Keywords：方药研究, 实验研究, 配方资产, 转化沟通, 3.1 裴氏升血颗粒对荷瘤小鼠5-Fu化疗减毒的影响
Section Index
3.3 Effects of Pei’s Shengxue Granules Combined with 5-Fu on Peripheral Blood Parameters in Tumor-Bearing Mice
As shown in Table 2, there were no significant differences in peripheral blood WBC, RBC, HGB, and PLT values between the normal group and the model group. However, all treatment groups had lower values than the model group, with the 5-Fu group showing statistically significant differences compared with the model group (P<0.05). In the low-, medium-, and high-dose Pei’s Shengxue Granules combined with 5-Fu groups, the WBC values increased significantly, with statistically significant differences compared with the 5-Fu group (P<0.05). Similarly, the PLT values also increased significantly in the low-, medium-, and high-dose Pei’s Shengxue Granules combined with 5-Fu groups, with the medium- and high-dose groups showing statistically significant differences compared with the 5-Fu group (P<0.05). The RBC and HGB numbers in the low-, medium-, and high-dose Pei’s Shengxue Granules combined with 5-Fu groups also increased, but there were no statistically significant differences compared with the 5-Fu group (P>0.05). See Table 2, Figures 2, 3, 4, and 5 for details.
Table 2: Effects of Pei’s Shengxue Granules Combined with 5-Fu on Blood Counts in Tumor-Bearing Mice (n=10, x̄±s)
| Group | Dosage (g·kg⁻¹) | WBC (10⁹/L) | RBC (10¹²/L) | HGB (g/L) | PLT (10⁹/L) |
|---|---|---|---|---|---|
| Normal Group | — | 10.8±2.1 | 8.33±0.72 | 149±9 | 917±94 |
| Model Group | — | 11.6±2.2 | 7.83±1.03 | 144±17 | 895±100 |
| 5-Fu Group | 0.02 | 3.7±0.7* | 5.96±1.00* | 111±15* | 517±106* |
| Low-Dose Pei’s Shengxue Granules + 5-Fu | 2.5+0.02 | 5.2±1.2△ | 6.06±1.05 | 113±5 | 698±124 |
| Medium-Dose Pei’s Shengxue Granules + 5-Fu | 5.0+0.02 | 6.2±0.8△ | 6.30±0.99 | 119±10 | 723±114△ |
| High-Dose Pei’s Shengxue Granules + 5-Fu | 10.0+0.02 | 5.5±1.4△ | 6.09±0.67 | 118±6 | 714±118△ |
Note: *P<0.05 compared with the model group, △P<0.05 compared with the 5-Fu group
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