中文摘要

4.1

One week after modeling in mice, the Hb, RBC, and PLT levels in the model group decreased significantly compared with the normal group (p<0.05 or p<0.01). However, no significant decrease was observed in red blood cells, suggesting that external factors only inhibited bone marrow function, affecting early cell proliferation and division. Since mature red blood cells have a relatively long lifespan, their numbers did not show a downward trend in the short term. Similarly, throughout the experiment, the increase in red blood cells after drug administration was also insignificant, likely due to the same reasons mentioned above. After 20 days of medication, blood analysis showed that blood cell counts in all treatment groups increased to varying degrees. However, after 40 days, the high-dose Peishengxue Granule group not only failed to see an increase in HB and WBC levels but actually experienced a decline, possibly due to excessive dosage of traditional Chinese medicine, which may have caused certain toxic side effects. Additionally, excessive use of traditional Chinese medicine can affect gastrointestinal function in mice, thereby disrupting normal physiological functions throughout the body. Therefore, it is crucial to carefully control the dosage of traditional Chinese medicine in clinical practice. Furthermore, most of the PLT values measured at 40 days were 999×10⁹/L, because the maximum PLT value displayed by the Japanese Jitai CA-800 three-class blood analyzer (Department of Laboratory Medicine, Qilihe District People’s Hospital, Lanzhou City) is 999×10⁹/L, while the PLT count in mice is 100–300 times higher than in humans. Thus, the final PLT value for mice could not be accurately measured or statistically analyzed. Nevertheless, examining the three blood analyses reveals that PLT levels in all medication groups showed an increasing trend.