Keywords：方药研究, 实验研究, 配方资产, 转化沟通, 1 裴氏升血颗粒抗肿瘤的作用机制
Section Index
3.4 Effects of Pei’s Shengxue Granules Combined with 5-Fu on Bone Marrow DNA Content in Tumor-Bearing Mice
As shown in Table 3, there was no significant difference in bone marrow DNA content between the normal group and the model group (P>0.05); however, the bone marrow DNA content in the 5-Fu group was significantly lower, with statistically significant differences compared with the model group (P<0.05). In the high- and medium-dose Pei’s Shengxue Granules combined with 5-Fu groups, the bone marrow DNA content increased, with the high- and medium-dose groups showing statistically significant differences compared with the 5-Fu group (P<0.05). See Table 3 and Figure 6 for details.
Table 3: Effects of Pei’s Shengxue Granules Combined with 5-Fu on Bone Marrow DNA Content in Tumor-Bearing Mice (n=10, x̄±s)
| Group | Dosage (g·kg⁻¹) | Bone Marrow DNA Content (OD Value) |
|---|---|---|
| Normal Group | — | 0.278±0.099 |
| Model Group | — | 0.263±0.092 |
| 5-Fu Group | 0.02 | 0.119±0.070* |
| Low-Dose Pei’s Shengxue Granules + 5-Fu | 2.5+0.02 | 0.166±0.075 |
| Medium-Dose Pei’s Shengxue Granules + 5-Fu | 5.0+0.02 | 0.388±0.101△ |
| High-Dose Pei’s Shengxue Granules + 5-Fu | 10.0+0.02 | 0.347±0.104△ |
(*P<0.05 compared with the model group, △P<0.05 compared with the 5-Fu group)
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