4.6.2 Pei’s Soft Liver and Anti-Bloating Pill Inhibits Bcl-2 Expression in Tumor Tissue of Tumor-Bearing Mice

4.6.2 Pei’s Soft Liver and Anti-Bloating Pill Inhibits Bcl-2 Expression in Tumor Tissue of Tumor-Bearing Mice

Apoptosis was first proposed by Kerr et al. in 1972 as a morphological concept and remains a research hotspot in the medical community today. Apoptosis refers to an inherent form of cell death during normal organ development and tissue homeostasis, serving as one of the body’s important ways to maintain a relatively constant number of cells, also known as programmed cell death (PCD). Bcl-2 is one of the important regulatory proteins in the apoptosis family, consisting of three exons and one intron, encoding a protein molecule weighing 26 KD, composed of 229 amino acid residues and functioning as a membrane-associated protein. Bcl-2’s main function is to inhibit cell apoptosis rather than affect cell proliferation, thereby extending cell life and playing an important role in apoptosis regulation.

The experimental results show that the positive expression of Bcl-2 in tumor tissue of the low-, medium-, and high-dose groups of PR-GXP, as well as the BM group, was lower than that of the model control group, all statistically significant compared with the model control group (P<0.05). The medium-dose group’s Bcl-2 expression in tumor tissue was lower than that of the BM group, statistically significant compared with the BM group (P<0.05). Pei’s Soft Liver and Anti-Bloating Pill may reduce Bcl-2 expression, possibly one of the mechanisms by which it promotes liver cancer tissue apoptosis.

This experiment initially tested the expression of P27 and Bcl-2 proteins, with other genes related to cell proliferation and apoptosis yet to be further studied.

Conclusion