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Pei Zhengxue Clinical Collection, Volume 2
Western medical diagnosis: Lupus nephritis.
Traditional Chinese Medicine Diagnosis: Liver and Kidney Deficiency, Blood Stasis in the Meridians. Treatment should focus on nourishing the liver and kidneys, clearing heat and detoxifying, activating blood circulation and resolving blood stasis. The formula used was Kelerang Decoction, combined with modifications to the Taohong Siwu Decoction.

Formulation: 10g of Polygonum cuspidatum, 10g of Epimedium, 10g of Cuscuta, 10g of Radix Rehmannia, 12g of Rehmannia Root, 10g of Ophiopogon, 10g of Ligustrum Lucidum, 10g of Eucommia Bark, 15g of Lythrum, 10g of Alisma, 10g of Angelica Sinensis, 10g of Paeonia lactiflora, 6g of Carthamus, 10g of Peach Kernel, 20g of Clematis armandii, 20g of Salvia miltiorrhiza, 15g of Anemarrhena asphodeloides, 15g of Hedyotis diffusa, 20g of Plantago major, 10g of Platycodon grandiflorus, and 10g of Glycyrrhiza uralensis. Take 14 doses, decocted in water, once daily.

Second Consultation: After taking the medication, the low back pain and edema subsided, the redness on the facial skin faded, though she still experienced insomnia and frequent dreams. Proteinuria remained at 2+, hematuria was negative. She added 20g each of Albizia julibrissa bark and Polygala senega, and continued taking the medication for another 14 doses. Third Consultation: All symptoms showed significant improvement—proteinuria was negative, hematuria was also negative. Her blood pressure was 120/80 mmHg, her tongue was red, her tongue coating was minimal, and her pulse was fine and rapid. The diagnosis indicated Liver and Kidney Deficiency; therefore, she removed White Hedyotis diffusa, Anemarrhena asphodeloides, Hedyotis diffusa, Plantago major, and Platycodon grandiflorus, adding 10g of Goji Berries, 10g of Chrysanthemum, 10g of Cornus Fruit, and 10g of Dioscorea opposita to nourish the liver and kidneys and consolidate the foundation.

After more than a year of continuous use, her condition improved significantly, and she continues to take the medication to consolidate her recovery. According to Pei Zhengxue, “Lupus nephritis is characterized by deficiency in the root and excess in the symptoms; liver and kidney deficiency are the root cause, while wind, dampness, heat toxin, and phlegm-stasis are the external manifestations. Nourishing the liver and kidneys, nourishing blood and generating fluids are the fundamental principles for treating this condition, and we should also employ methods to dispel wind, remove dampness, activate blood circulation, and clear heat and detoxify.”

When nourishing the liver and kidneys, common herbs include Ligustrum Lucidum, Lythrum, Goji Berries, Rehmannia Root, Cornus Fruit, Epimedium, Cuscuta, Eucommia Bark, and others. When heat toxin is severe and wind and fire are exacerbated, high fever persists, limbs swell, and joints ache—add herbs like Honeysuckle, Forsythia, Dandelion, Bidens pilosa, White Hedyotis diffusa, Anemarrhena asphodeloides, and other herbs to clear heat and detoxify.

If heat toxicity damages Yin, then it’s essential to add Radix Rehmannia, Rehmannia Root, Ophiopogon, Dendrobium, Cortex Phellodendri, and other Yin-nourishing herbs. When ESR increases, immune complex deposits, lupus cells, and other signs indicate phlegm, dampness, and blood stasis—use herbs like Cortex Phellodendri, Cortex Phellodendri, Alisma, Poria, and Polygonum cuspidatum to clear heat and remove dampness. When blood stasis obstructs the meridians, add Peach Kernel, Carthamus, Angelica Sinensis, Red Peony, Chuanxiong, Salvia miltiorrhiza, and Clematis armandii to nourish blood and activate blood circulation while dispelling wind—this approach embodies the principle of “treat wind first by treating blood.”

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April 10, 2014, China Journal of Traditional Chinese Medicine

Chapter 16: Pei’s Formulas
Ma Huang Gui Zhi Compound Qi Qin, Zheng Fangjiang
Pei Zhengxue, male, born in 1938, is a renowned modern scholar of integrated Chinese and Western medicine in China, a guiding teacher for the academic inheritance program of senior traditional Chinese medicine experts nationwide, a well-known TCM physician in Gansu Province, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, a chief physician, professor, and chief expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Institute of Medical Sciences, an honorary president of the Gansu Provincial Association for Integrated Chinese and Western Medicine, editor-in-chief of the journal “Integrated Chinese and Western Medicine Research,” and a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine.” Pei Zhengxue has been engaged in clinical practice for 55 years, publishing over 80 papers, possessing a deep academic foundation and rich clinical experience, specializing in the use of classic formulas to treat tumors, liver diseases, blood disorders, and other complex internal medicine conditions. The Ma Huang Gui Zhi Compound he developed is composed of Ma Huang Decoction, Gui Zhi Decoction, along with Chuanxiong, Bai Zhi, Xi Xin, Qiang Du Huo, and Fang Feng. It has proven highly effective in treating upper respiratory tract infections, neural headaches, acute and chronic rhinitis, sinusitis, cheilitis, oral inflammation, acute and chronic nephritis, and other conditions, making it worthy of wider application.

Usage: Soak the above ingredients in about 1500ml of water for half an hour, then simmer over low heat for 40 minutes. Repeat the decoction (using 500ml of water, simmering for 30 minutes). Combine the two decoctions and drink them in two doses throughout the day. Avoid eating cold, spicy, or irritating foods.

Function: Promotes sweating to release exterior pathogens, opens the lungs to relieve cough, and clears heat to benefit the throat.

Indications: The Ma Huang Gui Zhi Compound can both release exterior pathogens and dispel cold, warm the meridians and relieve pain, while also harmonizing the vital energy and defensive qi, replenishing deficiency and draining excess—making it suitable for treating head and facial ailments such as upper respiratory tract infections, neural tinnitus, chronic rhinitis, and other conditions.

Formula Explanation: Ma Huang and Gui Zhi are pungent and warming, opening the skin’s pores to disperse wind and cold, while also harmonizing the vital energy and defensive qi; Apricot Kernel promotes lung qi, relieves cough, and calms asthma; Raw Gypsum clears lung heat; Qiang Du Huo and Du Huo eliminate wind, cold, and dampness in the exterior; Chuanxiong, Bai Zhi, and Xi Xin disperse wind and cold, open dampness and blockages, and promote blood circulation and qi flow, relieving head and body pain; Gan Cao opens the lungs and promotes qi flow, clearing the throat.

Additions and Subtractions: For patients with upper respiratory tract infections accompanied by excessive phlegm and chest tightness, add Ma Xing Shi Gan Tang, Dry Ginger, Xi Xin, Wu Wei Zi, and Ban Xia; for patients with white, sticky phlegm and itchy throat, add Zhiku San; for patients with thin phlegm and dry throat, add Xing Su San; for patients with fever, add Honeysuckle, Forsythia, Dandelion, Da Qing Ye, and Ban Lan Gen—other antiviral herbs—and use up to 30–60g of Gypsum; for patients with chronic headaches that have entered the meridians due to long-term illness, add Taohong Siwu Decoction to activate blood circulation and resolve blood stasis; for severe headaches, add White Silkworm Moth, Whole Scorpion, and Centipede to search for wind and relieve pain; if the headache is caused by excessive liver yang, add Tianma, Gou Teng, and Shi Jue Ming to calm the liver and lower yang, and to extinguish wind and relieve pain; for patients with purulent nasal discharge due to rhinitis, add Honeysuckle, Forsythia, and Dandelion to clear heat and detoxify; for patients with allergic rhinitis, add Cicada Egg and Xinyi to open nasal passages; for patients with proteinuria due to nephritis, add Su Jing, Cicada Egg, and Motherwort to reduce proteinuria; for patients with hematuria, add Bambusa Root, Side-Tree Leaves, Ligustrum Lucidum, and Large and Small Thistle to clear heat and stop bleeding.

February 21, 2013, China Journal of Traditional Chinese Medicine

450

Chapter 16: Pei’s Formulas
Hua Yu Lian Yang Tang Zhan Wenguo

Pei Zhengxue, male, born in 1938, is a renowned expert in integrated Chinese and Western medicine in China, one of the first 500 senior traditional Chinese medicine practitioners nationwide, a distinguished TCM physician in Gansu Province, a chief physician, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, a national-level mentor for advanced students, a lifetime director of the Chinese Society of Traditional Chinese Medicine, a chief expert at Gansu Provincial Cancer Hospital, and a professor at the Gansu Provincial Institute of Medical Sciences, receiving special government allowances from the State Council. He currently serves as a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine” and as the editor-in-chief of “Integrated Chinese and Western Medicine Research,” as well as the president of the Gansu Provincial Association for Integrated Chinese and Western Medicine.

Professor Pei Zhengxue has been engaged in clinical practice for over 50 years, publishing more than 100 academic papers and authoring over 20 monographs. With a deep academic foundation and rich clinical experience, he specializes in treating blood disorders, tumors, digestive system diseases, and various complex internal medicine conditions.

Peptic ulcers fall under the category of “stomach pain” in traditional Chinese medicine. Traditional Chinese Medicine posits that their onset is related to cold invasion of the stomach, dietary damage to the stomach, liver qi attacking the stomach, and spleen and stomach weakness. Ulcers often worsen due to diet, emotions, fatigue, cold dampness, and other factors. Clinical manifestations include upper abdominal pain and discomfort, which is chronic, periodic, and rhythmic; gastric ulcers often occur after eating, while duodenal ulcers tend to appear when hungry, with nighttime pain or accompanied by acid reflux and vomiting. Professor Pei Zhengxue particularly emphasizes that long-standing gastric ulcers often enter the meridians, where gastric meridians are congested and blocked, with both deficiency and excess conditions present, or even symptoms such as stomach Yin deficiency, Qi deficiency, spleen Yang deficiency, or kidney Qi deficiency. He stresses the importance of activating blood circulation and resolving blood stasis in the treatment of gastritis and gastric ulcers. Based on the pathological characteristics of peptic ulcers—“long-term illness entering the meridians,” “long-term illness often involves blood stasis”—Professor Pei Zhengxue focused on activating blood circulation and resolving blood stasis, promoting qi flow and relieving pain, and formulated the “Hua Yu Lian Yang Tang.”

Composition: 10g of Fried Sophora Flower, 10g of Five-Flavor Seed, 6g each of Prepared Milkweed, 10g of Salvia Miltiorrhiza, 10g of Angelica Sinensis, 30g of Astragalus, 6g of Galangal, 6g of Frankincense, 10g of Ligusticum, 10g of Curcuma Longa, 6g of Amomum Villosum, 6g of Cinnamon, 6g of Clove, 6g of Cardamom, 6g of Nutmeg, 6g of Star Anise, 6g of Fennel, 6g of Cumin, 6g of Black Pepper, 6g of Turmeric, 6g of Ginger, 6g of Garlic, 6g of Onion, 6g of Celery, 6g of Parsley, 6g of Basil, 6g of Mint, 6g of Coriander, 6g of Cilantro, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of Dill, 6g of......

Input: The basic treatment principles include tonifying kidney qi, promoting blood circulation to remove stasis, and clearing heat and eliminating dampness. Based on these principles, Professor Pei developed the compound formula Fufang Yishen Tang for treating chronic nephritis and nephrotic syndrome caused by kidney qi deficiency and damp-heat or blood stasis, which has shown remarkable efficacy.

This formula primarily uses Guifu Dihuang Tang as its base, warming the kidneys and strengthening yang energy to nourish and replenish kidney qi, thereby replenishing the source of fire to eliminate yin obstruction—a fundamental approach to treatment. As the saying goes: “Those who are good at tonifying yang must seek yang within yin; when yang is supported by yin, it can generate and transform without being chaotic.” External wind pathogens or heat toxins that damage the kidneys are major factors leading to kidney infections; therefore,

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To address these conditions, it is necessary to use herbs that clear heat and detoxify, such as Lonicera japonica, Forsythia suspensa, Taraxacum mongolicum, Herba Leonuri, and Isatidis root, to combat bacteria and reduce inflammation, eliminate the underlying causes, and lessen the deposition of immune complexes in the kidneys—this is a method aimed at addressing the symptoms. Chronic diseases often lead to tissue damage and stasis; the basement membrane of renal glomeruli and capillary networks are prone to hypercoagulation, where immune complexes deposit, causing renal circulatory disorders. This leads to pathological changes such as hyperlipidemia, increased blood viscosity, and hypertension. The application of Taohong Siwu Tang to promote blood circulation and remove stasis not only improves the permeability of renal glomeruli and blood circulation but also reduces the burden on the kidneys to some extent, enhancing renal function and providing an early opportunity for treating this condition—and it can also be used as a complementary therapy. Stasis of blood serves both as a cause and a pathogenic factor; Taohong Siwu Tang enters the blood vessels to promote blood circulation and remove stasis while nourishing and replenishing blood. However, its ability to remove stasis is limited; therefore, adding Danshen and Shui Zhi to enhance the effect of removing stasis is beneficial. These two herbs work to remove stasis without harming the body’s righteous qi, stop bleeding without leaving behind residual blood—especially effective for visceral stasis, arterial hardening plaques, and vascular obstructions.

The presence of proteinuria and occult blood in urine is also associated with the deposition of self‑antigen–antibody immune complexes, which are part of an immune hypersensitivity reaction. Professor Pei often uses Su Bing, Chan Yi, and Yimu Cao in combination to regulate the body’s reactivity and improve immune function.

[Case Study] Ma, female, 24 years old. First visit, May 21, 2010. Chief Complaint: Recurrent edema for six months. Medical History: Six months ago, she experienced facial edema due to a cold, along with cough, headache, and decreased urination. After antibiotic treatment, the edema subsided, and her cough improved. One month later, she began experiencing bilateral lower limb edema, decreased urination, and fatigue. A routine urine test at a local hospital revealed: Proteinuria (++), occult blood (++), with no elevated blood pressure. 24-hour urine protein quantification was 3.0 mg. Triglycerides were 2.6 mmol/L, total protein was 65 g/L, plasma albumin was 30 g/L, and globulin was 35 g/L. Current Symptoms: Edema, reduced urination, susceptibility to colds, feeling cold with spontaneous sweating, lower back pain and leg discomfort, red tongue with white coating, pulse characterized by deep and fine texture. Western medical diagnosis: Chronic nephritis, nephrotic syndrome. Traditional Chinese Medicine diagnosis: Edema. TCM pattern differentiation: Kidney Yang deficiency, Qi failing to transform water.

Treatment Principles: Tonify the kidneys and warm yang, transform Qi and promote water flow, while also removing stasis and clearing heat. Prescription: Fufang Yishen Tang with modifications.

Prescription: Gui Zhi 10 g, Fu Zi 6 g, Shan Yu Rou 10 g, Shan Yao 10 g, Fu Ling 10 g, Dan Pi

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Pei Zhengxue Clinical Collection, Volume Two 6 g, Ze Xie 10 g, Tao Ren 10 g, Hong Hua 6 g, Dang Gui 10 g, Yimu Cao 15 g, Dan Shen 20 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Su Bing 15 g, Chan Yi 6 g, Huang Qi 30 g, Chao Bai Zhu 10 g, Fang Feng 10 g. Decocted in water and taken once daily. Second Visit, September 30, 2010. After two months of taking the above formula, all symptoms had improved. Urine tests showed: Proteinuria (+), occult blood (-), 24-hour urine protein quantification was 1.0 mg. Triglycerides were 1.7 mmol/L, total protein was 70 g/L, plasma albumin was 38 g/L, globulin was 32 g/L. Abdominal distension and fullness were present, appetite was poor, and fatigue persisted. Tongue was red, coated with thin white coating, pulse was deep, slow, and strong. The condition was characterized by spleen and kidney deficiency; the formula was adjusted to reduce the amount of herbs that promote blood circulation and remove stasis, as these herbs can harm the stomach if used excessively, so Dan Pi, Ze Xie, Tao Ren, Chuan Xiong, Bai Shao, and Sheng Di were removed. Additionally, Jin Yin Hua, Lian Qiao, and Taraxacum mongolicum were replaced with Dang Gui, Poria, and other herbs that nourish and strengthen the spleen and kidneys, while also consolidating and tightening the protein. Thirty doses were administered.

Third Visit, November 10, 2010. The patient continued taking the formula for over a month, and her condition remained stable, with all symptoms completely resolved. Urine tests showed negative results for both proteinuria and occult blood. A formula was prepared using Gui Fu Dihuang Tang with adjustments to consolidate the therapeutic effect: Prescription: Gui Zhi 50 g, Fu Zi 30 g, Shan Yu Rou 50 g, Shan Yao 50 g, Dang Gui 50 g, Bai Shao 50 g, Yimu Cao 75 g, Dan Shen 100 g, Jin Yin Hua 75 g, Lian Qiao 75 g, Huang Qi 100 g, Chao Bai Zhu 50 g, Dang Gui 75 g, Tu Si Zi 50 g, Han San Qi 30 g, Shui Zhi 100 g. All herbs were ground into powder, each dose weighing 10 g, taken three times daily. Alternatively, the medicine could be made into pills for further consolidation of the therapeutic effect. Follow-up visits were conducted for two years, during which the patient’s condition remained stable and no recurrence occurred.

[Reflections] Professor Pei’s treatment of nephrotic syndrome focuses primarily on tonifying the kidneys, alternating between kidney-tonifying and spleen‑strengthening therapies, while also employing methods to clear heat, detoxify, and promote blood circulation to remove stasis. He always kept in mind the importance of protecting gastric qi, invigorating the middle burner, and warming the yang energy of the spleen and kidneys. As the Yellow Emperor’s Inner Canon states: “Yang qi is like heaven and the sun—when it is lost, one’s lifespan is shortened and one’s brilliance is diminished.” To warm yang and tonify the kidneys, to transform qi and promote water flow, Gui Fu Dihuang Tang should be prioritized, warming and nourishing the fire of the Mingmen, replenishing the source of fire to eliminate yin obstruction.

In the formula, Gui Zhi and Fu Zi warm yang and replenish fire to strengthen kidney yang—these are the principal herbs; Shan Yao and Shan Yu Rou nourish and tonify kidney yin, restraining excess fire and preventing it from running wild, serving as complementary herbs; Fu Ling, Dan Pi, Ze Xie, Bai Zhu, and Huang Qi strengthen the spleen and promote diuresis, collectively acting as minister herbs; Su Bing regulates qi and transforms dampness, aiding the minister herbs in regulating qi and promoting water flow; Tao…

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Tao Ren, Hong Hua, Dang Gui, and Dan Shen promote blood circulation and remove stasis—these are auxiliary herbs; Jin Yin Hua, Lian Qiao, and Yimu Cao clear heat and detoxify—these are main herbs. Chan Yi is a unique herb, as it helps dispel wind and counteract allergies. Since kidney disease involves not only glomerular lesions but also autoimmune hypersensitivity reactions, Professor Pei combined Chan Yi with Yimu Cao to improve the kidney’s immune mechanisms, regulate immunity, and promote disease recovery. Together, these herbs work to warm yang, tonify the kidneys, promote blood circulation, remove stasis, and clear heat and detoxify.

Clinical Adjustments: For positive occult blood in urine, add Xianhe Cao, Han Lian Cao, Zicao, Bi Xie, etc., to nourish yin, clear heat, and stop bleeding; for difficulty in urination, add Long Kui, Feng Wei Cao, Ban Zhi Lian, Bai Ying, Han Lian Cao, Che Qian Cao, etc., to clear heat and promote diuresis; for hypertension, add Sheng Long Mu, Zhen Zhu Mu, Gou Teng to calm the liver and lower yang; for high blood lipids, add Shan Zha, Yi Mi, Gan He Ye, Yin Chen, etc., to clear heat and eliminate dampness.

2015, China Journal of Traditional Chinese Medicine

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Pei Zhengxue Clinical Collection, Volume Two Pei Zhengxue’s Clinical Experience: Combining Diagnosis and Treatment with Mashi Shigan Tang Zhang Chouchou Foreword: Professor Pei Zhengxue of Gansu Provincial Cancer Hospital is a renowned expert in the integration of traditional Chinese and Western medicine in China. As early as the 1980s, he proposed the sixteen-character principle of “Western medical diagnosis, TCM pattern differentiation, herbal medicine as the primary treatment, and Western medicine as a supplementary approach,” a concept that has garnered significant attention from Chinese and Western medical professionals nationwide. He was particularly adept at utilizing classic formulas in clinical practice, yet he did not rigidly adhere to their usage, achieving remarkable therapeutic effects. Today, our newspaper is pleased to launch the “Pei Zhengxue’s Clinical Experience” column, introducing his academic characteristics and sharing his insights with readers.

Mashi Shigan Tang, also known as Ma Huang Xing Ren Gan Cao Shi Jiao Tang, possesses the properties of dispersing lung qi with a pungent and cool nature, clearing the lungs and relieving asthma. However, Professor Pei applied it flexibly, following the “sixteen-character principle”: first, conduct modern medical examinations to establish a Western medical diagnosis, clearly identifying the disease’s diagnosis, site of onset, and progression of the illness; then proceed with TCM pattern differentiation. He adapted ancient formulas to treat various conditions, learning from the past without being bound by it—resulting in highly effective treatments.

Lung Disorders The Shanghan Lun records: “After sweating, do not administer Gui Zhi Tang again; if sweating occurs and the patient experiences shortness of breath without high fever, Ma Huang Xing Ren Gan Cao Shi Jiao Tang may be used.” This indicates that after sweating to release exterior pathogens, the patient may feel a slight improvement in heat, but their shortness of breath becomes more pronounced, as wind-cold has entered the interior and transformed into fire. From a modern medical perspective, this formula is suitable for all types of bronchial and pulmonary infections—including acute and chronic bronchitis, bronchopneumonia, as well as pulmonary infections caused by emphysema and cardiopulmonary disease.

Professor Pei added Sangbai Pi, Dige Pi, Tingli Zi, Da Zao, Huang Qin, and Yu Xing

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Chapter Sixteen: Pei’s Formulas to treat various pulmonary infections, allowing most patients to avoid the hardship of injections and infusions—making it even more convenient and cost-effective for patients in grassroots healthcare settings.

This formula, when combined with Suxing San, demonstrates remarkable efficacy in treating chronic bronchitis, emphysema, cardiopulmonary disease, and heart failure. When used in combination with Jiang Xin, Xi Xin, Wu Wei Zi, Ban Xia, and Bai Shao, it exhibits significant effects in relaxing smooth muscles of the trachea and gastrointestinal tract, as well as in raising blood pressure, making it useful for treating cough and wheezing in bronchial asthma.

[Case Study] Wang, male, 40 years old, first visited on January 15, 2008. Cough, expectoration, and shortness of breath for over a month. Despite taking multiple Western medications, no significant improvement was observed, so he sought combined Chinese-Western treatment. His symptoms included: cough, yellow sputum, severe shortness of breath, red tongue with a thin yellow coating, and a slippery, rapid pulse.

Diagnosis: Chronic bronchitis, emphysema, cardiopulmonary disease. Pattern Differentiation: Lung heat accumulation, treated with

dispelling lung qi and clearing heat.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Zi Su Ye 10 g, Bai Qian 10 g, Qian Hu 10 g, Ban Xia 10 g, Chen Pi 6 g, Fu Ling 10 g, Jie Geng 20 g, Zhi Ke 10 g, Pu Gong Ying 15 g, Baisai Cao 15 g.

After seven doses, his shortness of breath and cough were significantly alleviated. At the follow-up visit, Huang Qin 20 g and Yu Xing Cao 20 g were added. After another ten-plus doses, most of his symptoms had disappeared.

Kidney Edema The Golden Chamber Essentials states: “For those with fluid retention, if swelling occurs below the waist, promote urination; if swelling occurs above the waist, induce sweating.” This emphasizes that inducing sweating and promoting urination are two key principles for treating edema. Professor Pei believed that Mashi Shigan Tang indeed has a significant diuretic and edema‑reducing effect. Traditional Chinese medicine often refers to this approach as “dispelling lung qi and promoting water flow,” “guiding water to the surface,” “opening the door to the heavens and cleansing the internal organs,” and other similar terms.

Modern physician Cao Yingfu once compared this practice as follows: If there is a small hole in the lid of a teapot, just like the opening of the lungs, water can pour out from the spout; if there is no small hole, water is difficult to drain from the spout—just as if the lungs are not fully open, and the kidney qi fails to descend! In TCM, the lungs belong to metal, while the kidneys belong to water; metal can generate water, and metal and water mutually generate each other.

The human body is a unified whole, with organs maintaining dynamic balance in osmotic pressure through endocrine functions, metabolism, and fluid circulation. When lung qi is not fully opened, the pressure balance between the lungs and kidneys tends to break down, leading to difficulty in urination and edema. Professor Pei employed this method in clinical treatment of chronic nephritis, nephrotic syndrome, and purpuric nephritis.

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Pei Zhengxue Clinical Collection, Volume Two When treating edema in chronic nephritis, nephrotic syndrome, or purpuric nephritis, Professor Pei used this approach.

TCM pattern differentiation: Spleen and kidney yang deficiency, treated with dispelling lung qi and promoting water flow, strengthening the spleen and tonifying the kidneys.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Zhi Pi Ye 15 g, Shan Yao 10 g, Huang Qi 20 g, Tu Si Zi 15 g, Nü Zhen Zi 15 g, Han Lian Cao 15 g, Bai Qian 10 g, Qian Shi 30 g, Jin Yin Hua 30 g, Dang Gui 10 g, Bai Zhu 10 g, Fu Ling 12 g, Gan Cao 6 g. After ten doses, the edema had largely subsided; urine protein was (2+). After more than twenty additional doses, urine analysis returned to normal.

Childhood Enuresis This formula is used for children with lung heat-related enuresis, whose pattern is characterized by cough, wheezing, thirst, and a yellow tongue coating with a rapid pulse. The Su Wen’s “Pulse Channel Analysis” states: “Fluids overflow in the stomach, circulating through the essence and qi, rising to the spleen; the spleen’s qi disperses the essence, sending it upward to the lungs, regulating the water pathways, and ultimately draining to the bladder.” The lungs govern the movement of fluids; when lung heat accumulates and the lungs’ ability to disperse and descend is impaired, fluid movement becomes disrupted. Moreover, since children’s kidney qi is not yet fully developed and their ability to retain fluids is insufficient, the bladder’s opening and closing become unbalanced, leading to frequent enuresis. The treatment should focus on clearing lung heat.

Professor Pei used Mashi Shigan Tang as the primary formula for treating this condition, combining it with Qian Shi, Jin Yin Hua, Yizhi Ren, Sang Piao Xiao, and Wuyao to tonify the kidneys and strengthen the bowels, thus clearing lung heat and enabling the lungs to properly distribute qi and descend, while also restoring the proper function of the water pathways, leading to spontaneous resolution of enuresis.

[Case Study] Li, male, 7 years old, first visited on March 20, 2008. The child had been experiencing nocturnal enuresis for two years, waking up 1–2 times per night, often thirsty, with slightly yellow urine, a yellow tongue coated with a thin white layer, and a rapid pulse. Diagnosis: Enuresis. Pattern Differentiation: Lung heat stagnation, treated with dispelling lung qi and clearing heat, tonifying the kidneys and strengthening the bowels.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Gui Zhi 10 g, Fu Zi 6 g, Sheng Di 12 g, Shan Yao 10 g, Shan Zhu Yu 6 g, Dan Pi 6 g, Fu Ling 12 g, Ze Xie 10 g, Jing Wei 10 g, Bai Xian Pi 15 g, Di Fu Zi 12 g, Wuyao 6 g, Chan Tui 6 g.

After ten doses, the frequency of enuresis had significantly decreased, and after another ten-plus doses, the child was fully cured. Urticaria Urticaria is often accompanied by intense itching; itching is caused by wind. Wind resides in the skin and hair, and the lungs are the organ responsible for governing wind. Therefore, Professor Pei used Mashi Shigan Tang as a foundation to clear lung heat and treat skin diseases like urticaria, combining it with the four substances formula for nourishing blood and promoting blood circulation—this is the principle of “treat wind by activating blood, and when blood is active, wind naturally disappears”; for heat, use Jin Yin Hua and Lian Qiao; for cold, use Huang Qi and Jing Wei; for dampness, use Cang Zhu, Huang Bo, and Qiang Du Hua; for severe itching, add Bai Xian Pi, Di Fu Zi, Wuyao, and Chan Tui.

[Case Study] Sun, female, 35 years old, first visited on April 20, 2008. The patient experienced intermittent itching on both upper limbs for one month, accompanied by circular wheals of varying sizes, reddish in color, and intense itching. Her tongue was red with a thin yellow coating, and her pulse was floating and rapid. Diagnosis: Urticaria. Treatment focused on clearing lung heat and dispersing wind while nourishing blood.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Dang Gui 10 g, Chuan Xiong 6 g, Sheng Di 12 g, Chi Shao 10 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Bai Zhi 6 g, Fang Feng 12 g, Jing Wei 10 g, Bai Xian Pi 15 g, Di Fu Zi 12 g, Wuyao 6 g, Chan Tui 6 g.

After seven doses, the number of itching episodes decreased significantly compared to before. After removing Jin Yin Hua and Lian Qiao from the formula, the patient continued taking the medication for ten additional doses and was fully cured.

Conjunctivitis Conjunctivitis is often linked to allergies; allergy sufferers are affected by wind. When wind attacks the body, it first affects the lungs—the lungs govern the skin and hair—and when heat accumulates in the lungs, Mashi Shigan Tang is used as the primary formula to clear lung heat, followed by the combination with Dan Zhi Xiao Yang, which helps to clear the liver and brighten the eyes, allowing these conditions to be treated.

[Case Study] Wei, female, 30 years old, first visited on March 10, 2008. The patient had been experiencing intermittent eye itching for three to four days, with red streaks covering her eyes. She had tried various antibiotic eye drops but saw no significant improvement, so she came for treatment. Her symptoms included: red and swollen eyes, conjunctival congestion, mild pain, and intense itching; her tongue was red with a yellow coating, and her pulse was floating and rapid. Diagnosis: Acute conjunctivitis. Treatment focused on dispelling lung heat and clearing the liver while brightening the eyes.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Dan Pi 6 g, Shan Zhi Zi 10 g, Dang Gui 10 g, Bai Shao 15 g, Chai Hu 10 g, Bai Zhu 10 g, Fu Ling 12 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Bai Zhi 10 g, Di Fu Zi 15 g, Wuyao 10 g.

After seven doses, the redness and swelling subsided, the itching was significantly reduced, conjunctival congestion also lessened, and at the follow-up visit, Jin Yin Hua and Lian Qiao were removed from the formula, and instead, Bai Xian Pi 15 g, Shi Jue Ming 15 g, and Mu Cuo Cao 10 g were added. After another seven doses, most of the aforementioned symptoms had completely disappeared.

Sinusitis The lungs open to the nose; this condition is often associated with heat accumulation in the lung meridian. Therefore, Mashi Shigan Tang can be used as the primary formula to clear heat accumulated in the lung meridian, treating the root cause, while also combining it with spicy, warming herbs like Cang Er Zi and Xin Yi to help disperse the heat.

[Case Study] Zhang, male, 20 years old, first visited on May 14, 2008. The patient had been suffering from nasal congestion, thick mucus, and headaches for over two years. He had visited multiple clinics, all of which diagnosed him with sinusitis, but despite taking various medications, no significant improvement was seen. Later, he was referred to Professor Pei for treatment. His symptoms included: headache, nasal congestion, thick mucus, a yellow tongue coated with a thin, greasy layer, and a rapid pulse. Diagnosis: Chronic sinusitis. Treatment focused on dispelling lung heat and clearing the liver while transforming turbidity.

Prescription: Ma Huang 10 g, Xing Ren 10 g, Sheng Shi Jiao 30 g, Gan Cao 6 g, Gui Zhi 10 g, Chuan Xiong 6 g, Bai Zhi 6 g, Xi Xin 3 g, Qiang Du Hua 10 g, Fang Feng 12 g, Cang Er Zi 15 g, Xin Yi 10 g.

After seven doses, the headache was significantly alleviated, nasal congestion and mucus production improved, and Jin Yin Hua 15 g and Lian Qiao 15 g were added. After continuing to take the formula for fourteen doses, the headache disappeared, and nasal congestion and mucus production became occasional.

January 13, 2014, China Journal of Traditional Chinese Medicine

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Chapter Sixteen: Pei’s Formulas Pei Zhengxue’s Approach to Diagnosis and Treatment Through Reflection Zhang Guiqiong [Abstract] Professor Pei Zhengxue of Gansu Provincial Cancer Hospital integrates traditional Chinese and Western medicine, combining his clinical experience with…

10g, White Crotalaria 20g, Prepared Milkweed 6g, Licorice 6g.
Function: Tonifies Qi and collects blood, clears heat and resolves fire, dissolves blood stasis and stops bleeding, regulates the liver to calm blood.
Indications: Idiopathic thrombocytopenic purpura, where the syndrome is characterized by Qi deficiency and blood heat.
Usage: Take one dose daily, add an appropriate amount of water; brew the first decoction for 30 minutes, the second for 40 minutes, mix the two decoctions together, and take in divided doses in the morning and evening after meals.

Formula Explanation: Idiopathic thrombocytopenic purpura (ITP) is an immune-mediated thrombocytopenia syndrome. Clinically, it primarily manifests as skin, mucous membranes, and internal organ bleeding, along with a decrease in peripheral blood platelets, while bone marrow megakaryocytes are normal or increased, and there are also signs of maturation disorders. This condition falls under the categories of "blood disorders," "skin lesions," and "hemorrhagic rash" in traditional Chinese medicine.

Pei Zhengxue believes that the underlying cause of this disease is both deficiency and excess, with spleen deficiency and weak Qi being the root cause, while internal heat and stagnation of blood are the external manifestations. Liver dysfunction in regulating blood flow and blood retention are key factors contributing to the chronic nature of the disease. Treatment should focus on strengthening the spleen, tonifying Qi, collecting blood, clearing heat, resolving fire, and stopping bleeding—this is the primary therapeutic approach, supplemented by regulating the liver and dissolving blood stasis, which mutually enhance each other’s effects.

The Zhenqi Sanhuang Decoction uses Codonopsis, Atractylodes macrocephala, Astragalus, and Licorice to strengthen the spleen and tonify Qi, thereby achieving the effect of gathering Qi and collecting blood. Tang Rongchuan once said, “In cases of blood disorders where Qi is abundant and fire is strong, eight out of ten patients experience this condition,” and “To clear the heart is to clear fire; to clear fire is to stop bleeding.” Therefore, the Sanhuang Decoction is used to clear heat and resolve fire, while cooling the blood and stopping bleeding. The liver stores blood and governs its discharge; when the liver fails to release blood properly, blood storage becomes impaired, or when liver stagnation leads to fire, causing blood to be forced to flow excessively, bleeding and skin lesions are easily triggered. Tang Rongchuan also stated, “The liver stores blood—every case of blood disorder ultimately revolves around the liver.” Thus, White Crotalaria is used to soothe the liver, clear heat, regulate the liver, and calm blood. When Qi is deficient and not transported, when Qi stagnates and blood stasis forms, blood that has left the vessels may remain and become stagnant, leading to recurrent bleeding that is difficult to heal. If blood stasis is not resolved, new blood cannot be generated; preparing milkweed to dissolve blood stasis and generate new blood avoids the drawback of exhausting Qi, making it particularly suitable for use. This formula integrates the four principles of “stopping bleeding, resolving blood stasis, calming blood, and replenishing deficiency,” employing both tonification and diuresis, addressing both the root cause and the symptoms, making it an excellent treatment for this condition.

Additions and Subtractions: For patients with long-term illness affecting the kidneys, or those with both kidney and spleen deficiency, add 15g of North Sandalwood, 15g of Prince’s Ginseng, 15g of ginseng root, 12g of Rehmannia Root, and 30g of Cornus Fruit; for patients with blood deficiency and blood loss, add 10g of Turtle Shell Gelatin (dissolved), 10g of Antler Gelatin (dissolved), 30g of Chicken Blood Vine, 30g of Herba Lysimachiae, and increase the amount of White Crotalaria to 30g; for patients with Yin Deficiency and Excess Heat, add 10g of Bamboo Shoot Rhizome, 20g of Polygonum cuspidatum, 15g of Rheum officinale, 12g of Rehmannia Root, 15g of Forsythia, and Turtle Shell.

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Pei Zhengxue Clinical Collection, Volume 2 15g; for patients with prolonged illness affecting the meridians, add 6g of Silkworm Moth, 6g of Whole Scorpion, 1 piece of Centipede, and 6g of Earthworm; for patients with heavy bleeding and dense red spots, add 30g of Bambusa Root, 30g of Herba Lysimachiae, 20g of Lotus Root Carbon, 15g of Purple Grass, and 15g of Red Lotus Leaf; for patients with nosebleeds, add 10g of Rheum Root Carbon, 10g of Paeonia Root Carbon, 10g of Cassia Seed Carbon, and 10g of Lotus Leaf Carbon; for patients with gingival bleeding, combine with Yu Nu Decoction; for patients with stool bleeding, combine with Huang Tu Soup; for patients with Yin Damage from Heat-Toxin, combine with Wan Xiang Chen’s Formula for Idiopathic Thrombocytopenic Purpura.

March 3, 2014, China Journal of Traditional Chinese Medicine

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Chapter 16: Pei’s Formulas
Pei Zhengxue’s Clinical Experience: Kelerang Decoction for Lupus Nephritis
Zhan Wenguo
Lupus nephritis is a chronic inflammatory condition resulting from kidney damage secondary to systemic lupus erythematosus (SLE), and it is one of the leading causes of death in SLE patients, commonly occurring in young women. Its typical clinical features include proteinuria, hematuria, edema, hypertension, joint pain, fever, hepatosplenomegaly, and more. Some patients test positive for antinuclear antibodies and exhibit decreased complement C3 levels.

In response to these conditions, Professor Pei Zhengxue of Gansu Provincial Cancer Hospital proposed the therapeutic principle of supporting righteous qi, strengthening the body’s foundation, eliminating pathogenic factors, and treating the symptoms. Treatment focuses on nourishing the liver and kidneys, nourishing blood and generating fluids, dispelling wind and removing dampness, activating blood circulation and resolving blood stasis, and clearing heat and detoxifying—these approaches have yielded remarkable therapeutic results when combined with Kelerang Decoction and Taohong Siwu Decoction with modifications. Kelerang Decoction is a specialized formula compiled by Pei Zhengxue for the treatment of lupus nephritis.

Li Mou, female, 42 years old, presented for her first consultation on March 12, 2010.

Chief Complaint: Low back pain accompanied by edema for 1 month. The patient had previously suffered from systemic lupus erythematosus complicated by lupus nephritis for 2 years. She was treated with prednisone at a maximum dose of 60 mg/day, but her dosage was later reduced to 10 mg/day, and she continued to take 3 tablets of Indomethacin per day, with improvement in her condition. She had not taken any medication for the past month, but still experienced low back pain and sudden onset of edema, which progressed rapidly. She developed nephrotic syndrome and progressive deterioration of renal function, eventually progressing to uremia within weeks to months—a poor prognosis. Biochemical tests revealed specific immune complex deposits, lupus cells were found in her blood, her erythrocyte sedimentation rate was elevated, serum globulin levels were increased, urine output was reduced, joint pain in her fingers worsened, she experienced hot flashes, night sweats, insomnia with frequent dreams, fatigue, dizziness, blurred vision; butterfly-shaped pigmentation appeared on her facial area, her tongue was dark red with a thin yellow coating, bruising was present at the edges, and her pulse was wiry and fine. Her blood pressure was 140/90 mmHg. Laboratory findings included an ESR of 39 mm/h, proteinuria (2+), hematuria (+), and positive antinuclear antibodies.

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Pei Zhengxue Clinical Collection, Volume 2 Western medical diagnosis: Lupus nephritis. Traditional Chinese Medicine Diagnosis: Liver and Kidney Deficiency, Blood Stasis in the Meridians. Treatment should focus on nourishing the liver and kidneys, clearing heat and detoxifying, activating blood circulation and resolving blood stasis. The formula used was Kelerang Decoction, modified with Taohong Siwu Decoction.

Formulation: 10g of Polygonum cuspidatum, 10g of Epimedium, 10g of Cuscuta, 10g of Radix Rehmanniae, 12g of Rehmannia Root, 10g of Ophiopogon, 10g of Ligustrum Lucidum, 10g of Eucommia Bark, 15g of Lythrum, 10g of Alismatis, 10g of Angelica sinensis, 10g of Paeonia lactiflora, 6g of Carthamus, 10g of Peach Kernel, 20g of Clematis armandii, 20g of Salvia miltiorrhiza, 15g of Anemarrhena asphodeloides, 15g of Hedyotis diffusa, 20g of Plantago major, 10g of Platycodon grandiflorus, and 10g of Ledebouriella seseloides. Take 14 doses, decocting the herbs in water, once daily.

Second Consultation: After taking the medication, the low back pain and edema subsided, the red patches on the face became lighter in color, though she still experienced insomnia and frequent dreams. Proteinuria remained at 2+, hematuria was negative. She added 20g each of Albizia bark and Polygala tenuifolia to the formula, and continued taking the medication for another 14 doses.

Third Consultation: All symptoms showed significant improvement—proteinuria was negative, hematuria was also negative. Her blood pressure was 120/80 mmHg, her tongue was red, her tongue coating was minimal, and her pulse was fine and rapid. Her condition was characterized by liver and kidney deficiency; therefore, she removed White Flower Snake Tongue Herb, Half-Branched Lily, Flea Beetle, Plantain, and Platycodon grandiflorus, adding 10g of Goji Berries, 10g of Chrysanthemum flowers, 10g of Cornus Fruit, and 10g of Chinese Yam to nourish the liver and kidneys and strengthen the body’s foundation.

After further adjustments over the course of more than a year, her condition improved, and she continues to take the medication to consolidate her therapeutic effects. According to Pei Zhengxue, “Lupus nephritis is characterized by deficiency in the root and excess in the symptoms; liver and kidney deficiency are the root cause, while wind, dampness, heat, and toxic substances, along with phlegm and blood stasis, are the external factors. Nourishing the liver and kidneys and nourishing blood and generating fluids are the fundamental principles for treating this condition, while also assisting in dispelling wind, removing dampness, activating blood circulation, and clearing heat and detoxifying.”

When nourishing the liver and kidneys, common herbs include Ligustrum Lucidum, Lythrum, Goji Berries, Rehmannia Root, Cornus Fruit, Epimedium, Cuscuta, Eucommia Bark, and others. When heat and toxicity are severe, and when wind and fire are exacerbating the condition, high fever persists, accompanied by limb edema and joint swelling; in such cases, use herbs like Honeysuckle, Forsythia, Dandelion, Bidens pilosa, White Flower Snake Tongue Herb, Half-Branched Lily, Raw Gypsum, Cortex Moutan, Polygonum cuspidatum, and other herbs to clear heat and detoxify.

If heat is excessive and it damages Yin, then it is essential to add Radix Rehmanniae, Rehmannia Root, Ophiopogon, Dendrobium, Cortex Moutan, and other Yin-nourishing herbs. When the ESR increases, immune complex deposits, lupus cells, and other conditions indicate phlegm, dampness, and blood stasis; use herbs like Raw Gypsum, Cortex Moutan, Alismatis, Poria, Polygonum cuspidatum, and others to clear heat and remove dampness. When blood stasis obstructs the meridians, add Peach Kernel, Carthamus, Angelica Sinensis, Red Peony, Chuanxiong, Salvia Miltiorrhiza, and Chicken Blood Vine to nourish blood and activate blood circulation, while also dispelling wind—this aligns with the principle of “treat wind by treating blood.”

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April 10, 2014, China Journal of Traditional Chinese Medicine

Chapter 16: Pei’s Formulas
Ma Huang Gui Zhi Compound Qi Qin, Zheng Fangjiang Pei Zhengxue, male, born in 1938, is a renowned modern scholar of integrated Chinese and Western medicine in China, a guiding teacher for the academic inheritance program of senior traditional Chinese medicine experts nationwide, a renowned TCM physician in Gansu Province, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, a chief physician, professor, and chief expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Institute of Medical Sciences, as well as the honorary president of the Gansu Provincial Association for Integrated Chinese and Western Medicine, editor-in-chief of the journal “Integrated Chinese and Western Research,” and a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine,” and a staff member of the Gansu Provincial Museum of Literature and History. Pei Zhengxue has practiced clinical medicine for 55 years, publishing more than 80 academic papers, possessing a deep academic foundation and rich clinical experience, specializing in the use of classic formulas to treat tumors, liver diseases, blood disorders, and other complex internal medicine conditions. The Ma Huang Gui Zhi Compound he developed is composed of Ma Huang Decoction, Gui Zhi Decoction, along with Chuanxiong, Bai Zhi, Xi Xin, Qiang Du Huo, and Fang Feng. It has proven highly effective in treating upper respiratory tract infections, neural headaches, acute and chronic rhinitis, sinusitis, cheilitis, oral inflammation, acute and chronic nephritis, and other conditions, and is worthy of wider dissemination.

Usage: Soak the above herbs in about 1500ml of water for half an hour, then simmer over low heat for 40 minutes, followed by a second decoction (500ml of water, simmering for 30 minutes). Combine the two decoctions and drink them in two doses throughout the day. Avoid eating cold, spicy, or irritating foods.

Function: Promotes sweating to relieve exterior symptoms, opens the lungs to stop cough, and clears heat to benefit the throat.

Indications: Ma Huang Gui Zhi Compound can both disperse cold and warm the meridians to relieve pain, while also harmonizing the vital energy and blood, replenishing deficiency and draining excess—making it effective for treating head and facial ailments such as upper respiratory tract infections, neural tinnitus, chronic rhinitis, sinusitis, and other conditions.

Formula Explanation: Ma Huang and Gui Zhi are pungent and warming, opening the skin’s pores to disperse wind and cold, while also harmonizing the vital energy and blood; Apricot Kernel promotes lung qi, stops cough, and calms asthma; Raw Gypsum clears lung heat; Qiang Du Huo and Du Huo eliminate wind, cold, and dampness in the exterior; Chuanxiong, Bai Zhi, and Xi Xin disperse wind and cold, open dampness and blockages, and promote blood circulation and qi flow, relieving head and body pain; Gan Cao opens the lungs and promotes qi flow, clearing the throat.

Additions and Subtractions: For patients with upper respiratory tract infections who have excessive phlegm and chest tightness, add Ma Xing Shi Gan Tang, Dry Ginger, Xi Xin, Wu Wei Zi, and Ban Xia; for patients with white phlegm and itchy throat, add Zhisu San; for patients with thin phlegm and dry throat, add Xing Su San; for patients with fever, add Honeysuckle, Forsythia, Dandelion, Da Qing Ye, and Ban Lan Gen—other antiviral herbs—and use up to 30–60g of Raw Gypsum; for patients with chronic headaches that have entered the meridians due to long-term illness, add Taohong Siwu Decoction to activate blood circulation and resolve blood stasis; for patients with severe headaches, add White Silkworm Moth, Whole Scorpion, and Centipede to search for wind and relieve pain; if the headache is caused by excessive liver yang, add Tianma, Gou Teng, and Stone Seashell to calm the liver and lower yang, and to suppress wind and relieve pain; for patients with purulent nasal discharge due to rhinitis, add Honeysuckle, Forsythia, and Dandelion to clear heat and detoxify; for patients with allergic rhinitis, add Cicada Egg and Xinyi to open nasal passages; for patients with proteinuria due to nephritis, add Su Jing, Cicada Egg, and Motherwort to reduce proteinuria; for patients with hematuria, add Bambusa Root, Side-Berry Leaves, Ligustrum Lucidum, and Large and Small Thistle to clear heat and stop bleeding.

February 21, 2013, China Journal of Traditional Chinese Medicine

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Chapter 16: Pei’s Formulas
Hua Yu Lian Yang Tang Zhan Wenguo

Professor Pei Zhengxue has practiced clinical medicine for over 50 years, publishing more than 100 academic papers and authoring over 20 monographs. With a deep academic foundation and rich clinical experience, he specializes in treating blood disorders, tumors, digestive system diseases, and various complex internal medicine conditions.

Peptic ulcers fall under the category of “Stomach Pain” in traditional Chinese medicine. Traditional Chinese medicine believes that their onset is related to cold invading the stomach, dietary indiscretion damaging the stomach, liver qi disturbing the stomach, and spleen and stomach weakness. Ulcers often worsen due to diet, emotions, fatigue, cold dampness, and other factors. Clinical manifestations include upper abdominal pain and discomfort, which is chronic, periodic, and rhythmic; gastric ulcers often occur after eating, while duodenal ulcers tend to appear during fasting, accompanied by nighttime pain or even acid reflux and vomiting. Professor Pei Zhengxue pays particular attention to ulcers that have persisted for a long time and have entered the meridians, where gastric meridians are congested and blood stasis exists, or where symptoms such as Yin deficiency, Qi deficiency, Spleen Yang deficiency, or Kidney Qi deficiency coexist. He emphasizes the importance of activating blood circulation and resolving blood stasis in the treatment of gastritis and gastric ulcers. Based on the pathological characteristics of peptic ulcers—“long-term illness entering the meridians,” “long-term illness often involves blood stasis”—Professor Pei Zhengxue prioritizes activating blood circulation and resolving blood stasis, promoting qi flow and relieving pain, and formulated the “Hua Yu Lian Yang Tang.”

Composition: 10g of Fried Sophora Flavescens, 10g of Five-Flavor Berry, 6g each of Prepared Milkweed, 10g of Salvia Miltiorrhiza, 10g of Angelica Sinensis, 30g of Astragalus, 6g of Galangal, 6g of Frankincense, 10g of Ligusticum Chuanxiong, 10g of Curcuma Longa, 6g of Amomum Villosum, 6g of Turmeric, 6g of Ginger, 6g of Citrus Peel, 10g of Citrus Peel, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum, 10g of Amomum Villosum,......10g, White Tribulus Terrestris 20g, Prepared Milkweed 6g, Licorice 6g.
Function: Tonifies Qi and collects blood, clears heat and resolves fire, dissolves blood stasis and stops bleeding, regulates the liver to calm blood.
Indications: Idiopathic thrombocytopenic purpura, where the syndrome is characterized by Qi deficiency and blood heat.
Usage: Take one dose daily, add an appropriate amount of water; brew the first decoction for 30 minutes, the second decoction for 40 minutes, mix the two decoctions together, and take in two doses, once in the morning and once in the evening, after meals.

Pei Zhengxue believes that the underlying cause of this disease is both deficiency and excess, with spleen deficiency and weak Qi, Qi deficiency leading to insufficient control, as the root cause; internal heat and dampness, which force blood to run abnormally, serve as the external manifestation. Liver dysfunction in regulating blood flow, combined with blood stasis, are key factors contributing to chronic and difficult-to-treat conditions. Treatment should focus on strengthening the spleen, tonifying Qi, and collecting blood, while clearing heat, resolving fire, and stopping bleeding—this is the primary therapeutic approach. Additionally, it’s important to regulate the liver and resolve blood stasis, as these approaches complement each other and enhance therapeutic effects.

The Zhenqi Sanhuang Decoction uses Codonopsis, Atractylodes macrocephala, Astragalus, and Licorice to strengthen the spleen and tonify Qi, thereby achieving the effect of gathering Qi and collecting blood. Tang Rongchuan once said, “In cases of blood disorders where Qi is abundant and fire is strong, eight out of ten patients experience this condition,” and “To clear the heart is to clear fire; to clear fire is to stop bleeding.” Therefore, the Sanhuang Decoction is used to clear heat and resolve fire, while cooling the blood and stopping bleeding. The liver stores blood and governs its discharge; when the liver fails to release blood properly, blood stagnates within the body, or when liver qi becomes stagnant and generates fire, causing blood to rush outward, bleeding and skin lesions are more likely to occur. Tang Rongchuan also stated, “The liver stores blood—every blood disorder ultimately revolves around the liver.” Thus, White Tribulus Terrestris is used to soothe the liver, clear heat, and regulate the liver to calm blood. When Qi is deficient and not transported, Qi stagnation leads to blood stasis; blood that has left the vessels can become stagnant and form blood clots, making bleeding recurrent and difficult to heal. To prevent blood stasis from persisting, new blood cannot be generated; prepared milkweed helps dissolve blood stasis and generate new blood without harming Qi, making it a suitable choice for treatment. This formula integrates the four principles of “stopping bleeding, resolving blood stasis, calming blood, and replenishing deficiency,” employing both tonification and regulation, addressing both the root cause and the symptoms, making it an effective remedy for this condition.

Additions and Subtractions: For patients with long-term illness affecting the kidneys, or those with both kidney and spleen deficiency, add 15g of North Sandalwood, 15g of Prince’s Ginseng, 15g of ginseng root, 12g of Rehmannia Root, and 30g of Cornus Fruit; for those with blood and essence deficiency, add 10g of Turtle Shell Gelatin (dissolved), 10g of Antler Gelatin (dissolved), 30g of Chicken Blood Vine, 30g of Herba Lysimachiae, and increase the amount of White Tribulus Terrestris to 30g; for those with Yin deficiency and excessive fire, add 10g of Bamboo Shoot, 20g of Polygonatum Scolopendrium, 15g of Rheum Palmatum, 12g of Rehmannia Root, 15g of Forsythia, and Turtle Shell…

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Pei Zhengxue Clinical Collection, Volume 2 15g of Plantago Seed; for patients with prolonged illness affecting the meridians, add 6g of Silkworm Moth, 6g of Whole Scorpion, 1 piece of Centipede, and 6g of Earthworm; for patients with heavy bleeding and dense red spots, add 30g of Bambusa Root, 30g of Herba Lysimachiae, 20g of Lotus Root Carbon, 15g of Purple Grass, and 15g of Red Lotus Leaf; for patients with nosebleeds, add 10g of Rheum Palmatum Carbon, 10g of Paeonia Radix Cortex Carbon, 10g of Cinnamomum Cassia Carbon, and 10g of Lotus Leaf Carbon; for patients with gingival bleeding, combine with Yu Nu Decoction; for patients with stool bleeding, combine with Huang Tu Soup; for those with yin damage caused by heat toxins, combine with Wan Xiang Chen’s Formula for Idiopathic Thrombocytopenic Purpura.

March 3, 2014, China Journal of Traditional Chinese Medicine

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In response to this, Professor Pei Zhengxue of Gansu Provincial Cancer Hospital proposed the therapeutic principle of supporting righteous qi, reinforcing the root, eliminating pathogenic factors, and treating the symptoms. Treatment focuses on nourishing the liver and kidneys, nourishing blood and generating fluids, dispelling wind and removing dampness, activating blood circulation and resolving blood stasis, and clearing heat and detoxifying. The Kelerang Decoction, combined with modifications to the Tao Hong Si Wu Tang, has shown remarkable therapeutic effects. The Kelerang Decoction is a specialized formula compiled by Pei Zhengxue for the treatment of lupus nephritis.

Li Mou, female, 42 years old, presented for her first consultation on March 12, 2010.

Chief Complaint: Low back pain accompanied by edema for 1 month. The patient had previously suffered from systemic lupus erythematosus complicated by lupus nephritis for 2 years. She was treated with prednisone at a maximum dose of 60 mg/day, but her dosage was later reduced to 10 mg/day, and she continued to take 3 tablets of Indomethacin per day, with improvement in her condition. In the past month, she had not taken any medication, but she still experienced low back pain and sudden onset of edema, which progressed rapidly. She developed nephrotic syndrome and progressive deterioration of renal function, eventually developing uremia within weeks to months. The prognosis for this patient was poor. Biochemical tests revealed specific immune complex deposits, lupus cells were found in her blood, her erythrocyte sedimentation rate was elevated, serum globulin levels were increased, urine output was reduced, joint pain in the fingers worsened, she experienced hot flashes, night sweats, insomnia with frequent dreams, fatigue, dizziness, blurred vision, butterfly-shaped patches appeared on her facial skin, her tongue was dark red with a thin yellow coating, ecchymoses were present at the edges of the tongue, her pulse was wiry and fine. Her blood pressure was 140/90 mmHg. Laboratory findings included an ESR of 39 mm/h, proteinuria (2+), hematuria (+), and positive antinuclear antibodies.

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Pei Zhengxue Clinical Collection, Volume 2 Western medical diagnosis: Lupus nephritis. Traditional Chinese Medicine Diagnosis: Liver and Kidney Deficiency, Blood Stasis in the Meridians. Treatment should focus on nourishing the liver and kidneys, clearing heat and detoxifying, activating blood circulation and resolving blood stasis. The formula used was Kelerang Decoction, combined with modifications to the Tao Hong Si Wu Tang.

Formulation: 10g of Polygonum cuspidatum, 10g of Epimedium, 10g of Cuscuta seeds, 10g of Radix Rehmannia, 12g of Rehmannia root, 10g of Ophiopogon, 10g of Ligustrum lucidum, 10g of Eucommia bark, 15g of Lythrum salicifolium, 10g of Alisma, 10g of Angelica sinensis, 10g of Paeonia lactiflora, 6g of Carthamus tinctorius, 10g of Prunella vulgaris, 15g of Lysimachia barbarum, 15g of Houttuynia cordata, 15g of Artemisia selengensis, 15g of Dianthus caryophyllus, and 10g of Polygonum cuspidatum. Take 14 doses, decocted in water, once daily.

Third Consultation: All symptoms showed significant improvement—proteinuria was negative, hematuria was also negative. Blood pressure was 120/80 mmHg, her tongue was red, her tongue coating was minimal, and her pulse was fine and rapid. The diagnosis indicated Liver and Kidney Deficiency. The formula was adjusted to remove Houttuynia cordata, Lysimachia barbarum, Dianthus caryophyllus, Plantago major, and Alisma, adding 10g of Goji berries, 10g of Chrysanthemum, 10g of Cornus fruit, and 10g of Dioscorea opposita to nourish the liver and kidneys and strengthen the root.

After more than a year of continuous use, her condition improved significantly, and she continues to take the formula to consolidate her therapeutic effects. According to Pei Zhengxue, “Lupus nephritis is characterized by deficiency in the root and excess in the symptoms; liver and kidney deficiency are the root cause, while wind, dampness, heat toxin, and phlegm-stasis are the external manifestations. Nourishing the liver and kidneys, nourishing blood and generating fluids are the fundamental principles for treating this condition, and we should also employ methods to dispel wind, remove dampness, activate blood circulation, and clear heat and detoxify.”

When nourishing the liver and kidneys, common herbs include Ligustrum lucidum, Lythrum salicifolium, Goji berries, Rehmannia root, Cornus fruit, Epimedium, Cuscuta seeds, Eucommia bark, and others. When heat toxin is severe and wind and fire are exacerbated, high fever persists, limbs swell, and joints ache—add herbs like Honeysuckle, Forsythia, Dandelion, Bidens pilosa, Houttuynia cordata, Lysimachia barbarum, raw gypsum, Zhi Mu, Polygonum cuspidatum, and other herbs to clear heat and detoxify.

If heat toxicity damages Yin, add Radix Rehmannia, Rehmannia root, Ophiopogon, Dendrobium, Paeonia lactiflora, and other Yin-nourishing herbs. When ESR increases, immune complex deposits, lupus cells, and other signs indicate phlegm, dampness, and blood stasis—use raw gypsum, Zhi Mu, Alisma, Poria, Polygonum cuspidatum, and other herbs to clear heat and remove dampness. When blood stasis obstructs the meridians, add Carthamus tinctorius, Paeonia lactiflora, Angelica sinensis, Red Peony, Chuanxiong, Dendrobium, and other herbs to nourish blood and activate blood circulation to dispel wind—this aligns with the principle of “treat wind first by treating blood.”

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April 10, 2014, China Journal of Traditional Chinese Medicine

Chapter 16: Pei’s Formulas
Ma Huang Gui Zhi Compound Qi Qin, Zheng Fangjiang Pei Zhengxue, male, born in 1938, is a renowned modern scholar of integrated Chinese and Western medicine in China, a guiding teacher for the academic inheritance program of senior traditional Chinese medicine experts nationwide, a renowned TCM physician in Gansu Province, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, a chief physician, professor, and chief expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Institute of Medical Sciences, as well as the honorary president of the Gansu Provincial Association for Integrated Chinese and Western Medicine, editor-in-chief of the journal “Integrated Chinese and Western Medicine Research,” and a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine.” Pei Zhengxue has been engaged in clinical practice for 55 years, having published over 80 papers, possessing a deep academic foundation and rich clinical experience, specializing in the use of classic formulas to treat tumors, liver diseases, blood disorders, and other complex internal medicine conditions. The Ma Huang Gui Zhi Compound he developed is composed of Ma Huang Decoction, Gui Zhi Decoction, along with Chuanxiong, Bai Zhi, Xi Xin, Qiang Du Huo, and Fang Feng. It has proven highly effective in treating upper respiratory tract infections, neural headaches, acute and chronic rhinitis, sinusitis, cheilitis, oral inflammation, acute and chronic nephritis, and other conditions, making it worthy of wider application.

Function: Promotes sweating to relieve exterior symptoms, opens the lungs to stop cough, and clears heat to benefit the throat.

Indications: The Ma Huang Gui Zhi Compound can both disperse cold and warm the meridians to relieve pain, while also harmonizing the vital energy and blood, replenishing deficiency and reducing excess—making it effective for treating head and facial ailments such as upper respiratory tract infections, neural tinnitus, chronic rhinitis, sinusitis, and other conditions.

Formula Explanation: Ma Huang and Gui Zhi are pungent and warming, opening the skin’s pores to disperse wind-cold, while also harmonizing the vital energy and blood; Apricot Kernel promotes lung qi, stops cough, and calms asthma; Raw Gypsum clears lung heat; Qiang Du Huo and Du Huo eliminate wind-cold and dampness in the exterior; Chuanxiong, Bai Zhi, and Xi Xin disperse wind-cold, promote dampness and arthritis, and relieve head and body pain; Gan Cao opens the lungs and promotes qi, clearing the throat.

Additions and Subtractions: For patients with upper respiratory tract infections accompanied by excessive phlegm and chest tightness, add Ma Xing Shi Gan Tang, Dry Ginger, Xi Xin, Wu Wei Zi, and Ban Xia; for patients with white phlegm and itchy throat, add Zhui Sou San; for patients with thin phlegm and dry throat, add Xing Su San; for patients with fever, add Honeysuckle, Forsythia, Dandelion, Da Qing Ye, and Ban Lan Gen—other antiviral herbs—and use up to 30–60g of Gypsum; for patients with chronic headaches that have entered the meridians due to long-term illness, add Tao Hong Si Wu Tang to activate blood circulation and resolve blood stasis; for patients with severe headaches, add Bai Jiang Chan, Whole Scorpion, and Centipede to search for wind and relieve pain; if liver yang is excessively elevated, add Tianma, Gou Teng, and Shi Jue Ming to calm the liver and lower yang, and to suppress wind and relieve pain; for patients with purulent nasal discharge due to rhinitis, add Honeysuckle, Forsythia, and Dandelion to clear heat and detoxify; for patients with allergic rhinitis, add Chuan Yi and Xin Yi to open the nasal passages; for patients with proteinuria due to nephritis, add Su Jing, Chuan Yi, and Motherwort to reduce proteinuria; for patients with hematuria, add Bambusa Root, Side-Tree Leaves, Ligustrum lucidum, and Large and Small Thistle to clear heat and stop bleeding.

February 21, 2013, China Journal of Traditional Chinese Medicine

450

Chapter 16: Pei’s Formulas
Hua Yu Lian Yang Tang Zhan Wenguo

Pei Zhengxue, male, born in 1938, is a renowned expert in integrated Chinese and Western medicine in China, one of the first 500 senior TCM physicians in the country, a distinguished TCM physician in Gansu Province, a chief physician, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, a national-level mentor for advanced students, a lifetime director of the Chinese Society of Traditional Chinese Medicine, a chief expert at Gansu Provincial Cancer Hospital, and a professor at the Gansu Provincial Institute of Medical Sciences, who enjoys a special government allowance from the State Council. He currently serves as a member of the editorial board of “Chinese Journal of Integrated Chinese and Western Medicine” and as the editor-in-chief of “Integrated Chinese and Western Medicine Research,” as well as the president of the Gansu Provincial Association for Integrated Chinese and Western Medicine.

Peptic ulcers fall under the category of “Stomach Pain” in traditional Chinese medicine. Traditional Chinese medicine believes that their onset is related to cold invasion of the stomach, dietary damage to the stomach, liver qi invading the stomach, and spleen and stomach weakness. Ulcers often worsen due to diet, emotions, fatigue, cold dampness, and other factors. Clinical manifestations include upper abdominal pain and discomfort, which is chronic, periodic, and rhythmic; gastric ulcers often hurt after eating, while duodenal ulcers tend to be painful when hungry, with nighttime pain or accompanied by acid reflux and vomiting. Professor Pei Zhengxue particularly emphasizes the fact that long-standing gastric ulcers often enter the meridians, where gastric meridians become congested and stagnant, with both deficiency and excess symptoms, or even symptoms of stomach yin deficiency, qi deficiency, spleen yang deficiency, or kidney qi deficiency. He stresses the importance of activating blood circulation and resolving blood stasis in the treatment of gastritis and gastric ulcers. Based on the pathological characteristics of peptic ulcers—“long-term illness entering the meridians,” “long-term illness often involves blood stasis”—Professor Pei Zhengxue focused on activating blood circulation and resolving blood stasis, promoting qi circulation and relieving pain, and formulated the “Hua Yu Lian Yang Tang.”

Input: Medical technology knowledge is integrated into a single framework: using instrument examination results to validate clinical experience, applying clinical experience to analyze examination results, conducting comprehensive thinking, integrating various examination findings for thorough analysis, and combining this with the patient’s disease course and clinical manifestations to correct errors in an instant and snatch life from the brink of death. Pei Zhengxue often said, “As a doctor—especially an oncologist—pathological diagnosis is certainly important, but reading images is an indispensable skill.” He accumulated extensive experience throughout his life; here, I will only briefly share my insights gained from studying under him.

“Using formulas to diagnose” to identify lung cancer

Lung masses are commonly found in clinical practice, and various diseases such as lung cancer, pulmonary tuberculosis, and pneumonia exhibit distinct patterns on X-ray images, which are thoroughly discussed in numerous textbooks. However, for atypical cases, it can be quite challenging to make an accurate diagnosis. At such times, Pei Zhengxue would comprehensively analyze other diagnostic data and employ clinical methods to either confirm or refute certain diagnoses.

In March 2009, a patient from Tianshui City visited a local hospital due to “cough and sputum production for one month.” A chest X-ray revealed a high-density shadow in the right middle lobe of the lung. To further confirm the diagnosis, the patient came to our hospital.

A chest CT scan failed to provide a definitive diagnosis; multiple sputum cytology tests yielded no cancer cells. Two bronchoscopies were performed, and tissue biopsies were taken, but no cancerous tissue was found. The tuberculin test and serum tuberculosis antibodies were both negative, and all tumor markers were

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Pei Zhengxue Clinical Collected Volume II within normal ranges. The diagnosis remained inconclusive, making treatment difficult to proceed.

To reach a quick diagnosis, Pei Zhengxue analyzed that, based on the current examination results, pulmonary tuberculosis could be ruled out; the remaining possibility was to differentiate between inflammatory pseudotumors and malignant tumors. If the lesion was an inflammatory pseudotumor, anti-infective treatment would likely lead to shrinkage of the lesion; however, if it was a malignant tumor, the lesion would not change in size, and might even continue to grow. Accordingly, Pei Zhengxue initiated anti-infective therapy while continuing sputum cytology tests and performing another bronchoscopy for tissue biopsy.

One week later, a follow-up chest X-ray showed that the lesion had increased in size. Pei Zhengxue clearly identified the patient as having “lung cancer” and took appropriate measures. At that time, no cancer cells were still detected in the sputum. Just two days after the diagnosis was confirmed, the pathology report indicated the presence of adenocarcinoma cells, confirming the diagnosis of “lung cancer.”

In this case, Pei Zhengxue used just two chest X-rays and antibiotics to diagnose a condition that could not be accurately determined by other advanced diagnostic techniques available in the hospital—this was an example of applying traditional Chinese medicine’s theory of “using formulas to diagnose” in Western medical diagnostics.

Another patient was diagnosed with “pulmonary tuberculosis” in 2007. A chest X-ray revealed “snowflake-like patchy shadows throughout both lungs.” After six months of anti-tuberculosis treatment, the patient’s condition improved, with good mental state, appetite, and overall physical recovery. A follow-up chest X-ray showed that the patchy shadows had disappeared, and a chest CT scan indicated calcification in the lower lobe of the left lung. One year later, a repeat chest CT scan revealed a mass in the left hilum, accompanied by encapsulated pleural effusion and a small amount of pericardial effusion, along with left lung atrophy. Most radiologists believed this was “lung cancer.” However, after carefully reviewing each CT image, Pei Zhengxue pointed out that it was actually pulmonary tuberculosis.

First, the margins of the mass on the CT scan did not show obvious spiciness. Second, there was a small amount of encapsulated pleural effusion near the mass, along with a small amount of pericardial effusion, but no pleural effusion in the thoracic cavity—these factors ruled out malignant lesions. If it were lung cancer, pericardial effusion would already be present, and the thoracic cavity would definitely contain a large amount of fluid, yet the patient did not have such symptoms. Third, the CT scan showed significant atrophy of the left lung; if it were a malignant lesion, such severe atrophy of the lung lobe would never have occurred. If these changes had already developed, the patient should have shown signs of cachexia long ago—but the patient’s mental state and physical condition were both excellent. Moreover, the patient had a history of tuberculosis. Based on these three points, the patient’s condition could be ruled out as malignant, and the patient was recommended to undergo tumor marker testing. The results were

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All results were negative, so the patient did not receive specialized oncology treatment. The patient remains healthy to this day.

Distinguishing liver masses through morphological changes

Clinically, it is often difficult to distinguish between nodular primary liver cancer, multiple hepatic metastases, and multiple hepatic cysts. With the rise of interventional therapies, many patients with multiple hepatic cysts have undergone interventional treatment.

Pei Zhengxue corrected numerous misdiagnoses in clinical practice. He pointed out that when differentiating between nodular primary liver cancer and multiple hepatic metastases, in addition to focusing on the arterial and venous phases shown on enhanced CT scans, one should also consider that the former often exhibits elevated AFP levels, while the latter generally has normal AFP levels. Furthermore, it is crucial not to overlook the liver function characteristics of both conditions; they must be analyzed in conjunction. He often said, “It’s like building a wall to block water—if you only use stones, you’ll surely fail to stop the water; the water will still seep through the cracks. But if you combine stones with soil, you can indeed block the water. A liver mass is like a stone; if it’s a metastatic cancer, then using only stones to block the water means that liver metabolism continues normally, bile flows through the cracks, liver function remains generally normal, and jaundice does not occur. However, if it’s primary liver cancer, then the liver is like a stone combined with soil—liver metabolism is affected, bile flow becomes impaired, and liver function is generally compromised, leading to jaundice.”

When distinguishing between these conditions and multiple hepatic cysts, it is especially important to focus on the overall morphological changes of the liver. Hepatic cysts are benign lesions; typically, the liver’s shape remains unchanged, with a complete and regular liver capsule. In contrast, malignant lesions often exhibit significant morphological changes in the liver.

Additionally, it is essential to understand the anatomical structure and functions of the organ. For instance, masses occurring within the gallbladder generally do not cause jaundice; masses located in the bile ducts also rarely cause jaundice. However, masses in the hepatic ducts or common bile ducts are more likely to trigger jaundice, sometimes even causing severe obstructive jaundice.

Since CT scans primarily depict imaging findings, it can be difficult to pinpoint the exact location of masses in these areas solely based on CT images. By combining this information with liver function and jaundice symptoms, one can determine the precise location of the mass. By applying these experiences in conjunction with the patient’s disease course, clinical manifestations, and general health status, it becomes easy to read images accurately and quickly, enabling a reliable diagnosis.

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Pei Zhengxue Clinical Collected Volume II 3. Identifying pancreatic cancer through five key characteristics

Pancreatic masses are often difficult to distinguish between benign and malignant based solely on CT scans, and their prognosis can vary greatly. However, Pei Zhengxue used his own experience to classify many pancreatic masses as either benign or malignant.

He noted that patients with pancreatic cancer often exhibit the following key symptoms: First, abdominal pain—commonly felt in the upper or mid-abdomen. Second, jaundice—often accompanied by severe obstructive jaundice. Third, a marked increase in CA199 levels, typically above 1000 U/ml. Fourth, patients usually do not develop ascites. Fifth, the disease course is short, and patients often progress to cachexia very quickly.

In May 2009, a patient was transferred to our department from another hospital. The patient was female, and her initial diagnosis at the external hospital was “pancreatic cancer, pancreatic tail metastasis, liver metastasis, and peritoneal metastasis.” She had already undergone one interventional treatment for a pancreatic mass. Upon admission, the patient had no upper or mid-abdominal pain, no jaundice, no abdominal distension, and her CA199 levels were normal. A chest CT scan revealed multiple masses in the pancreas, liver, and peritoneal cavity, along with substantial ascites.

After reviewing all medical records, examining the patient, and asking about her medical history, Pei Zhengxue immediately dismissed the diagnosis of “pancreatic cancer,” recommending that she undergo CA125 testing and pelvic ultrasound. The results showed CA125 levels over 30 times higher than normal. A pelvic ultrasound suggested a mass in the right adnexal region, possibly originating from the ovaries. Ultimately, the patient was diagnosed with “ovarian cancer.”

Source: China Journal of Traditional Chinese Medicine, March 8, 2014

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Chapter Sixteen: Pei’s Formulas Professor Pei Zhengxue’s Insights on the Clinical Application of Salvia Miltiorrhiza Qu Qing, Zhang Hong, Zhao Xiaopeng, Zhang Guangshe, Gansu College of Traditional Chinese Medicine [Abstract] “In chronic diseases, blood stasis is inevitable,” and the therapeutic approach of promoting blood circulation and resolving blood stasis is widely applied in the treatment of various chronic illnesses and complex, intractable diseases. Salvia miltiorrhiza is known for its ability to nourish blood and promote blood circulation, while also being gentle on new blood, replenishing blood without leaving behind stagnant blood—making it an excellent remedy for both promoting blood circulation and resolving blood stasis. Professor Pei Zhengxue is a renowned expert in the integration of traditional Chinese and Western medicine in China, adept at treating various chronic illnesses and complex, intractable diseases through the principle of resolving blood stasis using blood-activating and blood-regulating herbs. Salvia miltiorrhiza is one of his most frequently used herbs, and it has demonstrated remarkable clinical efficacy. This article summarizes Professor Pei Zhengxue’s clinical experience with salvia miltiorrhiza, hoping to offer some practical benefits to clinicians. [Keywords] Salvia miltiorrhiza; Pei Zhengxue; Clinical Experience

Pei Zhengxue, male, chief physician, born in February 1938 in Wushan, Gansu Province. He graduated from the Medical Department of Xi’an Medical University in 1961 and served as deputy director of the Gansu Provincial Institute of Medical Science. He currently serves as dean of the Gansu College of Traditional Chinese Medicine and receives a special government allowance from the State Council. In 1994, Professor Pei was recognized as a national advanced worker in the integration of traditional Chinese and Western medicine. His major works include “Commentary on Blood Disorders,” “New Compilation of Traditional Chinese Medicine Formulas,” “Pharmacology and Clinical Applications of Rheum,” “Diagnosis and Treatment of Hepatitis B,” “Selected Cases of Pei Shen,” “New Compilation of Warm Disease Studies,” “Practical Internal Medicine in the Integration of Traditional Chinese and Western Medicine,” among others [1]. The “Sixteen-Character Principle” he proposed for the integration of traditional Chinese and Western medicine has garnered widespread attention within the Chinese medical community and has become an important school of thought in the field of Chinese and Western medicine today. As the “Bencao Bian Du” states: “Salvia miltiorrhiza shares the same effects as the ‘Four Herbs’—it can remove blood stasis to generate new blood… It is the first choice for regulating the blood system.” Thus, salvia miltiorrhiza is known for its ability to nourish blood and promote blood circulation, while also being gentle on new blood and replenishing blood without leaving behind stagnant blood—making it an excellent remedy for both promoting blood circulation and resolving blood stasis. Pei

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Pei Zhengxue Clinical Collected Volume II Professor Zhengxue (hereafter referred to as Old Master Pei) is a renowned expert in the integration of traditional Chinese and Western medicine in China, specializing in the clinical treatment of arrhythmias, cirrhosis, aplastic anemia, esophageal cancer, and various other complex and intractable diseases. During my studies at Gansu College of Traditional Chinese Medicine, I had the privilege of learning from Old Master Pei by copying prescriptions and drawing upon his writings. Though I may not be well-versed in his work, I have selected and summarized Old Master Pei’s clinical experience with salvia miltiorrhiza below, hoping to offer valuable insights for clinicians. I. Clinical Applications (1) Combining Salvia miltiorrhiza with Kudzu Root for the Treatment of Arrhythmias A 62-year-old male, a cadre, presented to our hospital due to palpitations accompanied by discomfort in the precordial region for eight years. His pulse was 100 beats per minute, his blood pressure was 16/10 kPa, and cardiac examination revealed clear heart sounds and irregular heartbeat, with 6–10 premature beats per minute heard each minute. No pathological murmurs were auscultated in the precordial region. An electrocardiogram showed: 1) insufficient myocardial blood supply; 2) frequent, multi-source premature beats. Combined with a thin, rapid pulse with occasional pauses, a red tongue with a thin yellow coating bearing bruising points, the traditional Chinese medicine diagnosis was qi-yin deficiency with internal blood stasis. Treatment focused on tonifying qi and nourishing yin while resolving blood stasis. Prescription: 20g of roasted licorice root, 10g of cinnamon twig, 6g of fresh ginger, 10g of donkey-gelatin (dissolved), 4 dates, 10g of codonopsis, 20g of rehmannia root, 20g of ophiopogon root, 10g of sesame seeds, 20g of salvia miltiorrhiza, 20g of kudzu root, 10g of loquat fruit, 10g of Chinese chives, 6g of pinellia, 6g of saffron, 10g of chuanxiong, decocted and taken daily. After more than 20 doses, the chest pain had subsided, though he still experienced mild palpitations, occasional fatigue, and discomfort in the epigastric region. His tongue was red, with a thin yellow coating, and his pulse was thin and rapid. The above formula was adjusted with chuanxiong and saffron, adding 6g of sandalwood, 6g of agarwood, 10g of white atractylodes, and 12g of poria, followed by more than 20 doses, during which all symptoms disappeared. His heart rate returned to 86 beats per minute, with only 1–2 premature beats per minute heard each minute. An electrocardiogram showed occasional atrial premature beats [2]. Commentary: Arrhythmias are similar to the symptoms described in “Shanghan Lun” – “when the pulse is slow and irregular, and the heart beats rapidly”—with the original prescription using roasted licorice root. When treating this condition, Old Master Pei often added 30g of salvia miltiorrhiza and 30g of kudzu root to the base of roasted licorice root soup, which proved highly effective [3]. Salvia miltiorrhiza promotes blood circulation and resolves blood stasis, making it particularly suitable for this patient whose condition involved internal blood stasis. The role of kudzu root in regulating heart rhythm is well-known; when these two herbs are used together, combining disease identification with syndrome differentiation, they achieve remarkable therapeutic effects—and this approach is worth learning from. (2) Combining Salvia miltiorrhiza with Astragalus for the Treatment of Cirrhosis

A 30-year-old male, hospitalized under number 11595, was employed by a company in a certain county in Gansu Province. The patient was admitted for treatment due to persistent black stools lasting 15 days, accompanied by abdominal distension for one week. He reported discomfort and fullness in both flanks, weakness, loss of appetite, a bitter taste in his mouth, and throat discomfort. On examination: his mental state was low, his complexion was pale yellow, his sclera showed slight jaundice, cardiac and pulmonary auscultation were normal, the liver dullness boundary was unremarkable, his spleen was slightly enlarged, with moderate consistency, abdominal distension, and no edema in the lower limbs. Ultrasound examination revealed cirrhosis with ascites and splenic enlargement (thickness 5.0 cm). Esophageal endoscopy revealed severe esophageal varices. Laboratory tests showed positive fecal occult blood (++), hemoglobin level of 80 g/L, globulin 42 g/L, albumin 32 g/L, A/G ratio 0.76. The Western medical diagnosis was decompensated cirrhosis. The traditional Chinese medicine diagnosis was liver stagnation with spleen deficiency—long-term stagnation leading to fire, spleen deficiency resulting in dampness, and water-dampness accumulation, along with qi stagnation and blood stasis. Old Master Pei treated the patient primarily with Danzhi Xiaoyao San. The prescription was as follows: 6g of peony bark, 10g of gardenia, 15g of white peony, 10g of angelica root, 10g of bupleurum, 12g of poria, 10g of white atractylodes, 6g of licorice root, 30g of salvia miltiorrhiza, 30g of astragalus, 20g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of coptis root, 10g of polygonum cuspidatum, 15g of ophiopogon root, 10g of turtle shell, 15g of polygonum cuspidatum, 15g of calyx, 15g of cucurbitacin, 10g of plantain seed, decocted and taken daily. The traditional Chinese medicine was combined with Western medicine to achieve hemostasis and albumin supplementation. After more than a month of hospitalization, the patient reported relief from abdominal distension, and all other symptoms disappeared. A follow-up examination showed negative fecal occult blood, improvement in esophageal varices, disappearance of ascites, improvement in liver function, and no further enlargement of the spleen. The patient recovered and was discharged after more than two months [2]. Commentary: In addition to common symptoms like bitter mouth, dry throat, poor appetite, and discomfort in both flanks—symptoms indicative of liver stagnation with spleen deficiency—the clinical presentation of liver cirrhosis often included fatigue, tenderness in the left flank (spleen enlargement), darkened complexion, ecchymoses along the tongue edges, and a weak, sluggish pulse—indicative of qi deficiency and blood stasis. When treating such patients, Old Master Pei often followed the principle from “Jin Gui Yao Lü”: “When you see liver disease, know that liver disease affects the spleen; first treat the spleen.” He used formulas like Xiao Chai Hu Tang and Danzhi Xiaoyao San, adjusting them according to the specific condition. In addition, he frequently used 30g of salvia miltiorrhiza to nourish blood and promote blood circulation, complementing it with 30g of astragalus to tonify qi. This case exemplifies this approach. As the saying goes, “Chronic illness leads to deficiency, chronic illness leads to blood stasis.” When qi flows, blood flows; when blood stasis occurs, qi becomes blocked. Salvia miltiorrhiza’s ability to nourish blood and promote blood circulation, combined with astragalus’s qi-tonifying and blood-moving properties, mutually enhance each other. Long-term use of these herbs significantly improved the patient’s symptoms of qi deficiency and blood stasis. After treatment, the patient’s ascites disappeared, liver function improved, and the spleen was no longer enlarged—both of which were closely linked to the use of salvia miltiorrhiza. Modern pharmacology has also proven that salvia miltiorrhiza can promote liver cell regeneration and has anti-fibrotic effects on the liver [4]. Based on his understanding of syndrome differentiation and treatment principles, Old Master Pei added 30g of salvia miltiorrhiza and 30g of astragalus to his treatment regimen for liver cirrhosis, a practice worthy of emulation.

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Pei Zhengxue Clinical Collected Volume II (3) Combining Salvia miltiorrhiza with herbs that strengthen the spleen and tonify the kidneys for the treatment of aplastic anemia A 16-year-old male, diagnosed with anemia at a hospital through bone marrow aspiration, was admitted to the hospital. His complexion was pale yellow, he experienced nosebleeds, and scattered petechial hemorrhages were visible all over his body. His hemoglobin level was 65 g/L, red blood cells were 2.41×10¹²/L, white blood cells were 3.10×10⁹/L, neutrophils accounted for 32%, lymphocytes 68%, and platelets were 65×10⁹/L. His six pulses were thin and rapid, his tongue was pale, thick, and had tooth marks, with a thin, white, greasy coating—indicating qi and blood deficiency, qi failing to control blood. The prescription was formulated with Gui Pi Tang, modified with additional ingredients. The prescription contained: 10g of codonopsis, 10g of white atractylodes, 20g of astragalus, 12g of poria, 6g of farfara, 15g of roasted jujube kernels, 6g of wood fragrance, 10g of cinnamon bark, 10g of angelica root, 10g of cornelian cherry, 15g of women’s kidney, 20g of chicken blood vine, 10g of psoralia, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum. Decocted and taken daily. After 20 doses, the nosebleeds stopped, the scattered petechial hemorrhages on his body faded, and he never again experienced such spots. His hemoglobin level rose to 84 g/L. The prescription was adjusted to remove farfara, jujube kernels, and wood fragrance, adding 20g of salvia miltiorrhiza, 3g of saffron, 3g of deer antler (taken in divided doses), and 10g of leeches (taken in divided doses). The patient continued taking the medication for more than 30 doses, and no further news of him was heard. Three years later, a healthy adult came to the clinic, holding a prescription in his hands, folded like cardboard. Old Master Pei examined it and realized that it was the same prescription he had prescribed three years earlier. He said that he had taken this prescription for over 200 doses, and the more he took, the better he felt. Now his physical strength was like that of a normal person, his spirits were good, and his appetite was excellent. His complexion was rosy, his energy was abundant, and when his blood count was checked, his hemoglobin level was 150 g/L, red blood cells were 5.70×10¹²/L, white blood cells were 4.28×10⁹/L, and platelets were 160×10⁹/L. The patient had recovered and was advised to take Liu Wei Di Huang Wan and Gui Pi Wan regularly to maintain his health [5].

Commentary: Aplastic anemia is often referred to as “recovery anemia,” a condition characterized by impaired hematopoietic function in the bone marrow, leading to a reduction in all three blood cell lineages. Clinically, the main symptoms include anemia, bleeding, and infection. This condition falls under the category of “deficiency-related diseases” in traditional Chinese medicine. The kidneys govern bone formation and marrow production, serving as the innate foundation; the spleen and stomach are the source of qi and blood, the acquired foundations. Therefore, the practice of strengthening the spleen and tonifying the kidneys is a common method for treating aplastic anemia. At the second consultation, Old Master Pei added a large dose of salvia miltiorrhiza—20g of salvia miltiorrhiza, along with other herbs that strengthen the spleen and tonify the kidneys—together with the existing formulas of codonopsis, white atractylodes, astragalus, cornelian cherry, polygonum cuspidatum, women’s kidney, polygonum cuspidatum, psoralia, and polygonum cuspidatum—creating a unique and innovative treatment approach. Old Master Pei believed that for most patients, adding a few blood-activating herbs to the basic regimen of strengthening the spleen and tonifying the kidneys could “add the finishing touch.” By activating blood circulation, these herbs reached the diseased area directly; while strengthening the spleen and tonifying the kidneys ensured that qi and blood were abundantly generated and replenished. These two approaches complemented each other and worked in harmony. Modern medicine has also confirmed that blood circulation activation is highly beneficial for improving bone marrow circulation [5]. After taking this medication for over 200 doses, the patient finally recovered.

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Chapter Sixteen: Pei’s Formulas It is evident that although salvia miltiorrhiza is a gentle herb, when used appropriately, it can still play a significant role. (4) Combining Salvia miltiorrhiza with Poria and Curcuma for the Treatment of Esophageal Cancer

Input: The basic treatment principles include tonifying kidney qi, promoting blood circulation to remove stasis, and clearing heat and eliminating dampness. Professor Pei, based on these treatment principles, developed the compound formula Fufang Yishen Tang for treating chronic nephritis and nephrotic syndrome caused by kidney qi deficiency, dampness, and blood stasis, which has shown remarkable efficacy.

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To treat these conditions, it is necessary to use herbs that clear heat and detoxify, such as Lonicera japonica, Forsythia suspensa, Taraxacum mongolicum, Herba Leonuri, and Isatidis root, to combat bacteria and reduce inflammation, eliminate the underlying causes, and lessen the deposition of immune complexes in the kidneys—this is a method aimed at addressing the symptoms. Chronic diseases often lead to tissue damage and stasis; long-standing illnesses invariably result in blood stasis. The basement membrane of the glomeruli in the kidneys operates under a hypercoagulable state, where immune complexes tend to deposit, causing renal circulatory disorders. This leads to pathological changes such as hyperlipidemia, increased blood viscosity, and hypertension. The application of Taohong Siwu Tang to promote blood circulation and remove stasis not only improves the permeability of renal glomeruli and blood circulation but also reduces the burden on the kidneys to some extent, enhancing renal function and providing an early opportunity for treating this condition—and it can also serve as a complementary therapy. Stasis of blood is both a cause and a pathogenic factor; Taohong Siwu Tang enters the blood vessels to promote blood circulation and remove stasis while nourishing and replenishing blood. However, its ability to remove stasis is limited; therefore, adding Sanqi and Shui Zhi can enhance the effect of removing stasis. These two herbs work to remove stasis without harming the body’s righteous qi, stop bleeding without leaving behind residual blood—especially effective for visceral blood stasis, arterial hardening plaques, and vascular obstructions.

The presence of proteinuria and occult blood in urine is also associated with the deposition of self-antigen-antibody immune complexes, which are part of an immune-mediated hypersensitivity reaction. Professor Pei often uses Su Bing, Chan Yi, and Yimu Cao in combination to regulate the body’s reactivity and improve immune function.

[Case Study] Ma, female, 24 years old. First visit, May 21, 2010. Chief complaint: Recurrent edema for six months. Medical history: Six months ago, she experienced facial edema due to a cold, along with cough, headache, and decreased urination. After antibiotic treatment, the edema subsided, and her cough improved. One month later, she began to experience bilateral lower limb edema, decreased urination, and fatigue. A urine test at a certain hospital revealed: Proteinuria (++), occult blood (++), with no elevated blood pressure. 24-hour urine protein quantification was 3.0 mg. Triglycerides were 2.6 mmol/L, total protein was 65 g/L, plasma albumin was 30 g/L, and globulin was 35 g/L. Current symptoms: Edema, reduced urine output, susceptibility to colds, feeling cold with spontaneous sweating, lower back pain and leg discomfort, red tongue with white coating, and a deep, fine pulse. Western medical diagnosis: Chronic nephritis, nephrotic syndrome. Traditional Chinese Medicine diagnosis: Edema. TCM syndrome differentiation: Kidney yang deficiency, qi failing to transform water. Treatment principle: Tonify the kidneys and warm yang, transform qi and promote water flow, while also removing stasis and clearing heat. Prescription: Fufang Yishen Tang with modifications.

Prescription: Gui Zhi 10 g, Fu Zi 6 g, Shan Yu Rou 10 g, Shan Yao 10 g, Fu Ling 10 g, Dan Pi

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Pei Zhengxue Clinical Collection, Volume Two 6 g, Ze Xie 10 g, Tao Ren 10 g, Hong Hua 6 g, Dang Gui 10 g, Yimu Cao 15 g, Danshen 20 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Su Bing 15 g, Chan Yi 6 g, Huang Qi 30 g, Chao Bai Zhu 10 g, Fang Feng 10 g. Decocted in water and taken once daily. Second visit, September 30, 2010. After taking the above formula for two months, all symptoms had improved. Urine tests showed: Proteinuria (+), occult blood (-), 24-hour urine protein quantification was 1.0 mg. Triglycerides were 1.7 mmol/L, total protein was 70 g/L, plasma albumin was 38 g/L, and globulin was 32 g/L. There was abdominal distension and fullness, poor appetite, and fatigue. Tongue was red with a thin white coating, pulse was deep, slow, and strong. The syndrome was characterized by spleen and kidney deficiency; the formula was adjusted by reducing the amount of herbs that promote blood circulation and remove stasis, as these herbs can harm the body’s righteous qi if used excessively, and their bitter and cold nature may damage the stomach. Therefore, Dan Pi, Ze Xie, Tao Ren, Chuan Xiong, Bai Shao, and Sheng Di were removed, and herbs like Jin Yin Hua, Lian Qiao, and Taraxacum Mongolicum were added, along with 15 g of Dang Gui, 30 g of Qian Shi, 30 g of Jin Yingzi, 20 g of Huang Jing, 10 g of Yang Yang Huo, 10 g of Po Gu Zhi, and 10 g of Tu Si Zi to strengthen the spleen and tonify the kidneys, while also consolidating and tightening the protein. Thirty doses were taken. Third visit, November 10, 2010. The patient continued to take the medicine for over a month, and her condition remained stable, with all symptoms completely resolved. Urine tests showed negative results for both proteinuria and occult blood. A formula was prepared using Gui Fu Dihuang Tang with adjustments to consolidate the therapeutic effect. The prescription was as follows: Gui Zhi 50 g, Fu Zi 30 g, Shan Yu Rou 50 g, Shan Yao 50 g, Dang Gui 50 g, Bai Shao 50 g, Yimu Cao 75 g, Danshen 100 g, Jin Yin Hua 75 g, Lian Qiao 75 g, Huang Qi 100 g, Chao Bai Zhu 50 g, Dang Gui 75 g, Tu Si Zi 50 g, San Qi 30 g, Shui Zhi 100 g. All herbs were ground into powder, each dose weighing 10 g, taken three times a day. Alternatively, the medicine could be made into pills for further consolidation of the therapeutic effect. Follow-up visits after two years showed that the patient’s condition remained stable, with no recurrence.

[Reflections] Professor Pei treated nephrotic syndrome primarily by tonifying the kidneys, alternating between tonifying the kidneys and strengthening the spleen, while also employing methods to clear heat, detoxify, and promote blood circulation to remove stasis. He always kept in mind the importance of protecting gastric qi, invigorating the middle burner, and warming the yang energy of the spleen and kidneys. As the Yellow Emperor’s Inner Canon says: “Yang qi is like heaven and the sun—when it is lost, one’s lifespan is shortened and one’s brilliance is diminished.” To warm yang and tonify the kidneys, to transform qi and promote water flow, Gui Fu Dihuang Tang should be the first choice, warming and nourishing the fire of the Mingmen, replenishing the source of fire to eliminate yin obstruction. In the formula, Gui Zhi and Fu Zi warm yang and replenish fire to strengthen kidney yang as the chief herbs; Shan Yao and Shan Yu Rou nourish and tonify kidney yin, restraining excess fire and preventing it from acting recklessly—as complementary herbs; Fu Ling, Dan Pi, Ze Xie, Bai Zhu, and Huang Qi strengthen the spleen and promote diuresis, serving as assistant herbs; Su Bing regulates qi and transforms dampness, aiding the assistant herbs in regulating qi and promoting water flow; Tao…

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Ren, Hong Hua, Dang Gui, and Danshen promote blood circulation and remove stasis as auxiliary herbs; Jin Yin Hua, Lian Qiao, and Yimu Cao clear heat and detoxify as main herbs. Chan Yi is a unique herb, as its use lies in dispelling wind and combating allergies. Since kidney disease involves not only glomerular lesions but also autoimmune hypersensitivity reactions, Professor Pei combined Chan Yi with Yimu Cao to improve the kidney’s immune mechanisms, regulate immunity, and promote disease recovery. Together, these herbs work to warm yang, tonify the kidneys, promote blood circulation, remove stasis, and clear heat and detoxify.

Clinical adjustments: When occult blood is present in urine, add Xianhe Cao, Han Lian Cao, Zicao, Bi Xie, etc., to nourish yin, clear heat, and stop bleeding; when there is difficulty urinating, add Long Kui, Feng Wei Cao, Ban Zhi Lian, Bai Ying, Han Lian Cao, Che Qian Cao, etc., to clear heat and promote diuresis; for hypertension, add Sheng Long Mu, Zhen Zhu Mu, Gou Teng to calm the liver and subdue yang; for high blood lipids, add Shan Zha, Yi Mi, Gan He Ye, Yin Chen, etc., to clear heat and eliminate dampness.

2015, China Journal of Traditional Chinese Medicine

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Pei Zhengxue Clinical Collection, Volume Two Pei Zhengxue’s Clinical Experience: Combining Acupuncture with Herbal Formulas Zhang Chouchou Foreword: Professor Pei Zhengxue of Gansu Provincial Cancer Hospital is a renowned expert in the integration of traditional Chinese medicine and Western medicine in China. As early as the 1980s, he proposed the sixteen-character principle of “Western medical diagnosis, TCM syndrome differentiation, herbal medicine as the primary treatment, and Western medicine as a supplementary approach,” a concept that has garnered significant attention from the national TCM and Western medicine communities. His clinical practice is distinguished by his mastery of classic formulas, yet he does not rigidly adhere to their usage, achieving remarkable therapeutic effects. Today, our newspaper specially launches the “Pei Zhengxue’s Clinical Experience” column to introduce his academic characteristics and share his insights with readers. Masheng Shigan Tang, also known as Ma Huang Xingren Gancao Shigao Tang, has the effects of dispersing lung qi with a pungent and cool nature, clearing the lungs and relieving asthma. However, Pei Zhengxue applied it flexibly, following the “sixteen-character principle” in his treatment: first, he used modern medical diagnostic tools to conduct “Western medical diagnosis,” clarifying the disease’s diagnosis, the site of onset, and the progression of the illness, then proceeded with “TCM syndrome differentiation”; he then adapted ancient formulas to address various conditions, learning from the past without being bound by it, achieving excellent therapeutic results. Lung-related diseases The Shanghan Lun states: “After sweating, do not administer Gui Zhi Tang again; if the sweat has subsided but the patient still experiences shortness of breath and no high fever, then Ma Huang Xingren Gancao Shigao Tang may be used.” This indicates that after sweating to release exterior pathogens, the patient may feel a slight improvement in heat, but their shortness of breath becomes more pronounced, as wind-cold has entered the interior and transformed into fire. From a modern medical perspective, this formula is suitable for all types of bronchial and pulmonary infections—including acute and chronic bronchitis, bronchopneumonia, as well as pulmonary infections in patients with emphysema and cardiopulmonary disease.

Pei Zhengxue added Sangbai Pi, Dige Pi, Tingli Zi, Da Zao, Huang Qin, and Yu Xing

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This formula, when combined with Suxing San, demonstrates remarkable efficacy in treating chronic bronchitis, emphysema, cardiopulmonary disease, and heart failure. When used in combination with Gan Jiang, Xi Xin, Wu Wei Zi, Ban Xia, and Bai Shao, it exhibits significant effects in relaxing smooth muscles of the trachea and gastrointestinal tract, as well as in raising blood pressure, making it suitable for treating coughs and wheezing in patients with bronchial asthma.

[Case Study] Wang, male, 40 years old, first visited on January 15, 2008. Cough, expectoration, and shortness of breath for more than a month. Despite taking multiple Western medications, no significant improvement was observed, so he sought combined Chinese-Western treatment. Symptoms included: cough, yellow sputum, severe shortness of breath, red tongue with a thin yellow coating, and a slippery, rapid pulse.

Diagnosis: Chronic bronchitis, emphysema, cardiopulmonary disease. Syndrome differentiation: Lung heat accumulation, treated with

dispelling lung qi and clearing heat. Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Zisu Ye 10 g, Bai Qian 10 g, Qian Hu 10 g, Ban Xia 10 g, Chen Pi 6 g, Fu Ling 10 g, Juge 20 g, Zhi Ke 10 g, Pu Gong Ying 15 g, Baisai 15 g.

After seven doses, shortness of breath and cough significantly eased. At the follow-up visit, Huang Qin 20 g and Yu Xing Cao 20 g were added. After another ten-plus doses, most symptoms had completely disappeared.

Kidney-related edema The Golden Chamber Essentials states: “For those with fluid retention, if swelling occurs below the waist, then promote urination; if swelling occurs above the waist, then induce sweating.” This emphasizes that inducing sweating and promoting urination are two key principles for treating edema. Pei Zhengxue believed that Masheng Shigan Tang indeed has a significant diuretic and edema-reducing effect. Traditional Chinese medicine often refers to this approach as “dispelling lung qi and promoting water flow,” “guiding water to the surface,” “opening the door to the heavens and cleansing the internal organs,” and other similar terms.

Modern physician Cao Yingfu once compared it thus: “There is a small hole in the lid of a teapot—just like the opening of the lungs, allowing water to flow out through the spout; if there were no small hole, water would struggle to escape from the spout, just as lung qi is not fully opened, and kidney qi cannot descend!” In TCM, the lungs are considered to belong to metal, while the kidneys belong to water—metal can generate water, and metal and water mutually generate each other. The human body is an integrated whole, with organs maintaining dynamic balance in osmotic pressure through endocrine functions, metabolism, and fluid circulation. When lung qi is not fully opened, the pressure balance between the lungs and kidneys tends to break down, resulting in difficulty urinating and edema. Pei Zhengxue employed this method in clinical treatment of chronic nephritis, nephrotic syndrome, and purpuric nephritis.

[Case Study] Jin, female, 15 years old, visited on August 10, 2007. One year ago, after a cold, she began experiencing facial edema, accompanied by fatigue and loss of appetite. She was admitted to a local hospital for chronic nephritis; after treatment with hormones and other Western medicines, the edema subsided, and the proteinuria dropped from (3+) to trace levels. After discharge, she stopped using hormones, but the condition relapsed, so she came for consultation. Symptoms included: generalized edema, fatigue, pale tongue with fat-like markings, a thin, whitish coating, a deep, fine pulse, and blood pressure of 120/90 mmHg. Urine analysis showed proteinuria (3+). Western medical diagnosis: chronic nephritis. TCM syndrome differentiation: Spleen and kidney yang deficiency, treated with dispelling lung qi and promoting water flow, strengthening the spleen and tonifying the kidneys. Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Zhì Li Pu Ye 15 g, Shan Yao 10 g, Huang Jing 20 g, Tu Si Zi 15 g, Nü Zhen Zi 15 g, Han Lian Cao 15 g, Bai Qian 10 g, Qian Shi 30 g, Jin Yingzi 30 g, Dang Gui 10 g, Bai Zhu 10 g, Fu Ling 12 g, Gan Cao 6 g. After ten doses, the edema had largely subsided; urine protein was (2+), and after more than twenty additional doses, urine analysis returned to normal.

Childhood enuresis This formula is used for cases of lung heat causing enuresis, where the syndrome is characterized by coughing, wheezing, thirst, and a yellow tongue coating with a rapid pulse. The Su Wen’s “Pulse Classic” states: “Fluids overflow in the stomach, circulating through the essence and qi, rising to the spleen; the spleen’s qi disperses the essence, sending it upward to the lungs, regulating the water pathways, and ultimately draining to the bladder.” The lungs play a crucial role in controlling the movement of fluids; when lung heat accumulates and the lungs’ ability to ventilate and descend is impaired, fluid movement becomes disrupted. Coupled with insufficient kidney qi in children, weak control over the bladder’s opening and closing, frequent enuresis occurs. Treatment should focus on clearing lung heat. Pei Zhengxue used Masheng Shigan Tang as the primary formula for treating this condition, combining it with Qian Shi, Jin Yingzi, Yizhi Ren, Sang Piao Xiao, and Wuyao to tonify the kidneys and strengthen the bowels, clearing lung heat and enabling the lungs to ventilate and descend, thus restoring proper fluid regulation and resolving enuresis naturally.

[Case Study] Li, male, 7 years old, first visited on March 20, 2008. The child had been experiencing nocturnal enuresis for two years, waking up 1–2 times per night, often feeling thirsty, with slightly yellow urine, a red tongue with a thin yellow coating, and a rapid pulse. Diagnosis: Enuresis. Syndrome differentiation: Lung heat stagnation, treated with dispelling lung qi and clearing heat, tonifying the kidneys and strengthening the bowels. Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Gui Zhi 10 g, Fu Zi 6 g, Sheng Di 12 g, Shan Yao 10 g, Shan Zhu Yu 6 g, Dan Pi 6 g, Fu Ling 12 g, Ze Xie 10 g, Jing Wei 10 g, Bai Xian Pi 15 g, Di Fu Zi 12 g, Wuyao 6 g, Chan Tui 6 g. After ten doses, the frequency of enuresis had significantly decreased, and after another ten-plus doses, the child was fully cured. Urticaria Urticaria is often accompanied by intense itching; itching is caused by wind. Wind resides in the skin and hair, and the lungs are the principal organ governing wind. Therefore, Pei Zhengxue used Masheng Shigan Tang as a foundation to clear lung heat and treat skin conditions represented by urticaria, combining it with the four substances formula for nourishing blood and promoting blood circulation—this is the principle of “treat wind by activating blood circulation first; when blood is active, wind will naturally subside.” For heat, use Jin Yin Hua and Lian Qiao; for cold, use Huang Qi and Jing Wei; for dampness, use Cang Zhu, Huang Bo, and Qiang Du Huo; for severe itching, add Bai Xian Pi, Di Fu Zi, Wuyao, and Chan Tui. [Case Study] Sun, female, 35 years old, first visited on April 20, 2008. The patient experienced intermittent itching on both upper limbs for one month, accompanied by circular wheals of varying sizes, reddish in color, and marked itching. Her tongue was red with a thin yellow coating, and her pulse was floating and rapid. Diagnosis: Urticaria. Treatment focused on clearing lung heat and dispersing wind while nourishing blood.

Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Dang Gui 10 g, Chuan Xiong 6 g, Sheng Di 12 g, Chi Shao 10 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Bai Zhi 6 g, Fang Feng 12 g, Jing Wei 10 g, Bai Xian Pi 15 g, Di Fu Zi 12 g, Wuyao 6 g, Chan Tui 6 g. After seven doses, the number of itching episodes decreased significantly compared to before. After removing Jin Yin Hua and Lian Qiao from the formula, the patient continued to take the medicine for ten more doses and was fully cured. Conjunctivitis Conjunctivitis is often linked to allergies; allergy sufferers are prone to wind. When wind attacks the body, it first affects the lungs—the lungs govern the skin and hair—and when heat accumulates in the lungs, Masheng Shigan Tang is used as the primary formula to clear lung heat, followed by the combination of Dan Zhi Xiao Yang, which helps to clear the liver and brighten the eyes, allowing these conditions to be treated. [Case Study] Wei, female, 30 years old, first visited on March 10, 2008. The patient had been experiencing eye itching for nearly three to four days, with red streaks covering her eyes. She had tried self-administered chloramphenicol eye drops, but without significant improvement. She came for consultation. Symptoms included: red and swollen eyes, congested conjunctiva, mild pain, and significant itching. Her tongue was red with a thin yellow coating, and her pulse was floating and rapid. Diagnosis: Acute conjunctivitis. Treatment focused on dispelling lung qi and clearing heat, clearing the liver and brightening the eyes. Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Dan Pi 6 g, Shan Zhi Zi 10 g, Dang Gui 10 g, Bai Shao 15 g, Chai Hu 10 g, Bai Zhu 10 g, Fu Ling 12 g, Jin Yin Hua 15 g, Lian Qiao 15 g, Bai Zhi 10 g, Di Fu Zi 15 g, Wuyao 10 g. After seven doses, the redness and swelling subsided, the itching significantly lessened, the conjunctival congestion also decreased, and at the follow-up visit, Jin Yin Hua and Lian Qiao were removed from the formula, and Bai Xian Pi 15 g, Shi Jue Ming 15 g, and Mu Cuo Cao 10 g were added. After another seven doses, most of the aforementioned symptoms had completely disappeared. Sinusitis The lungs open to the nose; the onset of this condition is often associated with heat accumulation in the lung meridian. Therefore, Masheng Shigan Tang can be used as the primary formula to clear heat accumulated in the lung meridian and treat the root cause, combined with herbs like Cang Er Zi and Xin Yi, which have a pungent and warming nature to disperse wind. [Case Study] Zhang, male, 20 years old, first visited on May 14, 2008. The patient had been suffering from nasal congestion, thick nasal discharge, and headaches for more than two years. He had visited multiple clinics, all of which diagnosed sinusitis, but despite taking various medications, no significant improvement was seen. Later, he was referred to us for consultation. Symptoms included: headache, nasal congestion, thick nasal discharge, a yellow tongue with a thin oily coating, and a rapid pulse. Diagnosis: Chronic sinusitis. Treatment focused on dispelling lung qi and clearing heat, and clearing the liver to transform turbidity. Prescription: Ma Huang 10 g, Xingren 10 g, Sheng Shi Gao 30 g, Gan Cao 6 g, Gui Zhi 10 g, Chuan Xiong 6 g, Bai Zhi 6 g, Xi Xin 3 g, Qiang Du Huo 10 g, Fang Feng 12 g, Cang Er Zi 15 g, Xin Yi 10 g. After seven doses, the headache significantly eased, nasal congestion and nasal discharge both improved. Jin Yin Hua 15 g and Lian Qiao 15 g were added. After continuing to take the above formula for fourteen doses, the headache disappeared, and nasal congestion and nasal discharge occurred only occasionally.

January 13, 2014, China Journal of Traditional Chinese Medicine

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Chapter Sixteen: Pei’s Formulas Pei Zhengxue’s Approach to Diagnosis and Treatment Zhang Guiqiong [Abstract] Professor Pei Zhengxue of Gansu Provincial Cancer Hospital integrates traditional Chinese and Western medicine, combining his clinical experience with…

Input: 某 ,男 ,56 岁。自觉吞咽困难 ,伴胃脘胀满 3 月余。西医诊断 : 食管上段鳞癌、萎缩性胃炎并肠化。曾经钴 60 照射 20 次 ,总量达 6000CGY ,吞咽功能较前略有好转 ,仅能进食牛乳及茶水等 , 胃脘胀满较前加重 ,求诊于裴老。刻诊除上述症状外 ,大便干结、小便色赤疼痛 ,舌质红 ,舌苔厚腻发黄 ,脉象沉数略弦。处以承气泻心合启膈散加味 :大黄 10g , 黄连 3g , 黄芩 10g , 枳实 10g , 厚朴 10g , 芒硝 10g , 茯苓 10g , 郁金 6g , 丹参 10g , 牡丹皮 10g , 木香 10g , 浙贝母 10g ,砂仁 6g ,杵头糠 20g ,荷叶 10g。水煎服 , 1 日 1 剂。服药 10 剂 , 患者吞咽明显通利 ,能够进食松软普食。二便通畅 , 胃脘部胀满疼痛明显缓减 ,舌苔厚腻变薄。遂依上方减芒硝 ,加生地黄 12g , 山茱萄 10g , 山药 10g ,泽泻 10g ,水煎服 , 1 日 1 剂。服药十剂后所患症状明显缓减 , 自觉胃脘胀痛消失 ,舌质红 ,苔薄腻微黄。随症加减 , 处以六味地黄、三黄泻心、丹参饮、启膈散四方加味:大黄 6g ,黄连 3g ,黄芩 10g ,干姜 6g ,半夏 6g ,丹参 10g ,木香 6g ,砂仁 6g ,世生地黄 12g , 山药 10g ,牡丹皮 10g ,茯苓 10g ,泽泻 10g ,郁金 6g ,浙贝母 10g ,荷叶蒂 10g ,粳米 20g。水煎服 , 1 日 1 剂 ,令长服之。患者遵医嘱服上方近百余剂后 ,病患诸症全消 ,在当地医院复查已无病变。嘱患者用前方 10 剂之量 ,粉碎过箩 ,炼蜜为丸 , 每丸 6g 重 ,饭后服 , 日服 3 次 ,每次 1 丸 , 以善其后 [5]。

按语:食管癌患者以进行性吞咽困难、饮食难下为主要临床表现 ,属于中医学"噎嗝"的范畴 ,预后差。裴老认为"噎嗝"的病机为痰瘀气结 ,常选用启膈散加减化裁以治疗。对于启膈散 ,裴老体会尤深 ,认为此方之核心系茯苓、丹参、郁金三味 ,盖茯苓健脾利湿化痰 , 丹参活血化瘀 ,郁金行气解郁 ,三味药配合 ,正中噎嗝病机 ,令痰消瘀散气行 ,多数患者都有不同程度的疗效 ,有些患者甚至能彻底痊愈。此案患者服用启膈散加减的方药 100 余剂 ,终获痊愈 , 由此可

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裴正学临床荟萃第二辑见 ,启膈散确为治疗食管癌的良方 ,丹参诚为治疗食管癌不可挪移之品。也许有人不禁要问:此病之治疗可否以其他活血化瘀药代替丹参?以裴老的经验来看是不行的。裴老常说:"古人的经验方能流传至今 ,是大浪淘沙 ,经过无数次临床验证的 ,不可轻易加减 [7]。二、小结裴老曾感言:"中医典籍浩如烟海 ,苍苍茫茫看不见尽头。黄帝内经、伤寒杂病、六朝医典、金元诸说 ... ... o 让视野五彩缤纷 , 眼花缭乱。活人的法宝 ,济生的良策就在此中 ,却又云深难见。张仲景是太阳 ,李时珍是月亮 ,太阳和月亮率领群雄、轮番起舞 ,于是天庭彩云翻飞 ,霞光万道 ,这就是举世无双的中医宝库。五千年的积淀 ,亿万人的积累 ,造就了华夏人民的繁衍 ,成全了神州大地的开发 ,积淀和积累中最为壮观的风景线 ,就是这举世无双的中医宝库。 "鉴于笔者医道浅陋 , 本文仅从 4 方面介绍了裴老应用丹参的临床经验:①与苦参合用 ,辨病与辨证结合治疗心律不齐 ;②与黄芪合用 , 气血相配治疗肝硬化 ;③与健脾补肾药合用 ,匠心独运治疗再生障碍性贫血 ;④与茯苓、郁金合用 ,慧眼识珠治疗食管癌。足证裴老应用丹参 ,善于灵活配伍 ,且临床疗效颇佳 ,值得学习和借鉴。著名中医学家岳美中先生曾说"慢性病要有方有守",丹参性较平和 , 临床上慢性病瘀血证严重者 ,如上述之肝硬化、食管癌等 ,非大剂量、守方难以奏功。"久病入络 "时尚应加入虫类药以搜剔浊邪 ,化瘀通络。然活血药有耗气之弊 ,不可久用 , 当中病即止 ,必要时应辅之以益气药 ,庶不致偾事。参考文献 [1]薛文翰●裴正学教授治疗白血病经验拾粹[J]●中医药学刊 , 2004 ,22(8):1385~1386●

[2]裴正学●裴正学医学经验集[M]●兰州 :甘肃科学技术出版

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第十六章裴氏方药社 ,2008:366~367 ,318~319●

[3]王晓丽●裴正学教授治疗再生障碍性贫血经验[J]●甘肃中

医学院学报 ,2006 ,23(1):3~4 [4]高学敏●中药学[M]●北京: 中国中医药出版社 ,2007:322

323●

[5]裴正学●裴正学医话医案集[M]●兰州 :甘肃科学技术出版社 ,2008 : 175~176 ,219~220 ,235~237●

[6] 杨国栋 ● 裴正学教授辨治传染性肝炎学术思想特色探述

[J]●中医药学刊 ,2006 ,24(7):1209~1210

[7]鲁维德●裴正学教授中西医结合学术思想探讨[J]●中医研究 , 2010 ,23(8):62~63

《世界中医药》2013 年第 11 期

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裴正学临床荟萃第二辑 桂枝茯苓丸临床应用举隅 展文国【摘要】桂枝茯苓丸方出《金贵要略》,有活血化瘀 ,缓消症块之功。临床可用于子宫肌瘤 ,盆腔炎 , 月经不调 ,崩漏 , 附睾结核 , 中小型视网膜炎 ,精索静脉曲张等。同时列举七个病例以阐述其临床应用。【关键词】桂枝茯苓丸 , 中医辨证 ,案例 , 临床应用裴正学教授是我国著名的中西医结合专家 ,主任医师 ,博士研究生导师 , 国家级高徒导师 , 中国中医药学会终身理事。擅长治疗各种疑难杂症。本人有幸师从于裴老 ,现将裴老运用桂枝茯苓丸治疗治疗疾病的临床经验报告如下。一、桂枝茯苓丸桂枝茯苓丸出自张仲景《金匮要略》。有桂枝、茯苓、丹皮、桃仁、白芍组成 [1] 。有活血化瘀、消散癥块之功。此方药性平和 ,组方精当 ,破瘀不耗血 ,攻坚不伤正 [2] 。主治妇人小腹宿有包块 ,腹痛拒按 ,或下血色晦暗而有瘀块 ,舌质紫暗 ,脉沉涩。仲景《金匮要略》中说:"妇人素有癥病 ,经断未及三月 ,而得漏下不止 ,胎动在脐上者 , 为癥痼害。妊娠六月动者 ,前三月经水利时 ,胎也。下血者 ,后断三月 ,

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Input: Medical technology knowledge is integrated into a single framework: using instrument examination results to validate clinical experience, applying clinical experience to analyze examination results, conducting comprehensive thinking, integrating various examination findings for thorough analysis, and combining this with the patient’s disease course and clinical manifestations to correct errors in an instant and snatch life from the brink of death. Pei Zhengxue often said, “As a doctor—especially an oncologist—pathological diagnosis is certainly important, but reading images is an indispensable skill.” He accumulated rich experience throughout his life; here, I will only briefly share my insights gained from studying under him.

“Using formulas to diagnose” to identify lung cancer

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Pei Zhengxue Clinical Collected Volume II within normal ranges. The diagnosis remained inconclusive, making treatment difficult to proceed.

To reach a quick diagnosis, Pei Zhengxue analyzed that, based on the current examination results, pulmonary tuberculosis could be ruled out; the remaining possibility was to differentiate between inflammatory pseudotumors and malignant tumors. If the lesion was an inflammatory pseudotumor, anti-infective therapy would likely lead to shrinkage of the lesion; however, if it was a malignant tumor, the lesion would not change in size, and might even continue to grow. Accordingly, Pei Zhengxue initiated anti-infective treatment while continuing sputum cytology tests and performing another bronchoscopy for tissue biopsy.

One week later, a follow-up chest X-ray showed that the lesion had increased in size. Pei Zhengxue clearly identified the patient’s condition as “lung cancer” and took appropriate measures. At that time, no cancer cells were still detected in the sputum. Just two days after the diagnosis was confirmed, the pathology report indicated the presence of adenocarcinoma cells, confirming the diagnosis of “lung cancer.”

One year later, a repeat chest CT scan revealed a mass in the left hilum, accompanied by encapsulated pleural effusion and a small amount of pericardial effusion, along with left lung atrophy. Most radiologists considered this to be “lung cancer.” However, after carefully reviewing each CT image, Pei Zhengxue pointed out that it was actually pulmonary tuberculosis.

First, the margins of the mass on the CT scan did not show obvious spiciness. Second, there was a small amount of encapsulated pleural effusion near the mass, along with a small amount of pericardial effusion, but no pleural effusion in the thoracic cavity—these factors ruled out malignant lesions. If it were lung cancer, pericardial effusion would already be present, and the thoracic cavity would definitely contain a large amount of fluid, yet the patient did not have such symptoms. Third, the CT scan showed significant atrophy of the left lung; if it were a malignant lesion, such severe atrophy of the lung lobe would never have occurred. If these changes had already developed, the patient should have shown signs of cachexia long ago—but the patient’s mental state and overall physical condition were excellent. Moreover, the patient had a history of tuberculosis. Based on these three points, the malignancy was ruled out, and the patient was recommended to undergo tumor marker testing. The results were

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All results were negative, so the patient did not receive specialized oncology treatment. The patient remains healthy to this day.

Distinguishing liver masses through morphological changes

Pei Zhengxue corrected numerous misdiagnoses in clinical practice. He pointed out that when differentiating between nodular primary liver cancer and multiple hepatic metastases, in addition to focusing on the arterial and venous phases as depicted on enhanced CT scans, one should also consider that the former often shows elevated AFP levels, while the latter generally has normal AFP levels. Furthermore, it is crucial not to overlook the liver function characteristics of both conditions; they must be analyzed in conjunction. He often said, “It’s like building a wall to block water—if you only use stones, you’ll surely fail to stop the water; the water will still seep through the cracks. But if you combine stones with soil, you can indeed block the water. A liver mass is like a stone; if it’s a metastatic cancer, then using only stones to block the water means that liver metabolism continues normally, bile flows through the gaps, liver function remains generally normal, and jaundice does not occur. However, if it’s primary liver cancer, then the liver is like a stone combined with soil—liver metabolism is affected, bile flow becomes impaired, and liver function is generally compromised, leading to jaundice.”

When comparing these conditions with multiple hepatic cysts, it is especially important to focus on the overall morphological changes of the liver. Liver cysts are benign lesions; typically, the liver’s shape remains unchanged, with a complete and regular liver capsule. In contrast, malignant lesions often exhibit significant morphological changes in the liver.

Additionally, it is essential to understand the anatomical structure and functions of the organ. For instance, masses occurring within the gallbladder generally do not cause jaundice; masses located in the bile ducts also rarely cause jaundice, whereas masses in the hepatic ducts or common bile ducts are more likely to trigger jaundice, sometimes even leading to severe obstructive jaundice.

Since CT scans primarily depict imaging findings, it can be difficult to pinpoint the exact location of masses in these areas solely based on CT images. By combining this information with liver function and jaundice symptoms, one can determine the precise location of the mass. By applying these experiences in conjunction with the patient’s disease course, clinical manifestations, and general condition, it becomes easy to read images accurately and quickly, enabling a reliable diagnosis.

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Pei Zhengxue Clinical Collected Volume II 3. Identifying pancreatic cancer through five key characteristics

Pancreatic masses are often difficult to distinguish between benign and malignant based solely on CT scans, and their prognosis can be uncertain. However, Pei Zhengxue utilized his own extensive experience to differentiate between benign and malignant pancreatic masses.

He noted that patients with pancreatic cancer often exhibit the following key symptoms: First, abdominal pain—typically localized in the upper or mid-abdomen. Second, jaundice—often accompanied by severe obstructive jaundice. Third, a marked elevation in CA199 levels, usually above 1000 U/ml. Fourth, patients generally do not experience ascites. Fifth, the disease course is short, with rapid development of cachexia.

In May 2009, a patient was transferred to our department from another hospital. The patient was female, and her initial diagnosis at the external hospital was “pancreatic cancer, pancreatic tail metastasis, liver metastasis, and peritoneal metastasis.” She had already undergone one interventional treatment for a pancreatic mass. Upon admission, the patient did not experience upper or mid-abdominal pain, nor did she have jaundice or abdominal distension; CA199 levels were normal, and a chest CT scan revealed multiple masses in the pancreas, liver, and peritoneal cavity, along with substantial ascites.

After reviewing all medical records and examining the patient, Pei Zhengxue immediately dismissed the diagnosis of “pancreatic cancer,” recommending CA125 testing and pelvic ultrasound. The results showed CA125 levels over 30 times higher than normal. A pelvic ultrasound suggested a mass in the right adnexal region, possibly originating from the ovaries. Ultimately, the patient was diagnosed with “ovarian cancer.”

Source: China Journal of Traditional Chinese Medicine, March 8, 2014

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Chapter Sixteen: Pei’s Formulas Professor Pei Zhengxue’s Insights on Using Danshen in Clinical Practice Qu Qing, Zhang Hong, Zhao Xiaopeng, Zhang Guangshe, Gansu College of Traditional Chinese Medicine [Abstract] “In chronic diseases, blood stasis is inevitable,” and the therapeutic approach of promoting blood circulation and resolving blood stasis is widely applied in the treatment of various chronic illnesses and complex, difficult-to-diagnose conditions. Danshen is known for its ability to nourish blood and promote blood circulation, balancing blood activity without harming new blood, and replenishing blood without leaving behind stagnant blood—making it an excellent remedy for promoting blood circulation and resolving blood stasis. Professor Pei Zhengxue is a renowned expert in the integration of traditional Chinese and Western medicine in China, adept at treating various chronic illnesses and complex, difficult-to-diagnose conditions using blood circulation and blood-stasis resolving herbs. Danshen is one of his most frequently used herbs, and it has demonstrated remarkable clinical efficacy. This article summarizes Professor Pei Zhengxue’s clinical experience with Danshen, hoping to offer practical benefits to clinicians. [Keywords] Danshen; Pei Zhengxue; Clinical Experience

Pei Zhengxue, male, chief physician, born in February 1938 in Wushan, Gansu Province. He graduated from the Medical Department of Xi’an Medical University in 1961 and served as deputy director of the Gansu Provincial Institute of Medical Science. He currently serves as dean of the Gansu College of Traditional Chinese Medicine and receives a special government allowance from the State Council. In 1994, Professor Pei was recognized as a national advanced worker in the integration of traditional Chinese and Western medicine. His major works include “Commentary on Blood Disorders,” “New Compilation of Traditional Chinese Medicine Formulas,” “Pharmacology and Clinical Applications of Rheum,” “Diagnosis and Treatment of Hepatitis B,” “Selected Cases of Pei Shen,” “New Compilation of Warm Disease Studies,” “Practical Internal Medicine in the Integration of Traditional Chinese and Western Medicine,” among others [1]. The “Sixteen-Character Principle” he proposed for the integration of traditional Chinese and Western medicine has garnered widespread attention within the Chinese medical community and has become an important school of thought in the field of Chinese and Western medicine today. As the “Bencao Bian Du” states: “Danshen shares the same effects as Si Wu, capable of removing blood stasis to generate new blood… It is the first choice for regulating the blood system.” Thus, Danshen is known for its ability to nourish blood and promote blood circulation, balancing blood activity without harming new blood, and replenishing blood without leaving behind stagnant blood—making it an excellent remedy for promoting blood circulation and resolving blood stasis. Pei

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Pei Zhengxue Clinical Collected Volume II Professor Pei (hereinafter referred to as Old Master Pei) is a renowned expert in the integration of traditional Chinese and Western medicine in China, specializing in the clinical treatment of arrhythmias, cirrhosis, aplastic anemia, esophageal cancer, and various other complex and difficult-to-diagnose conditions. During my studies at the Gansu College of Traditional Chinese Medicine, I had the privilege of learning from Old Master Pei by copying prescriptions and drawing upon his writings. Though I may not possess great expertise, I have selected and summarized Old Master Pei’s clinical experience with Danshen below, hoping to offer valuable insights for clinical practice. Please feel free to offer criticism and suggestions if any inaccuracies are discovered. I. Clinical Applications (1) Combining Danshen with Kudam to Treat Arrhythmias

A 62-year-old male, a cadre, presented to our hospital due to palpitations accompanied by discomfort in the precordial region for eight years. His pulse was 100 beats per minute, his blood pressure was 16/10 kPa, and cardiac examination revealed clear heart sounds and irregular heartbeat, with 6–10 premature beats per minute heard each minute. No pathological murmurs were auscultated in the precordial region. An electrocardiogram showed: 1) insufficient myocardial blood supply; 2) frequent multi-source premature beats. Combined with a thin, rapid pulse with occasional pauses, a red tongue with a thin yellow coating bearing bruising points, the traditional Chinese medicine diagnosis was qi-yin deficiency with internal blood stasis. Treatment focused on tonifying qi and nourishing yin while resolving blood stasis. Prescription: 20g of roasted licorice root, 10g of cinnamon twig, 6g of fresh ginger, 10g of donkey-gelatin (dissolved), 4 jujubes, 10g of codonopsis, 20g of rehmannia root, 20g of ophiopogon root, 10g of sesame seeds, 20g of danshen, 20g of kudam, 10g of loquat fruit, 10g of scallion bulb, 6g of pinellia, 6g of saffron, 10g of chuanxiong, decocted in water. After more than 20 doses, the chest pain had subsided, though he still felt mild palpitations, occasionally experiencing fatigue and discomfort in the epigastric region. His tongue was red with a thin yellow coating, and his pulse was thin and rapid. The above formula was adjusted with chuanxiong and saffron, adding 6g of sandren, 6g of frankincense, 10g of white atractylodes, and 12g of poria, followed by another 20 doses, during which all symptoms disappeared. His heart rate returned to 86 beats per minute, with only 1–2 premature beats per minute heard each minute. An electrocardiogram showed occasional atrial premature beats [2]. Commentary: Arrhythmias are similar to the symptoms described in “Shanghan Lun,” where “the pulse is slow and irregular, with palpitations,” and the original prescription was based on Zhigan Tang. When treating this condition, Old Master Pei often added 30g of danshen and 30g of kudam to Zhigan Tang, adjusting the dosage according to the patient’s condition—especially for children and those with weak constitutions—and achieved remarkable results [3]. Danshen promotes blood circulation and resolves blood stasis, making it particularly suitable for this patient whose blood stasis was internal. The role of kudam in regulating heart rhythm is well known; when these two herbs are used together, combining disease identification with syndrome differentiation, they achieve effective results—worth learning from. (2) Combining Danshen with Astragalus to Treat Cirrhosis

A 30-year-old male, patient number 11595, employed by a company in a certain county in Gansu Province. The patient was admitted to the hospital due to persistent black stools lasting 15 days, accompanied by abdominal distension for one week. He reported discomfort and fullness in both flanks, weakness, loss of appetite, a bitter taste in his mouth, and throat discomfort. On examination, he appeared fatigued, his complexion was pale yellow, his sclera showed slight jaundice, his heart and lungs were auscultated normally, the liver dullness boundary was unremarkable, his spleen was slightly enlarged, with moderate consistency, abdominal distension, and no edema in the lower limbs. A ultrasound revealed cirrhosis with ascites and splenic enlargement (with a thickness of 5.0 cm). Esophagogastroduodenoscopy showed severe esophageal varices. Laboratory tests showed positive occult blood in stool (++), hemoglobin level of 80 g/L, globulin 42 g/L, albumin 32 g/L, A/G ratio of 0.76. The Western medical diagnosis was decompensated cirrhosis. The traditional Chinese medicine diagnosis was liver stagnation with spleen deficiency—long-term stagnation leading to fire, spleen deficiency causing dampness, and water-dampness accumulation, resulting in qi stagnation and blood stasis. Old Master Pei treated the patient primarily with Danzhi Xiaoyao San. The prescription was as follows: 6g of peony bark, 10g of gardenia, 15g of white peony, 10g of angelica root, 10g of bupleurum, 12g of poria, 10g of white atractylodes, 6g of licorice root, 30g of danshen, 30g of astragalus, 20g of polygonum cuspidatum, 10g of three-cornered lotus root, 10g of coptis root, 10g of polygonum cuspidatum, 10g of angelica root, 10g of cornelian cherry, 15g of turtle shell, 15g of dried abalone, 10g of pumpkin skin, 15g of gourd skin, 10g of plantain seeds, decocted in water, one dose per day. The traditional Chinese medicine was combined with Western medicine to achieve hemostasis and albumin supplementation. After more than a month in the hospital, the patient felt reduced abdominal distension, and all other symptoms disappeared. A follow-up examination showed negative occult blood in stool, improvement in esophageal varices, disappearance of ascites, improvement in liver function, and no further enlargement of the spleen. The patient recovered and was discharged after more than two months [2]. Commentary: In addition to common symptoms like bitter mouth, dry throat, poor appetite, and discomfort in the flanks associated with liver stagnation and spleen deficiency, patients with cirrhosis may also exhibit fatigue, tenderness in the left flank (due to spleen enlargement), darkened complexion, ecchymoses on the tongue edges, and a thready pulse—symptoms of qi deficiency and blood stasis. When treating such patients, Old Master Pei often followed the principle from “Jinkui Yaolüe”: “When you see liver disease, know that liver disease affects the spleen; first treat the spleen.” He used formulas such as Xiao Chaihu Tang and Danzhi Xiaoyao San, modified as needed. In addition, he frequently used 30g of danshen to nourish blood, promote blood circulation, and resolve blood stasis, complemented by 30g of astragalus to tonify qi. This case is a prime example. As the saying goes, “Chronic illness leads to deficiency, chronic illness leads to blood stasis.” When qi flows, blood flows; when blood stasis occurs, qi becomes blocked. Danshen’s ability to nourish blood, promote blood circulation, and resolve blood stasis, combined with astragalus’s qi-tonifying and blood-moving properties, work synergistically. Long-term use of these herbs significantly improves symptoms of qi deficiency and blood stasis in patients. In this case, after treatment, the ascites disappeared, liver function improved, and the spleen was not enlarged (with a thickness of 4.0 cm)—both were closely linked to the use of danshen. Modern pharmacology has also proven that danshen can promote liver cell regeneration and has anti-fibrotic effects on the liver [4]. Based on his syndrome differentiation and treatment principles, Old Master Pei added 30g of danshen and 30g of astragalus to his treatment regimen for cirrhosis, and his experience in treating cirrhosis is worth learning from.

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Pei Zhengxue Clinical Collected Volume II (3) Combining Danshen with Tonifying Spleen and Nourishing Kidney Herbs to Treat Aplastic Anemia

A 16-year-old male, diagnosed with anemia at a hospital through bone marrow aspiration, was admitted to the hospital with a diagnosis of aplastic anemia. Upon consultation, the patient’s complexion was pale yellow, he experienced nosebleeds, and scattered petechial hemorrhages were visible all over his body. His hemoglobin level was 65 g/L, red blood cells were 2.41×10¹²/L, white blood cells were 3.10×10⁹/L, neutrophils accounted for 32%, lymphocytes 68%, and platelets were 65×10⁹/L. His six pulses were thin and rapid, his tongue was pale, swollen, with tooth marks, and his tongue coating was thin, white, and greasy—a sign of both qi and blood deficiency, qi failing to control blood. The prescription was formulated with Guipi Tang, modified as needed. Prescription: 10g of codonopsis, 10g of white atractylodes, 20g of astragalus, 12g of poria, 6g of farfara, 15g of roasted jujube kernels, 6g of wood fragrance, 10g of cinnamon bark, 10g of angelica root, 10g of cornelian cherry, 15g of female ginseng, 20g of chicken blood vine, 10g of psoralia, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum, 10g of polygonum cuspidatum. Decocted in water, one dose per day. After 20 doses, the nosebleeds stopped, the scattered petechial hemorrhages on the body faded, and no more spots appeared. His hemoglobin level rose to 84 g/L. The prescription was adjusted to remove farfara, jujube kernels, and wood fragrance, adding 20g of danshen, 3g of saffron, 3g of deer antler (split and taken separately), and 10g of leeches (split and taken separately). The patient was instructed to continue taking the medication for more than 30 doses, and no further news about him was received. Three years later, a healthy adult came to the clinic, holding a prescription in his hands, folded like cardboard. Old Master Pei examined it and realized that it was the same prescription he had prescribed three years earlier. He said that he had taken this prescription for over 200 doses, and the more he took, the better he felt. Now his physical strength was like that of a normal person, his spirits were good, and his appetite was excellent. His complexion was rosy, his energy was abundant. A follow-up blood test showed hemoglobin levels of 150 g/L, red blood cells of 5.70×10¹²/L, white blood cells of 4.28×10⁹/L, and platelets of 160×10⁹/L. The patient had fully recovered and was advised to take Liuwei Dihuang Wan and Guipi Wan regularly to maintain his health [5].

Commentary: Aplastic anemia is often referred to as “recovery anemia,” a condition characterized by impaired hematopoietic function in the bone marrow, leading to a reduction in all three blood cell lineages. Clinically, the main symptoms include anemia, bleeding, and infection. It falls under the category of “deficiency-related diseases” in traditional Chinese medicine. The kidneys govern bone formation and marrow production, serving as the innate foundation; the spleen and stomach are the source of qi and blood, the acquired foundation. Therefore, tonifying the spleen and nourishing the kidneys is a common treatment approach for aplastic anemia. At the second consultation, Old Master Pei added a high dose of danshen—20g—on top of the traditional Chinese medicine formulas for tonifying the spleen and nourishing the kidneys, including codonopsis, white atractylodes, astragalus, cornelian cherry, polygonum cuspidatum, female ginseng, polygonum cuspidatum, psoralia, and polygonum cuspidatum—along with other herbs to promote blood circulation and resolve blood stasis [6]. This approach was truly innovative. Old Master Pei believed that for most patients, adding a few blood-circulating herbs to the basic formula for tonifying the spleen and nourishing the kidneys could “add the finishing touch.” By activating blood circulation, the herbs reached the affected areas directly, while tonifying the spleen and nourishing the kidneys ensured that qi and blood were abundantly generated and replenished. These two approaches complemented each other and worked in harmony. Modern medicine has also confirmed that blood circulation and blood stasis play a vital role in improving bone marrow circulation [5]. After taking this prescription for over 200 doses, the patient finally recovered.

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Chapter Sixteen: Pei’s Formulas It is evident that although danshen is a gentle herb, when used appropriately, it can still achieve remarkable results. (4) Combining Danshen with Poria and Curcuma to Treat Esophageal Cancer

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Chapter Sixteen: Pei’s Herbal Formulas 3. Acute and Chronic Pelvic Inflammation Liu Mou, female, 28 years old, presented with prolonged lochia after a miscarriage, accompanied by lower abdominal pain, low back and leg pain, a feeling of fullness and heaviness in the lower abdomen, a red tongue with a yellowish greasy coating, and a fine, tight pulse. Ultrasound showed intrauterine residues and adnexitis. She underwent gynecological curettage to remove any remaining embryonic tissue and received anti-infective treatment. Diagnosis: Acute pelvic inflammatory disease, incomplete abortion. Traditional Chinese Medicine diagnosis: Post-miscarriage infection with toxic pathogens, leading to stagnation of blood in the uterine cavity. Treatment focused on activating blood circulation to resolve stasis, clearing heat and detoxifying. The formula used was Xuefu Zhuyu Tang, Guizhi Fuling Wan, and Wumei Xiaoduan Yin, with modifications. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, licorice 6g, fresh barley 30g, cinnamon twig 10g, poria 10g, red peony bark 6g, dandelion 15g, and motherwort 15g. The herbs were decocted in water and taken as one dose per day. At the second visit, the lochia and abdominal pain had subsided, and the discharge was clean. The lower back pain, lower abdominal fullness and heaviness, fatigue, and weakness were also alleviated. The above formula was modified by removing dandelion and adding roasted eucommia, chuanxiong, codonopsis, and astragalus each at 10g; after more than 20 doses, combined with Guipi Wan, the patient’s condition improved and she was fully recovered.

Commentary: Incomplete abortion, residual embryonic tissue in the uterus, prolonged lochia—these symptoms indicate that damp-heat toxins remain unresolved, binding with blood and causing blood stasis in the uterine cavity, leading to dysfunction of the internal organs, imbalance of qi and blood, and obstruction of the Chong and Ren meridians. [4] “When acute conditions arise, treat the symptoms,” so after gynecological curettage to clear blood stasis and administer anti-infective therapy, combined with Tao Hong Si Wu Tang to activate blood circulation and resolve stasis; dandelion, motherwort, and fresh barley to clear heat and eliminate dampness; codonopsis and astragalus to tonify qi and strengthen the spleen; eucommia and chuanxiong to tonify the kidneys and strengthen the lower back, ensuring smooth flow of the meridians, allowing damp-heat to be eliminated, and thus curing all symptoms.

Menopausal Neurosis

[Case] Li Mou, female, 48 years old, sought medical attention due to six months of insomnia and dizziness. The patient experienced irritability, restlessness, anxiety, dry mouth, thirst, dizziness, lightheadedness, sunspots on her face, palpitations, shortness of breath, light menstrual flow, scant vaginal discharge, a dark red tongue with ecchymoses, tortuous purple veins under the tongue, and a fine, rapid pulse. Diagnosis: Menopausal neurosis. TCM diagnosis indicated liver and kidney yin deficiency, qi and blood stasis. Treatment focused on activating blood circulation to resolve stasis and nourishing liver and kidney. The formula used was Xuefu Zhuyu Tang, with modifications to Qiju Dihuang Tang. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, licorice 6g, goji berries 10g, chrysanthemum 10g, cornelian cherry 10g, raw gypsum and raw oyster shell each 15g, roasted Zao Ren 15g, Albizia bark 30g, and Cuculus japonicus 30g. The herbs were decocted in water and taken as one dose per day. At the second visit, the patient’s irritability, restlessness, and dizziness had improved.

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Pei Zhengxue Clinical Collection, Volume Two The sunspots on her face were noticeably reduced. Bupleurum was removed, and instead, 15g of processed Polygonum cuspidatum, women’s orchid, black nightshade, and turtle shell glue were added to nourish yin and replenish blood, nourish blood and lighten spots. After more than six months of modification, all symptoms improved. Commentary: The pathogenesis of menopausal neurosis lies in the decline of the female “Tian Kui” energy, liver and kidney deficiency, yin and blood deficiency, yin failing to contain yang, and yang overstepping externally. Irritability, anxiety, thirst, insomnia, dizziness, light menstrual flow with dark color, a dark red tongue with ecchymoses—all these are signs of blood stasis in the uterine cavity. Xuefu Zhuyu Tang is used to soothe the liver and resolve stasis, Qiju Dihuang Tang nourishes liver and kidney, roasted Zao Ren, Albizia bark, and Cuculus japonicus nourish blood and calm the mind; processed Polygonum cuspidatum, women’s orchid, black nightshade, and turtle shell glue nourish yin and replenish blood, nourish blood and lighten spots—thus curing all symptoms. 5. Chest Injury Li Mou, male, 28 years old. He suffered a chest injury from a car accident, resulting in chest pain, chest tightness, shortness of breath, dry mouth and thirst, and headache without nausea or vomiting. X-ray examination revealed no signs of hemothorax or pneumothorax, and no fractures were found in the chest and ribs. The tongue was dark red, with a yellowish greasy coating, and the pulse was tense and tight. Diagnosis: Chest injury. The condition was classified as post-traumatic chest blood stasis. Treatment focused on activating blood circulation to resolve stasis and regulating qi to relieve pain. The formula used was Xuefu Zhuyu Tang, with modifications to Xiao Xianxiong Tang. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, citrus peel 10g, achyranthes root 15g, platycodon root 20g, licorice 6g, coptis chinensis 6g, pinellia 6g, trichosanthes fruit 10g, and earthworm 10g. The herbs were decocted in water and taken as one dose per day. At the second visit, the chest pain and shortness of breath had improved; although rib pain remained, the original formula was modified with 6g each of processed milk thistle and other herbs. After 14 doses, the chest pain had eased, and all symptoms were cured. Commentary: The chest is where “Zong Qi” gathers; after trauma, qi in the chest becomes stagnant, blood stasis accumulates in the chest, leading to qi disruption, chest and flank pain, and the use of Xuefu Zhuyu Tang to activate blood circulation and resolve stasis, while Hua Sanqi and earthworm enhance the effect of resolving stasis and relieving pain; coptis chinensis, pinellia, and trichosanthes fruit clear heat and transform phlegm, opening up the chest and dispersing nodules. As Shen Ji of the Ming Dynasty wrote in “Zheng Ti Lou Yao,” “When the limbs are damaged externally, qi and blood are harmed internally, and the vital energy and defensive qi fail to flow properly, leading to disharmony in the internal organs.” For soft tissue edema, ligament injuries, or muscle-fascial pain caused by blood stasis, the method of activating blood circulation can be used for treatment [5]. 6. Fever of Unknown Origin [Case] Zhang Mou, male, 36 years old, presented with fever for one week without obvious triggers, with a temperature between 38°C and 39°C. Despite multiple treatments, his condition did not improve, so he sought treatment from traditional Chinese medicine. Examination: T38.2°C, patient was fatigued and weak.

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He was tired and thin, with dry mouth and thirst, heartburn, poor sleep, headache, poor appetite, constipation, yellow urine, a dark red tongue with a yellowish greasy coating and ecchymoses along the edges, a fine, tight, and slippery pulse. Chest X-ray, blood count, ESR, anti-O, and RF tests were all normal. Upon further inquiry into his medical history, it was discovered that seven years ago he had suffered an arm and knee injury while riding a motorcycle. Diagnosis: Fever of unknown origin. TCM diagnosis indicated post-traumatic blood stasis fever combined with qi deficiency and excessive stomach fire. Treatment focused on activating blood circulation to resolve stasis, using sweet and warm herbs to clear heat, and supporting intestinal function to release heat. The formula used was Xuefu Zhuyu Tang, with modifications to Bu Zhong Yi Qi Tang. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, achyranthes root 15g, platycodon root 20g, licorice 6g, codonopsis 10g, white atractylodes 10g, astragalus 10g, cimicifuga 10g, artemisia 10g, turtle shell 15g, and rhubarb 10g (added later). The herbs were decocted in water and taken as one dose per day. At the follow-up visit, the fever had subsided to 37°C, mental state and appetite had improved, and the treatment continued as before. The original formula was continued for another 10 doses, and all symptoms were cured. Follow-up visits showed no recurrence over six months.

Commentary: Fever can be caused by infections, tumors, autoimmune diseases, blood disorders, and many other factors. However, approximately 5–10% of fevers remain unexplained [6]. “Blood stasis fever, thirst, heartburn, and sharp pain in the limbs. When blood stasis resides in the middle burner, chest and flank pain may occur; when blood stasis affects the superficial layers, there may be disharmony in the vital energy and defensive qi, leading to fever and chills; when blood stasis resides in the muscles, there may be a buzzing fever, with both spontaneous sweating and night sweats. Xuefu Zhuyu Tang is the primary formula for treating such conditions [7]. Qi deficiency fever arises when the internal organs—such as the spleen and stomach—are injured, and external wind-cold attacks damage the body’s form. When the internal organs are deficient, we replenish them; warmth can dispel excess heat, and Bu Zhong Yi Qi Tang is the primary formula for strengthening the body [8].” 7. Post-Concussion Syndrome

[Case] Wang Mou, male, 35 years old, suffered a head injury from a car accident and lost consciousness for two days. Cranial CT scan showed acute subdural hematoma, but no fractures were found in the skull. The patient suddenly lost consciousness after hitting his left side of the head and was rushed to the hospital for emergency treatment. His mental status was unclear, he fell into a deep coma, and he occasionally experienced nausea and vomiting. Blood pressure: 140/90 mmHg. CT scan revealed patchy hemorrhagic foci within the left cerebral cortex, with compression and deformation of the right lateral ventricle, and the midline shifted to the right, along with a subdural hematoma. The hospital performed emergency craniotomy to decompress and remove the hematoma. Twelve hours after surgery, his mental status was clear, and he reported headaches and dizziness, dry mouth and thirst, excessive sweating, heartburn, soreness in the lower back and knees, a red tongue with a yellowish greasy coating and ecchymoses along the edges, and a tense, slippery pulse. Western medicine administered anti-infective drugs, decompression, volume expansion, and symptomatic supportive care. Diagnosis: Brain contusion, post-acute subdural hematoma, post-concussion syndrome. TCM diagnosis: Kidney yin deficiency, blood stasis lingering in the meridians after trauma. Treatment principle: Nourish yin and tonify the kidneys, activate blood circulation to resolve stasis.

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Pei Zhengxue Clinical Collection, Volume Two The formula used was Xuefu Zhuyu Tang, with modifications to Zhi Bai Di Huang Tang. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, bupleurum 10g, citrus peel 10g, achyranthes root 15g, platycodon root 20g, licorice 6g, zhi mu 20g, phellodendron 10g, Chinese yam 10g, cornelian cherry 10g, and raw rhubarb 10g (added later). The herbs were decocted in water and taken as one dose per day, for 7 doses. At the follow-up visit, the dizziness and headache had lessened, sweating decreased, blood pressure was 130/80 mmHg, sleep was poor, and the original formula was modified with 10g each of roasted Zao Ren, farwen, and stone calamus, and the treatment was continued for more than three months, with improvement in the patient’s condition. Commentary: Acute subdural hematoma results from ruptured cortical blood vessels following brain contusion, characterized by prolonged coma or progressively worsening loss of consciousness, and increased intracranial pressure [9]. Acute subdural hematoma progresses rapidly and is severe, requiring early surgical intervention. Post-surgery, traditional Chinese medicine focuses on activating blood circulation to resolve stasis, reduce swelling and relieve pain, and improve the body’s responsiveness. Xuefu Zhuyu Tang is the preferred formula for this purpose. Stone calamus, farwen, turtle shell, raw oyster shell, and roasted Zao Ren help calm the mind and soothe the liver, while also enhancing the efficacy of the main formula. 8. Reflections All seven typical cases mentioned above were treated using Xuefu Zhuyu Tang with modifications. Wang Qing used Xuefu Zhuyu Tang to treat various conditions involving “blood stasis in the chest,” incorporating Tao Hong Si Wu Tang with Si Ni San, platycodon root, and chuanxiong. The chest and flanks are areas where the liver meridian runs; when blood stasis accumulates in the chest, qi stagnation occurs, leading to chest pain. If blood stasis persists and turns to heat, or if qi stagnation leads to fire, then fever and heat may arise in the evening. According to “Xue Zheng Lun,” “When blood stasis rises to the upper burner, symptoms such as chest, back, shoulder, and arm pain, numbness, and chest and flank fullness may appear—these conditions are best treated with Xuefu Zhuyu Tang.” “Using Tao Hong Si Wu Tang to resolve stasis and nourish blood, bupleurum to soothe the liver and resolve depression, plating the lung qi to open the lungs and carry the herbs upward, combining citrus peel to widen the chest and regulate qi, achyranthes root to promote blood flow and guide blood downward, and licorice to harmonize all herbs—when these herbs are combined, they not only address blood stasis in the blood vessels but also help disperse qi stagnation, eliminating stasis without worrying about blood loss, while promoting qi without causing dryness or heat. Together, they achieve the effects of activating blood circulation to resolve stasis, regulating qi to relieve pain, and dispersing stagnation while clearing heat [10]. ‘Xue Zheng Lun’ states, “If blood stasis is not resolved, new blood will certainly not be generated; and if new blood is not generated, old blood cannot be produced either.” “Every condition that cannot be cured has its roots in improper blood removal; those who treat blood must first focus on removing blood stasis.” Xuefu Zhuyu Tang uses blood removal as a key approach to treating blood-related conditions—whether it’s headaches caused by qi stagnation and blood stasis, chest pain, hypertension, pelvic blood stasis syndrome, menopausal syndrome, fever of unknown origin, or post-concussion syndrome, this formula can be used with modifications. Experimental research has shown that Tao Hong Si Wu Tang is highly effective for gynecological diseases, traumatic injuries, migraines, rheumatoid arthritis, angina pectoris, diabetic peripheral neuropathy, alopecia areata, cervical spondylosis, and other conditions [11–12]. References [1] Wang Qingren. Medical Reform and Correction [M]. Shenyang: Liaoning Science and Technology Press, 1999, pp. 7–8. [2] Xu Jiqun. Textbook for Higher Medical Colleges, Formulae [M]. Shanghai: Shanghai Science and Technology Press, 1998, pp. 10, 148–149. [3] Dong Chao, Geng Chaohui, Gao Feng. Modern clinical applications and experimental research progress of Xuefu Zhuyu Tang [J]. Shizhen National Medicine and Pharmacy, 2009, 12(20):36–37.

[4] Xu Xiangyu. Xuefu Zhuyu Tang for the Treatment of Pelvic Inflammation [J]. Jilin Chinese Medicine, 2008, 8(6):42–43. [5] Fan Chenghu, Ma Zhiyong, Chai Jimei. Treatment of 130 cases of acute soft tissue injuries with Xiaoding Paste [J]. Gansu Chinese Medicine, 2010, 23(11):47–48. [6] Kuang Heling, Hu Pinjin. Diagnostic Differential Diagnosis of Internal Diseases [M]. Beijing: People’s Health Publishing House, 2009, pp. 6–12. [7] Pei Zhengxue. Commentary on Xue Zheng Lun [M]. Lanzhou: Science and Technology Press, 2008, pp. 129–130. [8] Pei Zhengxue. New Compilation of Formulae [M]. Lanzhou: Science and Technology Press, 2008, pp. 95–96. [9] Dong Qian. Clinical Applications of Xuefu Zhuyu Tang [J]. Hebei Chinese Medicine, 2008, 5:25–26. [10] Li Shuying, Ma Xiaoyong. Clinical experiences with Tao Hong Si Wu Tang [J]. Shaanxi Chinese Medicine, 2001, 23(5):55–58. [11] Song Xin, Zhang Yayun. Tao Hong Si Wu Tang for the Treatment of Migraine [J]. Practical Chinese Medicine Journal, 2006, 8:33–35. Hebei Chinese Medicine (Core), April 2013 issue

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Pei Zhengxue Clinical Collection, Volume Two Chapter Seventeen: Newspaper Abstracts Record of China’s Famous Integrated Traditional Chinese and Western Medicine Expert, Professor Pei Zhengxue, a Renowned Chinese Medicine Doctor of Gansu Province Qi Qin, Yang Yin Hong, Zheng Fangjiang A Great Master of the Xinglin Realm Warmly Embraces the Land of China Since ancient times, Gansu has been known as the “Home of Qihuang in China,” renowned for its abundant medicinal resources, numerous famous doctors, and profound Chinese medicine culture. In the field of Chinese medicine, a formula named after a place—known as the “Champion of Blood Disorders,” the “Lanzhou Formula”—has made Gansu’s traditional Chinese medicine famous both domestically and internationally. The creator of this formula is Pei Zhengxue, a renowned integrated traditional Chinese and Western medicine expert who currently serves as Chief Expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Academy of Medical Sciences, as well as a doctoral supervisor. He also holds the position of Professor at Gansu College of Traditional Chinese Medicine and Honorary Chairman of the Gansu Association for Integrated Traditional Chinese and Western Medicine. Throughout his more than 50-year career in medicine, Pei has skillfully leveraged the strengths of both Chinese and Western medicine to benefit patients, achieving fruitful results in teaching, medical practice, and research—and becoming a great master of the Xinglin realm deeply loved by people across Gansu and even throughout China. “Three Generations of Qihuang Are Not Remarkable” “Three Generations of Qihuang Are Not Remarkable—when you study medicine, you should become a true physician. You should lead your children to the path of medicine, and do not let arrogance lead you astray.” This is a famous saying from Pei’s father, Pei Shen, which he often used to encourage his children.

Pei was born in February 1938, from Wushan, Gansu Province, and came from a family of traditional Chinese medicine practitioners. His grandfather, Pei Shaojian, devoted his life to healing others. His father, Pei Shen, studied at Central University and authored several medical books. “Two Poems Encouraging My Children” was written to inspire his children to continue their medical heritage and uphold the traditions of their ancestors. Under the influence of his strong interests and his family’s legacy, Pei Zhengxue developed the dream of becoming a doctor from a young age, and he was admitted to the Medical Department of Xi’an Medical University with excellent grades.

Pei’s youth was marked by many hardships. In 1958, a nationwide campaign against rightists swept through the country. While Pei was a sophomore, his father was wrongly labeled a rightist and subjected to persecution, spending several months under criticism as a rightist. In 1961, after graduating from university, Pei Zhengxue could have stayed on campus to excel academically, but during the political review process, due to his family’s background and his father’s historical issues, he was transferred to TianShui Hospital. During the Cultural Revolution, Pei Zhengxue was labeled as one of the “Black Five Classes” and sent to the remote Ganquan Health Center in TianShui. Here, Pei did not lose heart or give up; instead, he saw this as a rare opportunity to delve deeper into the lives of the people, understand their hardships, and encounter countless ailments. These difficult trials and heavy pressures became invaluable assets in his life.

“Reviving the Dead”: The Lanzhou Formula In 1967, while working in the Internal Medicine Department of TianShui Regional Hospital, Pei Zhengxue treated a young man named Ma Changsheng, who had leukemia. Ma Changsheng was a young soldier who, despite receiving full treatment at both military hospitals and local clinics, still did not see improvement in his condition. When his hemoglobin level dropped to just 2g, the hospital leadership decided to send him back to his hometown of TianShui for a final farewell with his parents. With a sense of hope, Ma Changsheng’s parents went to seek treatment from Dr. Pei Zhengxue. At that time, the primary treatment methods for leukemia both domestically and internationally were chemotherapy. However, the toxic side effects of chemotherapy were quite severe. Dr. Pei used TCM diagnostic principles and an integrated approach of Chinese and Western medicine to develop a treatment plan for Ma Changsheng. After one month of medication, his high fever subsided; after more than a hundred doses of herbal medicine, a miracle occurred. A year later, his hemoglobin level had risen to 14g, and multiple bone marrow smear examinations showed complete remission. Professor Zhang Aicheng, who had previously treated Ma Changsheng in Lanzhou, was astonished upon learning of this case, exclaiming, “Miracle! Miracle!” In 1973, at a national conference on blood disorders held in Suzhou, this case was unanimously praised by the experts attending the meeting. The conference ultimately designated the main formula for this case as “Lanzhou Formula,” which has since been widely promoted and used in hospitals across China for many years, yielding remarkable therapeutic results. That patient, Ma Changsheng, has remained healthy ever since his recovery under Dr. Pei’s care, never experiencing a recurrence. “The Sixteen-Character Principle Creates the Pei School” As medical practice continued to evolve, Mr. Pei Zhengxue’s contributions to medical research grew richer and richer…

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Input: Domains have also achieved substantial results, successively serving as an editorial board member of the China Journal of Integrated Traditional Chinese and Western Medicine, Chief Editor of the Journal of Integrated Traditional Chinese and Western Medicine, a director of the Chinese Society of Integrated Traditional Chinese and Western Medicine, Vice Chairman and Secretary-General of the Gansu Society of Integrated Traditional Chinese and Western Medicine, a member of the Gansu Provincial Committee of the Chinese People's Political Consultative Conference, and a member of the Gansu Provincial Committee of the Chinese People's Political Consultative Conference. His major works include "Commentary on Blood Disorders," "New Compilation of Traditional Chinese Medicine Formulae," "Pharmacology and Clinical Applications of Rheum," "Diagnosis and Treatment of Hepatitis B," "Selected Cases of Dr. Pei," "New Compilation of Warm Disease Studies," "Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine," among others. In addition, he has published more than 60 papers in academic journals at various levels, and he has received one First Prize, two Second Prizes, five Third Prizes for National Outstanding Works, as well as five Provincial Outstanding Paper Awards and two Provincial Science and Technology Progress Awards.

In 1980, Pei Zhengxue’s “Commentary on Blood Disorders” was published and distributed, and after its circulation in Japan, it garnered a strong response. In May 1985, Professor Tan Eiichi, President of Shizuoka Medical University in Japan, traveled specifically to Lanzhou to consult with Professor Pei on issues related to the book. In the 1990s, Pei Zhengxue proposed the 16-character principle of “Western medicine diagnosis, traditional Chinese medicine syndrome differentiation, traditional Chinese medicine as the primary treatment, and Western medicine as a supplementary approach,” which drew widespread attention from the Chinese and Western medicine communities nationwide. The “Pei School” became an important school of thought in the field of Chinese and Western medicine today.

His edited work, the first comprehensive monograph on integrated Chinese and Western medicine in contemporary times, “Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine,” won the “International Gold Award for Outstanding Contribution” at the World Conference on Traditional Medicine held in the United States in 1996. Professor Pei Zhengxue himself was honored with the title of “One of the World’s 100 Stars of Ethnic Medicine.” In 1997, the State Administration of Traditional Chinese Medicine recognized him as one of the 500 renowned veteran Chinese medicine practitioners nationwide, and he was subsequently invited as a visiting professor by three domestic Chinese medicine universities, including Hong Kong University of Chinese Medicine.

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Chapter 17: Newspaper Abstract A Physician’s Benevolent Heart, Compassionate to All Living Beings

Since beginning his medical career, Mr. Pei Zhengxue has always approached patients with a “benevolent heart” attitude. For decades, he has warmed patients’ hearts like a gentle spring breeze, contributing to harmonious relationships between doctors and patients, and setting an example for all.

In 2000, Liu Ligang, a student from Jiangxi who was studying at Lanzhou University, unfortunately suffered from “ALL acute lymphoblastic leukemia.” Despite various rounds of chemotherapy and treatment, his condition showed little improvement, and doctors predicted that his recovery would cost around 300,000 yuan. Through an introduction, he found Mr. Pei at Gansu Provincial Cancer Hospital. Faced with this young man struggling on the brink of death, Mr. Pei gave him “Pei’s Blood-Raising Granules,” a remedy he had developed himself. When Mr. Pei learned that Liu Ligang was planning to return to his hometown in Jiangxi, he warmly said, “You can contact me anytime when you go home—I’ll send you the prescription in time.” In May of the same year, Liu Ligang returned to Nanchang, Jiangxi, and was admitted to the Second Affiliated Hospital of Jiangxi Province for long-term chemotherapy. The chemotherapy had caused his bone marrow hematopoietic system to lose its immune function entirely, leaving him increasingly weak and exhausted. Upon learning of this situation, Mr. Pei immediately prescribed another traditional Chinese medicine formula for him and entrusted someone to deliver the specially prepared pills to him. After Liu Ligang took the traditional Chinese medicine as directed, the toxic side effects of chemotherapy were significantly alleviated, and indicators such as red blood cells, white blood cells, and platelets quickly returned to normal. The intervals between chemotherapy sessions were also gradually extended. Later, Mr. Pei sent Liu Ligang another new traditional Chinese medicine formula; after taking it, a miracle occurred! He no longer needed to undergo chemotherapy, as all his indicators had returned to normal. Today, Liu Ligang has recovered and completed his studies, but every year he returns to Lanzhou to visit Mr. Pei, repaying him for saving his life. The year 2008 marked the 50th anniversary of Mr. Pei Zhengxue’s medical career. On February 23, Gansu Province held a “50th Anniversary Symposium on Professor Pei Zhengxue’s Medical Research and Teaching” in Lanzhou. Vice Governor Xian Hui, who attended the symposium, highly praised his noble medical ethics and superb medical skills. On March 22, 2011, the inaugural edition of “Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine” (revised edition), edited by him, was launched in Lanzhou. Leaders including Liu Weiping, Deputy Secretary of the Gansu Provincial Party Committee and Governor of Gansu Province; Li Xiaojie, Member of the Standing Committee of the Gansu Provincial Party Committee and Minister of the Gansu Provincial Party Committee’s Propaganda Department; Xian Hui, Vice Governor; and Li Peiweng, Secretary-General of the Gansu Provincial Government, attended the launch event. Although Mr. Pei is now over 70 years old, he remains full of energy and continues to dedicate himself to the medical field—seeing patients, practicing medicine, writing books, and nurturing the next generation. With concrete actions, he has reciprocated the deep love and encouragement he has received from all sectors of society. He hopes to use his…

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Pei Zhengxue Clinical Collection, Volume II To truly follow the motto “An old ox knows its own sunset is short—no need to whip it into action, just keep forging ahead,” to prove the true value of life!

2012-24, China Traditional Chinese Medicine News

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Chapter 17: Newspaper Abstract Memories Spanning Half a Century—Reading Mr. Pei Zhengxue’s Collection of Short Stories and Essays, “Great Wind Melody”
Nie Zhongmin

Although Wushan, located in the southwest of Tianshui, has long been regarded as a culturally underdeveloped county in the eyes of Gansu’s literary community, this year’s literary scene in Wushan has been filled with joy and excitement. Recently, Pei Zhengxue’s collection of short stories and essays, “Great Wind Melody,” published by Gansu People’s Publishing House, has become a standout work. Chen Tiangui’s essay collection, “New Rhymes of the Wei River,” has been met with rave reviews. Additionally, Chen Yongheng’s novel “The Wei River Flows Slowly,” Xiao Zuorong’s academic essay collection “History of Five Flavors—Now Superior,” Wang Cheng’s local education textbook “Lovely Wushan,” and He Hui’s novel “Sensual Black Night” have all been published one after another, all of which demonstrate that Wushan’s literary scene is rapidly rising in a healthy and thriving manner. Faced with so many publications, let us talk today about Mr. Pei Zhengxue and his works.

Mr. Pei Zhengxue is the son of the renowned physician Pei Shen, who is celebrated as a master of traditional Chinese medicine in the region. He is widely respected in China’s medical community for his exquisite medical skills, noble medical ethics, and profound knowledge coupled with diligent thinking. Mr. Pei and I are both natives of Wushan; he is not only an outstanding physician but also an accomplished writer. In Wushan’s literary world, Mr. Pei Zhengxue has filled a gap in the creation of medium-length novels that had long existed. I had heard that Mr. Pei possessed vast knowledge, exceptional talents, and excellent character—but I had never had the chance to meet him. Fortunately, I am a young man who is not afraid of challenges; I occasionally posted a few short pieces on the bustling internet, and unexpectedly, they caught Mr. Pei’s attention.

During the years I spent making a living in Chongqing, in order to ease my loneliness away from home, I would often find myself…

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Pei Zhengxue Clinical Collection, Volume II Together with my friend Ding Sheng from Tianshui, I founded the Tianshui Literary Website, which soon gained attention from travelers far from home. Around March of this year, I received an email from Mr. Pei, which contained words of encouragement and high praise for my literary creations. After several exchanges of letters, and after much persistence, Mr. Pei Zhengxue sent me some of his poems and prose via email. After reading them carefully, I posted them on the literary website to satisfy the needs of some readers. After a phone call, Mr. Pei warmly invited me to visit Lanzhou. This May, I had the privilege of visiting Mr. Pei Zhengxue and Mr. Qi Ziyang in Lanzhou. Even though Mr. Pei was busy, he made time to warmly welcome my brother Ding Sheng and me. That day, Mr. Pei presented us with his recently published “Great Wind Melody” and his father’s collection of Pei Shen’s poetry and prose as gifts. We toured Lanzhou’s scenic spots, and Mr. Pei happily took photos with us and engaged in lively conversations. Later, at a dinner table with Ma Dahu Zi, Mr. Pei spontaneously composed a poem: “May in Jin City brings back the spring again; the talented scholars of our homeland bloom like flowers. I do not believe that even old age is a waste—let me be a stepping stone for others to soar.” Mr. Pei constantly reminded us that as young literary enthusiasts, we must live with integrity, study diligently, and contribute our modest efforts to the cultural development of our hometown. Through our first encounter, Mr. Pei’s genuine nature and warm-heartedness became a unique source of strength in his personality. When I finished reading Mr. Pei’s collection of works, I had already resigned from my job and was free to pursue my interests. I had always wanted to write a few words—yet the feeling of being at a dead end kept me putting off my efforts. One day, I received a call from Ding Qiang, who sent me photos of Lanzhou. He also told me that Mr. Pei had written a calligraphy scroll for me, inscribed with the words “Fragrant Orchids and Fragrant Grass.” At first, I was quite surprised. Asking Mr. Pei for calligraphy was something I had planned to do, but I hadn’t had time to write it down. What I didn’t expect was that Mr. Pei hadn’t forgotten such a small matter. I usually didn’t keep in touch with Mr. Pei, and what’s more, I worried that too much interaction might distract him from his valuable time. Not long ago, when I saw Mr. Pei again, I began to consider framing his works and hanging them in Wufei Zhai as a way to encourage myself. If the role of medicine is simply to save lives and treat injuries, then the role of literature is to save the soul of humanity. To achieve both, one could say that one has truly lived a fulfilling life. Mr. Pei Zhengxue is exactly like that. Although Mr. Pei is over 70 years old, his complexion remains rosy and his body is still strong—he is a man who loves life. In recent years, he has made significant scientific breakthroughs in the research of leukemia and liver disease treatment, and in 1997, he was included among the “100 Renowned Veteran Chinese Medicine Practitioners Nationwide.”

Mr. Pei Zhengxue has students all over the Loess Plateau, and he has authored numerous works, publishing more than ten medical monographs in succession. In his literary creations, Mr. Pei has achieved remarkable success. He has published many literary works in publications such as Gansu Daily, Feitian, Zhengyou, Gansu History and Culture, Tianshui Daily, Lanzhou Evening News, and Silk Road, earning a prominent place in Gansu’s ever-expanding literary scene and adding a vibrant stroke to the flourishing of Wushan’s literary culture.

Upon reading the beautifully bound “Great Wind Melody,” one finds that the book contains a novella, along with eleven essays and literary critiques. The preface to Mr. Pei’s collection was written by his close friend, Mr. Yang Limin, former Secretary of the Inner Mongolia Autonomous Region Party Committee. The works collected within are all texts Mr. Pei had previously published in newspapers over the years, focusing on events he personally experienced and the people around him. With a simple yet vivid style and a lively penmanship, these works vividly reflect the historical changes that have taken place in China’s cities and rural areas over half a century. His works are imbued with deep affection for his family and fellow villagers in his hometown. At the same time, they expose certain social problems in the course of social development and national construction—a sense of concern for the world before one’s own worries, and a spirit of sharing joys and sorrows with others—often expressed through his writing. As the renowned literary critic Liang Shengming once said, “Reading Pei Zhengxue’s ‘Great Wind Melody’ is like seeing ordinary people reflecting on a grand stage, observing the wider world through small events. It allows readers to savor life’s insights and contemplate life’s philosophies in sincere, simple narratives, finding spiritual joy and intellectual enlightenment.”

Mr. Pei Zhengxue’s novella “Great Wind Melody” can be considered an autobiographical work. The author uses the love story that unfolded during his youth, amidst the special historical context of the “Anti-Rightist Campaign,” as its theme. The story follows the tragic love affair between Bai Liping, a gifted medical student, and Zhang Yalan, a beautiful and kind university girl, and deeply reveals the deeper roots of the “Anti-Rightist Campaign.” Using a plain, unadorned style, the author successfully portrays the typical characters of a party committee member who is both academically and morally corrupt, as well as Tian Jinpeng, the head of the academic affairs office, who is indifferent to the world and lacks both talent and virtue; Luo Renyi, the branch secretary who is overly compliant and lacking in substance; and Huang Jiancheng, the party branch leader who is righteous, pragmatic, and steadfast in his principles. At the beginning of the story, the author presents a poignant reflection on how, more than 20 years later, the two lovers meet at an international academic conference, sparking endless memories of the past. In the novel, the author gently recounts the passionate love between Bai Liping, the male protagonist, and Zhang Yalan, the female protagonist…

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Pei Zhengxue Clinical Collection, Volume II Bai Liping, after signing a large poster exposing Tian Jinpeng’s problems during the Anti-Rightist Campaign, was suddenly pursued by Luo Renyi, who joined forces with Tian Jinpeng to retaliate against Zhang Yalan. Zhang Yalan’s mental state collapsed completely under immense stress and pressure, leading her to take a leave of absence and return home for recuperation. Although Bai Liping was protected by the righteous faction and was not labeled as a rightist, their love was shattered by various vile acts, leaving readers with an inexplicable sense of pain. Therefore, the author deliberately set up foreshadowing in the novel. As for the work itself, the characters are vivid and lifelike, with sharply contrasting personalities, a twisting and turning plot, and a naturally clever structural arrangement. It is worth mentioning that the language is fresh and natural, with emotions that are calm and delicate—perhaps the tragedy no longer feels like a fate-bound constraint on human beings. The author’s skillful handling of details reveals that, even in old age, Mr. Pei Zhengxue maintained a simple, open-minded, and serene mindset, free from the complexities of worldly affairs. Compared to Mr. Pei Zhengxue’s novels, I prefer his essays and short pieces. Pei Zhengxue’s essays fall within the realm of traditional literary forms, with broad themes and a natural, relaxed writing style. I think his greatest strength lies in his heartfelt emotions and innovative ideas. Moreover, his essays on themes related to his hometown resonate deeply with readers—whether he writes about the cultural heritage and daily life of his first hometown, Wushan, or about his second hometown, Lanzhou, where his hometown serves as a spiritual haven, almost permeating his real-life experiences. In works such as “Missing My Hometown” and “The Wei River Flows Slowly,” the author paints a vivid picture of the Wei River’s rich, fragrant landscapes, capturing the essence of childhood days and presenting a long scroll of the river’s beauty. The Wei River, one of the main rivers in our hometown, not only nurtured our fellow villagers struggling for survival but also sparked the author’s extraordinary creativity and artistic talent. In the author’s hands, his hometown is a land covered in lush greenery, with tiny streams gurgling through the fields, fragrant rice paddies filling the air, and flocks of crested ibises dancing lightly in the morning light. Yet, as one reads these works, the hometown flows through the reader’s heart in a beautiful, graceful manner. In “Morning Melodies Along the Riverside Road,” the author captures the picturesque scenery of Lanzhou’s Yellow River, with its enchanting charm and diverse beauty, creating a visual experience that evokes both visual delight and emotional resonance. After discussing essays on themes related to his hometown, let us turn to his other essays. In today’s popular essay genre, his essays such as “Notes from Western Europe,” “Visiting …,” and “Travelogue of Tianshui” offer readers a fresh perspective. Pei Zhengxue’s essays are deeply thoughtful and logically argued. In “Recalling a Poem,” the author pays tribute to the ancient poem “Emperor Yao Abandoned His Throne, Yu Refused Office,” using it to mercilessly satirize and criticize those in contemporary society who seek power through bribery, who remain in positions without fulfilling their duties, who eat government funds without serving the people, and who exploit their high-ranking positions for personal gain. In “Talking About Cattle,” the author expresses the spirit of cattle. Indeed, the spirit of cattle can also be seen as Mr. Pei’s own mindset—peaceful, hardworking, selfless, and undeterred in the face of societal challenges. Isn’t this precisely the spirit of “frowning and coldly facing the criticism of thousands, bowing down to serve as a humble ox,” as described by Lu Xun? In “Commentary on the TV Series ‘Taiping Heavenly Kingdom,’” the author uses his extensive knowledge of history and literature, his unique scholarly insights, and his quick, artistic discernment to express a strong sense of concern for society and life. At the same time, in “Remembering Mr. Guo Weiping” and “Medical Ethics Across the Loess Plateau—Famous Calligraphy and Painting in Nine Provinces,” the author speaks with simple, concise, elegant, and beautiful language, expressing his deep longing for his friends and his father. These writings are simple yet tender, heartfelt and sincere.

In today’s society, it’s almost impossible to find a true scholar. If someone declares themselves a scholar, they may end up offending others. Though debates between folk writers and intellectuals have raged for years, there is still no definitive answer. Today, we see beautiful women writers writing about their bodies, while tomorrow we may see fashionable university professors writing in a fast-food style. Amidst this restless literary environment, there are still many elderly intellectuals like Mr. Pei Zhengxue who uphold the spirit of “bearing the weight of righteousness on their shoulders, crafting wonderful works with their skilled hands.” I firmly believe that in just a few years, Mr. Pei will present even more outstanding works to readers. May Mr. Pei live a long and healthy life, producing more masterpieces in the future.

December 26, 2006, originally published in Tianshui Daily

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Pei Zhengxue Clinical Collection, Volume II Pei Zhengxue’s Hands of Medicine: Crafting Miracles Zheng Fangjiang, China Traditional Chinese Medicine News Born into a family of traditional Chinese medicine practitioners, he went on to study at a Western medicine university, combining the strengths of traditional Chinese medicine with the advantages of Western medicine—and thus making the “Pei School” a beacon of hope in the field of Chinese and Western medicine today. He possesses hands that can bring life back to the sick, having formulated the “Sixteen-Character Principle” for treating diseases with both Chinese and Western medicine; and he has a pair of pens that can create brilliant works, writing books and making contributions to the world. As the Zuo Zhuan, Year 24 of Duke Xiang, states: “First comes moral integrity, then achievements, and finally words.” This is the goal and ideal of many benevolent and ambitious individuals throughout history—and Mr. Pei’s life can perfectly be summed up by the phrase “three kinds of achievement.” He is Pei Zhengxue, a specialist in integrated Chinese and Western medicine at Gansu Provincial Cancer Hospital. Moral Integrity: Crafting Miracles with Hands of Medicine In 1972, Pei Zhengxue, who worked in the internal medicine department of a hospital in Tianshui, Gansu, treated a patient named Ma Changsheng, a young soldier suffering from leukemia. Despite intensive treatment at both the army hospital and local hospitals, his condition did not improve at all. Ma Changsheng’s parents were always hopeful, and when his hemoglobin level dropped to just 2g, they decided to try their luck and seek treatment from Pei Zhengxue. At that time, the primary treatments for leukemia both domestically and internationally were chemotherapy. Pei Zhengxue used traditional Chinese medicine’s diagnostic methods and the combination of Chinese and Western medicine to develop a treatment plan for Ma Changsheng. After just one month of medication, his fever subsided; after one year of taking traditional Chinese medicine, a miracle occurred: Ma Changsheng’s hemoglobin level rose to 14g, and multiple bone marrow smear tests all showed complete remission. Ma Changsheng recovered and has remained healthy ever since, with no recurrence. The same thing happened to a patient who had advanced pancreatic cancer. Zhou Xiang…

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Chapter 17: Newspaper Abstract Zhou Xiang was a wheat expert in Gansu Province, who was diagnosed with advanced pancreatic cancer in early 2010. Subsequently, accompanied by his family, he went to a major hospital in Shanghai for further examinations and treatment. Because Zhou Xiang’s condition had already deteriorated severely, and he was nearly 70 years old, doctors told him that he could no longer undergo chemotherapy or surgery—his prognosis was only three months left, and he should return home to rest and recover.

Input: Kexian: Blood pressure 13/8 kPa, intraocular pressure is not high, left eye vision 0.2, right eye vision 0.8, macular edema is obvious, central reflex of light has disappeared, accompanied by slight exudation, conjunctiva of the eyeball is congested, retinal vessels are tortuous. The patient reports blurred vision, distorted vision, decreased visual acuity, photophobia and tearing. The tongue is red with a white, slightly greasy coating, and the pulse is wiry and fine. Diagnosis: Central retinitis. Syndrome differentiation: Damp-heat in Liver Meridian with blood stasis, Yin deficiency with excess Fire. Treatment principle: Clear heat and remove dampness, activate blood circulation and resolve stasis, nourish Yin and descend Fire. Prescription: Danzhi Xiaoyao San, Qiju Dihuang Tang, Gui Zhi Fuling Wan with modifications. Herbal composition: Gui Zhi 10g, Fuling 10g, Danpi 6g, Taoren 10g, Zhizi 10g, Danggui 10g, Baishao 10g, Chaihu 10g, Baizhu 10g, Fuling 10g, Gancao 6g, Qiju Zi 10g, Juhua 10g, Shengdi 10g, Shan Yao 10g, Shan Zhu Rou 10g, Ze Xie 10g, Bai Ti Li 20g, Shi Jue Ming 15g, Mu Che Cao 10g. In the second consultation, after taking 10 doses of medication, left eye vision improved to 0.4, right eye vision to 1.2; macular edema was reduced. The original formula included Ze Xie 30g, Baizhu 30g, and Zhu Ling 10g, enhancing the effect of promoting water metabolism and removing dampness. After 10 doses, the condition improved further. In the third consultation: left eye vision improved to 0.8, right eye vision to 1.2, macular edema improved, and the central reflex of light returned to normal. The above formula was modified by removing Ze Xie and Zhu Ling, adding Danshen, Chishao, Sanling, and Ezhong to activate blood circulation and resolve stasis, while softening scars. Continued treatment for one month, and the patient’s condition recovered completely.

According to the clinical presentation, the main symptoms of central retinitis include decreased visual acuity, distorted vision, and darkening of the macular area on fundus examination, along with retinal edema. These conditions are often associated with colds, excessive work, mental stress, lack of sleep, or excessive smoking and drinking. The primary pathogenic mechanisms include damp-heat in Liver Meridian with blood stasis, and Yin deficiency with excess Fire. Danzhi Xiaoyao San helps to regulate liver and gallbladder qi, Qiju Dihuang Tang nourishes Yin and clears Fire, Bai Ti Li, Juhua, Shi Jue Ming, and Mu Che Cao clear the liver and improve eyesight, Gui Zhi Fuling Wan activates blood circulation and resolves stasis, while Danshen, Chishao, Sanling, and Ezhong activate blood circulation and resolve stasis, softening scars.

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Chapter Sixteen: Pei’s Prescriptions (7) Varicocele [Case] Ma, male, 34 years old, with lower abdominal pain, radiating to the testes with a feeling of heaviness and distension, fear of cold, frequent urination, clear and long urine, red tongue with a white, greasy coating, and a wiry, fine pulse. Physical examination: a cord-like hardening can be palpated on the medial inguinal region. Ultrasound showed varicocele on the left side. Diagnosis: epididymitis, varicocele. Syndrome differentiation: Cold congealing Liver Meridian, Qi stagnation and blood stasis. Treatment principle: warm the liver and dispel cold, transform stasis and regulate Qi to relieve pain. Prescription: Tiantai Wuyao San, Gui Zhi Fuling Wan. Herbal composition: Wuyao 10g, Muxiang 6g, Huaxiang 10g, Qingpi 6g, Gaoliangjiang 6g, Binlang 10g, Chuan Lianzi 15g, Gui Zhi 10g, Danpi 6g, Taoren 10g, Baishao 10g, Fuling 10g, Gancao 6g, Ju He 15g, Lizhi He 15g, Yuan Hu 10g. In the second consultation, after taking 7 doses of medication, testicular swelling and pain subsided, but pain in the inguinal region persisted. The prescription was modified with 10g Jingjie, 10g Fangfeng, 15g Chuichuanwu each (first decocted for 1 hour), 10g Duohuo, 5g Quanxie, 10g Danggui, 10g Chuanxiong. After more than 30 doses, the varicocele improved, and the epididymitis was cured. According to the clinical presentation, lower abdominal pain and testicular heaviness with radiating to the testes, along with clear and long urine, indicate cold congealing Liver Meridian and Qi stagnation with blood stasis. Wuyao, Xiaoxiang, Muxiang, and Qingpi warm the liver and dispel cold, regulating Qi and relieving pain; Danggui, Chuanxiong, Yuan Hu, and Chuan Lianzi transform stasis and relieve pain; Ju He and Lizhi He soften and disperse nodules to relieve pain; Chuichuanwu and Quanxie dispel cold and eliminate arthritis to relieve pain. The toxic nature of Quanxie makes it an important medicine for treating inguinal pain when combined with other herbs. References

[1] Fan Yongsheng. Jin Gui Yao Lü [M]. Beijing: China Traditional Chinese Medicine Press, 2007, pp. 228–290.

[2] Pei Zhengxue. New Compilation of Chinese Medicine Formulas [M]. Lanzhou: Gansu Science and Technology Press, 2008, pp. 199–200.

[3] Luo Yuanqi. Chinese Medicine Obstetrics and Gynecology [M]. Shanghai: Shanghai Science and Technology Publishing House, 1989, p. 150.

[4] Pei Zhengxue. A Brief Discussion on Gui Zhi Fuling Wan [M]. Collection of Medical Talks and Case Studies by Pei Zhengxue, Lanzhou: Gansu Science and Technology Press, 2005, p. 2, p. 17.

[5] Xiong Manqi. On Cold Damage [M]. Beijing: China Traditional Chinese Medicine Press, 2007, p. 104.

[6] Fan Yongsheng. Jin Gui Yao Lü [M]. Beijing: China Traditional Chinese Medicine Press, 2007, p. 6:

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Pei Zhengxue Clinical Collected Volume II pp. 319–320.

[7] Lü Jingshan. Shi Jinmo’s Drug Combinations [M]. Beijing: People’s Military Medical Press, 2010, pp. 358–359.

October 2013, Gansu Medicine

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Chapter Sixteen: Pei’s Prescriptions Professor Pei Zhengxue’s Techniques for Handling Middle-Aged and Elderly Patients Zhao Xiaopeng, Wang Xin, Chen Guangyan [Abstract] This article introduces Professor Pei Zhengxue’s techniques for diagnosing and treating common diseases in middle-aged and elderly patients, including circulatory, metabolic, digestive system disorders, bone and joint diseases, gynecological disorders, respiratory diseases, and malignant tumors. Professor Pei often combines the four diagnostic methods—observation, inquiry, palpation, and auscultation—when seeing patients, with observation focusing primarily on body shape, complexion, and posture. Inquiry is then used to gather information about the chief complaint, current medical history, and past medical history. Additionally, palpation is also crucial, especially in diagnosing circulatory and metabolic disorders as well as digestive system diseases. [Keywords] Techniques; Diagnosis; Pei Zhengxue; Middle-Aged and Elderly Patients Document Identification Code: A; Article Number: 1004–2725(2013)12–0939–03

Professor Pei Zhengxue (hereafter referred to as “Old Master Pei”) is a renowned expert in integrated traditional Chinese and Western medicine in China, a lifetime director of the Chinese Association of Traditional Chinese Medicine, and one of the first group of renowned senior TCM physicians in Gansu Province. With over fifty years of clinical experience, he is highly experienced and skilled in integrating TCM and Western medicine to treat common and frequently occurring diseases in middle-aged and elderly patients. He is widely known throughout Gansu Province and deeply trusted and loved by many patients. I had the privilege of studying under him and discovered that Old Master Pei pays great attention to the techniques involved in diagnosing and treating middle-aged and elderly patients. Below, we will introduce some of Old Master Pei’s techniques for handling these patients.

I. Characteristics of Disease in Middle-Aged and Elderly Patients Unlike young people, middle-aged and elderly patients exhibit distinct characteristics in their disease patterns. Due to age-related changes, the structural integrity of the body in middle-aged and elderly patients undergoes degenerative changes, leading to reduced physiological functions and increased susceptibility to disease. Combined with long-term exposure to environmental risk factors and the accumulation of chronic illnesses, middle-aged and elderly patients become a population prone to chronic diseases. Common chronic conditions include atherosclerosis, hypertension, type 2 diabetes, metabolic syndrome, chronic cholecystitis, chronic pancreatitis, chronic obstructive pulmonary disease, and malignant tumors. Moreover, in addition to hormonal changes, middle-aged and elderly women are also more likely to develop degenerative osteoarthritis and gynecological disorders. II. Old Master Pei’s Techniques for Handling Middle-Aged and Elderly Patients (A) Circulatory and Metabolic Disorders When treating middle-aged and elderly patients, Old Master Pei first observes their physical form, then performs pulse diagnosis. If a patient is overweight, their pulses are wiry and long, with a deep, weak radial pulse and a floating, strong central pulse, Old Master Pei suspects they may have hypertension. According to Old Master Pei’s experience, approximately 70% of such patients also have hypertension, while the remaining 30% may not necessarily have hypertension, and some patients were originally found to have low blood pressure in their youth. At this point, the suspicion of hypertension and atherosclerosis becomes clear. Next, Old Master Pei asks whether the patient experiences dizziness, headache, tinnitus, blurred vision, chest tightness, palpitations, shortness of breath, or pain in the precordial region, to determine if they have cerebral atherosclerosis or coronary heart disease. Afterwards, Old Master Pei checks the patient’s blood glucose, blood lipids, and serum uric acid levels to assess whether they have hyperglycemia, hyperlipidemia, hyperuricemia, gout, or metabolic syndrome. If the patient reports abnormal urine tests, Old Master Pei must carefully differentiate between atherosclerotic renal damage, nephrogenic hypertension, and diabetic nephropathy, as these conditions are often difficult to distinguish based solely on medical history and symptoms alone. (B) Digestive System Disorders If the patient’s six pulses are wiry, smooth, and strong, with a dominant central pulse, and their tongue is dark red with a thick, greasy yellow coating, Old Master Pei should first ask whether the patient experiences bitter taste in the mouth or discomfort in the right flank, extending to the shoulder and back, to determine if there are lesions in the gallbladder or bile ducts—such as inflammation, stones, or post-cholecystectomy syndrome. In most cases, the patient’s responses are affirmative. Then, Old Master Pei asks whether the patient experiences discomfort in the left flank to determine if they have chronic pancreatitis. Next, Old Master Pei asks whether the patient experiences discomfort in the upper abdomen, behind the sternum, or in the throat to determine if they have bile reflux gastritis, esophagitis, or pharyngitis. Based on his many years of clinical experience, Old Master Pei has learned that hepatitis B and autoimmune liver disease can often be complicated by cholecystitis. Clinically, this manifests as right flank pain extending to the shoulder and back. Therefore, when treating patients with cholecystitis, Old Master Pei also asks whether they have a history of hepatitis B or autoimmune liver disease, to avoid missing a diagnosis and delaying treatment.

(C) Bone and Joint Disorders Due to hormonal changes and the wear and tear of joint cartilage, middle-aged and elderly patients often suffer from degenerative osteoarthritis. Rural patients, who engage in strenuous labor, are more likely to develop rheumatoid arthritis and rheumatoid arthritis. Therefore, when treating middle-aged and elderly patients without obvious joint deformities or limited range of motion, Old Master Pei often asks them whether they experience joint stiffness or pain. If patients do have joint problems, Old Master Pei also asks whether they have gastrointestinal symptoms, as well as hypertension or diabetes, because long-term use of traditional Chinese medicine or Western medicine for joint pain can easily irritate the stomach and lead to elevated blood pressure and blood sugar levels. (D) Gynecological Disorders For middle-aged and elderly women, Old Master Pei first observes their facial appearance, then performs pulse diagnosis, and finally asks about their menstrual cycle. If the patient’s face is flushed, with six pulses that are wiry and rapid, often indicating early menstruation or dysmenorrhea, it suggests internal heat, where heat forces blood to flow; if the patient’s face appears pale or even develops dark spots or melasma, with slow, fine pulses, it often indicates late menstruation or scanty menstrual flow, suggesting cold or qi and blood deficiency; if the patient’s face is dull and the pulse is wiry and tense, it often indicates dark-colored menstrual flows or prolonged, irregular bleeding, suggesting qi stagnation and blood stasis. Middle-aged and elderly women, especially those in perimenopause, often experience endocrine dysfunction, sometimes accompanied by organic lesions. Observing color and pulse, and asking detailed questions about the menstrual cycle, helps to gain a comprehensive understanding of the condition and to tailor treatment accordingly. (E) Respiratory Diseases Chronic Obstructive Pulmonary Disease (COPD) develops slowly due to chronic lung lesions, often triggered by acute colds. If the patient’s face is cyanotic, their lips are purplish, they cough, wheeze, and have phlegm, with a dark red or pale, moist tongue, a thick, greasy yellow coating, and a floating, rapid pulse, it often indicates an acute exacerbation of COPD. Old Master Pei frequently checks for signs such as hepatomegaly, ascites, lower limb edema, and jugular vein distension to determine if the patient has right heart failure. To trace the root cause, Old Master Pei also often examines the throat for redness or swelling, asking whether the patient experiences throat discomfort, nasal congestion, runny nose, or forehead pain, to determine if they have chronic pharyngitis, chronic rhinitis, sinusitis, or other upper respiratory tract disorders. In addition, Old Master Pei asks about relevant medical history and symptoms to determine if the patient has gastroesophageal reflux disease or pneumoconiosis, thereby clarifying the cause and providing targeted treatment. (F) Malignant Tumors Malignant tumors are common among middle-aged and elderly patients. For these patients, Old Master Pei often reassures them, saying, “Although this disease is complex, with gradual treatment, you can alleviate suffering, improve quality of life, and extend survival.” This helps patients reduce their fear of the disease and increases their confidence in fighting it. Old Master Pei also encourages them to continue taking medication, focusing on tonifying the body and strengthening the fundamental principles of health, preserving gastric qi and vital energy, and attacking the pathogen at the appropriate time. Most patients can alleviate their suffering, improve their quality of life, and extend their survival; some patients can even achieve complete recovery. III. Summary In conclusion, Old Master Pei often combines the four diagnostic methods—observation, inquiry, palpation, and auscultation—when treating patients. Observation is paramount, as “to see what is hidden, one must look closely,” and the focus of observation is on body shape, complexion, and posture. Inquiry is next, with the emphasis on the chief complaint, current medical history, and past medical history. Additionally, palpation is also crucial, especially in diagnosing circulatory and metabolic disorders as well as digestive system disorders. Middle-aged and elderly patients often suffer from multiple diseases simultaneously, with a wide variety of symptoms and complex conditions. Old Master Pei has learned through clinical experience that only by mastering certain diagnostic techniques can one quickly grasp a patient’s condition, identify the core issues underlying the disease, and prescribe effective formulas tailored to the primary symptoms. References [1] Zhao Kehong, Shen Jiangming. Clinical Investigation and Analysis of Common Chronic Diseases in Hospitalized Elderly Patients [J]. South China Journal of Defense Medicine, 2005, 19(4):34–36. [2] Zhang Guiqiong. Pei Zhengxue Clinical Collected Works [M]. Lanzhou: Gansu Science and Technology Press, 2012:20. [3] Pei Zhengxue. Collection of Pei Zhengxue’s Medical Experiences [M]. Lanzhou: Gansu Science and Technology Press, 2008:311–312.

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Chapter Sixteen: Pei’s Prescriptions Clinical Applications of Xuefu Zhuyu Tang Zhan Wenguo [Abstract] By reviewing clinical cases where Professor Pei Zhengxue used Xuefu Zhuyu Tang as a base formula and achieved excellent therapeutic results, we present representative cases for colleagues’ exchange and learning. [Keywords] Xuefu Zhuyu Tang; Pathogen Analysis; Clinical Cases; Pei Zhengxue Xuefu Zhuyu Tang is derived from Wang Qingren’s “Yilin Gai Cuo,” composed of ingredients such as angelica sinensis, rehmannia glutinosa, peony root, peach kernel, safflower, bupleurum, citrus peel, achillea millefolium, platycodon grandiflorus, and licorice. It has the effects of activating blood circulation, resolving stasis, and regulating qi to relieve pain. It is primarily indicated for blood stasis in the chest, clinically manifesting as chest tightness, palpitations, chest pain, headaches, restless sleep, hot flashes in the back of the head, hiccups, nausea, and irritability. The tongue is dark red with bruise-like spots on the edges, and the pulse is wiry and tight. According to my clinical experience following Professor Pei Zhengxue, this formula, with additions and subtractions, has been used to treat several stubborn diseases with remarkable efficacy. Below, we report a case study. I. Coronary Heart Disease

[Case] Wang, male, 50 years old, presented with chest tightness, shortness of breath, and dizziness for one month. He experienced chest pain, restlessness, dry mouth, irritability, tension in the top of his head and the back of his head, poor sleep, frequent dreams, a dark red tongue with bruise-like spots on the edges, a white, oily coating, and a wiry, tight pulse. His blood pressure was 140/90 mmHg (1 mmHg = 0.133 kPa), and his triglyceride level was 2.8 mmol/L. Diagnosis: primary hypertension with atherosclerosis, coronary heart disease. Traditional Chinese Medicine diagnosed him as having excess liver yang rising, qi stagnation and blood stasis. Treatment focused on calming the liver and lowering yang, activating blood circulation and resolving stasis. The prescription was Xuefu Zhuyu Tang combined with Guatou Xiebai Banxia Tang with modifications. Red flower 6g, angelica sinensis 10g, peony root 10g, bupleurum 10g, citronella 10g, salvia 20g, bupleurum 10g, citrus peel 10g, achillea millefolium 15g, morinda officinalis 15g, gastrodia 10g, Uncaria rhynchophylla 15g, wind-resistant herb 10g, fragrant grass 10g, and creeping thyme 10g. The formula was decocted and taken once daily. In the second consultation, after taking the medication, his headache and dizziness lessened, his blood pressure dropped, and his sleep remained poor. The prescription was modified with 10g roasted ziziphus seeds and 10g polygala root, and after seven doses, he fully recovered. Commentary: Hypertension arises from yin deficiency and yang excess, with water failing to nourish wood, leading to dizziness and headache. Dry mouth and insomnia result from liver qi stagnation. When liver qi is blocked, blood stasis forms, causing headaches and tension in the head. When qi stagnates, blood becomes stagnant, resulting in chest tightness and shortness of breath. Peony root, bupleurum, safflower, citronella, and salvia activate blood circulation and resolve stasis, expanding coronary arteries; bupleurum and citrus peel soothe the liver and regulate qi, opening up the chest and dispersing stasis; achillea millefolium guides blood downward; raw turtle shell, raw dragon's blood, gastrodia, and Uncaria rhynchophylla nourish yin, calm yang, and soothe the liver to stop wind. Experimental studies have shown that Xuefu Zhuyu Tang improves microcirculation, dilates blood vessels, increases blood flow to ischemic organs, lowers blood lipids and blood pressure, prevents atherosclerosis, protects against myocardial ischemia, prolongs clotting time, and increases pain threshold. [3] II. Neural Pain

[Case] Li, female, 35 years old. She had headaches accompanied by insomnia for 10 years. A CT scan of her head revealed no abnormalities. She experienced headaches on both sides, with a feeling of tightness and a needle-like pain in her head, which worsened after emotional distress or exposure to cold. Her menstrual cycle was delayed by one week, and she experienced abdominal pain during menstruation. Her tongue was red, with a thin, white coating and bruise-like spots on the edges, and her pulse was wiry and tight. Diagnosis: neural headache, menstrual irregularities. Traditional Chinese Medicine diagnosed her as being affected by wind invading the crown, with cold congealing blood stasis. Treatment focused on dispersing wind and cold, activating blood circulation and resolving stasis. The prescription was Xuefu Zhuyu Tang combined with Qing Shang Qun Tang. Red flower 6g, angelica sinensis 10g, peony root 10g, bupleurum 10g, rehmannia glutinosa 12g, bupleurum 10g, licorice 6g, angelica dahurica 6g, asarum 3g, clematis armandii 10g, wind-resistant herb 10g, fragrant grass 10g, creeping thyme 10g, and one centipede. The formula was decocted and taken once daily. In the second consultation, after taking the medication, her headaches lessened, and her menstrual pain also improved. The original formula was modified with ligusticum wallichii and motherwort to regulate menstruation and relieve pain; after two months of continuous treatment, her condition fully recovered. Commentary: The head is the meeting place of all yang energies, “only wind can reach the crown.” When external wind and cold invade the solar meridian and affect the crown, clear yang is blocked, leading to headaches. Yang deficiency causes cold to congeal, and cold leads to contraction; when the uterus is cold and blood stasis occurs, menstrual cycles are delayed, and abdominal pain occurs during menstruation.

Input: Zhou Xiangchun returned to Lanzhou when his health was already extremely weak; he remained bedridden for most of the day, and suffered from diarrhea more than 20 times a day, causing him great suffering.

Later, upon his friend's recommendation, his family took Zhou Xiangchun to see Pei Zhengxue for treatment. After more than six months of treatment using traditional Chinese medicine methods, Pei Zhengxue, who was already over 70 years old, saw a miracle: Zhou Xiangchun’s CT scan showed that the pancreatic head cancer had shrunk from 4.8 cm × 4.2 cm to 2.1 cm × 1.8 cm, and his diarrhea had decreased to 3–4 times per day. Every morning, after taking traditional Chinese medicine and receiving an intravenous infusion of white protein at the hospital, Zhou Xiangchun could go home on his own in the afternoon—and even went to report work at the Gansu Provincial Department of Science and Technology, where he was able to participate in several science and technology activities organized by the province. This brought great joy to his family, and allowed Zhou Xiangchun to regain his former vigor.

Achievements: The 16-character principle spread far and wide across the country. In the 1990s, Pei Zhengxue’s “Western medical diagnosis, Traditional Chinese Medicine syndrome differentiation, Traditional Chinese Medicine as the primary treatment, Western medicine as a supplementary approach” 16-character principle gained widespread attention within China’s TCM and Western medicine communities, and the “Pei School” became an important school of thought in the field of TCM and Western medicine today.

Pei Zhengxue’s student Cai Zhengliang told reporters that Pei Zhengxue’s 16-character principle was primarily compiled in his book “Collected Medical Experiences of Pei Zhengxue.” The first part of the book focuses on academic thought, primarily detailing Pei Zhengxue’s theories on the integration of TCM and Western medicine; the middle part covers clinical practice, mainly presenting cases and successful experiences of Pei Zhengxue’s application of TCM and Western medicine in treating various diseases; the final part consists of reports from his students, sharing their personal insights and experiences in applying Pei Zhengxue’s teachings across different regions. Throughout the book, Pei Zhengxue’s ideas on the “sixteen-character principle” of integrating TCM and Western medicine are central, representing a significant contribution to the theoretical research on TCM and Western medicine in China.

Because Pei Zhengxue used integrated TCM and Western medicine approaches to treat many complex and difficult-to-treat conditions, coupled with the influence of his online consultations on Weibo, patients from Inner Mongolia, Xinjiang, Guangzhou, Beijing, and other places flocked to seek his treatment. According to feedback from some patients in Beijing, their illnesses had been treated unsuccessfully in major hospitals in Beijing for a long time—but Pei Zhengxue’s simple prescriptions were able to cure their ailments, allowing them to…

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Pei Zhengxue Clinical Collected Volume II As a result, doctors at some hospitals in Beijing specifically requested Pei Zhengxue’s prescriptions from patients, studied them carefully, and copied the formulas for use in treating patients with similar conditions.

Speaking of words: A doctor who is both a healer and a scholar, leaving behind a fragrant legacy of ink. The contemporary masterpiece on internal medicine integrating TCM and Western medicine, “Practical Internal Medicine of TCM and Western Medicine,” edited by Pei Zhengxue, won the “International Gold Award for Outstanding Contribution” at the Third World Conference on Traditional Medicine held in the United States in 1996. Pei Zhengxue himself was honored as one of the “100 World Stars of Ethnic Medicine,” and in 1997, he was recognized by the State Administration of Traditional Chinese Medicine as one of the 500 nationally renowned veteran TCM physicians.

In the 1970s, Pei Zhengxue meticulously read the representative works of modern TCM masters such as Tang Rongchuan, Zhang Xichun, and Shi Jinmo. He devoted particularly deep study to Tang Rongchuan’s “On Blood Disorders,” gaining profound insights into the subject. During the Cultural Revolution, Pei Zhengxue worked tirelessly for two years to complete “Commentary on ‘Blood Disorders,’” which was published in 1978. After its release in Japan, the book drew significant attention and strong reactions from the academic community. In 1985, Tian Rongyi, President of Shigaoka University of Medicine in Japan, traveled specially to Lanzhou to consult Pei Zhengxue about issues related to the book. Based on the theories presented in the book, Pei Zhengxue developed a specialized formula for treating leukemia, which was officially designated as the “Lanzhou Formula” at the National Hematology Conference in 1974.

Pei Zhengxue’s student Chen Guangyan told reporters that during his career as a physician, apart from five and a half days a week spent in outpatient clinics, Pei Zhengxue spent the rest of his days—decades-long—daily in his renowned TCM inheritance studio. He delved into the teachings of Qihuang, summarized patient cases, and developed medicinal formulas; what truly delighted him was his relentless dedication to writing and publishing books, including 15 major works such as “New Compilation of TCM Formulas,” “Diagnosis and Treatment of Hepatitis B,” “Pharmacology and Clinical Applications of Rheum,” and “New Compilation of Warm Disease Studies.” While serving as Vice President and Secretary-General of the Gansu Provincial Association for Integrated TCM and Western Medicine, he also founded the journal “Integrated TCM and Western Medicine Research” and served as its editor-in-chief.

Pei Zhengxue possessed not only the skill of “dual spring,” but also the gift of eloquent prose; under his guidance, every word he spoke—whether it was laughter or anger—could be turned into a literary masterpiece. While compiling medical works, he also published collections of novels and essays such as “Great Wind Songs,” as well as poetry and prose collections like “Spring Breeze Songs,” “Autumn Breeze Songs,” “Pei Zhengxue Calligraphy Collection,” and “Introductory Notes on Medicine in Handwriting.” This February, his new work “Pei Zhengxue’s Health Weibo” and his collection of poetry and calligraphy, “Snowy Footprints on the Mud,” were published and released, marking yet another testament to his 55 years of medical practice.

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Chapter 17: Newspaper Summaries Pei Zhengxue: Not a Good Minister, But a Good Physician Zheng Fangjiang, Qi Qin “Thank you, Professor Pei Zhengxue, for your superb medical skills—throughout our lives, you’ve shown us what it means to be a true physician with a compassionate heart. You always manage to ease our psychological burdens with a smile, bringing hope for life to our entire family.” These were the words of a patient who wrote a letter of gratitude to Professor Pei Zhengxue. Online, countless heartfelt expressions of appreciation for Professor Pei Zhengxue abound: “My father’s illness had relapsed for many years, and we only found you when we were at our wits’ end. Just after taking two doses of the medicine you prescribed, his condition began to improve. I would like to take this opportunity to sincerely thank you…” … Three generations of Qihuang are not remarkable—learning medicine should always aim to become a good physician.

Pei Zhengxue is a renowned expert in the integration of TCM and Western medicine in China, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, and a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Institute of Medical Sciences. Born into a family steeped in TCM, Pei Zhengxue’s grandfather, Pei Shaojian, dedicated his life to healing others, while his father, Pei Shen, was one of the ten most famous TCM physicians in modern Gansu. Influenced by the rich medical environment of his family, Pei Zhengxue made a solemn vow from a young age: “If I cannot become a good minister, then I will become a good physician.” Later, he entered the Medical Department of Xi’an Medical University with excellent grades, truly beginning his more than 50-year journey of practicing medicine and saving lives.

Through continuous expansion of his clinical practice, Pei Zhengxue also achieved remarkable results in medical research. In 1980, his book “Commentary on Blood Disorders” was published and distributed, sparking a strong response after its release in Japan. In May 1985, Professor Tian Rongyi, President of Shigaoka University of Medicine in Japan, traveled specially to Lanzhou to consult Pei Zhengxue about issues related to the book. In the 1990s, Pei Zhengxue’s “16-character principle”—Western medical diagnosis, TCM syndrome differentiation, TCM as the primary treatment, Western medicine as a supplementary approach—gained widespread attention within China’s TCM and Western medicine communities, becoming an important school of thought in the field of integrated TCM and Western medicine today.

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Pei Zhengxue Clinical Collected Volume II Pei Zhengxue’s contemporary masterpiece on internal medicine, “Practical Internal Medicine of TCM and Western Medicine,” published in 1996 at the Third World Conference on Traditional Medicine, won the “International Gold Award for Outstanding Contribution”; in 1997, the State Administration of Traditional Chinese Medicine recognized Pei Zhengxue as one of the 500 nationally renowned veteran TCM physicians.

To care for the people, to bring them comfort and hope—this is the spirit of a true physician. “Old Fengshan’s voice still echoes endlessly.” At the age of 76 this year, when a devastating earthquake struck the Loess Plateau, Pei Zhengxue continued to travel to major provincial hospitals to treat patients, dedicating himself with unwavering energy, giving back to the land that had nurtured him with the spirit of a true son.

Since beginning his medical career, Pei Zhengxue has always approached his patients with a “compassionate heart,” offering warmth and care to patients like a gentle rain over decades. “Yesterday I went to the countryside, but when I returned, I felt uneasy. A young patient suffered from a minor illness, yet he lost his life due to poverty.” This was a small poem Pei Zhengxue composed while practicing medicine, titled “Compassion for the Poor,” and throughout the lines, one can clearly feel his deep concern and compassion for those who lived in poverty. Every year, there are patients like this who come to visit Mr. Pei Zhengxue. Once a freshman at Lanzhou University, he unfortunately contracted “ALL Acute Lymphoblastic Leukemia.” Despite numerous rounds of chemotherapy and other treatments, his condition did not improve significantly. At the most critical moment of his life, Pei Zhengxue saved this university student who was struggling on the brink of death.

His name was Liu Ligang. Pei Zhengxue cured his leukemia, restoring his bone marrow and blood counts to normal. After three years of treatment and recovery, Liu Ligang returned to school, completed his bachelor’s degree, and later went on to pursue graduate studies. “I will forever be grateful for his lifesaving kindness,” said a patient who had been healed by Old Master Pei. “He would see patients even without a scheduled appointment—he would cover the costs for patients who couldn’t afford treatment.” “He treated men, women, young children, the rich, the poor—without discrimination.” These praises were shared by Pei Zhengxue’s colleagues, disciples, and patients alike. In their eyes, Mr. Pei was a kind elder, a physician who saved lives and cared for others, and above all, a great man of virtue and righteousness—a white-clad angel who gave his all to save lives.

An old ox knows its sunset is short—yet it keeps striding forward without needing to be urged on.

In 2011, Pei Zhengxue’s “Practical Internal Medicine of TCM and Western Medicine” (Revised Edition) was published.

The inaugural event was held in Lanzhou. 2013 marked Pei Zhengxue’s 75th birthday and the 55th anniversary of his contributions to medicine, education, and research. His new work, “Pei Zhengxue’s Health Weibo,” was released.

For decades, Pei Zhengxue spent his days—except for five and a half days a week in outpatient clinics—spending the rest of his time in his renowned TCM inheritance studio. He worked diligently, never stopping to write, developing new theories, and publishing 15 major medical works, including “New Compilation of TCM Formulas,” “Selected Cases of Pei Shen,” and “Pei Zhengxue’s Medical Notes.” While serving as Vice President and Secretary-General of the Gansu Provincial Association for Integrated TCM and Western Medicine, he also founded the journal “Integrated TCM and Western Medicine Research” and served as its editor-in-chief.

Pei Zhengxue was a versatile TCM master who achieved remarkable accomplishments in poetry, calligraphy, and painting. In recent years, he published collections of novels and essays such as “Great Wind Songs,” as well as poetry and prose collections like “Spring Breeze Songs,” “Autumn Breeze Songs,” and calligraphy and painting collections including “Pei Zhengxue Calligraphy Collection” and “Introductory Notes on Medicine in Handwriting.”

“I’m currently answering questions from patients who send me messages via Weibo, along with my doctoral students. I’ve already answered 5 questions, and I still have 2 left—please wait a moment while you enjoy your tea.” During an interview with reporters, Pei Zhengxue was busy answering patients’ questions through Weibo. He constantly learned new technologies, striving to help more people understand TCM and master its therapeutic methods.

Even in his advanced years, Pei Zhengxue continued to serve patients day after day, year after year. For the sake of medical advancement, he generously shared his lifelong knowledge with his disciples, nurturing a generation of talented practitioners who now flourish across the Loess Plateau and have become the backbone of TCM clinical practice.

“An old ox knows its sunset is short—yet it keeps striding forward without needing to be urged on.” Pei Zhengxue often used this verse as a source of encouragement. Though he was over 70 years old, he continued to fight tirelessly on the front lines of medicine, saving lives, training new generations, engaging in literary and artistic creation, and continuing to shine brightly, making new contributions to society. Looking back over seven decades, Pei Zhengxue’s life was filled with brilliance, proving that a true physician with a compassionate heart must possess the responsibility and commitment of a great healer.

February 28, 2014, China Traditional Chinese Medicine News

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Pei Zhengxue Clinical Collected Volume II Pei Zhengxue’s Long Road of Writing Zheng Fangjiang, Qi Qin, China Traditional Chinese Medicine News At 75 years old, Pei Zhengxue, a renowned TCM and Western medicine scholar in China, a lifetime member of the Chinese Society of Traditional Chinese Medicine, a member of the editorial board of China Journal of TCM and Western Medicine, a renowned TCM physician in Gansu Province, and a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Cancer Hospital, has written extensively over the years, never stopping to write. He has published more than 20 large-scale monographs, authored 86 papers, and received over 20 scientific awards at various levels. Professor Pei Zhengxue is a prominent TCM scholar in China, Honorary Chairman of the Gansu Provincial Association for Integrated TCM and Western Medicine, an expert who enjoys a special government allowance, one of the first 500 nationally renowned veteran TCM physicians, and a mentor guiding the academic experience of senior TCM experts nationwide. He has long been dedicated to the cause of TCM and Western medicine integration, and his “16-character” clinical treatment guideline for TCM and Western medicine has been widely endorsed by the Ministry of Health, the State Administration of Traditional Chinese Medicine, and the academic community of TCM and Western medicine in China, forming a highly influential TCM and Western medicine school within the country. With 55 years of clinical practice, Pei Zhengxue excels in treating blood disorders, tumors, liver diseases, and various complex and difficult-to-treat conditions, especially with unique insights into the treatment of leukemia, earning him the trust and high praise of patients. He has published 20 monographs, authored 86 academic papers, and received 13 research awards at various levels. Behind these remarkable achievements lies the immense hardship and effort Pei Zhengxue put into forging this brilliant path in life—let us hear his story. From a family steeped in TCM traditions, Pei Zhengxue was born in 1938 in Peijia Zhuang, Lomen Town, Wushan County, Gansu Province, into a family of TCM scholars and a family steeped in scholarly tradition. His grandfather, Pei Shaojian, was a renowned Confucian scholar and physician, known as a respected figure in eastern and southern Gansu. His father, Pei Shen, studied in Nanjing during his early years, attending Central University, where he first learned classical Chinese literature, then established “Shen Gong Middle School” in Lomen Town, Wushan County, serving as its principal. Later, he abandoned his studies to pursue medicine, a compassionate physician with a noble heart…

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Chapter 17: Newspaper Summaries His medical skills were celebrated throughout the Loess Plateau, and his poetry, calligraphy, and painting were equally accomplished. He was known as “Longxiang Board Bridge,” and in 2012, he was honored as one of the ten most famous TCM physicians in modern Gansu Province. Pei Zhengxue was gifted with extraordinary talent, and influenced by his ancestors, he developed a deep passion for TCM. From a young age, he was diligent in his studies, determined to dedicate his life to medicine and to save the people. In 1961, he graduated from the Medical Department of Xi’an Medical University. On the long road of life, he devoted himself to the medical field, practicing medicine, caring for others, mastering artistry, and earning respect through his virtuous conduct. He continued to write and publish, becoming a renowned giant in the domestic TCM and Western medicine fields, a leading figure in the medical community, deeply versed in the classics and the interpretation of “Blood Disorders.”

Pei Zhengxue’s youth was marked by many hardships. In 1958, a nationwide wave of anti-rightist campaigns swept through the country. Pei Zhengxue, who was a sophomore at the time, was wrongly labeled a rightist and subjected to persecution for several months. In 1961, after graduating from university, Pei Zhengxue could have stayed on campus, but during the political review, his family background and his father’s historical status led to his transfer to Tianshui Hospital. During the Cultural Revolution, Pei Zhengxue was labeled as one of the “Black Five Categories” and sent to the remote Ganquan Health Center in Tianshui. Here, Pei Zhengxue did not lose heart or give up; instead, he saw this as a rare opportunity. Even in the freezing winter, he persisted in reciting classic texts like “Shanghan Lun,” “Jin Gui Yao Lü,” and “Neijing Zhi Yao” in the forest every day. Whenever he encountered difficult problems, he sought advice from many sources, discussing and refining his understanding, hoping to gain insight. Unexpectedly, this arduous period laid a solid foundation for his later writings and publications.

Books contain golden houses, books contain beautiful faces. In the 1970s, Pei Zhengxue carefully read the representative works of modern TCM masters such as Tang Rongchuan, Zhang Xichun, Shi Jinmo, Yu Wuyan, and Shi Yi Ren. He devoted particular effort to Tang Rongchuan’s “On Blood Disorders,” gaining profound insights. During the Cultural Revolution, he spent two years writing “Commentary on ‘Blood Disorders,’” which was published in 1978 by People’s Health Publishing House. After its release in Japan, the book attracted significant attention and strong reactions from the academic community.

In April 1982, Professor Tian Rongyi, President of Shigaoka University of Medicine in Japan, traveled specially to Lanzhou to consult Pei Zhengxue about issues related to the book. Based on the theories presented in the book, Pei Zhengxue developed a specialized formula for treating leukemia, which was officially designated as the “Lanzhou Formula” at the National Hematology Conference in 1974. His biography was subsequently included in “Biographies of Contemporary World Celebrities,” “Contemporary TCM Celebrities,” “Contemporary Chinese Famous Doctors Dictionary,” “Chinese Famous People Dictionary,” and “British Cambridge World Celebrities” (Foreign Language Edition). Pei Zhengxue’s integration of TCM and Western medicine gave rise to the “Pei School.”

In February 1992, Pei Zhengxue organized 21 renowned TCM and Western medicine experts from the five northwestern provinces to compile “Practical Internal Medicine of TCM and Western Medicine,” the first contemporary masterpiece on internal medicine integrating TCM and Western medicine. The book, totaling over 150,000 characters in a luxurious hardcover edition, was officially published in May 1995. In April 1996, at the Third World Conference on Traditional Medicine held in the United States, the book won the “International Gold Award for Outstanding Contribution,” followed by the “National Excellent TCM Book First Prize” and the “Gansu Provincial Science and Technology Progress Second Prize.” Pei Zhengxue himself was honored as one of the “100 World Stars of Ethnic Medicine.” The “16-character clinical treatment guideline” he proposed—Western medical diagnosis, TCM syndrome differentiation, TCM as the primary treatment, Western medicine as a supplementary approach—was adopted by Chen Minzhang, then Minister of Health, and became widely recognized within China’s TCM and Western medicine communities, eventually becoming a major school of thought in the field of integrated TCM and Western medicine today.

Based on revisions to existing TCM syndrome differentiation content, Pei Zhengxue and his clinical and academic team incorporated the latest advancements in the field of integrated TCM and Western medicine over the past 20 years. In March 2011, they reissued “Practical Internal Medicine of TCM and Western Medicine (Second Edition),” featuring over 2 million characters. This work received significant attention and support from the Party and the government. Liu Weiping, Deputy Secretary of the Gansu Provincial Committee of the Communist Party of China and Governor of Gansu Province, Li Xiaojie, Member of the Standing Committee of the Gansu Provincial Committee and Head of the Provincial Propaganda Department, Xian Hui, Vice Governor, and Li Peiwén, Secretary-General of the Provincial Government, attended the inaugural event and offered high praise.

Over nearly 40 years since the 1970s, Pei Zhengxue spent his days—except for five and a half days a week in outpatient clinics—spending the rest of his time in his renowned TCM inheritance studio. He pursued the teachings of Qihuang, worked diligently, never stopped writing, developed new theories, and published works such as “New Compilation of TCM Formulas,” “Diagnosis and Treatment of Hepatitis B,” “Pharmacology and Clinical Applications of Rheum,” “New Compilation of Warm Disease Studies,” “Selected Cases of Pei Shen,” “Integrated TCM and Western Medicine Treatment of Common Diseases,” “Pei Zhengxue’s Medical Notes,” “Pei Zhengxue’s Medical Essentials,” and “Pei Zhengxue’s Medical Talks.”

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Chapter Sixteen: Pei’s Herbal Formulas 3. Acute and Chronic Pelvic Inflammation Liu Mou, female, 28 years old, presented with prolonged lochia after a miscarriage, accompanied by lower abdominal pain, lumbago, and a feeling of fullness and heaviness in the lower abdomen. Her tongue was red with a yellowish greasy coating, and her pulse was fine and tight. Ultrasound showed intrauterine residues and adnexitis. She underwent gynecological curettage to remove any remaining embryonic tissue and received anti-infective treatment. Diagnosis: Acute pelvic inflammatory disease, incomplete abortion. Traditional Chinese Medicine diagnosis: Post-miscarriage infection with toxic pathogens, leading to stagnation of blood in the uterine cavity. Treatment focused on activating blood circulation to resolve stasis, clearing heat and detoxifying. The formula used was Xuefu Zhuyu Tang, Guizhi Fuling Wan, and Wumei Xiaoduan Yin, with modifications. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, licorice 6g, fresh barley 30g, cinnamon twig 10g, poria 10g, phellodendron bark 6g, dandelion 15g, and motherwort 15g. The herbs were decocted in water and taken as one dose per day. At the second visit, the lochia and abdominal pain had subsided, and the discharge was clean. She also experienced lumbago, lower abdominal fullness and heaviness, fatigue, and weakness. The herbal formula was adjusted to remove dandelion and add roasted eucommia, chuanxiong, codonopsis, and astragalus each 10g. After taking the modified formula for over 20 doses, combined with Guipi Wan, her condition improved and she was fully recovered.

Commentary: Incomplete abortion, residual embryonic tissue in the uterus, prolonged lochia, foul-smelling discharge—these symptoms indicate that damp-heat residue had not yet been completely cleared, forming a binding relationship with blood, causing blood stasis in the uterine cavity, leading to dysfunction of the internal organs, imbalance of qi and blood, and obstruction of the Chong and Ren meridians. [4] “When the condition is acute, treat the symptoms,” so after gynecological curettage to clear blood stasis and treat infection, the patient was treated with Tao Hong Si Wu Tang to activate blood circulation and resolve stasis; dandelion, motherwort, and fresh barley were used to clear heat and eliminate dampness; codonopsis and astragalus replenished qi and strengthened the spleen; eucommia and chuanxiong tonified the kidneys and strengthened the lumbar region to ensure smooth flow of the meridians, allowing damp-heat to be eliminated, and all symptoms were cured.

Menopausal Neurosis

[Case Study] Li Mou, female, 48 years old, sought medical attention due to six months of insomnia and dizziness. The patient experienced irritability, restlessness, anxiety, dry mouth, thirst, dizziness, lightheadedness, sunspots on her face, palpitations, shortness of breath, light menstrual flow, scant vaginal discharge, a dark red tongue with ecchymoses, tortuous purple veins under the tongue, and a fine, rapid pulse. Diagnosis: Menopausal neurosis. TCM diagnosis indicated liver and kidney yin deficiency, qi and blood stasis. Treatment focused on activating blood circulation to resolve stasis and nourishing the liver and kidneys. The formula used was Xuefu Zhuyu Tang, supplemented with Qiju Dihuang Tang with modifications. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, licorice 6g, goji berries 10g, chrysanthemum 10g, cornelian cherry 10g, raw gypsum and raw oyster shell each 15g, roasted Zao Ren 15g, Albizia bark 30g, and Cuculus japonicus 30g. The herbs were decocted in water and taken as one dose per day. At the second visit, the patient’s irritability, restlessness, and dizziness had improved.

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Pei Zhengxue Clinical Collection, Volume Two The facial sunspots were noticeably reduced, and the herbal formula was adjusted to remove bupleurum and add prepared Polygonum cuspidatum, Ligustrum lucidum, and Turtle Shell Gelatin each 15g to nourish yin and replenish blood, nourish blood and lighten spots. After more than six months of treatment with these adjustments, all symptoms improved. Commentary: The pathogenesis of menopausal neurosis lies in the decline of the female “Tian Kui” system, liver and kidney deficiency, yin and blood deficiency, yin failing to contain yang, and yang drifting outward. Irritability, anxiety, thirst, insomnia, dizziness, light menstrual flow with dark color, a dark red tongue with ecchymoses—all these are signs of blood stasis in the uterine cavity. Xuefu Zhuyu Tang was used to soothe the liver and resolve stasis, Qiju Dihuang Tang nourished the liver and kidneys, roasted Zao Ren, Albizia bark, and Cuculus japonicus nourished blood and calmed the mind; prepared Polygonum cuspidatum, Ligustrum lucidum, Cornelian Cherry, and Turtle Shell Gelatin nourished yin and replenished blood, nourished blood and lightened spots—thus all symptoms were cured.

Chest Injury Li Mou, male, 28 years old. He suffered a chest injury from a car accident, resulting in chest pain, chest tightness, shortness of breath, dry mouth, and thirst, along with headaches without nausea or vomiting. Chest X-ray showed no signs of hemothorax or pneumothorax, and no fractures were detected in the thoracic and rib bones. His tongue was dark red, coated with a yellowish greasy film, and his pulse was tense and tight. Diagnosis: Chest injury. The condition was classified as post-traumatic chest blood stasis. Treatment focused on activating blood circulation to resolve stasis and regulating qi to relieve pain. The formula used was Xuefu Zhuyu Tang, with modifications to Xiao Xianxiong Tang. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, citrus peel 10g, processed Achyranthes bidentata 15g, platycodon root 20g, licorice 6g, coptis chinensis 6g, pinellia 6g, trichosanthes fruit 10g, and earthworm 10g. The herbs were decocted in water and taken as one dose per day. At the second visit, the chest pain and shortness of breath had improved after medication. Although there was still some pain in the ribs, the original formula was adjusted to include 6g of processed milk thistle, and after 14 doses, the chest pain had subsided, and all symptoms were resolved. Commentary: The chest is where “Zong Qi” gathers; after trauma, qi in the chest becomes stagnant, blood stasis accumulates in the chest, leading to qi disruption, chest and flank pain, and the use of Xuefu Zhuyu Tang to activate blood circulation and resolve stasis, while Hua Sanqi and Earthworm enhance the effect of resolving stasis and relieving pain; coptis chinensis, pinellia, and trichosanthes fruit clear heat and transform phlegm, opening up the chest and dispersing nodules. As Shen Yi of the Ming Dynasty wrote in “Zheng Ti Lou Yao,” “When the limbs are damaged externally, qi and blood are harmed internally, and the vital energy and defensive qi fail to flow properly, leading to disharmony in the internal organs.” For soft tissue edema, ligament injuries, or muscle-fascial pain caused by blood stasis, the method of activating blood circulation can be used to treat them [5].
Fever of Unknown Cause [Case Study] Zhang Mou, male, 36 years old, presented with fever for one week without any obvious trigger, with a temperature between 38°C and 39°C. Despite multiple treatments, the condition did not improve, so he sought treatment from traditional Chinese medicine. Examination revealed a temperature of 38.2°C, and the patient reported fatigue and exhaustion.

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Chapter Sixteen: Pei’s Herbal Formulas

He was fatigued and emaciated, with dry mouth and thirst, heartburn, poor sleep, headache, poor appetite, constipation, and dark red tongue with a yellowish greasy coating and ecchymoses at the edges, a fine, slippery pulse. Chest X-ray, blood count, ESR, anti-O, and RF tests were all normal. Upon further inquiry into his medical history, it was discovered that seven years ago he had suffered an arm and knee injury while riding a motorcycle. Diagnosis: Fever of unknown cause. TCM diagnosis indicated post-traumatic blood stasis fever combined with qi deficiency and excessive stomach fire. Treatment focused on activating blood circulation to resolve stasis, using sweet and warm herbs to clear heat, and supporting bowel movement to release heat. The formula used was Xuefu Zhuyu Tang, supplemented with Buzhong Yiqi Tang with modifications. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, rehmannia root 12g, bupleurum 10g, processed Achyranthes bidentata 15g, platycodon root 20g, licorice 6g, rehmannia root 20g, white atractylodes rhizome 10g, astragalus root 10g, poria 10g, astragalus root 10g, ledebouriella root 10g, and rhubarb 10g (added later). The herbs were decocted in water and taken as one dose per day. At the follow-up visit, the fever had subsided to 37°C, mental state and appetite had improved, and the treatment remained effective. The original formula was continued for another 10 doses, and all symptoms were cured. Follow-up visits showed no recurrence over six months.

Commentary: Fever can be caused by infections, tumors, autoimmune diseases, blood disorders, and many other factors. However, approximately 5–10% of fevers remain unexplained [6]. “Blood stasis fever, with thirst, heartburn, and sharp pain in the limbs. When blood stasis resides in the middle burner, it causes chest and flank pain, as well as stabbing pain in the waist and navel area; when blood stasis resides in the superficial layers, it leads to disharmony in the vital energy and defensive qi, causing fever with chills; when blood stasis resides in the muscles, it causes a buzzing fever, with both spontaneous sweating and night sweats.” Xuefu Zhuyu Tang is the primary formula for treating such conditions [7]. Qi deficiency fever arises from internal damage to the spleen and stomach, which impairs qi, while external exposure to wind and cold damages the body’s form. Internal damage results in deficiency; to replenish deficiency, we must strengthen the body. Warmth can dispel excess heat, and Buzhong Yiqi Tang is the primary formula for replenishing qi [8].

Post-Concussion Syndrome

[Case Study] Wang Mou, male, 35 years old, suffered a head injury from a car accident and fell into a coma for two days. Cranial CT scan showed acute subdural hematoma, but no fractures were found in the skull. The patient experienced a left-sided impact to the head, followed by immediate loss of consciousness, and was rushed to the hospital for emergency treatment. His mental status was unclear, he fell into a deep coma, and he experienced frequent nausea and vomiting. Blood pressure was 140/90 mmHg. CT scan revealed patchy hemorrhagic foci within the left cortical region of the brain, with compression and deformation of the right lateral ventricle, and the midline shifted to the right, along with a subdural hematoma. The hospital performed emergency craniotomy to decompress and remove the hematoma. Twelve hours after surgery, his mental status was clear, and he reported headache and dizziness, along with thirst, dry mouth, excessive sweating, heartburn, soreness in the lower back and knees, a red tongue with a yellowish greasy coating and ecchymoses at the edges, and a tense, slippery pulse. Western medicine administered anti-infective drugs, decompression, volume expansion, and symptomatic supportive care. Diagnosis: Brain injury, acute subdural hematoma following surgery, post-concussion syndrome. TCM diagnosis: Kidney yin deficiency, with blood stasis lingering in the meridians after trauma. Treatment approach: Nourish yin and tonify the kidneys, activate blood circulation to resolve stasis.

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Pei Zhengxue Clinical Collection, Volume Two The formula used was Xuefu Zhuyu Tang, supplemented with Zhi Bai Dihuang Tang with modifications. Peach kernel 10g, safflower 6g, angelica sinensis 10g, red peony 10g, chuanxiong 10g, bupleurum 10g, citrus peel 10g, processed Achyranthes bidentata 15g, platycodon root 20g, licorice 6g, rehmannia root 20g, white atractylodes rhizome 10g, turtle shell 15g. The herbs were decocted in water and taken as one dose per day, for 7 doses. At the follow-up visit, the dizziness and headache had lessened, sweating decreased, blood pressure was 130/80 mmHg, sleep was poor, and the original formula was adjusted to include roasted Zao Ren, Yuan Zhi, and Shixiangpu each 10g. After more than three months of treatment, the patient’s condition improved. Commentary: Acute subdural hematoma is caused by rupture of cortical blood vessels following brain contusion, characterized by prolonged coma or progressively worsening altered consciousness, and increased intracranial pressure [9]. Acute subdural hematoma progresses rapidly and is severe, requiring early surgical intervention. Post-surgery, traditional Chinese medicine focuses on activating blood circulation to resolve stasis, reduce swelling and relieve pain, and improve the body’s responsiveness. Xuefu Zhuyu Tang is the preferred formula for this purpose. Shixiangpu, Yuan Zhi, turtle shell, raw oyster shell, and roasted Zao Ren help calm the mind and soothe the liver, while strengthening the efficacy of the main formula. 8. Reflections All seven typical cases mentioned above were treated using Xuefu Zhuyu Tang with modifications. Wang Qing used Xuefu Zhuyu Tang to treat various conditions involving “blood stasis in the chest,” incorporating Tao Hong Si Wu Tang with Four Reverse Decoction, Platycodon root, and Chuan Niuxi. The chest and flanks are areas through which the Liver Meridian flows; when blood stasis accumulates in the chest, qi stagnation occurs, leading to chest pain. If blood stasis persists and turns to heat, qi stagnation leads to fire, which then manifests as evening fever. According to “Xue Zheng Lun,” “When blood stasis rises to the upper burner, it causes pain, numbness, and discomfort in the chest, back, shoulders, and arms, as well as fullness in the chest and flanks. Xuefu Zhuyu Tang is the appropriate formula for such conditions.” Using Tao Hong Si Wu Tang to resolve stasis and nourish blood, bupleurum to soothe the liver and resolve depression, Platycodon root to open and clear lung qi, carrying the herbs upward, combined with citrus peel to broaden the chest and regulate qi, processed Achyranthes bidentata to promote blood flow and move blood downward, and licorice to harmonize all herbs—when these herbs are used together, they not only address blood stasis in the blood vessels but also help disperse qi stagnation, removing stasis without harming blood, while promoting qi without causing dryness or heat. Together, they achieve the effects of activating blood circulation to resolve stasis, regulating qi to relieve pain, and dispersing stagnation while clearing heat [10]. “Xue Zheng Lun” states, “If blood stasis is not removed, new blood will never be generated; if new blood is not generated, old blood cannot be produced either.” “Every condition that cannot be cured is often due to a failure to remove blood stasis. Anyone who treats blood should first focus on removing blood stasis.” Xuefu Zhuyu Tang uses blood removal as a key principle in treating blood-related conditions. Conditions such as qi stagnation and blood stasis in headaches, chest pain, hypertension, pelvic blood stasis syndrome, menopausal syndrome, fever of unknown cause, and post-concussion syndrome can all be treated with modifications to this formula. Experimental research has shown that Tao Hong Si Wu Tang is highly effective for gynecological diseases, traumatic injuries, migraines, rheumatoid arthritis, angina pectoris, diabetic peripheral neuropathy, alopecia areata, cervical spondylosis, and other conditions [11–12]. References [1] Wang Qingren. Medical Reform and Correction [M]. Shenyang: Liaoning Science and Technology Press, 1999, pp. 7–8. [2] Xu Jiqun. Textbook for Higher Medical Colleges, Formulae [M]. Shanghai: Shanghai Science and Technology Press, 1998, pp. 10, 148–149. [3] Dong Chao, Geng Chaohui, Gao Feng. Modern clinical applications and experimental research progress of Xuefu Zhuyu Tang [J]. Shizhen National Medicine and Pharmacy, 2009, 12(20):36–37.

[4] Xu Xiangyu. Xuefu Zhuyu Tang for the Treatment of Pelvic Inflammation [J]. Jilin Chinese Medicine, 2008, 8(20):42–43. [5] Fan Chenghu, Ma Zhiyong, Chai Jimei. Treatment of 130 cases of acute soft tissue injuries with Xiaoding Paste [J]. Gansu Chinese Medicine, 2010, 23(11):47–48. [6] Kuang Heling, Hu Pinjin. Differential Diagnosis of Internal Diseases [M]. Beijing: People’s Health Publishing House, 2009, pp. 6–12. [7] Pei Zhengxue. Commentary on Xue Zheng Lun [M]. Lanzhou: Science and Technology Press, 2008, pp. 129–130. [8] Pei Zhengxue. New Compilation of Formulae [M]. Lanzhou: Science and Technology Press, 2008, pp. 95–96. [9] Dong Qian. Clinical Applications of Xuefu Zhuyu Tang [J]. Hebei Chinese Medicine, 2008, 5:25–26. [10] Li Shuying, Ma Xiaoyong. Clinical experiences with Tao Hong Si Wu Tang [J]. Shaanxi Chinese Medicine, 2001, 23(5):55–58. [11] Li Shuying, Ma Xiaoyong. Clinical applications of Tao Hong Si Wu Tang for migraine [J]. Practical Chinese Medicine Journal, 2006, 8:33–35. Hebei Chinese Medicine (Core), April 2013 issue

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Pei Zhengxue Clinical Collection, Volume Two Chapter Seventeen: Newspaper Abstracts Record of a Famous Chinese-Western Integrated Expert in China—Professor Pei Zhengxue, a renowned Chinese medicine expert from Gansu Province Qi Qin, Yang Yinhong, Zheng Fangjiang A Great Master of the Medical Realm Brings Warmth to the Land of China Since ancient times, Gansu has been known as the “Home of Qihuang in China,” thanks to its abundant medicinal resources, numerous famous doctors, and profound Chinese medicine culture. In the field of Chinese medicine, a formula named after a place—known as the “Champion of Hematologic Diseases,” the “Lanzhou Formula”—has made Gansu’s traditional Chinese medicine famous both domestically and internationally. The creator of this formula is Professor Pei Zhengxue, a renowned Chinese-Western integrated expert in China, currently serving as Chief Expert at Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Academy of Medical Sciences, as well as a doctoral supervisor. He also serves as a professor at Gansu College of Traditional Chinese Medicine and as the Honorary Chairman of the Gansu Association for Chinese-Western Integrated Medicine. Throughout his more than 50-year career in medicine, Professor Pei has skillfully leveraged the strengths of both Chinese and Western medicine to benefit patients, achieving fruitful results in teaching, medical practice, and research, earning him the deep respect of people across Gansu and even throughout China. “Three Generations of Qihuang Are Not Remarkable” “Three Generations of Qihuang Are Not Remarkable—when you study medicine, you should become a good doctor. You should lead your children to come to you, not to follow the arrogant.” This is a famous quote from Professor Pei’s father, Pei Shen, who encouraged his children to strive for excellence.

Professor Pei was born in February 1938, originally from Wushan, Gansu. He came from a family of traditional Chinese medicine practitioners; his grandfather, Pei Shaojian, devoted his life to healing others. His father, Pei Shen, studied at Central University and authored several medical books. “Two Poems Encouraging My Children to Self-Motivate” was written to inspire his children to continue their family’s medical legacy. Driven by a strong interest in medicine and influenced by his family, Mr. Pei Zhengxue developed a lifelong dream of becoming a physician from a young age, eventually gaining admission to the Medical Department of Xi’an Medical University with excellent grades.

Mr. Pei’s youth was marked by many hardships. In 1958, a nationwide campaign against rightists swept through China. While Mr. Pei was a sophomore, his father was wrongly labeled a rightist and subjected to persecution, spending several months under criticism as a rightist. In 1961, after graduating from university, Mr. Pei could have stayed on campus to excel academically, but during the political review process, due to his family’s background and his father’s historical issues, he was transferred to TianShui Hospital. During the Cultural Revolution, Mr. Pei was labeled as one of the “Black Five Categories” and sent to work at the remote Ganquan Health Center in TianShui. Though discouraged, Mr. Pei did not lose heart; instead, he saw this as a rare opportunity to delve deeper into the lives of the people, understand their hardships, and encounter countless ailments. These difficult trials and heavy pressures became invaluable assets in his life.

“Reviving the Dead”: The Lanzhou Formula In 1967, while working in the Internal Medicine Department of TianShui Regional Hospital, Mr. Pei treated a young man named Ma Changsheng, who had leukemia. Ma Changsheng was a young soldier who, despite receiving full treatment at both military hospitals and local clinics, still did not show improvement in his condition. When his hemoglobin level dropped to just 2g, the hospital leadership decided to send him back to his hometown of TianShui for a final farewell. Ma Changsheng’s parents, hoping for a miracle, turned to Dr. Pei Zhengxue for help.

At that time, the primary treatment for leukemia both domestically and internationally was chemotherapy. However, chemotherapy’s toxic side effects were quite severe. Using TCM diagnostic methods and integrating Chinese and Western medicine, Mr. Pei developed a treatment plan for Ma Changsheng. After just one month of medication, his high fever subsided; after more than a hundred doses of Chinese herbal medicine, a miracle occurred. A year later, his hemoglobin level had risen to 14g, and multiple bone marrow smear examinations showed complete remission. Professor Zhang Aicheng, who had previously treated Ma Changsheng in Lanzhou, was astonished upon learning of this case, exclaiming, “Miracle! Miracle!” In 1973, at a national conference on blood diseases held in Suzhou, this case received unanimous high praise from the attending experts. The conference ultimately designated the main formula for this case as “Lanzhou Formula,” which has since been widely promoted and used in hospitals across China for many years, yielding remarkable therapeutic results. That patient, Ma Changsheng, has remained healthy ever since his recovery under Mr. Pei’s care, with no recurrence.

“The ‘Sixteen-Character’ Principle Creates the Pei School” As medical practice continued to evolve, Mr. Pei Zhengxue’s contributions to medical research grew steadily.

Medical Case Collection," "Pei Zhengxue Clinical Collected Works," and other 15 medical monographs have been published. During his tenure as Vice President and Secretary-General of the Gansu Provincial Association for Integrated Chinese and Western Medicine, he also founded the journal "Integrated Chinese and Western Medicine Research" and served as its editor-in-chief.

While compiling medical works, Pei Zhengxue's collection of novels and essays, titled "Da Feng Qu," along with his poetry and prose,

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His works such as "Chunfeng Qu," "Qiu Feng Qu," "Pei Zhengxue Calligraphy Collection," and "Introduction to Medicine - Running Cursive Script Posters" were also released one after another, becoming a beautiful sight in the realm of traditional Chinese medicine culture. To promote and record his life of seeking true knowledge, delving into the teachings of Qihuang, and benefiting all beings, his disciples wrote the biographical work "Famous Doctor Pei Zhengxue of Longshan," which was published and distributed in 2008. This year, Pei Zhengxue's two new works, "Pei Zhengxue Health Weibo" and his poetry and calligraphy collection "Xue Ni Hong Zha," were officially released. These works serve as significant tributes to mark the 75th anniversary of Pei Zhengxue's birth, the 55th anniversary of his medical career, and the 35th anniversary of his publication of medical works.

"An old ox knows its own sunset is short—no need to whip it again, just keep striding forward." "The green pouch does not fail the old man of Hua Yuan; it is never too late to benefit all beings..." Although Mr. Pei Zhengxue has passed his 70s, he remains full of vigor and continues to fight on the front lines of medical care, saving lives and healing the wounded, tirelessly writing and nurturing the next generation. His vast, selfless love is precisely the noble sentiment and spiritual light within the heart of a renowned physician.

May 20, 2013, China Traditional Chinese Medicine Daily

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**Pei Zhengxue and his "Lanzhou Formula" Qi Qin, Yang Yin Hong, Zheng Fangjiang

In the field of traditional Chinese medicine in Gansu Province, a formula named after a place—known both domestically and internationally as the "bane of blood diseases"—is called the "Lanzhou Formula." The creator of this formula is Pei Zhengxue, Chief Expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Academy of Medical Sciences.

"Three generations of Qihuang are not remarkable; when you study medicine, you should become a good doctor. You should be like a young child, led away by your parents—do not follow the path of arrogant soldiers who fall into ruin." These were the words of Pei Zhengxue's father, Pei Shen, who often encouraged his children. Influenced by his family, Pei Zhengxue developed an aspiration to practice medicine from a young age. He later gained excellent grades and was admitted to the Medical Department of Xi'an Medical University, where he was assigned to work at Tian Shui Hospital. Over more than 50 years in the medical profession, Pei Zhengxue leveraged the strengths of both Chinese and Western medicine, achieving fruitful results in teaching, medical practice, and research.

The "Lanzhou Formula" that brought about a miraculous recovery

In 1967, Pei Zhengxue, who worked in the Internal Medicine Department of Tian Shui Regional Hospital, treated a patient named Ma Changsheng, who had leukemia. Ma Changsheng was a young soldier; despite intensive treatment, his condition did not improve. At that time, the primary treatment method for leukemia both domestically and internationally was chemotherapy. However, the toxic side effects of chemotherapy were quite severe. Pei Zhengxue used traditional Chinese medicine’s diagnostic methods and integrated Chinese and Western medicine approaches to develop a treatment plan for Ma Changsheng. After just one month of medication, Ma Changsheng’s high fever subsided; after taking over a hundred doses of traditional Chinese medicine, his hemoglobin levels rose to 14 g, and multiple bone marrow smear examinations showed complete remission.

When the experts who had previously treated Ma Changsheng learned of this case, they were astonished and could hardly believe what they heard—calling it a "miracle."

In 1973, at the National Hematology Conference held in Suzhou, this case received unanimous high praise from the attending experts. The conference ultimately designated the main formula for this case as the "Lanzhou Formula," which has since been widely promoted and used in hospitals across China for many years, yielding remarkable therapeutic results. That patient named Ma Changsheng

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Chapter 17: Newspaper Summaries Since being cured by Old Master Pei, this patient has remained healthy to this day, with no recurrence. The "16-Character Principle" gave rise to the "Pei School."

As clinical medical practice continued to evolve, Pei Zhengxue also achieved substantial results in medical research. In 1980, Pei Zhengxue’s book "Commentary on Blood Disorders" was published and distributed. After being introduced to Japan, it received a strong response. In May 1985, Professor Tan Eiichi, President of Shizuoka Medical University in Japan, traveled specifically to Lanzhou to consult Old Master Pei about issues related to the book. In the 1990s, Pei Zhengxue’s “16-Character Principle”—“Western medicine diagnosis, traditional Chinese medicine diagnosis, traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach”—gained widespread attention throughout China’s Chinese and Western medicine communities, and the “Pei School” became an important school of thought in the field of Chinese and Western medicine today.

Pei Zhengxue’s edited, the first comprehensive modern work on integrated Chinese and Western medicine in internal medicine, "Practical Internal Medicine of Integrated Chinese and Western Medicine," won the "International Gold Award for Outstanding Contribution" at the Third World Conference on Traditional Medicine held in the United States in 1996. He himself was honored as one of the "World's Top 100 Stars of Ethnic Medicine." In 1997, the State Administration of Traditional Chinese Medicine recognized Pei Zhengxue as one of the 500 most renowned veteran Chinese physicians nationwide. He was subsequently invited as a guest professor by three domestic Chinese medicine schools, including the Hong Kong College of Traditional Chinese Medicine.

A Physician’s Benevolent Heart, Warmth for Patients

Since beginning his medical career, Pei Zhengxue has always approached patients with a "doctor’s benevolent heart." For decades, he has gently warmed the hearts of patients like a spring breeze, making significant contributions to harmonious doctor-patient relationships and setting an example for others.

In 2000, Liu Ligang, a student from Jiangxi studying at Lanzhou University, unfortunately suffered from ALL acute lymphoblastic leukemia. Despite various rounds of chemotherapy and treatment, his condition did not improve significantly, and doctors predicted that his treatment would cost around 300,000 yuan. Through an introduction, he found Pei Zhengxue. Old Master Pei handed over his newly developed "Pei’s Blood-Raising Granules" to this young man who was struggling on the brink of death. When he learned that Liu Ligang planned to return to his hometown in Jiangxi, Old Master Pei warmly said, "You can contact me anytime when you go home—I’ll send you the prescription in a timely manner."

That same May, Liu Ligang underwent long-term chemotherapy at the Second Affiliated Hospital of Jiangxi Province. The chemotherapy caused his bone marrow hematopoietic system to lose its immune function, leaving him increasingly weak. Upon learning of this situation, Pei Zhengxue immediately prescribed a traditional Chinese medicine formula for him and prepared specially formulated pills.

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He sent these medications to Liu Ligang through a trusted person. After Liu Ligang took the traditional Chinese medicine on time, the toxic side effects of chemotherapy were noticeably alleviated, and indicators such as red blood cells, white blood cells, and platelets quickly returned to normal. The intervals between chemotherapy sessions gradually increased. Old Master Pei then sent Liu Ligang his newly prepared traditional Chinese medicine; after taking it, Liu Ligang no longer needed to undergo chemotherapy, and his indicators miraculously returned to normal. Today, Liu Ligang has fully recovered and completed his studies. Every year, he returns to Lanzhou to visit Old Master Pei, expressing his gratitude for his lifesaving kindness.

Although Old Master Pei is now over 70 years old, he remains even more energetic, steadfastly working in the medical field—seeing patients, writing books, mentoring the next generation, and practicing the principle of "an old ox knows its own sunset is short—no need to whip it again, just keep striding forward," creating value in life.

May 2012, China Traditional Chinese Medicine Daily

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The Story of Pei Zhengxue and a Patient with Pancreatic Cancer

Dialectal Talk

According to a report from China National Radio, Lanzhou, January 10—In the city of Lanzhou, there is a famous physician who comes from a family steeped in traditional Chinese medicine, possessing deep roots in the teachings of Qihuang. He graduated from Xi’an Medical University with a solid foundation in Western medicine theory. Integrating Chinese and Western medicine, he has become a renowned scholar in China’s field of integrated Chinese and Western medicine. Rooted in the land of Longshan, he has cured tens of thousands of patients with difficult and complex conditions across the country, particularly achieving remarkable success in treating malignant tumors with traditional Chinese medicine, earning the admiration and trust of the public. He is Professor Pei Zhengxue, one of the first distinguished Chinese physicians in Gansu Province, Chief Expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Tumor Hospital.

"Meritorious Servant" Stricken with Serious Illness

Just after the Spring Festival in 2010, an elderly man and his family lost their usual joy and peace. This elderly man was the first recipient of science and technology awards in Gansu Province, a nationally renowned wheat breeding expert, revered by people as the "Wheat Breeding King of Longshan," the Zhou Xiangchun of Gansu—a figure known as the "Yuan Longping of Gansu."

During the Spring Festival, he often felt fatigued and weak, with a loss of appetite. He soon began experiencing intermittent pain in his upper abdomen, accompanied by increased bowel movements—three to four times a day, eventually rising to around ten times per day. After visiting several small hospitals for treatment and taking some common gastrointestinal medications, his condition actually worsened, with diarrhea increasing to around twenty times a day.

The news of Zhou Xiangchun’s illness drew the attention of Liu Weiping, Deputy Secretary of the Gansu Provincial Party Committee and Governor of Gansu Province. Liu Weiping issued instructions: in July 2010, Lanzhou First People’s Hospital conducted a comprehensive and detailed examination of Zhou Xiangchun, who was diagnosed with pancreatic cancer. The prognosis for this disease was poor, and for a 79-year-old man,

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On August 11, 2010, Zhou Xiangchun was admitted to the Hepatobiliary and Pancreatic Surgery Department of Ruijin Hospital affiliated with Shanghai Jiao Tong University, where a hospital-wide consultation confirmed a malignant tumor—the tail of the pancreas. The consultation concluded that surgery was not advisable, and recommended conservative medical treatment and traditional Chinese medicine therapy, estimating that his survival time would likely be only 3 to 6 months. On August 19, 2010, Zhou Xiangchun returned to Lanzhou and sought medical treatment everywhere, but his condition continued to worsen, with diarrhea increasing to over twenty times a day, and upper abdominal pain becoming increasingly severe.

Then, a turning point arrived when he met Old Master Pei.

At that moment, someone introduced him to Professor Pei Zhengxue, a renowned veteran physician at the Gansu Provincial Tumor Hospital.

Zhou Xiangchun went to the Tumor Hospital of Gansu Province on September 15, 2010, to receive treatment from Pei Zhengxue in the "Integrated Chinese and Western Medicine Department." This department was founded by Pei Zhengxue himself 25 years ago, and currently comprises numerous doctoral and master’s degree holders who form Pei Zhengxue’s clinical technical team. The traditional Chinese medicine expertise is truly "strong in both troops and horses." Pei Zhengxue carefully reviewed Zhou Xiangchun’s entire medical record, and after conducting a thorough examination—observing, listening, asking questions, and palpating—he carefully prescribed a treatment plan for Zhou Xiangchun. He entrusted his academic successor, Associate Chief Physician Zhang Huifang, to oversee the patient’s bedside care; he also appointed his graduate student, Chief Physician Zhang Guiqiong, to assist in managing the patient’s treatment; and he brought in Chief Nurse Qiu Yumei, Director Xue Wenhán, and Head Nurse Zhang Cailin to provide meticulous treatment and special care for Zhou Xiangchun. Pei Zhengxue repeatedly urged Zhang Huifang to closely monitor Zhou Xiangchun’s condition, ensuring that he took his traditional Chinese medicine on time and promptly provided CT scans, ultrasounds, tumor markers, and other relevant tests. At the same time, he employed Western medicines such as albumin, thymosin, fat emulsions, and compound amino acids to support treatment.

Traditional Chinese Medicine Proved Remarkable Effectiveness

After just one week of taking traditional Chinese medicine, Zhou Xiangchun’s bowel movements decreased from 20 times to 7 times, and the pain in his upper abdomen eased somewhat. Zhang Huifang, following Pei Zhengxue’s advice, observed carefully and responsibly, promptly adjusting the treatment plan based on Zhou Xiangchun’s condition, adjusting dietary combinations, and taking time to talk with him, offering psychological counseling and intervention to help him remain confident in his treatment.

After more than five months of treatment, Zhou Xiangchun’s upper abdominal pain had largely disappeared, his appetite had improved, his bowel movements returned to normal, the pain in his chest and both flanks had completely vanished, the yellowish greasy coating on his tongue had faded, and his bodily functions had basically returned to normal. A CT scan and ultrasound revealed that the tumor had shrunk from 4.2 cm × 4.8 cm to 1.8 cm × 1.2 cm, with the shape of the pancreas approaching normal, and the tumor marker CA19-9 had also returned to normal.

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The tumor had shrunk to a size that was almost normal.

Zhou Xiangchun’s condition experienced a miraculous recovery. He repeatedly expressed his gratitude to Old Master Pei and his medical team to the provincial leaders who came to visit him. Liu Weizhong, Director of the Gansu Provincial Health Department, acknowledged in a health system meeting that Pei Zhengxue and his team had played an important role in treating Zhou Xiangchun’s pancreatic cancer.

Although Zhou Xiangchun survived cancer for a year and a half, during his recovery at home, he unexpectedly suffered a fall, resulting in a persistent high fever. Shortly thereafter, he developed a fungal infection that led to kidney failure. Unfortunately, on August 20, 2011, he passed away. Yet, with his exquisite medical skills, Pei Zhengxue helped Zhou Xiangchun extend his life by a year and a half, allowing him to continue pursuing his experimental plans and make his final contribution to wheat breeding research.

January 10, 2014, Issue No. 4032 of China Traditional Chinese Medicine Daily

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Professor Pei Zhengxue Discusses Integrated Chinese and Western Medicine Treatment for Lung Cancer

Wang Bo, reporter for Gansu Daily

In recent years, the incidence of lung cancer in China has been steadily rising. Lung cancer has become the leading cause of all cancers, and it is also the leading cause of cancer-related deaths worldwide. Therefore, actively adopting effective prevention and treatment measures has become an urgent priority. Recently, a reporter visited the Gansu Provincial Tumor Hospital to interview Professor Pei Zhengxue, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, Honorary Chairman of the Gansu Provincial Association for Integrated Chinese and Western Medicine, and Chief Expert at the Gansu Provincial Academy of Medical Sciences.

Early symptoms of lung cancer are often atypical, making it difficult for patients to achieve a complete cure. Lung cancer, also known as "primary bronchogenic carcinoma," is a malignant tumor originating in the bronchi and lungs. According to statistics, 1.6 million new cases of lung cancer occur each year globally, accounting for 13% of all malignant tumors; annually, 1.4 million people die from lung cancer, representing 18% of all cancer-related deaths. Western medicine employs surgical procedures, radiation therapy, and chemotherapy to treat advanced lung cancer, achieving a 5-year survival rate of 70%. However, early-stage lung cancer often presents with few symptoms; more than 75% of patients are diagnosed when the tumor has already spread locally or metastasized, with a 5-year survival rate of less than 5%. In other words, once lung cancer develops, it often spreads extensively, leading to a poor prognosis and making a complete cure impossible. Clinical treatment focuses primarily on prolonging life. Professor Pei Zhengxue explained that in the 1980s, he was among the first to propose the "16-Character Method"—"Western medicine diagnosis, traditional Chinese medicine diagnosis, traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach." He was praised by Chen Minzhang, then Minister of Health, as the "16-Character Principle." He said, "Western medicine diagnosis" refers to using advanced Western medical equipment to identify and understand the common patterns of disease. In the early stages of lung cancer, in addition to relying on clinical symptoms and signs, the use of tumor markers, sputum cytology, percutaneous lung needle biopsy, fiberoptic bronchoscopy, exhaled breath analysis, and various imaging techniques can aid in the definitive diagnosis of lung cancer. Next, "traditional Chinese medicine diagnosis" involves combining common disease patterns with individual characteristics to enhance the scientific accuracy of diagnosis. He emphasized that lung cancer falls under the categories of "lung accumulation," "coughing with blood," and "chest oppression" in traditional Chinese medicine, with the underlying cause being deficiency of vital energy and excess of external factors, characterized by deficiency of both qi and yin, while phlegm-dampness, water retention, and blood stasis act as external factors.

As for "traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach," this emphasizes the therapeutic role of traditional Chinese medicine formulas. He believed that Western surgical treatments, radiation therapy, and chemotherapy target the pathogenic agents of the disease, capable of killing or inhibiting tumor cells; while traditional Chinese medicine supports the body’s natural defenses and strengthens the body’s ability to respond, greatly reducing the side effects of surgery, radiation therapy, and chemotherapy, thereby enhancing therapeutic efficacy. Professor Pei said that lung cancer treatment should focus primarily on traditional Chinese medicine to tonify vital energy and strengthen the body, while also paying attention to preserving the body’s original qi and stomach qi. He often used his own developed "Lanzhou Formula," adjusted according to the patient’s condition, to boost qi, strengthen the spleen, and nourish the kidneys.

He explained that in February 2010, a 63-year-old patient named Mr. Liu came to the hospital due to "intermittent chest tightness, shortness of breath, and cough for one year." After undergoing chest CT scans and bronchoscopy, he was diagnosed with "left lung cancer." Doctors recommended surgical treatment, and after taking 10 doses of the "Lanzhou Formula" prior to surgery, his shortness of breath improved. On February 19, 2010, Mr. Liu underwent a left lung resection and total left lung removal under general anesthesia. Following surgery, his chest tightness and shortness of breath eased, though he still felt fatigued and lacked appetite. After taking 14 doses of the "Lanzhou Formula" and "Xiangsha Liujun Tang," his fatigue and lack of appetite significantly improved, his chest tightness and shortness of breath eased—but he still continued to cough. Based on the original formula, he added one dose of millet husk and continued taking it for another 14 doses. By then, his fatigue and lack of appetite had disappeared, and he no longer experienced significant chest tightness or shortness of breath. Subsequently, he underwent four cycles of GP chemotherapy, and after repeated adjustments to the "Lanzhou Formula," after taking 20 doses, his gastrointestinal reactions had subsided, and his bone marrow suppression had improved. From then on, Mr. Liu continued to take Pei’s Blood-Raising Granules, and he has remained healthy ever since.

The Causes, Pathology, and Early Symptoms of Lung Cancer

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He noted that from a pathological perspective, lung cancer is mainly divided into two major categories: non-small cell lung cancer, which originates in epithelial cells and is the predominant type; and small cell lung cancer, which originates in the nerve or hormone-secreting cells of the lungs. For doctors, it is crucial to distinguish between small cell lung cancer and non-small cell lung cancer, as the treatment approaches differ. Non-small cell lung cancer is further divided into adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and mixed types.

Professor Pei Zhengxue believes that in the early stages of lung cancer, most patients experience no symptoms. Some patients may exhibit irritating dry cough, without sputum, or with a small amount of white, viscous sputum. For individuals over 40 who have smoked heavily for a long time, if they experience an irritating dry cough without obvious triggers that persists for 2–3 weeks, or if they have pre-existing chronic respiratory diseases with changes in their cough pattern, they should be especially vigilant. Additionally, patients may experience blood in their sputum, often appearing as streaks of blood or even blood in their sputum. Furthermore, early-stage lung cancer patients often experience mild chest tightness; when the disease affects the parietal pleura or directly invades the chest wall, it may cause persistent pain in that area. All of these symptoms should prompt caution regarding the possibility of lung cancer. In advanced stages of lung cancer, in addition to the aforementioned symptoms, patients often experience difficulty breathing, facial and neck edema, hoarseness, and weight loss. He said that distant metastases from lung cancer can lead to symptoms in different parts of the body, such as bone pain from metastasis, or headaches, dizziness, and weakness in one limb caused by brain metastasis—these symptoms should also be given particular attention.

Prevention, Treatment, and Precautions for Lung Cancer

Professor Pei Zhengxue stated that the primary mechanism behind lung cancer development is the depletion of vital energy, imbalance between yin and yang, and the invasion of harmful external factors into the body’s weakened defenses. As a result, strengthening vital energy becomes crucial. The saying goes, "Vital energy resides within the body—evil cannot take hold," where "vital energy" represents the body’s immune balance; "evil energy" encompasses carcinogenic factors such as smoking, nitrosamines in food, and psychological stress. These carcinogenic factors damage human DNA, disrupt tumor suppressor genes, and activate oncogenes, leading to malignant tumors when the body’s immune monitoring and killing mechanisms become imbalanced. Therefore, in preventing lung cancer and blocking precancerous lesions, we must first focus on strengthening vital energy and nourishing the body’s fundamentals, while avoiding carcinogenic factors—such as the ancient practice of "guidance techniques."

Input: Domains have also achieved substantial results, successively serving as an editorial board member of the China Journal of Integrated Traditional Chinese and Western Medicine, Chief Editor of the Journal of Integrated Traditional Chinese and Western Medicine, a director of the Chinese Society of Integrated Traditional Chinese and Western Medicine, Vice Chairman and Secretary-General of the Gansu Society of Integrated Traditional Chinese and Western Medicine, a member of the Gansu Provincial Committee of the Chinese People's Political Consultative Conference, and a member of the Gansu Provincial Committee of the Chinese People's Political Consultative Conference. His major works include "Commentary on Blood Disorders," "New Compilation of Traditional Chinese Medicine Formulae," "Pharmacology and Clinical Applications of Rheum," "Diagnosis and Treatment of Hepatitis B," "Selected Cases of Dr. Pei," "New Compilation of Warm Disease Studies," "Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine," among others. In addition, he has published more than 60 papers in academic journals at various levels, and he has received one First Prize, two Second Prizes, five Third Prizes for outstanding national-level works, as well as five provincial-level excellent paper awards and two provincial science and technology progress awards.

In 1980, Pei Zhengxue’s work "Commentary on Blood Disorders" was published and distributed, and after its circulation in Japan, it garnered a strong response. In May 1985, Professor Tan Eiichi, President of Shizuoka Medical University in Japan, traveled specifically to Lanzhou to consult with Professor Pei on issues related to the book. In the 1990s, Pei Zhengxue proposed the 16-character principle of “Western medicine diagnosis, traditional Chinese medicine syndrome differentiation, traditional Chinese medicine as the primary treatment, and Western medicine as a supplementary approach,” which drew widespread attention from the Chinese and Western medicine communities nationwide. The “Pei School” became an important school of thought in the field of Chinese and Western medicine today.

His edited work, the first comprehensive monograph on integrated Chinese and Western medicine in contemporary times, "Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine," won the "International Gold Award for Outstanding Contribution" at the World Congress of Traditional Medicine held in the United States in 1996. Professor Pei Zhengxue himself was honored with the title of "One of the World's Top 100 Stars of Ethnic Medicine." In 1997, the State Administration of Traditional Chinese Medicine recognized him as one of the 500 renowned veteran traditional Chinese medicine practitioners nationwide, and he was subsequently invited as a visiting professor by three domestic TCM institutions, including Hong Kong University of Traditional Chinese Medicine.

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Chapter 17: Newspaper Abstract A Physician’s Benevolent Heart, Compassionate to All Living Beings

Since beginning his medical career, Mr. Pei Zhengxue has always approached his patients with a “benevolent heart,” offering them warmth like a gentle spring breeze over the decades—warmth that has touched their hearts and contributed to harmonious relationships between doctors and patients, setting an example for future generations.

In 2000, Liu Ligang, a student from Jiangxi who was studying at Lanzhou University, unfortunately developed acute lymphoblastic leukemia. Despite undergoing chemotherapy and various other treatments, his condition did not improve significantly, and doctors predicted that his recovery would cost around 300,000 yuan. Through an introduction, Liu Ligang found Mr. Pei at Gansu Provincial Cancer Hospital. Faced with this young man struggling on the brink of death, Mr. Pei offered him “Pei’s Blood-Rising Granules,” a remedy he had developed himself. When Mr. Pei learned that Liu Ligang was planning to return to his hometown in Jiangxi, he warmly said, “You can contact me anytime when you go home—I’ll send you the prescription promptly.” In May of the same year, Liu Ligang returned to Nanchang, Jiangxi, and was admitted to the Second Affiliated Hospital of Jiangxi Province for long-term chemotherapy. The chemotherapy had caused his bone marrow hematopoietic system to lose its immune function entirely, leaving him increasingly weak and frail. Upon learning of this situation, Mr. Pei immediately prescribed another traditional Chinese medicine formula for him and entrusted someone to deliver the specially prepared pills to him. After Liu Ligang took the traditional Chinese medicine as directed, the toxic side effects of chemotherapy were noticeably alleviated, and indicators such as red blood cells, white blood cells, and platelets quickly returned to normal. The intervals between chemotherapy sessions were gradually extended. Later, Mr. Pei sent Liu Ligang a new traditional Chinese medicine formula he had newly prepared; after taking it, a miracle occurred! Liu Ligang no longer needed further chemotherapy, as all his indicators had returned to normal. Today, Liu Ligang has recovered and completed his studies, but every year he returns to Lanzhou to visit Mr. Pei, repaying him for his life-saving kindness.

The year 2008 marked the 50th anniversary of Mr. Pei Zhengxue’s medical career. On February 23, Gansu Province held a “Symposium Commemorating the 50th Anniversary of Professor Pei Zhengxue’s Medical and Research Achievements” in Lanzhou. Vice Governor Xian Hui, who attended the event, highly praised Mr. Pei’s noble medical ethics and exceptional medical skills. On March 22, 2011, the inaugural edition of “Practical Internal Medicine in Integrated Traditional Chinese and Western Medicine” (revised edition), edited by Mr. Pei, was launched in Lanzhou. Leaders including Liu Weiping, Deputy Secretary of the Gansu Provincial Party Committee and Governor of Gansu Province; Li Xiaojie, Member of the Standing Committee of the Gansu Provincial Party Committee and Minister of the Gansu Provincial Party Committee’s Propaganda Department; Xian Hui, Vice Governor; and Li Peiweng, Secretary-General of the Gansu Provincial Government, attended the launch ceremony. Although Mr. Pei is now over 70 years old, he remains full of energy and continues to dedicate himself to the medical profession—seeing patients, practicing medicine, writing books, and nurturing the next generation. With concrete actions, he has rewarded the deep affection and encouragement he has received from all sectors of society, striving to make use of his experience to…

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2012.24 China Traditional Chinese Medicine Daily

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Chapter 17: Newspaper Abstract Memories Spanning Half a Century—Reading Mr. Pei Zhengxue’s Collection of Short Stories and Essays, “Great Wind Melody”
Nie Zhongmin

Although Wushan, located in the southwest of Tianshui, has long been regarded as a culturally underdeveloped county in the eyes of Gansu’s literary community, this year’s literary scene in Wushan has been filled with joy and excitement. Recently, Pei Zhengxue’s collection of short stories and essays, “Great Wind Melody,” published by Gansu People’s Publishing House, has become a standout work. Chen Tiangui’s essay collection, “New Rhymes of the Wei River,” has been met with rave reviews. Additionally, Chen Yongheng’s novel “The Wei River Flows Slowly,” Xiao Zirong’s academic essay collection “History of Five Flavors—A New Chapter,” Wang Cheng’s local education textbook “Lovely Wushan,” and He Hui’s novel “Sensual Black Night” have all been published one after another, all of which demonstrate that Wushan’s literary scene is rapidly rising in a healthy and thriving manner. Amidst so many publications, let us today talk about Mr. Pei Zhengxue and his works.

Mr. Pei Zhengxue is the son of the renowned physician Pei Shen, who is celebrated as a master of traditional Chinese medicine in the region. In China’s medical community, Mr. Pei is known for his superb medical skills, noble medical ethics, and profound knowledge coupled with diligent thinking. Mr. Pei and I are both natives of Wushan; he is not only an outstanding physician but also an accomplished writer. In Wushan’s literary world, Mr. Pei Zhengxue has filled a long-standing gap in the creation of medium-length novels. I had heard that Mr. Pei possessed vast knowledge, diverse talents, and an impeccable character—but I had never had the chance to meet him. Fortunately, I am not afraid of challenges, and I occasionally posted a few short pieces online, hoping to catch Mr. Pei’s attention.

During the years I spent making a living in Chongqing, in order to ease my loneliness away from home, I often found myself…

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Pei Zhengxue Clinical Collection, Volume II Together with Ding Sheng, a fellow Wushan writer, I founded the Tianshui Literary Website, which soon gained attention from travelers far from home. Around March of this year, I received an email from Mr. Pei, filled with words of encouragement and praise for my literary creations. After several exchanges of letters, and after much persistence, Mr. Pei Zhengxue sent me some of his poems and prose via email. After reading them carefully, I posted them on the literary website to satisfy the needs of some readers. Following a phone call, Mr. Pei warmly invited me to visit Lanzhou. This May, I had the privilege of visiting Mr. Pei Zhengxue and Mr. Qi Ziyang in Lanzhou. Even amidst his busy schedule, Mr. Pei made time to warmly welcome both me and Brother Ding Sheng. That day, Mr. Pei presented us with his recently published “Great Wind Melody” and his father’s collection of Pei Shen’s poetry and prose as gifts. We toured Lanzhou’s scenic landmarks, and Mr. Pei happily posed for photos with us and engaged in lively conversations. Later, at a dinner table with Ma Dahu Zi, Mr. Pei spontaneously composed a poem: “May in Jin City brings back the spring again; the talented scholars of our homeland bloom like flowers. I do not believe that even old age is a waste—let me be a stepping stone for others to soar.” Mr. Pei constantly reminded us that as young literary enthusiasts, we must live with integrity, study diligently, and contribute our modest efforts to the cultural development of our hometown. Through our first encounter, Mr. Pei’s genuine nature and warm-hearted demeanor became a unique source of strength in his personality. When I finished reading Mr. Pei’s collection of works, I had already resigned from my job and taken up leisure time. I had always wanted to write a few words—yet the feeling of being at a dead end kept me putting off my efforts. One day, I received a call from Ding Qiang, who sent me photos of Lanzhou. He also told me that Mr. Pei had written a calligraphy scroll for me, inscribed with the words “Fragrant Orchids and Delicate Flowers.” At first, I was quite surprised. Asking Mr. Pei for calligraphy was something I had planned to do, but I hadn’t had the chance to write anything—so I didn’t expect Mr. Pei to remember such a small gesture. Besides, I usually didn’t keep in touch with Mr. Pei, and I worried that too much interaction might distract him from his valuable time. Not long ago, when I saw Mr. Pei again, I began to consider framing his works and hanging them in Wufei Zhai as a way to encourage myself. If the role of medicine is simply to save lives and treat injuries, then the role of literature is to save the human soul. To achieve both goals is truly to live a fulfilling life. Mr. Pei Zhengxue is just like that. Although Mr. Pei is over 70 years old, his complexion remains rosy, his body is still strong, and he is a person who loves life. In recent years, he has made significant scientific breakthroughs in the research of leukemia and liver disease treatment, and in 1997, he was included among the “100 Renowned Veteran Traditional Chinese Medicine Practitioners Nationwide.”

Mr. Pei Zhengxue has students all across the Loess Plateau, and he has authored numerous works, publishing more than ten medical monographs in succession. In his literary creations, Mr. Pei has achieved remarkable success. He has published many literary works in publications such as Gansu Daily, Feitian, Zhengyou, Gansu Historical Records, Tianshui Daily, Lanzhou Evening News, and Silk Road, earning a prominent place in Gansu’s ever-expanding literary scene and adding a vibrant stroke to the flourishing of Wushan’s literary culture.

Upon reading the beautifully bound “Great Wind Melody,” one finds that the book contains a novella, along with eleven essays and literary critiques. The preface to Mr. Pei’s collection was written by Yang Limin, former Secretary of the Inner Mongolia Autonomous Region, a close friend of Mr. Pei. The works collected within are all texts Mr. Pei had previously published in newspapers over the years, drawing inspiration from events he personally experienced and from the people around him. With a simple yet vivid style and a lively penmanship, these works offer a vivid portrayal of the historical changes that have unfolded in China’s cities and rural areas over the past half-century. His works are imbued with deep love for his hometown, for the relatives and people who live there. At the same time, they expose certain social issues in the course of social development and national construction—a sense of concern for the world before one’s own worries, and a spirit of sharing joys with others after one’s own concerns—often expressed through his writing. As the renowned literary critic Liang Shengming once said, “Reading Pei Zhengxue’s ‘Great Wind Melody’ is like seeing ordinary people reflecting on a grand stage, or observing the wider world through small events. It allows readers to savor life’s insights and find philosophical truths in simple, heartfelt narratives, while gaining spiritual joy and intellectual enlightenment.”

Mr. Pei Zhengxue’s novella “Great Wind Melody” can be considered an autobiographical work. The author uses the story of a love affair that arose during the special historical context of the “Anti-Rightist Campaign” in his youth as its theme. The narrative follows the tragic love story of Bai Liping, a gifted medical student, and Zhang Yalan, a beautiful and kind university girl, deeply revealing the underlying roots of the “Anti-Rightist Campaign.” Using a plain, straightforward style, the author successfully portrays the characters of Tian Jinpeng, a party committee member whose moral and academic standards were somewhat compromised, as well as Tian Jinpeng’s colleague and fellow party member, Luo Renyi, who was overly compliant and lacked both virtue and talent. The author also introduces the protagonist Bai Liping and the heroine Zhang Yalan, who meet again at an international academic conference more than twenty years later—and this encounter leads to endless memories of the past. In the novel, the author gently recounts the passionate feelings of the male protagonist Bai Liping and the female protagonist Zhang Yalan. Bai Liping, after signing a large poster exposing Tian Jinpeng’s problems during the Anti-Rightist Campaign, is suddenly pursued by Luo Renyi, who joins forces with Tian Jinpeng to retaliate against Zhang Yalan. Zhang Yalan suffers a severe mental breakdown under immense stress and pressure, leading her to take a leave of absence and return home for recuperation. Although Bai Liping was protected by righteous forces and was not labeled as a rightist, the love between the two was shattered by various vile acts, leaving readers with an inexplicable sense of pain. Therefore, the author deliberately set up foreshadowing in the novel. As for the characters themselves, they are vivid and lifelike, with distinct personalities and contrasting traits. The plot is full of twists and turns, and the structure is naturally cleverly arranged. What’s worth mentioning is that the language in the work is fresh and natural, with emotions that are calm and delicate—perhaps the tragedy no longer feels like a fate-bound cage for the characters. The author’s skillful handling of details reveals that, even in old age, Mr. Pei Zhengxue maintained a simple, open-minded, and serene perspective, free from the complexities of the world. Compared to Mr. Pei Zhengxue’s novels, I prefer his essays and short pieces. Mr. Pei Zhengxue’s essays fall within the realm of traditional literary forms, with a wide range of themes and a natural, relaxed writing style. I think his greatest strength lies in his sincere emotions and innovative ideas. Moreover, his essays on themes related to his hometown resonate deeply with readers—whether he writes about the cultural heritage and everyday life of his first hometown, Wushan, or about his second hometown, Lanzhou, where his hometown serves as a spiritual haven, almost permeating his personal experiences and feelings. In works such as “Missing My Hometown” and “The Wei River Flows Slowly,” the author paints a vivid picture of the ancient waters of the Wei River, capturing the fragrant aroma of rice fields and the graceful flow of small streams, the lush greenery of fields brimming with fragrance, and the graceful dance of storks in the morning light. Yet, throughout these works, his hometown flows through the reader’s heart in a beautiful, serene manner. In “Morning Melodies Along the Riverside Road,” the author describes Lanzhou’s Yellow River scenery with a sense of beauty and charm, creating a visual feast that evokes both visual delight and emotional resonance. Having spoken about his essays on hometown themes, let us now turn to his other essays. In today’s popular essay genre, his essays such as “Notes from Western Europe,” “Visiting…”
and “Travelogue of Tianshui” offer readers a fresh and refreshing experience. Mr. Pei Zhengxue’s essays are rich in depth and insightful in their reasoning. In “Recalling a Poem,” the author pays tribute to the song of Wushan’s hot springs, which tells the story of Emperor Yao yielding his throne to Yu, and the cruel faces of those in modern society who seek power without doing their duties, who eat government funds without serving the people, and who exploit high-ranking positions for personal gain—through merciless satire and sharp criticism. In “Talking About Cattle,” the author expresses the spirit of cattle. Indeed, the spirit of cattle can also be seen as Mr. Pei’s own mindset, a peaceful, hardworking, selfless, and unyielding attitude toward life in the face of society’s myriad challenges—wasn’t this exactly the very spirit described by Lu Xun’s famous line, “Frowning and coldly facing the tongues of thousands, bowing down to serve as a cow for the people”? In “Commentary on the TV Series ‘Taiping Heavenly Kingdom,’” the author uses his extensive knowledge of history and literature, his unique scholarly insights, and his quick artistic discernment to express a strong sense of concern for society and life. At the same time, in “Remembering Mr. Guo Weiping” and “Medical Ethics Across the Loess Plateau—Famous Calligraphy and Painting Across Nine Provinces,” the author speaks with deep affection and simplicity, using concise, refined, elegant, and beautiful language to honor his friends and his father. These writings are simple yet gentle, filled with heartfelt emotion and genuine sincerity.

In today’s society, it’s almost impossible to find a true scholar. If anyone calls themselves a scholar, they may end up offending others. Though debates between folk writers and intellectuals have raged for years, no definitive conclusion has yet been reached. Today, we see beautiful women writers writing about their bodies, tomorrow we may see fashionable university professors writing about fast food. Yet, in this restless literary environment, there are still many elderly intellectuals like Mr. Pei Zhengxue who uphold the spirit of “bearing the weight of righteousness on their shoulders and crafting wonderful works with their skilled hands.” I firmly believe that in just a few years, Mr. Pei will release even more outstanding works and reach more readers. May Mr. Pei live a long and healthy life, producing more masterpieces in the years to come.

December 26, 2006 – Originally published in Tianshui Daily

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Pei Zhengxue Clinical Collection, Volume II Pei Zhengxue’s Hands of Wisdom: Forging Miracles in the Realm of Medicine Zheng Fangjiang, China Traditional Chinese Medicine Daily Born into a family of traditional Chinese medicine practitioners, he went on to study at a Western medical university, combining the strengths of traditional Chinese medicine with the advantages of Western medicine and establishing the “Pei School” as a beacon of Chinese and Western medicine in today’s landscape. He possesses hands that can bring life back to the sick, having formulated the “Sixteen-Character Principle” for integrating Chinese and Western medicine in treatment; and he has a pen that can create wonders, wielding his brush to write books and share his knowledge. As recorded in the “Zuo Zhuan—Year 24 of Duke Xiang,” “The highest good lies in cultivating virtue; next best is to accomplish great deeds; the next best is to speak truthfully.” This is the goal and ideal of many benevolent and ambitious individuals throughout history—and Mr. Pei’s life can perfectly be summed up by the phrase “three pursuits.” He is Pei Zhengxue, a specialist in integrated Chinese and Western medicine at Gansu Provincial Cancer Hospital. Cultivating Virtue: Hands of Wisdom Forge Miracles In 1972, Pei Zhengxue, who worked in the internal medicine department of a hospital in Tianshui, Gansu, treated a patient named Ma Changsheng, a young soldier suffering from leukemia. Despite receiving intensive treatment at both the army hospital and local hospitals, his condition did not improve at all. Ma Changsheng’s parents were deeply disappointed, and when his hemoglobin level dropped to just 2g, they decided to try their luck and seek treatment from Pei Zhengxue. At that time, the main treatment methods for leukemia both domestically and internationally were chemotherapy. Pei Zhengxue used traditional Chinese medicine’s diagnostic methods and the integration of Chinese and Western medicine to develop a treatment plan for Ma Changsheng. After just one month of medication, Ma Changsheng’s fever subsided. A year later, after taking traditional Chinese medicine, a miracle occurred: Ma Changsheng’s hemoglobin level rose to 14g, and multiple bone marrow smear tests showed complete remission. Since recovering, Ma Changsheng has remained healthy and has never relapsed. The same happened to a patient who had advanced pancreatic cancer. Zhou Xiang…

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Chapter 17: Newspaper Abstract In early 2010, Zhou Xiang, a wheat expert in Gansu Province, was diagnosed with advanced pancreatic cancer. Subsequently, accompanied by his family, he went to a major hospital in Shanghai for further examination and treatment. Because Zhou Xiang’s condition had already deteriorated severely, and he was nearly 70 years old, doctors told him that chemotherapy was no longer an option, nor was surgery possible—he could only hope to live for another three months, so he was advised to rest at home and recover.

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This article is part of the series “Pei Zhengxue’s Hands of Wisdom: Forging Miracles in the Realm of Medicine,” originally published in China Traditional Chinese Medicine Daily. The series explores the life and contributions of Pei Zhengxue, a renowned traditional Chinese medicine practitioner who has made significant contributions to the field of integrated Chinese and Western medicine. The article highlights his dedication to his craft, his ability to combine traditional Chinese medicine with Western medical techniques, and his pioneering role in shaping the “Pei School” as a key force in the integration of Chinese and Western medicine. Pei Zhengxue’s work extends beyond his medical practice, as he has also authored numerous books and essays that continue to inspire and educate readers worldwide. His legacy is a testament to his commitment to preserving and advancing traditional Chinese medicine while embracing modern medical advancements.

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Chapter Seventeen: Newspaper Abstract

Radiation therapy;③Chemotherapy;④Interventional therapy;⑤Immunotherapy;⑥Molecular targeted therapy;⑦Gene therapy. In stage I and II, surgery is the primary treatment; in stages III and IV, it serves as palliative care. However, the main problems include severe side effects, poor quality of life, and limited improvements in survival rates, resulting in a poor prognosis. At the same time, it is also important to “focus on strengthening the body’s righteous energy and improving quality of life.” The distinctive features of traditional Chinese medicine’s syndrome differentiation and treatment have proven effective in alleviating patients’ clinical symptoms, helping them build confidence in their fight against disease, thereby enhancing their ability to resist illness. Clinically, both non-pharmacological therapies and pharmacological treatments are employed to strengthen the body’s righteous energy and protect the spleen and stomach, ultimately improving quality of life.

He told reporters that modern medicine believes the development, invasion, and metastasis of lung cancer are complex processes involving multiple stages of differentiation, multiple gene mutations, and gradual changes over several steps. The efficacy of treatment is directly related to the stage of the disease, yet only a small number of lung cancer patients are diagnosed at an early stage. Therefore, it is crucial to first focus on high-risk groups, be vigilant about symptoms and signs, conduct necessary examinations in a timely manner, and pay attention to early symptoms and signs, as well as emphasize screening. Secondly, we must “prevent progression once the disease has been diagnosed and prevent recurrence after recovery.” Traditional Chinese medicine can alleviate symptoms, stabilize lesions, and extend survival time in the treatment of lung cancer. Combining TCM with radiotherapy and chemotherapy can enhance therapeutic efficacy, enabling patients to live with the tumor and prolong their survival. After chemotherapy concludes, we should further strengthen the body’s righteous energy and eliminate harmful toxins, inhibiting any remaining cancerous cells and preventing their spread, thereby controlling tumor growth, reducing metastasis rates, and extending survival time.

August 29, 2013, Gansu Daily

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Pei Zhengxue Clinical Collected Volume Two Pei Zhengxue’s Three Lifetimes Fang Jianping, Wang Qian, China Traditional Chinese Medicine Reporter, Wei Qifeng, Correspondent Born into a family of traditional Chinese medicine practitioners, Pei Zhengxue went on to study at a Western medical university, combining the strengths of TCM with the advantages of Western medicine and making the “Pei School” a beacon in the field of TCM and Western medicine today. He possesses a pair of miraculous hands capable of restoring health, having developed the “16-Character Principle” for TCM and Western medicine treatment; he also has a pair of masterful pens that bring forth beautiful works, effortlessly writing books and articles. As the Zuo Zhuan, Chapter 24, states: “The highest level is to cultivate virtue; next comes to achieve merit; then comes to speak truthfully.” This is the goal and ideal of many benevolent scholars throughout history, and Pei Zhengxue’s life can perfectly be summed up by the term “three lifetimes.” He is Pei Zhengxue, an expert in integrated TCM and Western medicine at the Gansu Provincial Cancer Hospital.

Cultivating Virtue: A Master’s Hand in the Medical Field Creates Miracles In 1967, Pei Zhengxue, who was working in the internal medicine department of a hospital in Tianshui, Gansu Province, treated a patient named Ma Changsheng, a young soldier suffering from leukemia. Despite being treated with full efforts at both military hospitals and local hospitals, his condition did not improve in the slightest. Ma Changsheng’s parents were always unwilling to give up hope; when Ma Changsheng’s hemoglobin had dropped to just 2g, they turned to Pei Zhengxue, hoping for a chance to save him. At that time, the primary treatment for leukemia both domestically and internationally was chemotherapy. Pei Zhengxue used TCM’s syndrome differentiation and the combination of TCM and Western medicine to develop a treatment plan for Ma Changsheng. After one month of medication, Ma Changsheng’s high fever subsided; after one year of taking Chinese herbal medicine, a miracle occurred—Ma Changsheng’s hemoglobin increased to 14g, and multiple bone marrow smear tests all showed complete remission. Since his recovery, Ma Changsheng has remained healthy and has never relapsed. The same thing happened to a patient who had advanced pancreatic head cancer. Zhou Xiangchun, a wheat expert from Gansu Province, was diagnosed with advanced pancreatic head cancer in early 2010. Subsequently, accompanied by his family, he went to a large hospital in Shanghai for further examination.

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Chapter Seventeen: Newspaper Abstract Due to the severity of Zhou Xiangchun’s condition and his advanced age—almost 70 years old—doctors told him that he could no longer undergo chemotherapy or surgery, and that his life expectancy was only three months, so he should go home to recuperate. When Zhou Xiangchun returned to Lanzhou, his body was already extremely weak, lying in bed all day, and he suffered from diarrhea more than 20 times a day, causing him great distress.

Later, upon his friend’s recommendation, his family brought Zhou Xiangchun to see Pei Zhengxue for treatment. After six months of treatment using TCM methods, Pei Zhengxue miraculously saw results: Zhou Xiangchun’s pancreatic head cancer CT scan shrank from 4.8cm × 4.2cm to 2.1cm × 1.8cm, and his diarrhea decreased to 3–4 times per day. Every morning, after finishing his Chinese herbal medicine and receiving a protein infusion at the hospital, Zhou Xiangchun was able to go home on his own in the afternoon—and even report work at the Gansu Provincial Department of Science and Technology, participating in some provincial science and technology activities. This delighted his family, and allowed Zhou Xiangchun to regain his former vigor.

Cultivating Merit: The 16-Character Principle Spreads Across China In the 1990s, Pei Zhengxue’s “Western diagnosis, TCM syndrome differentiation, Chinese medicine as the primary treatment, Western medicine as a supplementary approach” 16-character principle gained widespread attention within the Chinese and Western medicine communities nationwide, and the “Pei School” became an important school of thought in the field of TCM and Western medicine today. Pei Zhengxue’s student Cai Zhengliang told reporters that Pei Zhengxue’s 16-character principle was largely contained in his book “Collected Medical Experiences of Pei Zhengxue.” The first part of the book focused on academic thought, primarily detailing Pei Zhengxue’s theories on the integration of TCM and Western medicine; the middle part covered clinical practice, mainly presenting cases and successful experiences of Pei Zhengxue’s application of TCM and Western medicine in treating various diseases; and the final part consisted of reports from students, sharing insights and experiences gained from applying Pei Zhengxue’s teachings across different regions. Throughout the entire book, Pei Zhengxue’s ideas on the “16-Character Principle” of TCM and Western medicine integration were consistently present, making a tremendous contribution to the theoretical research of TCM and Western medicine in China. Because Pei Zhengxue used TCM and Western medicine together to treat many difficult and complex conditions, coupled with the influence of his Weibo consultations, patients from Inner Mongolia, Xinjiang, Guangzhou, Beijing, and other places flocked to seek his treatment. According to feedback from some patients in Beijing, their illnesses had long been unresponsive to treatment at major hospitals in Beijing; however, Pei Zhengxue’s simple prescriptions cured their ailments. For this reason, doctors at some Beijing hospitals specifically requested Pei Zhengxue’s prescriptions from patients, studied them, copied the formulas, and used them to treat patients with similar conditions.

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Pei Zhengxue Clinical Collected Volume Two Cultivating Words: A Physician Who Also Writes, Leaving a Fragrant Legacy The first comprehensive TCM and Western medicine textbook in contemporary China, “Practical Internal Medicine of TCM and Western Medicine,” edited by Pei Zhengxue, won the “International Gold Award for Outstanding Contribution” at the Third World Conference on Traditional Medicine held in the United States in 1996. Pei Zhengxue himself was honored as one of the “World’s Top 10 Ethnic Medicine Stars,” and in 1997, he was recognized by the State Administration of Traditional Chinese Medicine as one of the 500 nationally renowned veteran TCM physicians. In the 1970s, Pei Zhengxue carefully read the representative works of modern TCM masters such as Tang Rongchuan, Zhang Xichun, and Shi Jinmo. He devoted particularly deep study to Tang Rongchuan’s “On Blood Disorders,” gaining valuable insights. During the Cultural Revolution, he worked tirelessly for two years to write “Commentary on ‘Blood Disorders,’” which was published in 1978. After its release in Japan, the book drew significant attention and strong reactions from the academic community. In 1985, Tian Rongyi, President of Shizuoka University of Medicine in Japan, traveled to Lanzhou specifically to consult Pei Zhengxue about issues related to the book. Based on the theories presented in the book, Pei Zhengxue developed a specialized formula for treating leukemia, which was designated as “Lanzhou Formula” at the National Hematology Conference in 1974.

Pei Zhengxue’s student Chen Guangyan told reporters that during his career as a physician, aside from spending five days a week in outpatient clinics, Pei Zhengxue spent decades each year in his renowned TCM inheritance studio. He explored the principles of Qi Huang, summarized clinical cases, and developed medicinal formulas—and what truly delighted him was his relentless dedication to writing and publishing books. His works include “New Compilation of TCM Formulas,” “Diagnosis and Treatment of Hepatitis B,” “Pharmacology and Clinical Applications of Rheum,” “New Compilation of Warm Disease Studies,” and 15 other monographs. While serving as Vice President and Secretary-General of the Provincial Association for Integrated TCM and Western Medicine, he also founded the journal “Integrated TCM Research” and served as its editor-in-chief.

Pei Zhengxue possessed not only miraculous hands capable of restoring health but also a pair of masterful pens that brought forth beautiful writings. While compiling medical works, he also published collections of novels and essays such as “Great Wind Songs,” as well as poetry collections like “Spring Breeze Songs,” “Autumn Breeze Songs,” “Pei Zhengxue Calligraphy Collection,” and “Introduction to Medicine – Running Script Posters.” In February of this year, his new work “Pei Zhengxue’s Health Weibo” and his collection of poetry and calligraphy, “Snowy Footprints,” were published, marking another testament to his 55 years of medical practice and a record of his achievements.

August 7, 2013, Comprehensive News Section of China Traditional Chinese Medicine Newspaper

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Chapter Seventeen: Newspaper Abstract Traditional Chinese Medicine Expert Pei Zhengxue Launches TCM Treatment for Disaster Victims Ren Jinchao, People’s Daily Online

People’s Daily Online, Lanzhou, July 25 (Ren Jinchao) — On July 25, in accordance with the arrangements and directives issued by the Provincial Health Department regarding TCM-based treatment for disaster victims, the TCM Management Office and Medical Affairs Office of Lanzhou Second Hospital invited renowned TCM expert Professor Pei Zhengxue to conduct syndrome differentiation and treatment for 19 injured patients admitted to the hospital, prescribing individualized treatment plans for each case.

Accompanied by medical staff from Lanzhou Second Hospital, Professor Pei went to the patients’ bedsides. After conducting necessary TCM examinations—such as observing, listening, inquiring, and palpating—the doctor prescribed Fuyuan Huoxue Decoction combined with Taohong Siwu Decoction for patients with multiple fractures, promoting wound healing and bone regeneration. For patients undergoing trauma surgery, he prescribed Duhuo Jisheng Decoction, Xiangsha Liu Junzi Decoction, and Shiquan Dabu Decoction to replenish vital energy and benefit stomach qi. For postoperative patients, he prescribed Taohong Siwu Decoction and Huoluo Xiaoling Dan to remove blood stasis and promote new tissue formation.

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Pei Zhengxue Clinical Collected Volume Two Pei Zhengxue Builds a High-Rise of TCM Using a Western Medical Framework Wei Qifeng, China Traditional Chinese Medicine Reporter Pei Zhengxue is a physician in the Integrated TCM and Western Medicine Department of Gansu Provincial Cancer Hospital. Born into a family of traditional Chinese medicine practitioners, he was determined from a young age to pass on the family’s ancestral knowledge of TCM. His father once encouraged him to pursue Western medicine, saying that the better one’s understanding of Western medicine, the more effectively he could use Western medical “frameworks” to construct a “high-rise” of TCM. On his journey of learning, he faced three major hardships in life. Yet these challenges never wavered his original aspirations—he turned adversity into joy and used books as his guiding light. Amidst hardship, he wrote “Commentary on Blood Disorders”; through continuous accumulation and refinement, he created “Lanzhou Formula,” replicating countless stories of saving leukemia patients from the brink of death. Following his father’s teachings, Pei Zhengxue dedicated himself to spreading TCM while integrating Western medicine. Pei Zhengxue’s grandfather was a scholar during the Qing Dynasty and a renowned physician in his hometown. When his grandfather took the imperial examination for the juren degree, the imperial examination system was abolished. Thus, he immersed himself in the study of medicine, accumulating extensive medical experience. After Pei Zhengxue’s grandfather passed away, his father inherited the family’s medical traditions. Through constant study and practice, he accumulated rich clinical experience and was recognized as one of the ten most famous physicians in Gansu Province. Under his father’s guidance, Pei Zhengxue memorized books such as “Medical Three Character Classic,” “Binhu Pulse Study,” and “A Four Hundred-Ingredient Guide to Medicinal Properties,” mastering the fundamentals of medicine from a young age. Because his father knew very little about Western medicine, he often found himself at a loss when dealing with patients. Therefore, his father frequently advised him that TCM must be combined with modern medicine to truly flourish. The better Western medicine is, the deeper TCM can explore. Influenced by his father, Pei Zhengxue embarked on a long journey of studying TCM and Western medicine together.

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Chapter Seventeen: Newspaper Abstract Remembering His Original Aspiration: Cultivating a Reading Habit Amidst Hardship To fulfill his father’s wish, Pei Zhengxue entered Xi’an Medical College in 1956, where he ranked among the top students and received much attention from the moment he stepped onto campus. However, shortly after, an unfortunate event occurred. In 1958, a nationwide wave of anti-rightist campaigns swept through the country, and his father was labeled as a rightist. Pei Zhengxue was also implicated and became a target of criticism at school for four months. Though life’s setbacks did not change Pei Zhengxue’s original aspirations, every time he finished a round of criticism, he would pick up a medical text and read, casting aside all his hardships—this became a lifelong habit. In 1961, Pei Zhengxue completed all his courses. With excellent academic performance, he could have stayed on campus after graduation. But misfortune struck again. During the political review process, due to his family’s background and his father’s historical circumstances, he was assigned to TianShui Hospital. Pei Zhengxue did not lose heart; during this period, he continued to uphold the principles of saving lives, pursuing studies, and cultivating himself. However, his misfortunes did not end there—during the Cultural Revolution, Pei Zhengxue was labeled as one of the “black five categories” and was sent to the remote TianShui Ganquan Health Center.

Facing repeated blows, Pei Zhengxue remained steadfast in his original aspirations. While working at Ganquan Health Center, he would wake up early each day to study “Medical Treatise on Cold Damage” and “Golden Cabinet Essentials”; at night, he would stay up late, writing “Commentary on Blood Disorders.” Later, after the book was published in Japan, it had a profound impact. In May 1985, Professor Tian Rongyi, President of Shizuoka University of Medicine in Japan, traveled to Lanzhou specifically to consult Pei Zhengxue about issues related to the book.

Saving Lives: Accumulating Experience and Creating “Lanzhou Formula” In 1967, Pei Zhengxue, who was working in the internal medicine department of a hospital in TianShui, treated a patient named Ma Changsheng. Ma Changsheng was a 16-year-old soldier diagnosed with acute monocytic leukemia by professors at Lanzhou Medical College. Despite being treated with full effort at both military hospitals and local hospitals, his condition did not improve—it continued to worsen, and his hemoglobin had dropped to just 1 gram. Already despairing, Ma Changsheng only hoped to return to his hometown in TianShui to bid farewell to his family. When Ma Changsheng returned home, his parents did not give up hope and sought Pei Zhengxue’s help, holding onto a glimmer of hope. At that time, the primary treatment for leukemia both domestically and internationally was chemotherapy—but its toxic side effects were quite obvious. Pei Zhengxue used TCM’s syndrome differentiation and the combination of TCM and Western medicine to develop a treatment plan for Ma Changsheng.

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Miraculous Remedies and Replicable Stories of Saving Lives In 1970, Pei Zhengxue was sent to the Ganquan Commune Health Center in TianShui. One day, Chen Zhengyuan, the station manager of Qin’an County Bus Station, came to Pei Zhengxue seeking treatment. After examination, it was discovered that Chen Zhengyuan suffered from chronic nephritis and renal failure, with proteinuria reaching three plus levels, and non-protein nitrogen exceeding 70%, leading to end-stage uremia. From a Western medical perspective, the patient was destined to die. However, Pei Zhengxue did not give up on Chen Zhengyuan; he prescribed a treatment plan for him and encouraged him to go home and continue taking the medicine. After taking more than 300 doses of medicine that year, Chen Zhengyuan not only survived but also grew stronger with each dose.

In 2000, Liu Li-gang, a student at Lanzhou University, unfortunately developed acute lymphoblastic leukemia. After undergoing chemotherapy, her treatment yielded little success. Later, she found Pei Zhengxue at the Gansu Provincial Cancer Hospital. To save this young man’s life, Pei Zhengxue used “Pei’s Blood-Raising Granules,” which he had developed himself. He then prescribed a traditional Chinese medicine formula and prepared some pills for her to take regularly. Soon, Liu Li-gang not only did not need to undergo chemotherapy, but her indicators also returned to normal, allowing her to return to school and continue her studies.

Personnel Links Pei Zhengxue, born in Wushan County, Gansu Province, in 1938 into a family with three generations of medical expertise, graduated from the Medical Department of Xi’an Medical College in 1961. He is a chief physician, professor, doctoral supervisor, and a renowned Chinese-TCM expert, recipient of a special government allowance, and one of the fourth group of national veteran TCM physicians.

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Chapter Seventeen: Newspaper Abstract

Academic mentor and guide for the inheritance of TCM’s professional experience.

Friday, November 21, 2014, China Traditional Chinese Medicine Newspaper

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Achievements: The 16-character principle spread far and wide across the country. In the 1990s, Pei Zhengxue’s “Western medical diagnosis, Traditional Chinese Medicine syndrome differentiation, Traditional Chinese Medicine as the primary approach, Western medicine as a supplementary tool” 16-character principle gained widespread attention within China’s TCM and Western medicine communities, and the “Pei School” became an important school of thought in the field of TCM and Western medicine today.

Pei Zhengxue’s student Cai Zhengliang told reporters that Pei Zhengxue’s 16-character principle was primarily compiled in his book “Collected Medical Experiences of Pei Zhengxue.” The first part of the book focuses on academic thought, primarily detailing Pei Zhengxue’s theories on the integration of TCM and Western medicine; the middle part covers clinical practice, mainly presenting cases and successful experiences of Pei Zhengxue’s application of TCM and Western medicine in treating various diseases; and the final part consists of reports from his students, sharing their personal insights and experiences in applying Pei Zhengxue’s teachings. Throughout the book, Pei Zhengxue’s ideas on the “sixteen-character principle” of integrating TCM and Western medicine are central, representing a significant contribution to the theoretical research on TCM and Western medicine in China.

Because Pei Zhengxue used integrated TCM and Western medicine approaches to treat many complex and difficult-to-treat conditions, coupled with the influence of his online consultations via Weibo, patients from Inner Mongolia, Xinjiang, Guangzhou, Beijing, and other regions flocked to seek his treatment. According to feedback from some patients in Beijing, their illnesses had been treated unsuccessfully in major hospitals in Beijing for a long time—but Pei Zhengxue’s simple prescriptions were able to cure their ailments, allowing them to…

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Pei Zhengxue Clinical Collected Volume 2 As a result, doctors at some hospitals in Beijing specifically requested Pei Zhengxue’s prescriptions from patients, studied them, copied the formulas, and used them to treat patients suffering from similar conditions.

Speaking of words: A physician who is both a healer and a scholar, leaving behind a fragrant legacy of ink. The contemporary masterpiece on internal medicine integrating TCM and Western medicine, “Practical Internal Medicine of TCM and Western Medicine,” edited by Pei Zhengxue, won the “International Gold Award for Outstanding Contribution” at the Third World Conference on Traditional Medicine held in the United States in 1996. Pei Zhengxue himself was honored as one of the “100 World Stars of Ethnic Medicine,” and in 1997, he was recognized by the State Administration of Traditional Chinese Medicine as one of the 500 nationally renowned veteran TCM physicians.

In the 1970s, Pei Zhengxue carefully read the representative works of masters such as Tang Rongchuan, Zhang Xichun, and Shi Jinmo from the modern TCM integration school. He devoted particularly deep study to Tang Rongchuan’s “On Blood Disorders,” gaining profound insights. During the Cultural Revolution, he worked tirelessly for two years to complete “Commentary on ‘Blood Disorders,’” which was published in 1978. After its release in Japan, the book drew significant attention and strong reactions from the academic community. In 1985, Tian Rongyi, President of Shigaoka University of Medicine in Japan, traveled specially to Lanzhou to consult Pei Zhengxue about issues related to the book. Based on the theories presented in the book, Pei Zhengxue developed a specialized formula for treating leukemia, which was officially designated as the “Lanzhou Formula” at the National Hematology Conference in 1974.

Pei Zhengxue’s student Chen Guangyan told reporters that during his career as a physician, apart from five and a half days a week spent in outpatient clinics, he spent the rest of his time—day after day—for decades in his renowned TCM inheritance studio. He explored the principles of Qihuang, summarized patient cases, and developed medicinal formulas; what truly delighted him was his relentless dedication to writing and publishing books, including 15 major works such as “New Compilation of TCM Formulas,” “Diagnosis and Treatment of Hepatitis B,” “Pharmacology and Clinical Applications of Rheum,” and “New Compilation of Warm Disease Studies.” While serving as Vice President and Secretary-General of the Provincial Association for Integrative TCM and Western Medicine, he also founded the journal “Research on Integrative TCM and Western Medicine” and served as its editor-in-chief.

Pei Zhengxue possessed not only the skill of “dual spring,” but also the gift of eloquent prose; under his guidance, every word he spoke—whether it was a joke or a stern admonition—could become a piece of literature. While compiling medical works, he also published collections of novels and essays such as “Great Wind Songs,” as well as poetry and prose collections like “Spring Breeze Songs,” “Autumn Breeze Songs,” “Pei Zhengxue Calligraphy Collection,” and “Introductory Notes on Medicine in Handwriting.” This February, his new work “Pei Zhengxue’s Health Weibo” and his collection of poetry and calligraphy, “Snowy Footprints on the Mud,” were published, marking yet another testament to his 55 years of medical practice.

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Chapter 17: Newspaper Summaries Pei Zhengxue: Not a Good Minister, But a Good Physician Zheng Fangjiang, Qi Qin “Thank you, Professor Pei Zhengxue, for your superb medical skills—through your gentle demeanor, you’ve helped us understand what it means to be a true physician with a compassionate heart. You always manage to ease our psychological burdens with a smile, bringing hope for life to our entire family.” These were the words of a patient who wrote a letter of gratitude to Professor Pei Zhengxue. Online, countless heartfelt expressions of appreciation for Professor Pei Zhengxue abound: “My father’s illness had relapsed for many years, and we only found you when we were at our wits’ end. Just after taking two doses of the medicine you prescribed, his condition began to improve. I would like to take this opportunity to sincerely thank you…” … Three generations of Qihuang are nothing remarkable—learning medicine should always aim to become a good physician.

Pei Zhengxue is a renowned expert in the integration of TCM and Western medicine in China, a doctoral supervisor at the China Academy of Traditional Chinese Medicine, and a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Institute of Medical Sciences. Born into a family steeped in TCM, Pei Zhengxue’s grandfather, Pei Shaojian, dedicated his life to healing others, while his father, Pei Shen, was one of the ten most famous TCM physicians of modern Gansu. Influenced by the rich medical environment of his family, Pei Zhengxue made a solemn vow from a young age: “If I cannot become a good minister, then I will become a good physician.” Later, he entered the Medical Department of Xi’an Medical University with excellent grades, truly beginning his more than 50-year journey of practicing medicine and saving lives.

With the continuous enrichment of his clinical practice, Pei Zhengxue also achieved remarkable results in medical research. In 1980, his book “Commentary on Blood Disorders” was published and, after being introduced to Japan, sparked a strong response. In May 1985, Professor Tian Rongyi, President of Shigaoka University of Medicine in Japan, traveled specially to Lanzhou to consult him about issues related to the book. In the 1990s, Pei Zhengxue’s “16-character principle”—Western medical diagnosis, TCM syndrome differentiation, TCM as the primary approach, Western medicine as a supplementary tool—gained widespread attention within China’s TCM and Western medicine communities, becoming an important school of thought in the field of integrative TCM and Western medicine today.

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Pei Zhengxue Clinical Collected Volume 2 Pei Zhengxue’s contemporary masterpiece on internal medicine, “Practical Internal Medicine of TCM and Western Medicine,” was awarded the “International Gold Award for Outstanding Contribution” at the Third World Conference on Traditional Medicine in 1996. In 1997, the State Administration of Traditional Chinese Medicine recognized Pei Zhengxue as one of the 500 nationally renowned veteran TCM physicians.

To serve the people, he risked everything—his spirit remained unshaken even as earthquakes struck the Loess Plateau. When the disaster struck, Pei Zhengxue still braved the dangers, rushing to major provincial hospitals to treat patients, repaying the land that had nurtured him with the selfless spirit of a true son.

Since beginning his medical career, Pei Zhengxue has always approached his patients with a “compassionate heart,” offering warmth and care to patients like rain in the spring, year after year.

“Yesterday I went to the countryside, but when I returned, I felt uneasy. A young patient, suffering from a minor illness, lost his life due to poverty.” This was a small poem Pei Zhengxue composed while practicing medicine, titled “Compassion for the Poor,” and throughout the lines, one can feel his deep concern and compassion for those who lived in poverty.

Every year, there are patients like this who come to visit Mr. Pei Zhengxue. Once a freshman at Lanzhou University, he unfortunately contracted “ALL Acute Lymphoblastic Leukemia,” and despite numerous rounds of chemotherapy, his condition did not improve significantly. At the most critical moment of his life, Pei Zhengxue saved this university student who was struggling on the brink of death.

“I will forever be grateful for his lifesaving kindness.” These words, spoken by so many patients like Liu Ligang who were healed by Mr. Pei, represent the heartfelt sentiments of countless others.

“He would provide medical care even without a prescription, covering the costs for patients who couldn’t afford it.” “He treated men, women, young children, the rich, the poor—without discrimination.” These praises were shared by Pei’s colleagues, disciples, and patients alike. In their eyes, Mr. Pei was a kind elder, a doctor who saved lives and cared for patients, and above all, a noble and righteous angel in white.

Even an old cow knows its sunset is short—so it doesn’t need to be urged to gallop, but it does so anyway.

In 2011, Pei Zhengxue’s “Practical Internal Medicine of TCM and Western Medicine” (Revised Edition) was published.

The inaugural event was held in Lanzhou. 2013 marked Pei Zhengxue’s 75th birthday and the 55th anniversary of his career in medicine, teaching, and research. His new work, “Pei Zhengxue’s Health Weibo,” was released.

For decades, Pei Zhengxue spent his time—except for five and a half days a week in outpatient clinics—spending the rest of his days in his renowned TCM inheritance studio. He worked diligently, never stopping to write, developing new theories, and publishing 15 major medical works, including “New Compilation of TCM Formulas,” “Selected Cases of Pei Shen,” and “Pei Zhengxue’s Medical Notes.” While serving as Vice President and Secretary-General of the Gansu Provincial Association for Integrative TCM and Western Medicine, he also founded the journal “Research on Integrative TCM and Western Medicine” and served as its editor-in-chief.

Pei Zhengxue was a versatile TCM master, achieving remarkable accomplishments in poetry, calligraphy, and painting. In recent years, he published collections of novels and essays such as “Great Wind Songs,” as well as poetry and prose collections like “Spring Breeze Songs,” “Autumn Breeze Songs,” and calligraphy and painting collections like “Pei Zhengxue Calligraphy Collection” and “Introductory Notes on Medicine in Handwriting.”

“I’m answering questions from patients who ask me online through Weibo, working alongside my doctoral students. I’ve already answered 5 questions, and I still have 2 left—please wait a moment while you enjoy your tea.” During an interview with reporters, Pei Zhengxue was busy answering patients’ questions via Weibo. He constantly learned new technologies, striving to help more people understand TCM and master its therapeutic methods.

Today, even in his advanced years, Pei Zhengxue continues to serve patients day after day, year after year. For the sake of medical advancement, he generously shared his lifelong knowledge with his disciples, nurturing a generation of talented practitioners who now flourish across the Loess Plateau and have become the backbone of TCM clinical practice.

“An old cow knows its sunset is short—so it doesn’t need to be urged to gallop, but it does so anyway.” Pei Zhengxue often used this verse as a source of encouragement. Though he was over 70 years old, he continued to fight tirelessly on the front lines of medicine, saving lives, training new generations, engaging in literary and artistic creation, and continuing to shine brightly, making new contributions to society. Looking back over the past 70 years, Pei Zhengxue’s life was filled with brilliance, proving that a true physician must possess the sense of responsibility that comes with compassion.

February 28, 2014, China Traditional Chinese Medicine News

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Pei Zhengxue Clinical Collected Volume 2 Pei Zhengxue’s Long Road of Writing Zheng Fangjiang, Qi Qin, China Traditional Chinese Medicine News At 75 years old, Pei Zhengxue, a renowned TCM and Western medicine scholar in China, a lifetime member of the Chinese Society of Traditional Chinese Medicine, an editorial board member of China Journal of Integrated TCM and Western Medicine, a renowned TCM physician in Gansu Province, and a chief expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Gansu Provincial Cancer Hospital, has spent decades writing and publishing, tirelessly dedicating himself to learning and creating. He has published more than 20 major monographs, authored 86 papers, and received over 20 scientific awards at various levels. Professor Pei Zhengxue is a prominent TCM scholar in China, Honorary Chairman of the Gansu Provincial Association for Integrative TCM and Western Medicine, an expert who enjoys a special government allowance, one of the first 500 nationally renowned veteran TCM physicians, and a mentor guiding the academic experience of senior TCM experts across the country. He has long been committed to the cause of TCM and Western medicine integration, proposing the “16-character” clinical approach to TCM and Western medicine, which has been widely endorsed by the Ministry of Health, the State Administration of Traditional Chinese Medicine, and the academic community of TCM and Western medicine in China, forming a highly influential TCM and Western medicine school domestically. With 55 years of clinical practice, he excels in treating blood disorders, tumors, liver diseases, and complex cases across various specialties, especially with unique insights into the treatment of leukemia, earning the trust and high praise of his patients. He has published 20 monographs, authored 86 academic papers, and received 13 research awards at various levels. Behind these remarkable achievements lies the immense hardship and effort Pei Zhengxue put into forging this brilliant path in life. Let us listen as he shares his story. From a family of TCM scholars, born into a scholarly household, Pei Zhengxue was born in 1938 in Peijia Zhuang, Lomen Town, Wushan County, Gansu Province—a family steeped in TCM and filled with scholarly traditions. His grandfather, Pei Shaojian, was a renowned Confucian scholar and physician, celebrated in Longdong and Longnan. His father, Pei Shen, studied at Central University in Nanjing early in life, first learning classical Chinese, then founding “Shen Gong Middle School” in Lomen Town, Wushan County, serving as its principal. Later, he abandoned his studies to pursue medicine, a compassionate physician with a noble heart…

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Chapter 17: Newspaper Summaries His medical skills were renowned throughout the Loess Plateau, and his poetry, calligraphy, and painting were equally accomplished. He was known as “Longshang Board Bridge,” and in 2012, he was honored as one of the ten most famous TCM physicians of modern Gansu Province. Pei Zhengxue possessed extraordinary talent, deeply influenced by his ancestors, and cultivated a profound love for TCM. From a young age, he was diligent and eager to learn, determined to dedicate his life to medicine and save the people. In 1961, he graduated from the Medical Department of Xi’an Medical University. On the long road of life, he devoted himself to the medical field, serving the people, mastering artistry, holding high moral standards, and tirelessly writing and publishing. He became a renowned figure in the domestic TCM and Western medicine fields, a towering figure in the medical world, thoroughly familiar with the classics and deeply interpreting “Blood Disorders.”

Pei Zhengxue’s youth was marked by many hardships. In 1958, a nationwide wave of anti-rightist campaigns swept through the country. Pei Zhengxue, who was a sophomore at the time, was wrongly labeled a rightist and subjected to persecution for several months. In 1961, after graduating from university, Pei Zhengxue could have stayed on campus, but during the political review, his family background and his father’s historical issues led to his transfer to Tian Shui Hospital. During the Cultural Revolution, Pei Zhengxue was labeled as one of the “Black Five Categories” and sent to the remote Ganquan Health Center in Tian Shui. Here, Pei Zhengxue did not lose heart or give up; instead, he saw this as a rare opportunity. Even in the freezing winter, he persisted in reciting classic texts like “Shanghan Lun,” “Jin Gui Yao Lü,” and “Neijing Zhi Yao” in the forest every day. Whenever he encountered difficulties, he sought advice from many sources, discussing and refining his understanding, striving for success. Unexpectedly, this arduous period laid a solid foundation for his later writings and publications.

Books contain golden houses, books contain beautiful faces. In the 1970s, Pei Zhengxue carefully read the representative works of masters such as Tang Rongchuan, Zhang Xichun, Shi Jinmo, Yu Wuyan, and Shi Yi Ren. He devoted particular effort to Tang Rongchuan’s “On Blood Disorders,” gaining profound insights. During the Cultural Revolution, he spent two years writing “Commentary on ‘Blood Disorders,’” which was published in 1978 by People’s Health Publishing House. After its release in Japan, the book attracted significant attention and strong reactions from the academic community.

In February 1992, Pei Zhengxue organized 21 renowned TCM and Western medicine experts from the five northwestern provinces to compile “Practical Internal Medicine of TCM and Western Medicine,” the first comprehensive work on TCM and Western medicine in China. The 150,000-character精装 edition was officially published in May 1995. In April 1996, at the Third World Conference on Traditional Medicine held in the United States, the book won the “International Gold Award for Outstanding Contribution,” followed by the “National Excellent TCM Book First Prize” and the “Gansu Provincial Science and Technology Progress Second Prize.” Pei Zhengxue himself was honored as one of the “100 World Stars of Ethnic Medicine.” The “16-character clinical model of TCM and Western medicine,” proposed in the book—Western medical diagnosis, TCM syndrome differentiation, TCM as the primary approach, Western medicine as a supplementary tool—was adopted by Chen Minzhang, then Minister of Health, as the “16-character clinical approach,” gaining widespread attention within China’s TCM and Western medicine communities and becoming a major school of thought in the field of integrative TCM and Western medicine today.

Liu Weiping, Deputy Secretary of the Gansu Provincial Committee of the Communist Party of China and Governor of Gansu Province, Li Xiaojie, Member of the Standing Committee of the Gansu Provincial Committee of the Communist Party of China and Head of the Provincial Propaganda Department, Xian Hui, Vice Governor, and Li Peiwén, Secretary-General of the Provincial Government, attended the inaugural ceremony and offered high praise.

Over nearly 40 years since the 1970s, Pei Zhengxue spent decades—except for five and a half days a week in outpatient clinics—spending the rest of his time in his renowned TCM inheritance studio. He explored Qihuang, worked diligently, never stopped writing, developed new theories, and published works such as “New Compilation of TCM Formulas,” “Diagnosis and Treatment of Hepatitis B,” “Pharmacology and Clinical Applications of Rheum,” “New Compilation of Warm Disease Studies,” “Selected Cases of Pei Shen,” “Integrated TCM and Western Medicine for Common Diseases,” “Pei Zhengxue’s Medical Notes,” “Pei Zhengxue’s Medical Essentials,” and “Pei Zhengxue’s Medical Talks.”

Medical Case Collection," "Pei Zhengxue Clinical Collected Works" and other 15 medical monographs have been published. During his tenure as Vice President and Secretary-General of the Gansu Provincial Association for Integrated Chinese and Western Medicine, he also founded the journal "Integrated Chinese and Western Medicine Research" and served as its editor-in-chief.

While compiling medical works, Pei Zhengxue's collection of novels and essays, titled "Da Feng Qu," included poetry and prose.

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His works such as "Chunfeng Qu," "Qiu Feng Qu," "Pei Zhengxue Calligraphy Collection," and "Introduction to Medicine - Running Cursive Script Posters" were also published one after another, becoming a beautiful sight in the realm of traditional Chinese medicine culture. To promote and record his life of seeking true knowledge, delving into the teachings of Qihuang, and benefiting all beings, his disciples wrote the biographical work "Pei Zhengxue: A Famous Doctor from Longshan," which was published and distributed in 2008. This year, Pei Zhengxue's two new works, "Pei Zhengxue Health Weibo" and the poetry and calligraphy collection "Xue Ni Hong Zha," were released for the first time. These works serve as important tributes to mark the 75th anniversary of Pei Zhengxue's birth, the 55th anniversary of his medical career, and the 35th anniversary of his publication of medical works.

"An old ox knows its own sunset is short—no need to whip it, just keep forging ahead." "The green bag does not fail the old man of Hua Yuan; it is never too late to benefit all beings..." Although Mr. Pei Zhengxue has passed his 70s, he remains full of vigor and continues to fight on the front lines of medical care, saving lives and treating the injured, tirelessly writing and nurturing young practitioners. His vast, selfless love is precisely the noble sentiment and spiritual light within the heart of a great physician.

May 20, 2013, China Journal of Traditional Chinese Medicine

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**Pei Zhengxue and his "Lanzhou Formula" Qi Qin, Yang Yin Hong, Zheng Fangjiang

In the field of traditional Chinese medicine in Gansu Province, a formula named after a place—known both domestically and internationally as the "star of blood diseases"—is called the "Lanzhou Formula." The creator of this formula is Pei Zhengxue, Chief Expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Academy of Medical Sciences.

"Three generations of Qihuang are not remarkable; when you study medicine, you should become a good doctor. If you dedicate yourself to serving the people of Gansu, do not follow the path of arrogant soldiers who seek defeat." These were the words that Pei Zhengxue's father, Pei Shen, used to encourage his children. Influenced by his family, Pei Zhengxue developed an aspiration to practice medicine from a young age. He later gained excellent grades and was admitted to the Medical Department of Xi'an Medical University, where he was assigned to work at Tian Shui Hospital. Over more than 50 years in the medical profession, Pei Zhengxue leveraged his strengths in both Chinese and Western medicine, achieving fruitful results in teaching, medical practice, and research.

The "Lanzhou Formula" That Revives the Dead

In 1967, Pei Zhengxue, working in the Internal Medicine Department of Tian Shui Regional Hospital, treated a patient named Ma Changsheng, who had leukemia. Ma Changsheng was a young soldier; despite intensive treatment, his condition did not improve. At that time, the primary method for treating leukemia both domestically and internationally was chemotherapy. However, the toxic side effects of chemotherapy were quite severe. Pei Zhengxue employed traditional Chinese medicine’s diagnostic methods and integrated Chinese and Western medicine approaches to develop a treatment plan for Ma Changsheng. After only one month of medication, Ma Changsheng’s high fever subsided; after over a hundred doses of traditional Chinese medicine, his hemoglobin levels rose to 14 g, and multiple bone marrow smear examinations showed complete remission.

When the experts who had previously treated Ma Changsheng learned of this case, they were astonished and could hardly believe what they heard—calling it a "miracle."

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Since being cured by Old Master Pei, this patient has remained healthy to this day, with no recurrence. The "16-Character Principle" Creates the "Pei School"

As clinical medical practice continued to evolve, Pei Zhengxue also achieved substantial results in medical research. In 1980, Pei Zhengxue’s book "Commentary on Blood Disorders" was published and distributed. After being introduced to Japan, it garnered a strong response. In May 1985, Professor Tan Eiichi, President of Shizuoka Medical University in Japan, traveled specifically to Lanzhou to consult Old Master Pei about issues related to the book. In the 1990s, Pei Zhengxue’s “16-Character Principle”—“Western medicine diagnosis, traditional Chinese medicine diagnosis, traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach”—was recognized by the national Chinese and Western medicine communities, and the “Pei School” became an important school of thought in the field of Chinese and Western medicine today.

Pei Zhengxue’s edited, the first comprehensive monograph on integrated Chinese and Western medicine in contemporary times, "Practical Internal Medicine of Integrated Chinese and Western Medicine," won the "International Gold Award for Outstanding Contribution" at the Third World Conference on Traditional Medicine held in the United States in 1996. He himself was honored with the prestigious title of "One Hundred Stars of Ethnic Medicine Worldwide." In 1997, the State Administration of Traditional Chinese Medicine recognized Pei Zhengxue as one of the 500 renowned veteran Chinese physicians nationwide. He was subsequently invited as a guest professor by three domestic Chinese medicine institutions, including the Hong Kong College of Traditional Chinese Medicine.

A Physician’s Benevolent Heart, Warmth for Patients

In 2000, Liu Ligang, a student from Jiangxi studying at Lanzhou University, unfortunately suffered from ALL acute lymphoblastic leukemia. Despite extensive chemotherapy and various treatments, his condition did not improve significantly, and doctors predicted that his treatment would cost around 300,000 yuan. Through an introduction, he found Pei Zhengxue. Old Master Pei handed over his newly developed "Pei’s Blood-Raising Granules" to the young man who was struggling on the brink of death. When he learned that Liu Ligang planned to return to his hometown in Jiangxi, Old Master Pei warmly said, "You can contact me anytime when you go home—I’ll send you the prescription in a timely manner."

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He sent these medications to Liu Ligang through a trusted representative. After Liu Ligang took the traditional Chinese medicine on time, the toxic side effects of chemotherapy were noticeably alleviated, and indicators such as red blood cells, white blood cells, and platelets quickly returned to normal. The intervals between chemotherapy sessions gradually increased. Old Master Pei then sent Liu Ligang his newly prepared traditional Chinese medicine again; after taking it, Liu Ligang no longer needed to undergo chemotherapy, and his indicators miraculously returned to normal. Today, Liu Ligang has fully recovered and completed his studies. Every year, he returns to Lanzhou to visit Old Master Pei, expressing his gratitude for his lifesaving kindness.

Although Old Master Pei is now over 70 years old, he remains full of energy and continues to stay committed to the medical field—seeing patients, practicing medicine, writing books, mentoring young practitioners, and living up to the principle of "an old ox knows its own sunset is short; no need to whip it, just keep forging ahead," creating value in his life.

May 2012, China Journal of Traditional Chinese Medicine

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The Story of Pei Zhengxue and a Patient with Pancreatic Cancer

Dialectal News from Central Radio and Television Network, Lanzhou, January 10: In the city of Lanzhou, there is a famous physician who comes from a family steeped in traditional Chinese medicine, possessing deep roots in the teachings of Qihuang. He graduated from Xi’an Medical University with a solid foundation in Western medicine theory. He seamlessly integrated Chinese and Western medicine, becoming a renowned scholar in China’s field of integrated Chinese and Western medicine. Rooted in the land of Longshan, he has cured tens of thousands of patients with difficult and complex conditions across the country, particularly achieving remarkable success in treating malignant tumors with traditional Chinese medicine, earning the admiration and trust of the public. He is Professor Pei Zhengxue, one of the first distinguished Chinese physicians in Gansu Province, Chief Expert at the Gansu Provincial Hospital of Traditional Chinese Medicine and the Provincial Tumor Hospital.

"Meritorious Servant" Stricken with Serious Illness

Just after the Spring Festival in 2010, an elderly man and his family lost their original joy and peace. This elderly man was the first recipient of science and technology awards in Gansu Province, a nationally renowned wheat breeding expert, revered by the people as the "Wheat Breeding King of Longshan," the Zhou Xiangchun of Gansu—a figure often compared to Yuan Longping of Gansu.

During the Spring Festival, he frequently felt fatigued and lacked energy, with a loss of appetite. He soon began experiencing intermittent pain in his upper abdomen, along with increased bowel movements—three to four times a day, eventually rising to around ten times per day. After visiting several small hospitals for treatment and taking some common gastrointestinal medications, his condition actually worsened, with diarrhea increasing to around twenty times a day.

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It was clear that treatment would be quite challenging.

On August 11, 2010, Zhou Xiangchun was admitted to the Hepatobiliary and Pancreatic Surgery Department of Ruijin Hospital affiliated with Shanghai Jiao Tong University. A hospital-wide consultation confirmed that he had malignant tumor—specifically, cancer of the tail of the pancreas. The consultation concluded that surgery was not advisable, and recommended conservative internal medicine treatment and traditional Chinese medicine therapy, estimating his survival time to be only about 3 to 6 months. On August 19, 2010, Zhou Xiangchun returned to Lanzhou and sought medical treatment everywhere, but his condition continued to worsen, with diarrhea increasing to over twenty times a day, and upper abdominal pain becoming increasingly severe.

Unexpectedly, things turned around when he met Old Master Pei.

At that time, someone introduced him to Professor Pei Zhengxue, a renowned veteran physician at the Gansu Provincial Tumor Hospital.

Zhou Xiangchun went to the Gansu Provincial Tumor Hospital’s “Integrated Chinese and Western Medicine Department” on September 15, 2010, to receive treatment from Pei Zhengxue. This department was founded 25 years ago by Pei Zhengxue himself, and currently comprises many doctoral and master’s degree holders who form Pei Zhengxue’s clinical technical team. The traditional Chinese medicine expertise here is truly “strong in both troops and horses.” Pei Zhengxue carefully reviewed Zhou Xiangchun’s entire medical records. After conducting a thorough examination—observing, listening, asking questions, and palpating—he carefully prescribed a treatment plan for Zhou Xiangchun. He entrusted Associate Chief Physician Zhang Huifang, his academic successor, to oversee the patient’s bedside care; he also appointed his graduate student Zhang Guiqiong as the attending physician to collaborate on management; furthermore, he brought in Chief Nurse Qiu Yumei, Department Director Xue Wenhán, and Head Nurse Zhang Cailin to provide meticulous treatment and special care for Zhou Xiangchun. Pei Zhengxue repeatedly urged Zhang Huifang to closely monitor Zhou Xiangchun’s condition, ensuring he took his traditional Chinese medicine on time and promptly provided CT scans, ultrasounds, tumor markers, and other relevant tests. At the same time, he supported treatment with Western medicines such as albumin, thymosin, fat emulsions, and compound amino acids.

Traditional Chinese Medicine Proved Remarkable Effectiveness

After one week of taking traditional Chinese medicine, Zhou Xiangchun’s bowel movements decreased from 20 times to 7 times, and the pain in his upper abdomen eased somewhat. Zhang Huifang, following Pei Zhengxue’s advice, observed carefully and responsibly, promptly adjusting the treatment plan based on Zhou Xiangchun’s condition, adjusting his diet accordingly, and taking time to talk with him, offering psychological support and intervention to help him remain confident in his treatment.

After more than five months of treatment, Zhou Xiangchun’s upper abdominal pain had largely disappeared, his appetite had improved, his bowel movements were normal, the pain in his chest and both flanks had completely vanished, the yellowish greasy coating on his tongue had faded, and his bodily functions had basically returned to normal. CT and ultrasound scans revealed that the tumor had shrunk from 4.2 cm × 4.8 cm to 1.8 cm × 1.2 cm, with the shape of the pancreas approaching normal, and the tumor marker CA19-9 had also returned to normal.

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The patient’s condition took a miraculous turn. He repeatedly expressed his gratitude to Old Master Pei and his medical team to the provincial leaders who came to visit him. Liu Weizhong, Director of the Gansu Provincial Health Department, acknowledged in a health system meeting that Pei Zhengxue and his team had played an important role in treating Zhou Xiangchun’s pancreatic cancer.

Although Zhou Xiangchun survived for a year and a half after defeating cancer, he unexpectedly suffered a fall during his recovery at home, resulting in a persistent high fever. Shortly thereafter, he developed a fungal infection that led to kidney failure. Unfortunately, he passed away on August 20, 2011. Yet, with his exquisite medical skills, Pei Zhengxue helped prolong Zhou Xiangchun’s life for a year and a half, allowing him to continue pursuing his experimental plans and make his final contribution to wheat breeding research.

January 10, 2014, Issue No. 4032 of China Journal of Traditional Chinese Medicine

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Professor Pei Zhengxue Discusses Integrated Chinese and Western Medicine Treatment for Lung Cancer

Wang Bo, reporter for Gansu Daily

In recent years, the incidence of lung cancer in China has been steadily rising. Lung cancer has become the leading cause of all cancers, and it is also the leading cause of cancer-related deaths worldwide. Therefore, actively adopting effective prevention and treatment measures has become an urgent priority. Recently, we visited the Gansu Provincial Tumor Hospital to interview Professor Pei Zhengxue, a doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine, Honorary Chairman of the Gansu Provincial Association for Integrated Chinese and Western Medicine, and Chief Expert at the Gansu Provincial Academy of Medical Sciences, about integrated Chinese and Western medicine treatment for lung cancer.

Early symptoms of lung cancer are often atypical, making it difficult for patients to achieve a complete cure. Lung cancer, also known as "primary bronchogenic carcinoma," is a malignant tumor originating in the bronchi and lungs. According to data, 1.6 million new cases of lung cancer occur each year globally, accounting for 13% of all malignant tumors; annually, 1.4 million people die from lung cancer, representing 18% of all cancer-related deaths. Western medicine employs surgical procedures, radiation therapy, and chemotherapy to treat advanced lung cancer, achieving a 5-year survival rate of 70%. However, early-stage lung cancer often presents with few symptoms—more than 75% of patients are diagnosed when the tumor has already spread locally or metastasized, with a 5-year survival rate of less than 5%. In other words, once lung cancer develops, it often spreads extensively, leading to a poor prognosis and making it impossible to achieve a complete cure. Clinical treatment primarily focuses on extending life expectancy. Professor Pei Zhengxue explained that in the 1980s, he was among the first to propose the "16-Character Method"—"Western medicine diagnosis, traditional Chinese medicine diagnosis, traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach." He was praised by Chen Minzhang, then Minister of Health, as the "16-Character Principle." He said, "Western medicine diagnosis" refers to using advanced diagnostic equipment to understand and grasp the common patterns of disease. In the early stages of lung cancer, in addition to relying on clinical symptoms and signs, the use of tumor markers, sputum cytology, percutaneous lung needle biopsy, fiberoptic bronchoscopy, exhaled breath analysis, and various imaging techniques can aid in the definitive diagnosis of lung cancer. Next, "traditional Chinese medicine diagnosis" involves combining the common patterns of disease with individual characteristics to enhance the scientific accuracy of diagnosis. He emphasized that lung cancer falls under the categories of "lung accumulation," "coughing with blood," and "chest oppression" in traditional Chinese medicine, with the underlying cause being deficiency of both qi and yin, while phlegm-dampness and water-fluid retention are considered the external factors. As for "traditional Chinese medicine as the primary treatment, Western medicine as a supplementary approach," this emphasizes the therapeutic role of traditional Chinese medicine formulas. He believed that Western surgery, radiation therapy, and chemotherapy target the pathogenic agents of the disease, capable of killing or inhibiting tumor cells; while traditional Chinese medicine supports the body’s natural defenses and strengthens the body’s ability to respond, greatly reducing the side effects of surgery, radiation therapy, and chemotherapy, thereby enhancing therapeutic efficacy. Professor Pei said that lung cancer treatment should focus primarily on traditional Chinese medicine to support and strengthen the body, while also paying attention to preserving the body’s vital qi and stomach qi. He often used his own developed "Lanzhou Formula," adjusted according to the needs, to boost qi, strengthen the spleen, and nourish the kidneys.

He explained that in February 2010, a 63-year-old patient, Mr. Liu, presented with "intermittent chest tightness, shortness of breath, and cough for one year." After undergoing chest CT scans, bronchoscopy, and other tests, he was diagnosed with "left lung cancer." Doctors recommended surgical treatment, and after taking 10 doses of the "Lanzhou Formula" prior to surgery, his shortness of breath improved. On February 19, 2010, Mr. Liu underwent a left lung resection and total left lung removal under general anesthesia. Following surgery, his chest tightness and shortness of breath eased, though he still felt fatigued and had poor appetite. After taking 14 doses of the "Lanzhou Formula" and "Xiangsha Liujun Tang," his fatigue and poor appetite significantly improved, his chest tightness and shortness of breath eased—but he still experienced coughing. Based on the original formula, he added a dose of millet husk and continued taking it for another 14 doses. By then, his fatigue and poor appetite had disappeared, and he no longer experienced significant chest tightness or shortness of breath. Subsequently, he underwent four cycles of GP chemotherapy, and after repeated adjustments to the "Lanzhou Formula," after taking 20 doses, his gastrointestinal reactions disappeared, and his bone marrow suppression improved. Since then, Mr. Liu continued to take Pei’s Blood-Raising Granules, and he has remained healthy to this day.

The Causes, Pathology, and Early Symptoms of Lung Cancer

From Professor Pei’s perspective, the onset of lung cancer is associated with many factors, including smoking, secondhand smoke, indoor chemical pollution, mental stress, long-term exposure to cooking fumes, insufficient intake of fresh vegetables, and exposure to mineral radiation. From a pathological standpoint, lung cancer is mainly divided into two major types: non-small cell lung cancer, which originates in epithelial cells and is the most common type; and small cell lung cancer, which originates in the nerve or hormone-secreting cells of the lungs. For doctors, it is crucial to learn how to distinguish between small cell and non-small cell lung cancer—after all, the treatment approaches differ. Non-small cell lung cancer is further divided into adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and mixed-type cancers.

Professor Pei Zhengxue believes that in the early stages of lung cancer, most patients experience no symptoms. Some patients may exhibit irritating dry cough, without sputum, or with a small amount of white, viscous sputum. For individuals over 40 who have smoked heavily for a long time, if they experience an irritating dry cough without any obvious triggers, lasting for 2–3 weeks, or if they have pre-existing chronic respiratory diseases with changes in their cough pattern, they should be especially vigilant. Additionally, patients may experience bleeding, often in the form of streaky blood in their sputum or blood in their phlegm. Furthermore, early-stage lung cancer patients often experience mild chest tightness; when the disease affects the parietal pleura or directly invades the chest wall, it may cause persistent pain in that area. All of these symptoms should prompt careful consideration of the possibility of lung cancer. In advanced stages of lung cancer, patients often experience difficulty breathing, facial and neck edema, hoarseness, and weight loss. He said that distant metastases of lung cancer can lead to symptoms in different parts of the body—such as bone pain due to metastasis, or headaches, dizziness, and weakness in one limb due to brain metastasis—and these symptoms should also be given particular attention.

Prevention, Treatment, and Precautions for Lung Cancer

According to Professor Pei Zhengxue, the primary mechanism behind lung cancer development is the depletion of righteous qi, imbalance between yin and yang, and the invasion of harmful factors through weakened defenses. These harmful factors enter the body when the body’s natural defenses are compromised. Therefore, strengthening righteous qi is key. As he put it, “When righteous qi resides within, evil cannot take hold,” where “righteous qi” represents the body’s immune balance; “evil qi” encompasses carcinogenic factors such as smoking, nitrosamine compounds in food, and psychological stress. These carcinogenic factors damage human DNA, disrupt tumor suppressor genes, and activate oncogenes, leading to malignant tumors when the body’s immune monitoring and killing mechanisms are disrupted. To prevent lung cancer and block precancerous lesions, we must first focus on strengthening righteous qi and nourishing the body’s fundamentals, while avoiding carcinogenic factors—such as the ancient practice of “guidance techniques.”

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August 29, 2013, Gansu Daily

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August 7, 2013, Comprehensive News Section of China Traditional Chinese Medicine Newspaper

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Chapter Seventeen: Newspaper Abstract Traditional Chinese Medicine Expert Pei Zhengxue Launches TCM Treatment for Disaster Victims Ren Jinchao, People’s Daily Online

People’s Daily Online, Lanzhou, July 25 (Ren Jinchao) — On July 25, in accordance with the arrangements and directives issued by the Health Department regarding TCM-based treatment for disaster victims, the TCM Management Office and Medical Affairs Office of Lanzhou Second Hospital invited renowned TCM expert Professor Pei Zhengxue to conduct syndrome differentiation and treatment for 19 injured patients admitted to the hospital, prescribing individualized treatment plans for each case.

Accompanied by medical staff from Lanzhou Second Hospital, Professor Pei visited the patients’ bedsides. After conducting necessary TCM examinations—such as observing, listening, inquiring, and palpating—the doctor prescribed Fuyuan Huoxue Decoction combined with Taohong Siwu Decoction for patients with multiple fractures, promoting wound healing and bone regeneration. For patients undergoing trauma surgery, he prescribed Duhuo Jisheng Decoction, Xiangsha Liu Junzi Decoction, and Shiquan Dabu Decoction to replenish vital energy and benefit stomach qi. For postoperative patients, he prescribed Taohong Siwu Decoction and Hualuo Xiaoling Dan to remove blood stasis and promote new tissue formation.

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Pei Zhengxue Clinical Collected Volume Two Pei Zhengxue Builds a High-Rise of TCM Using a Western Medical Framework Wei Qifeng, China Traditional Chinese Medicine Reporter Pei Zhengxue is a physician in the Integrated TCM and Western Medicine Department of Gansu Provincial Cancer Hospital. Born into a family of traditional Chinese medicine practitioners, he was determined from a young age to carry forward his family’s legacy of TCM. His father once encouraged him to pursue Western medicine, saying that the better one’s knowledge of Western medicine, the more effectively he could use Western medical “frameworks” to build a “high-rise” of TCM. On his path of learning, he faced three major hardships in life. Yet these challenges never wavered his original aspirations—he turned adversity into joy and used books as his guiding light. Amidst hardship, he wrote “Commentary on Blood Disorders”; through sustained effort and careful reflection, he created “Lanzhou Formula,” replicating countless stories of saving leukemia patients from death. Following his father’s teachings, Pei Zhengxue dedicated himself to spreading TCM while integrating it with Western medicine. Pei Zhengxue’s grandfather was a scholar during the Qing Dynasty and a renowned physician in his hometown. When his grandfather took the imperial examination for the juren degree, the imperial examination system was abolished. Thus, he devoted himself to studying medicine, accumulating extensive medical experience. After Pei Zhengxue’s grandfather passed away, his father inherited the family’s medical traditions. Through continuous study and practice, he accumulated rich clinical experience and was recognized as one of the ten most famous physicians in Gansu Province. Under his father’s guidance, Pei Zhengxue memorized books such as “Medical Three Character Classic,” “Binhu Pulse Study,” and “A Four Hundred-Ingredient Guide to Medicinal Properties,” mastering the fundamentals of medicine from a young age. Because his father knew very little about Western medicine, he often found himself at a loss when dealing with patients. To help him, his father frequently reminded him that TCM must be combined with modern medicine in order to truly flourish. The better Western medicine is, the deeper TCM can explore. Influenced by his father, Pei Zhengxue embarked on a long journey of learning in the field of integrated TCM and Western medicine.

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Chapter Seventeen: Newspaper Abstract Remembering His Original Aspiration: Developing a Reading Habit Amidst Hardship To fulfill his father’s wish, Pei Zhengxue entered Xi’an Medical College in 1956, where he ranked among the top students and received much attention upon entering the school. However, shortly after, an unfortunate event occurred. In 1958, a nationwide wave of anti-rightist campaigns swept through the country, and his father was labeled as a rightist. Pei Zhengxue was caught up in the campaign and became a target of criticism at school for four months. Though life’s setbacks did not change Pei Zhengxue’s original aspirations, every time he finished a round of criticism, he would pick up a medical text and read, leaving all his hardships behind—this became a lifelong habit. In 1961, Pei Zhengxue completed all of his coursework. With excellent academic performance, he could have stayed at the school after graduation. But misfortune struck again. During the political review process, due to his family’s background and his father’s historical circumstances, he was ultimately assigned to Tianshui Hospital. Pei Zhengxue did not lose heart; during this period, he continued to uphold his ideals of saving lives, pursuing learning, and cultivating himself. However, his misfortunes did not end there—during the Cultural Revolution, Pei Zhengxue was labeled as one of the “Black Five Categories” and was sent to the remote Tianshui Ganquan Health Center.

Facing repeated blows, Pei Zhengxue remained steadfast in his original aspirations. While working at Ganquan Health Center, he would wake up early each day to study “Medical Treatises on Cold and Heat” and “Golden Cabinet Essentials”; at night, he would stay up late, writing “Commentary on Blood Disorders.” Later, after the book was published in Japan, it had a profound impact. In May 1985, Professor Tian Rongyi, President of Shizuoka University of Medicine in Japan, traveled to Lanzhou specifically to consult Pei Zhengxue about issues related to the book.

Saving Lives: Building a “Lanzhou Formula” Through Accumulation and Refinement In 1967, Pei Zhengxue, who was working in the internal medicine department of a hospital in Tianshui, treated a patient named Ma Changsheng. Ma Changsheng was a 16-year-old soldier diagnosed with acute monocytic leukemia by professors at Lanzhou Medical College. Despite being treated with full efforts at both military hospitals and local hospitals, his condition did not improve—it was actually worsening, and his hemoglobin had dropped to just 1 gram. Already despairing, Ma Changsheng only hoped to return to his hometown in Tianshui to bid farewell to his family. When Ma Changsheng returned home, his parents did not give up hope and sought Pei Zhengxue’s help, holding onto a glimmer of hope. At that time, the primary treatment for leukemia both domestically and internationally was chemotherapy—but its toxic side effects were quite obvious. Pei Zhengxue used TCM’s syndrome differentiation and the combination of TCM and Western medicine to develop a treatment plan for Ma Changsheng.

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Pei Zhengxue Clinical Collected Volume Two After one month of medication, Ma Changsheng’s high fever subsided, and after taking over 100 doses of Chinese herbal medicine, a miracle occurred. One year later, Ma Changsheng’s hemoglobin had increased to 14 grams, and multiple bone marrow smear tests all showed complete remission. He had completely come back from the brink of death. In 1973, at the National Hematology Conference held in Suzhou, conference chairman Chen Yue-shu specially invited Ma Changsheng to Suzhou, where experts from across the country re-examined him. They discovered that Ma Changsheng was no different from a healthy person, astonishing the experts present. The conference ultimately named the case’s main formula “Lanzhou Formula,” which has been widely promoted and used in hospitals across China for many years, with remarkable therapeutic effects. Moreover, Ma Changsheng is still alive today. Over the long course of time, after the 1990s, Pei Zhengxue proposed the “16-Character Principle”—Western diagnosis, TCM syndrome differentiation, Chinese medicine as the primary treatment, Western medicine as a supplementary approach—widely recognized by Chinese and Western medicine communities nationwide, and the “Pei School” became an important school of thought in the field of TCM and Western medicine today. Miraculous Remedies and Stories of Saving Lives That Can Be Replicated In 1970, Pei Zhengxue was sent to the Ganquan Commune Health Center in Tianshui. One day, Chen Zhengyuan, the station manager of Qin’an County Bus Station, came to Pei Zhengxue seeking treatment. After examination, it was discovered that Chen Zhengyuan suffered from chronic nephritis and renal failure, with proteinuria reaching 3+ levels and non-protein nitrogen exceeding 70%, leading to end-stage uremia. From a Western medical perspective, the patient was destined to die. However, Pei Zhengxue did not give up on Chen Zhengyuan; he prescribed a formula for him and instructed him to go home and continue taking the medicine. After taking more than 300 doses of medicine that year, Chen Zhengyuan not only survived but also grew stronger with each dose.

In 2000, Liu Li-gang, a student at Lanzhou University, unfortunately developed acute lymphoblastic leukemia. After undergoing chemotherapy, her treatment yielded little success. Later, she found Pei Zhengxue at the Gansu Provincial Cancer Hospital. To save this young man’s life, Pei Zhengxue used his own developed “Pei’s Blood-Raising Granules.” He then prescribed a traditional Chinese medicine formula and prepared some pills for her to take regularly. Soon, Liu Li-gang not only did not need to undergo chemotherapy, but her indicators also returned to normal, allowing her to return to school and continue her studies.

Personnel Links Pei Zhengxue, born in Wushan County, Gansu Province, in 1938, came from a family with three generations of medical expertise. He graduated from the Medical Department of Xi’an Medical College in 1961. He is a chief physician, professor, doctoral supervisor, a renowned Chinese-TCM expert, recipient of a special government allowance, and one of the fourth group of national veteran TCM physicians.

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He is also a mentor guiding the academic experience of inheriting the professional knowledge of TCM.

Friday, November 21, 2014, China Traditional Chinese Medicine Newspaper

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This chapter is prepared for online research and reading; for external materials, please align with original publications and the review process.