2 Methods

2 Methods

2.1 Clinical Data

2.1.1 Case Selection

Cases meeting the following diagnostic and staging criteria are included:

2.1.1.1 Diagnostic criteria for the chronic phase (CP):

• No obvious clinical symptoms: or mild manifestations such as fatigue, low-grade fever, excessive sweating, and weight loss;
• Blood parameters: elevated white blood cell count, predominantly neutrophils in the middle and late stages of maturation and band neutrophils, with blasts (type I + type II) less than 5%–10%, increased eosinophils and basophils, and occasional nucleated red blood cells;
• Bone marrow findings: marked to extreme hyperplasia, predominantly granulocytic lineage, with middle and late-stage neutrophils and band neutrophils.

Research on Pei's series of formulas and medications

Increased cell count, with blasts (type I + type II) less than 10%; 2.1.1.1.4 Presence of the Ph chromosome; 2.1.1.1.5 CFU-GM culture: colonies or clusters significantly increased compared with normal.