3.2 Effects of Pei’s Shengxue Granules on the immune organs—thymus and spleen—in tumor-bearing mice

3.2 Effects of Pei’s Shengxue Granules on the immune organs—thymus and spleen—in tumor-bearing mice

The results show that in the tumor-bearing model group, the thymus and spleen of the mice shrank in size and weight, with some thymuses showing unclear lobulation and a grayish-white color, while the spleens turned a lighter red. In contrast, the thymus index of mice in all PG dosage groups was higher than that of the model group, with the large- and medium-dose groups having thymus indices of 36.0 mg/10 g and 35.2 mg/10 g respectively, representing increases of 29.0% and 26.2% compared with the model group, which were highly significant (P<0.01) and significant (P<0.05) respectively. The spleen index of mice in all PG dosage groups was also higher than that of the model group, with the large-dose group having a spleen index of 64.4 mg/10 g, a 20.4% increase compared with the model group, which was highly significant (P<0.01). There was no significant difference between the various PG dosage groups and the ZG group (P>0.05). See Table 2, Figure 2, and Figure 3.

Table 2: Effects of Pei’s Shengxue Granules on the thymus and spleen indices of tumor-bearing mice (n=11, x̄±S)

Note: Compared with Con: *P<0.05, **P<0.01

Figure 2: Effect of Pei’s Shengxue Granules on the growth rate of the thymus index in tumor-bearing mice (n=11, x̄±S)

Figure 3: Effect of Pei’s Shengxue Granules on the growth rate of the spleen index in tumor-bearing mice (n=11, x̄±S)

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